AutismKB 2.0

Annotation Detail for FAM21C


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Basic Information Top
Gene Symbol:FAM21C ( FAM21A,KIAA0592,VPEF )
Gene Full Name: family with sequence similarity 21, member C
Band: 10q11.1
Quick LinksEntrez ID:253725; OMIM: NA; Uniprot ID:A8K5W5_HUMAN; ENSEMBL ID: ENSG00000172661; HGNC ID:
Relate to Another Database: SFARIGene; denovo-db
Unigene EST Top
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
embryoid body5 / 7076170
blastocyst8 / 62319128
fetus33 / 56401258
neonate1 / 3109732
infant0 / 236200 
juvenile0 / 555560 
adult96 / 193912149
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adrenal tumor0 / 127940 
bladder carcinoma0 / 174750 
breast (mammary gland) tumor6 / 9417863
cervical tumor2 / 3436658
chondrosarcoma6 / 8282372
colorectal tumor7 / 11424661
esophageal tumor0 / 172900 
gastrointestinal tumor2 / 11936916
germ cell tumor12 / 26384545
glioma3 / 10688328
head and neck tumor4 / 13630229
kidney tumor4 / 6895958
leukemia3 / 9584231
liver tumor4 / 9635941
lung tumor5 / 10312748
lymphoma4 / 7175555
non-neoplasia2 / 9725020
normal168 / 336030749
ovarian tumor2 / 7668226
pancreatic tumor6 / 10461657
primitive neuroectodermal tumor of the CNS1 / 1256807
prostate cancer9 / 10268087
retinoblastoma4 / 4635686
skin tumor2 / 12494916
soft tissue/muscle tissue tumor2 / 12519115
uterine tumor7 / 9025777
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adipose tissue0 / 131060 
adrenal gland0 / 331970 
ascites2 / 4001549
bladder0 / 297570 
blood6 / 12347848
bone3 / 7165541
bone marrow1 / 4880120
brain48 / 110098943
cervix4 / 4817183
connective tissue4 / 14925526
ear0 / 162120 
embryonic tissue15 / 21572269
esophagus0 / 202090 
eye19 / 21105490
heart15 / 89626167
intestine10 / 23447242
kidney8 / 21177737
larynx0 / 241450 
liver5 / 20774324
lung18 / 33697453
lymph4 / 4427090
lymph node6 / 9161065
mammary gland9 / 15327158
mouth2 / 6705229
muscle1 / 1077159
nerve0 / 157680 
ovary2 / 10205119
pancreas9 / 21481241
parathyroid4 / 20539194
pharynx0 / 413280 
pituitary gland1 / 1658560
placenta8 / 28082528
prostate14 / 18934573
salivary gland2 / 2015599
skin7 / 21057433
spleen0 / 539520 
stomach0 / 966190 
testis15 / 33044245
thymus6 / 8113173
thyroid6 / 47473126
tonsil3 / 16999176
trachea4 / 5241376
umbilical cord0 / 136800 
uterus19 / 23287881
vascular0 / 517800 
Microarray in BioGPS Top
Select probe  
  • Microarray Platform: GeneAtlas U133A, gcrma
  • Affymatrix Probe ID: 211068_x_at
Cell line Expression level Expression bar
721_B_lymphoblasts255.15
Adipocyte124.3
AdrenalCortex82.95
Adrenalgland71.1
Amygdala115.7
Appendix82.5
AtrioventricularNode52.35
BDCA4+_DentriticCells590.95
Bonemarrow98
BronchialEpithelialCells89
CD105+_Endothelial182.25
CD14+_Monocytes904.75
CD19+_BCells(neg._sel.)491.85
CD33+_Myeloid926.25
CD34+581.75
CD4+_Tcells817.55
CD56+_NKCells640.45
CD71+_EarlyErythroid476.3
CD8+_Tcells503.7
CardiacMyocytes109.4
Caudatenucleus87.85
Cerebellum108.8
CerebellumPeduncles135.95
CiliaryGanglion37.85
CingulateCortex98.1
Colorectaladenocarcinoma101.5
DorsalRootGanglion58.75
FetalThyroid131.35
Fetalbrain165.9
Fetalliver94.55
Fetallung139.6
GlobusPallidus57.45
Heart88.85
Hypothalamus228.9
Kidney74.4
Leukemia_chronicMyelogenousK-56288.35
Leukemia_promyelocytic-HL-6084.45
Leukemialymphoblastic(MOLT-4)76.3
Liver70.1
Lung76.85
Lymphnode175.6
Lymphoma_burkitts(Daudi)123.75
Lymphoma_burkitts(Raji)159.85
MedullaOblongata90.95
OccipitalLobe130.1
OlfactoryBulb83.65
Ovary69.85
Pancreas74.75
PancreaticIslet101.15
ParietalLobe100.8
Pituitary147.85
Placenta85.35
Pons81.15
PrefrontalCortex230.2
Prostate112.95
Salivarygland94.6
SkeletalMuscle93.9
Skin61
SmoothMuscle179.55
Spinalcord164.25
SubthalamicNucleus69.6
SuperiorCervicalGanglion83.8
TemporalLobe63.35
Testis66.05
TestisGermCell124
TestisIntersitial88.95
TestisLeydigCell93.45
TestisSeminiferousTubule113.1
Thalamus130.6
Thymus112.4
Thyroid218.35
Tongue79.35
Tonsil224
Trachea86
TrigeminalGanglion40.95
Uterus131.9
UterusCorpus83.5
WholeBlood228.6
Wholebrain92
colon104.45
pineal_day322.38
pineal_night348.16
retina146.05
small_intestine98.25
Allen Brain Atlas Top
Human Whole Brain Microarrayview in Allen Brain Atlas
  • Probe id     Donor id      
  • Probe name: CUST_3533_PI416261804
  • Donor H0351.2001
  • Sex: Male     Age: 24 years     Race/Ethnicity: African American     Handedness: Left
  • Tissue Receipt Date: 7/29/2009     Serology: Pass      Tissue pH :6.72     Additional Medical Information :History of asthma
  • Postmortem Interval: 23 hours (estimated time of death to time that tissue is frozen)
  • Toxicology: Positive for atropine and caffeine, at levels usually not toxicologically significant
Tissue Expression(mean ± stddev) Expression Bar
Amygdala9.04 ± 0.24
Basal Forebrain9.2 ± 0.3
Basal Part of Pons9.06 ± 0.35
Cerebellar Cortex9.34 ± 0.28
Cerebellar Nuclei9.22 ± 0.25
Claustrum9.46 ± 0.47
Epithalamus8.85 ± 0.39
Frontal Lobe9.03 ± 0.3
Globus Pallidus9.31 ± 0.22
Hypothalamus9.09 ± 0.33
Insula9.02 ± 0.22
Limbic Lobe9.24 ± 0.3
Mesencephalon9.26 ± 0.26
Myelencephalon9.15 ± 0.3
Occipital Lobe9.41 ± 0.28
Parietal Lobe9.19 ± 0.31
Pontine Tegmentum9.14 ± 0.27
Striatum9.06 ± 0.31
Subthalamus9.27 ± 0.19
Temporal Lobe9.05 ± 0.28
Thalamus9.21 ± 0.26
White Matter9.78 ± 0.28
Mouse Brain ISH
Peptide Top
Peptide Name Peptide Lengh Peptide Start Peptide End Peptide Sequence Source
PAp00064228 16 487 502 AVASPEATVSQTDENK Peptide Atlas

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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