Annotation Detail for FYN
Basic Information Top
| Gene Symbol: | FYN ( MGC45350,SLK,SYN ) |
|---|---|
| Gene Full Name: | FYN oncogene related to SRC, FGR, YES |
| Band: | 6q21 |
| Quick Links | Entrez ID:2534; OMIM: 137025; Uniprot ID:FYN_HUMAN; ENSEMBL ID: ENSG00000010810; HGNC ID: 4037 |
| Relate to Another Database: | SFARIGene; denovo-db |
- Unigene ID: Hs.390567
| Pool Name | Gene EST/Total EST in pool | Transcripts per million(TPM) | Bar based on TPM |
|---|---|---|---|
 | |||
| embryoid body | 7 / 70761 | 98 |  |
| blastocyst | 6 / 62319 | 96 | |
| fetus | 74 / 564012 | 131 | |
| neonate | 0 / 31097 | 0 | |
| infant | 2 / 23620 | 84 | |
| juvenile | 2 / 55556 | 35 |  |
| adult | 97 / 1939121 | 50 | |
| Pool Name | Gene EST/Total EST in pool | Transcripts per million(TPM) | Bar based on TPM |
|---|---|---|---|
| |||
| adrenal tumor | 0 / 12794 | 0 | |
| bladder carcinoma | 0 / 17475 | 0 | |
| breast (mammary gland) tumor | 3 / 94178 | 31 | |
| cervical tumor | 1 / 34366 | 29 | |
| chondrosarcoma | 4 / 82823 | 48 | |
| colorectal tumor | 2 / 114246 | 17 | |
| esophageal tumor | 0 / 17290 | 0 | |
| gastrointestinal tumor | 7 / 119369 | 58 | |
| germ cell tumor | 7 / 263845 | 26 | |
| glioma | 10 / 106883 | 93 | |
| head and neck tumor | 14 / 136302 | 102 | |
| kidney tumor | 4 / 68959 | 58 | |
| leukemia | 5 / 95842 | 52 | |
| liver tumor | 3 / 96359 | 31 | |
| lung tumor | 3 / 103127 | 29 | |
| lymphoma | 3 / 71755 | 41 | |
| non-neoplasia | 9 / 97250 | 92 | |
| normal | 264 / 3360307 | 78 | |
| ovarian tumor | 2 / 76682 | 26 | |
| pancreatic tumor | 4 / 104616 | 38 | |
| primitive neuroectodermal tumor of the CNS | 9 / 125680 | 71 | |
| prostate cancer | 0 / 102680 | 0 | |
| retinoblastoma | 0 / 46356 | 0 | |
| skin tumor | 9 / 124949 | 72 | |
| soft tissue/muscle tissue tumor | 3 / 125191 | 23 | |
| uterine tumor | 5 / 90257 | 55 | |
| Pool Name | Gene EST/Total EST in pool | Transcripts per million(TPM) | Bar based on TPM |
|---|---|---|---|
| |||
| adipose tissue | 3 / 13106 | 228 |  |
| adrenal gland | 0 / 33197 | 0 | |
| ascites | 0 / 40015 | 0 | |
| bladder | 0 / 29757 | 0 | |
| blood | 8 / 123478 | 64 | |
| bone | 5 / 71655 | 69 | |
| bone marrow | 0 / 48801 | 0 | |
| brain | 89 / 1100989 | 80 | |
| cervix | 2 / 48171 | 41 | |
| connective tissue | 5 / 149255 | 33 | |
| ear | 0 / 16212 | 0 | |
| embryonic tissue | 26 / 215722 | 120 | |
| esophagus | 0 / 20209 | 0 | |
| eye | 18 / 211054 | 85 | |
| heart | 6 / 89626 | 66 | |
| intestine | 11 / 234472 | 46 | |
| kidney | 10 / 211777 | 47 | |
| larynx | 2 / 24145 | 82 | |
| liver | 7 / 207743 | 33 | |
| lung | 16 / 336974 | 47 | |
| lymph | 1 / 44270 | 22 | |
| lymph node | 8 / 91610 | 87 | |
| mammary gland | 5 / 153271 | 32 | |
| mouth | 4 / 67052 | 59 | |
| muscle | 5 / 107715 | 46 | |
| nerve | 3 / 15768 | 190 | |
| ovary | 5 / 102051 | 48 | |
| pancreas | 7 / 214812 | 32 | |
| parathyroid | 0 / 20539 | 0 | |
| pharynx | 6 / 41328 | 145 | |
| pituitary gland | 1 / 16585 | 60 | |
| placenta | 6 / 280825 | 21 | |
| prostate | 2 / 189345 | 10 |  |
| salivary gland | 0 / 20155 | 0 | |
| skin | 18 / 210574 | 85 | |
| spleen | 12 / 53952 | 222 | |
| stomach | 8 / 96619 | 82 | |
| testis | 4 / 330442 | 12 | |
| thymus | 12 / 81131 | 147 | |
| thyroid | 14 / 47473 | 294 | |
| tonsil | 1 / 16999 | 58 | |
| trachea | 1 / 52413 | 19 | |
| umbilical cord | 0 / 13680 | 0 | |
| uterus | 10 / 232878 | 42 | |
| vascular | 2 / 51780 | 38 | |
- Microarray Platform: GeneAtlas U133A, gcrma
- Affymatrix Probe ID: 212486_s_at
| Cell line | Expression level | Expression bar |
|---|---|---|
| ||
| 721_B_lymphoblasts | 12.15 | |
| Adipocyte | 10.25 | |
| AdrenalCortex | 10.8 | |
| Adrenalgland | 8.65 | |
| Amygdala | 61.85 | |
| Appendix | 10.8 | |
| AtrioventricularNode | 8.95 | |
| BDCA4+_DentriticCells | 12.55 | |
| Bonemarrow | 10.05 | |
| BronchialEpithelialCells | 9.6 | |
| CD105+_Endothelial | 7.35 | |
| CD14+_Monocytes | 16.9 | |
| CD19+_BCells(neg._sel.) | 8.8 | |
| CD33+_Myeloid | 12.5 | |
| CD34+ | 10.2 | |
| CD4+_Tcells | 81.65 | |
| CD56+_NKCells | 131.75 | |
| CD71+_EarlyErythroid | 9.15 | |
| CD8+_Tcells | 98 | |
| CardiacMyocytes | 13.55 | |
| Caudatenucleus | 12.7 | |
| Cerebellum | 43.15 | |
| CerebellumPeduncles | 35.15 | |
| CiliaryGanglion | 8 | |
| CingulateCortex | 10.8 | |
| Colorectaladenocarcinoma | 9.9 | |
| DorsalRootGanglion | 8.5 | |
| FetalThyroid | 9.95 | |
| Fetalbrain | 36.85 | |
| Fetalliver | 8.6 | |
| Fetallung | 8.1 | |
| GlobusPallidus | 8.2 | |
| Heart | 13.3 | |
| Hypothalamus | 29.75 | |
| Kidney | 8.6 | |
| Leukemia_chronicMyelogenousK-562 | 7.85 | |
| Leukemia_promyelocytic-HL-60 | 8.2 | |
| Leukemialymphoblastic(MOLT-4) | 7.55 | |
| Liver | 14 | |
| Lung | 11.25 | |
| Lymphnode | 12.35 | |
| Lymphoma_burkitts(Daudi) | 13.25 | |
| Lymphoma_burkitts(Raji) | 14.3 | |
| MedullaOblongata | 11.1 | |
| OccipitalLobe | 14.95 | |
| OlfactoryBulb | 17.15 | |
| Ovary | 7.1 | |
| Pancreas | 7.8 | |
| PancreaticIslet | 10.45 | |
| ParietalLobe | 13.4 | |
| Pituitary | 11.5 | |
| Placenta | 8.95 | |
| Pons | 15 | |
| PrefrontalCortex | 47.5 | |
| Prostate | 9.7 | |
| Salivarygland | 8.1 | |
| SkeletalMuscle | 13 | |
| Skin | 9.8 | |
| SmoothMuscle | 11 | |
| Spinalcord | 31.55 | |
| SubthalamicNucleus | 14.3 | |
| SuperiorCervicalGanglion | 14.4 | |
| TemporalLobe | 11.45 | |
| Testis | 8.25 | |
| TestisGermCell | 8.35 | |
| TestisIntersitial | 8.25 | |
| TestisLeydigCell | 10.15 | |
| TestisSeminiferousTubule | 8.35 | |
| Thalamus | 10.55 | |
| Thymus | 7.85 | |
| Thyroid | 13.15 | |
| Tongue | 10.6 | |
| Tonsil | 9.9 | |
| Trachea | 8.25 | |
| TrigeminalGanglion | 10.75 | |
| Uterus | 7.85 | |
| UterusCorpus | 9.65 | |
| WholeBlood | 29.25 | |
| Wholebrain | 56.7 | |
| colon | 9.85 | |
| pineal_day | 14.72 | |
| pineal_night | 13.1 | |
| retina | 15.9 | |
| small_intestine | 8.8 | |
- Probe name: CUST_268_PI416408490
- Donor H0351.2001
- Sex: Male Age: 24 years Race/Ethnicity: African American Handedness: Left
- Tissue Receipt Date: 7/29/2009 Serology: Pass Tissue pH :6.72 Additional Medical Information :History of asthma
- Postmortem Interval: 23 hours (estimated time of death to time that tissue is frozen)
- Toxicology: Positive for atropine and caffeine, at levels usually not toxicologically significant
| Tissue | Expression(mean ± stddev) | Expression Bar |
|---|---|---|
| Amygdala | 8.02 ± 0.23 | ![](../"images/bar_3.png"){kind=small}   |
| Basal Forebrain | 7.75 ± 0.15 | |
| Basal Part of Pons | 7.33 ± 0.19 | |
| Cerebellar Cortex | 7.49 ± 0.22 | |
| Cerebellar Nuclei | 7.36 ± 0.3 | |
| Claustrum | 7.81 ± 0.33 | |
| Epithalamus | 7.39 ± 0.31 | |
| Frontal Lobe | 7.5 ± 0.26 | |
| Globus Pallidus | 7.98 ± 0.26 | |
| Hypothalamus | 7.45 ± 0.24 | |
| Insula | 7.53 ± 0.19 | |
| Limbic Lobe | 7.69 ± 0.26 | |
| Mesencephalon | 7.62 ± 0.24 | |
| Myelencephalon | 7.61 ± 0.29 | |
| Occipital Lobe | 7.73 ± 0.24 | |
| Parietal Lobe | 7.58 ± 0.25 | |
| Pontine Tegmentum | 7.62 ± 0.28 | |
| Striatum | 7.69 ± 0.28 | |
| Subthalamus | 7.2 ± 0.3 | |
| Temporal Lobe | 7.61 ± 0.22 | |
| Thalamus | 7.61 ± 0.26 | |
| White Matter | 8.17 ± 0.33 | |
Mouse Brain ISH 
| Gene Symbol | Brain Structure ID | Brain Structure Name | Express Desity/Level (Meatured by ISH) | Express Bar |
|---|---|---|---|---|
| Fyn | CB | Cerebellum | 32.51 | |
| 64.64 | | |||
| Fyn | CTX | Cerebral cortex | 63.67 | |
| 62.4 | | |||
| Fyn | HIP | Hippocampal region | 71.78 | |
| 88.18 | | |||
| Fyn | HPF | Hippocampal formation | 67.62 | |
| 77.07 | | |||
| Fyn | HY | Hypothalamus | 48.53 | |
| 47.96 | | |||
| Fyn | LSX | Lateral septal complex | 57.75 | |
| 57.65 | | |||
| Fyn | MB | Midbrain | 40.06 | |
| 43.34 | | |||
| Fyn | MY | Medulla | 43.69 | |
| 52.6 | | |||
| Fyn | OLF | Olfactory bulb | 68.75 | |
| 71.48 | | |||
| Fyn | P | Pons | 39.38 | |
| 47.53 | | |||
| Fyn | PAL | Pallidum | 42.32 | |
| 46.62 | | |||
| Fyn | RHP | Retrohippocampal region | 59.67 | |
| 60.14 | | |||
| Fyn | sAMY | Striatum-like amygdalar nuclei | 54.71 | |
| 54.9 | | |||
| Fyn | STR | Striatum | 48.28 | |
| 44.46 | | |||
| Fyn | STRd | Striatum dorsal region | 44.95 | |
| 40.42 | | |||
| Fyn | STRv | Striatum ventral region | 44.07 | |
| 37.71 | | |||
| Fyn | TH | Thalamus | 66.48 | |
| 69.43 | |
| Peptide Name | Peptide Lengh | Peptide Start | Peptide End | Peptide Sequence | Source |
|---|---|---|---|---|---|
| FYN_HUMAN_360 | 23 | 360 | 382 | ALKLPNLVDMAAQVAAGMAYIER | PRIDE |
| FYN_HUMAN_431 | 11 | 431 | 441 | WTAPEAALYGR | PRIDE |
| PAp00003108 | 13 | 293 | 305 | GSLLDFLKDGEGR | Peptide Atlas |