AutismKB 2.0

Annotation Detail for FYB


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Basic Information Top
Gene Symbol:FYB ( ADAP,PRO0823,SLAP-130 )
Gene Full Name: FYN binding protein
Band: 5p13.1
Quick LinksEntrez ID:2533; OMIM: 602731; Uniprot ID:FYB_HUMAN; ENSEMBL ID: ENSG00000082074; HGNC ID:
Relate to Another Database: SFARIGene; denovo-db
Unigene EST Top
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
embryoid body0 / 707610 
blastocyst0 / 623190 
fetus34 / 56401260
neonate3 / 3109796
infant0 / 236200 
juvenile3 / 5555653
adult63 / 193912132
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adrenal tumor1 / 1279478
bladder carcinoma0 / 174750 
breast (mammary gland) tumor0 / 941780 
cervical tumor0 / 343660 
chondrosarcoma5 / 8282360
colorectal tumor0 / 1142460 
esophageal tumor0 / 172900 
gastrointestinal tumor2 / 11936916
germ cell tumor13 / 26384549
glioma2 / 10688318
head and neck tumor3 / 13630222
kidney tumor1 / 6895914
leukemia8 / 9584283
liver tumor0 / 963590 
lung tumor0 / 1031270 
lymphoma3 / 7175541
non-neoplasia6 / 9725061
normal143 / 336030742
ovarian tumor4 / 7668252
pancreatic tumor1 / 1046169
primitive neuroectodermal tumor of the CNS0 / 1256800 
prostate cancer0 / 1026800 
retinoblastoma0 / 463560 
skin tumor3 / 12494924
soft tissue/muscle tissue tumor3 / 12519123
uterine tumor5 / 9025755
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adipose tissue0 / 131060 
adrenal gland1 / 3319730
ascites0 / 400150 
bladder0 / 297570 
blood32 / 123478259
bone0 / 716550 
bone marrow9 / 48801184
brain19 / 110098917
cervix0 / 481710 
connective tissue11 / 14925573
ear0 / 162120 
embryonic tissue0 / 2157220 
esophagus0 / 202090 
eye4 / 21105418
heart6 / 8962666
intestine6 / 23447225
kidney5 / 21177723
larynx0 / 241450 
liver1 / 2077434
lung9 / 33697426
lymph0 / 442700 
lymph node7 / 9161076
mammary gland4 / 15327126
mouth2 / 6705229
muscle1 / 1077159
nerve0 / 157680 
ovary4 / 10205139
pancreas1 / 2148124
parathyroid0 / 205390 
pharynx15 / 41328362
pituitary gland0 / 165850 
placenta10 / 28082535
prostate1 / 1893455
salivary gland1 / 2015549
skin4 / 21057418
spleen14 / 53952259
stomach6 / 9661962
testis1 / 3304423
thymus27 / 81131332
thyroid3 / 4747363
tonsil1 / 1699958
trachea1 / 5241319
umbilical cord0 / 136800 
uterus6 / 23287825
vascular1 / 5178019
Microarray in BioGPS Top
Select probe  
  • Microarray Platform: GeneAtlas U133A, gcrma
  • Affymatrix Probe ID: 205285_s_at
Cell line Expression level Expression bar
721_B_lymphoblasts10.3
Adipocyte10.25
AdrenalCortex13.7
Adrenalgland9.7
Amygdala10.2
Appendix13.95
AtrioventricularNode10.6
BDCA4+_DentriticCells18.9
Bonemarrow20
BronchialEpithelialCells9.2
CD105+_Endothelial10.1
CD14+_Monocytes64.2
CD19+_BCells(neg._sel.)10.35
CD33+_Myeloid73.95
CD34+11.2
CD4+_Tcells136.45
CD56+_NKCells53.6
CD71+_EarlyErythroid10.1
CD8+_Tcells82.9
CardiacMyocytes15.8
Caudatenucleus9.45
Cerebellum8.85
CerebellumPeduncles13.2
CiliaryGanglion9.2
CingulateCortex10.95
Colorectaladenocarcinoma9.85
DorsalRootGanglion10
FetalThyroid10.35
Fetalbrain10.15
Fetalliver9.85
Fetallung7.65
GlobusPallidus8.65
Heart14.95
Hypothalamus9.9
Kidney9.95
Leukemia_chronicMyelogenousK-5629.65
Leukemia_promyelocytic-HL-609.65
Leukemialymphoblastic(MOLT-4)14.65
Liver17.75
Lung11.25
Lymphnode10.4
Lymphoma_burkitts(Daudi)14.2
Lymphoma_burkitts(Raji)18.65
MedullaOblongata11.55
OccipitalLobe8.95
OlfactoryBulb8.15
Ovary7.6
Pancreas8.5
PancreaticIslet11.25
ParietalLobe12.6
Pituitary12.35
Placenta10.85
Pons10.45
PrefrontalCortex11.2
Prostate11.35
Salivarygland9.55
SkeletalMuscle17.8
Skin9.65
SmoothMuscle11.2
Spinalcord11.35
SubthalamicNucleus10.4
SuperiorCervicalGanglion25.3
TemporalLobe11.25
Testis8.85
TestisGermCell8.65
TestisIntersitial8.95
TestisLeydigCell12.15
TestisSeminiferousTubule8.95
Thalamus10.95
Thymus46.95
Thyroid11.85
Tongue13.35
Tonsil19.75
Trachea8.8
TrigeminalGanglion12.15
Uterus8.8
UterusCorpus11.75
WholeBlood54.7
Wholebrain8.2
colon10.35
pineal_day13.68
pineal_night12.54
retina12.375
small_intestine9.65
Allen Brain Atlas Top
Human Whole Brain Microarrayview in Allen Brain Atlas
  • Probe id     Donor id      
  • Probe name: A_23_P122127
  • Donor H0351.2001
  • Sex: Male     Age: 24 years     Race/Ethnicity: African American     Handedness: Left
  • Tissue Receipt Date: 7/29/2009     Serology: Pass      Tissue pH :6.72     Additional Medical Information :History of asthma
  • Postmortem Interval: 23 hours (estimated time of death to time that tissue is frozen)
  • Toxicology: Positive for atropine and caffeine, at levels usually not toxicologically significant
Tissue Expression(mean ± stddev) Expression Bar
Amygdala5.52 ± 0.53
Basal Forebrain5.61 ± 0.39
Basal Part of Pons6.29 ± 0.34
Cerebellar Cortex5.02 ± 0.4
Cerebellar Nuclei6.75 ± 0.33
Claustrum5.45 ± 0.55
Epithalamus6.82 ± 0.52
Frontal Lobe5.49 ± 0.65
Globus Pallidus7.31 ± 0.38
Hypothalamus5.7 ± 1.13
Insula5.71 ± 0.47
Limbic Lobe5.4 ± 0.59
Mesencephalon5.56 ± 0.7
Myelencephalon5.65 ± 0.6
Occipital Lobe4.99 ± 0.47
Parietal Lobe5.51 ± 0.61
Pontine Tegmentum5.34 ± 0.57
Striatum6.04 ± 0.43
Subthalamus6.4 ± 0.27
Temporal Lobe5.63 ± 0.55
Thalamus5.59 ± 0.5
White Matter6.94 ± 0.63
Mouse Brain ISH
Gene Symbol Brain Structure ID Brain Structure Name Express Desity/Level (Meatured by ISH) Express Bar
FybCBCerebellum100
100
FybCTXCerebral cortex100
100
FybHIPHippocampal region93.76
100
FybHPFHippocampal formation100
100
FybHYHypothalamus100
100
FybLSXLateral septal complex100
100
FybMBMidbrain92.58
94.64
FybMYMedulla97.37
100
FybOLFOlfactory bulb100
100
FybPPons74.25
83.58
FybPALPallidum99.29
100
FybRHPRetrohippocampal region100
100
FybsAMYStriatum-like amygdalar nuclei100
100
FybSTRStriatum100
100
FybSTRdStriatum dorsal region100
100
FybSTRvStriatum ventral region100
100
FybTHThalamus100
100
Peptide Top
Peptide Name Peptide Lengh Peptide Start Peptide End Peptide Sequence Source
PAp00033126 20 781 800 DLQVKPGESLEVIQTTDDTK Peptide Atlas

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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