AutismKB 2.0

Annotation Detail for FUS


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Basic Information Top
Gene Symbol:FUS ( ALS6,FUS1,HNRNPP2,POMP75,TLS )
Gene Full Name: fused in sarcoma
Band: 16p11.2
Quick LinksEntrez ID:2521; OMIM: 137070; Uniprot ID:FUS_HUMAN; ENSEMBL ID: ENSG00000089280; HGNC ID: 4010
Relate to Another Database: SFARIGene; denovo-db
Unigene EST Top
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
embryoid body42 / 70761593
blastocyst64 / 623191026
fetus115 / 564012203
neonate7 / 31097225
infant23 / 23620973
juvenile35 / 55556629
adult464 / 1939121239
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adrenal tumor2 / 12794156
bladder carcinoma2 / 17475114
breast (mammary gland) tumor34 / 94178361
cervical tumor17 / 34366494
chondrosarcoma10 / 82823120
colorectal tumor30 / 114246262
esophageal tumor8 / 17290462
gastrointestinal tumor43 / 119369360
germ cell tumor97 / 263845367
glioma25 / 106883233
head and neck tumor40 / 136302293
kidney tumor33 / 68959478
leukemia18 / 95842187
liver tumor17 / 96359176
lung tumor48 / 103127465
lymphoma50 / 71755696
non-neoplasia28 / 97250287
normal857 / 3360307255
ovarian tumor22 / 76682286
pancreatic tumor13 / 104616124
primitive neuroectodermal tumor of the CNS104 / 125680827
prostate cancer11 / 102680107
retinoblastoma21 / 46356453
skin tumor43 / 124949344
soft tissue/muscle tissue tumor30 / 125191239
uterine tumor32 / 90257354
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adipose tissue1 / 1310676
adrenal gland3 / 3319790
ascites18 / 40015449
bladder8 / 29757268
blood25 / 123478202
bone12 / 71655167
bone marrow2 / 4880140
brain336 / 1100989305
cervix21 / 48171435
connective tissue23 / 149255154
ear1 / 1621261
embryonic tissue163 / 215722755
esophagus8 / 20209395
eye48 / 211054227
heart32 / 89626357
intestine76 / 234472324
kidney66 / 211777311
larynx6 / 24145248
liver34 / 207743163
lung76 / 336974225
lymph36 / 44270813
lymph node19 / 91610207
mammary gland39 / 153271254
mouth7 / 67052104
muscle17 / 107715157
nerve6 / 15768380
ovary38 / 102051372
pancreas23 / 214812107
parathyroid2 / 2053997
pharynx0 / 413280 
pituitary gland0 / 165850 
placenta65 / 280825231
prostate22 / 189345116
salivary gland7 / 20155347
skin55 / 210574261
spleen19 / 53952352
stomach28 / 96619289
testis73 / 330442220
thymus26 / 81131320
thyroid23 / 47473484
tonsil0 / 169990 
trachea2 / 5241338
umbilical cord4 / 13680292
uterus84 / 232878360
vascular8 / 51780154
Microarray in BioGPS Top
Select probe  
  • Microarray Platform: GeneAtlas U133A, gcrma
  • Affymatrix Probe ID: 217370_x_at
Cell line Expression level Expression bar
721_B_lymphoblasts320.85
Adipocyte26.3
AdrenalCortex28.8
Adrenalgland26
Amygdala66.05
Appendix22.85
AtrioventricularNode21.6
BDCA4+_DentriticCells173
Bonemarrow28.7
BronchialEpithelialCells49.35
CD105+_Endothelial94.55
CD14+_Monocytes33.3
CD19+_BCells(neg._sel.)65.4
CD33+_Myeloid62.2
CD34+128.6
CD4+_Tcells262.3
CD56+_NKCells61.05
CD71+_EarlyErythroid45.05
CD8+_Tcells156.5
CardiacMyocytes81.8
Caudatenucleus27.4
Cerebellum50.35
CerebellumPeduncles64.8
CiliaryGanglion16.75
CingulateCortex30.25
Colorectaladenocarcinoma54.75
DorsalRootGanglion20.05
FetalThyroid18.6
Fetalbrain31.55
Fetalliver23.1
Fetallung20.4
GlobusPallidus22.7
Heart29.2
Hypothalamus33.45
Kidney28.2
Leukemia_chronicMyelogenousK-56238.4
Leukemia_promyelocytic-HL-6037.7
Leukemialymphoblastic(MOLT-4)29.85
Liver34.4
Lung53.8
Lymphnode28.6
Lymphoma_burkitts(Daudi)35.25
Lymphoma_burkitts(Raji)71.25
MedullaOblongata28.45
OccipitalLobe18.8
OlfactoryBulb19.8
Ovary24.1
Pancreas21.5
PancreaticIslet41.2
ParietalLobe26.4
Pituitary54.3
Placenta46.5
Pons27.65
PrefrontalCortex34.2
Prostate37.7
Salivarygland19.3
SkeletalMuscle26.6
Skin16.3
SmoothMuscle58.8
Spinalcord30.6
SubthalamicNucleus25.45
SuperiorCervicalGanglion26.8
TemporalLobe25.45
Testis27.9
TestisGermCell26.2
TestisIntersitial24.1
TestisLeydigCell25.65
TestisSeminiferousTubule28.95
Thalamus27.6
Thymus92.55
Thyroid91.6
Tongue24.25
Tonsil32.5
Trachea33.4
TrigeminalGanglion23.3
Uterus49.2
UterusCorpus21.5
WholeBlood30.65
Wholebrain34.15
colon68.25
pineal_day62.98
pineal_night59.32
retina35.2
small_intestine71.6
Allen Brain Atlas Top
Human Whole Brain Microarrayview in Allen Brain Atlas
  • Probe id     Donor id      
  • Probe name: CUST_15655_PI416261804
  • Donor H0351.2001
  • Sex: Male     Age: 24 years     Race/Ethnicity: African American     Handedness: Left
  • Tissue Receipt Date: 7/29/2009     Serology: Pass      Tissue pH :6.72     Additional Medical Information :History of asthma
  • Postmortem Interval: 23 hours (estimated time of death to time that tissue is frozen)
  • Toxicology: Positive for atropine and caffeine, at levels usually not toxicologically significant
Tissue Expression(mean ± stddev) Expression Bar
Amygdala9.73 ± 0.11
Basal Forebrain9.65 ± 0.04
Basal Part of Pons9.7 ± 0.26
Cerebellar Cortex9.92 ± 0.14
Cerebellar Nuclei9.64 ± 0.19
Claustrum9.59 ± 0.32
Epithalamus9.39 ± 0.29
Frontal Lobe9.57 ± 0.24
Globus Pallidus9.66 ± 0.29
Hypothalamus9.51 ± 0.16
Insula9.63 ± 0.21
Limbic Lobe9.7 ± 0.27
Mesencephalon9.56 ± 0.22
Myelencephalon9.61 ± 0.19
Occipital Lobe9.82 ± 0.24
Parietal Lobe9.6 ± 0.23
Pontine Tegmentum9.61 ± 0.25
Striatum9.71 ± 0.35
Subthalamus9.46 ± 0.13
Temporal Lobe9.62 ± 0.24
Thalamus9.64 ± 0.22
White Matter10.15 ± 0.1
Mouse Brain ISH
Gene Symbol Brain Structure ID Brain Structure Name Express Desity/Level (Meatured by ISH) Express Bar
FusCBCerebellum100
100
FusCTXCerebral cortex100
100
FusHIPHippocampal region100
100
FusHPFHippocampal formation100
100
FusHYHypothalamus100
100
FusLSXLateral septal complex100
100
FusMBMidbrain100
100
FusMYMedulla100
100
FusOLFOlfactory bulb100
100
FusPPons100
100
FusPALPallidum100
100
FusRHPRetrohippocampal region100
100
FussAMYStriatum-like amygdalar nuclei100
100
FusSTRStriatum100
100
FusSTRdStriatum dorsal region100
100
FusSTRvStriatum ventral region100
100
FusTHThalamus100
100
Peptide Top
Peptide Name Peptide Lengh Peptide Start Peptide End Peptide Sequence Source
FUS_HUMAN_317 12 317 328 TGQPMINLYTDR PRIDE
FUS_HUMAN_332 16 332 347 LKGEATVSFDDPPSAK PRIDE
FUS_HUMAN_356 16 356 371 GKEFSGNPIKVSFATR PRIDE
FUS_HUMAN_448 24 448 471 APKPDGPGGGPGGSHMGGNYGDDR PRIDE
PAp00001272 14 428 441 CPNPTCENMNFSWR Peptide Atlas

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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