AutismKB 2.0

Annotation Detail for LASS6


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Basic Information Top
Gene Symbol:LASS6 ( CerS6,MGC129949,MGC129950 )
Gene Full Name: LAG1 homolog, ceramide synthase 6
Band: 2q24.3
Quick LinksEntrez ID:253782; OMIM: NA; Uniprot ID:LASS6_HUMAN; ENSEMBL ID: ENSG00000172292; HGNC ID:
Relate to Another Database: SFARIGene; denovo-db
Unigene EST Top
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
embryoid body2 / 7076128
blastocyst2 / 6231932
fetus29 / 56401251
neonate0 / 310970 
infant1 / 2362042
juvenile2 / 5555635
adult51 / 193912126
embryoid body7 / 7076198
blastocyst0 / 623190 
fetus36 / 56401263
neonate0 / 310970 
infant0 / 236200 
juvenile0 / 555560 
adult73 / 193912137
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adrenal tumor1 / 1279478
bladder carcinoma0 / 174750 
breast (mammary gland) tumor2 / 9417821
cervical tumor0 / 343660 
chondrosarcoma0 / 828230 
colorectal tumor2 / 11424617
esophageal tumor2 / 17290115
gastrointestinal tumor3 / 11936925
germ cell tumor5 / 26384518
glioma0 / 1068830 
head and neck tumor4 / 13630229
kidney tumor1 / 6895914
leukemia2 / 9584220
liver tumor2 / 9635920
lung tumor0 / 1031270 
lymphoma1 / 7175513
non-neoplasia2 / 9725020
normal93 / 336030727
ovarian tumor5 / 7668265
pancreatic tumor2 / 10461619
primitive neuroectodermal tumor of the CNS2 / 12568015
prostate cancer3 / 10268029
retinoblastoma2 / 4635643
skin tumor0 / 1249490 
soft tissue/muscle tissue tumor0 / 1251910 
uterine tumor2 / 9025722
adrenal tumor0 / 127940 
bladder carcinoma0 / 174750 
breast (mammary gland) tumor4 / 9417842
cervical tumor0 / 343660 
chondrosarcoma5 / 8282360
colorectal tumor7 / 11424661
esophageal tumor0 / 172900 
gastrointestinal tumor2 / 11936916
germ cell tumor14 / 26384553
glioma7 / 10688365
head and neck tumor7 / 13630251
kidney tumor1 / 6895914
leukemia0 / 958420 
liver tumor2 / 9635920
lung tumor2 / 10312719
lymphoma0 / 717550 
non-neoplasia4 / 9725041
normal126 / 336030737
ovarian tumor4 / 7668252
pancreatic tumor2 / 10461619
primitive neuroectodermal tumor of the CNS2 / 12568015
prostate cancer1 / 1026809
retinoblastoma2 / 4635643
skin tumor0 / 1249490 
soft tissue/muscle tissue tumor2 / 12519115
uterine tumor4 / 9025744
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adipose tissue1 / 1310676
adrenal gland5 / 33197150
ascites1 / 4001524
bladder4 / 29757134
blood1 / 1234788
bone0 / 716550 
bone marrow0 / 488010 
brain26 / 110098923
cervix0 / 481710 
connective tissue0 / 1492550 
ear1 / 1621261
embryonic tissue9 / 21572241
esophagus2 / 2020998
eye8 / 21105437
heart4 / 8962644
intestine9 / 23447238
kidney3 / 21177714
larynx0 / 241450 
liver4 / 20774319
lung8 / 33697423
lymph0 / 442700 
lymph node1 / 9161010
mammary gland3 / 15327119
mouth1 / 6705214
muscle4 / 10771537
nerve0 / 157680 
ovary5 / 10205148
pancreas3 / 21481213
parathyroid1 / 2053948
pharynx0 / 413280 
pituitary gland0 / 165850 
placenta4 / 28082514
prostate4 / 18934521
salivary gland0 / 201550 
skin1 / 2105744
spleen0 / 539520 
stomach3 / 9661931
testis9 / 33044227
thymus2 / 8113124
thyroid3 / 4747363
tonsil0 / 169990 
trachea1 / 5241319
umbilical cord0 / 136800 
uterus6 / 23287825
vascular1 / 5178019
adipose tissue0 / 131060 
adrenal gland0 / 331970 
ascites0 / 400150 
bladder1 / 2975733
blood1 / 1234788
bone5 / 7165569
bone marrow1 / 4880120
brain49 / 110098944
cervix0 / 481710 
connective tissue3 / 14925520
ear0 / 162120 
embryonic tissue9 / 21572241
esophagus0 / 202090 
eye13 / 21105461
heart2 / 8962622
intestine15 / 23447263
kidney7 / 21177733
larynx0 / 241450 
liver2 / 2077439
lung23 / 33697468
lymph0 / 442700 
lymph node0 / 916100 
mammary gland5 / 15327132
mouth5 / 6705274
muscle2 / 10771518
nerve0 / 157680 
ovary6 / 10205158
pancreas12 / 21481255
parathyroid1 / 2053948
pharynx0 / 413280 
pituitary gland0 / 165850 
placenta3 / 28082510
prostate8 / 18934542
salivary gland0 / 201550 
skin4 / 21057418
spleen0 / 539520 
stomach2 / 9661920
testis14 / 33044242
thymus1 / 8113112
thyroid3 / 4747363
tonsil0 / 169990 
trachea1 / 5241319
umbilical cord0 / 136800 
uterus5 / 23287821
vascular1 / 5178019
Microarray in BioGPS Top
Select probe  
  • Microarray Platform: GeneAtlas U133A, gcrma
  • Affymatrix Probe ID: 212442_s_at
Cell line Expression level Expression bar
721_B_lymphoblasts289.15
Adipocyte45.8
AdrenalCortex58.8
Adrenalgland28.6
Amygdala281.3
Appendix49.15
AtrioventricularNode20.9
BDCA4+_DentriticCells804.85
Bonemarrow33.35
BronchialEpithelialCells138.75
CD105+_Endothelial71.95
CD14+_Monocytes216.55
CD19+_BCells(neg._sel.)110.9
CD33+_Myeloid294.65
CD34+416.2
CD4+_Tcells118.4
CD56+_NKCells130.15
CD71+_EarlyErythroid31.9
CD8+_Tcells130.25
CardiacMyocytes36.7
Caudatenucleus37.6
Cerebellum82.85
CerebellumPeduncles138.35
CiliaryGanglion27.1
CingulateCortex95.35
Colorectaladenocarcinoma100.15
DorsalRootGanglion30.1
FetalThyroid72.35
Fetalbrain292.55
Fetalliver34.55
Fetallung38.6
GlobusPallidus107.45
Heart42.65
Hypothalamus101.3
Kidney28.1
Leukemia_chronicMyelogenousK-56236.15
Leukemia_promyelocytic-HL-609.6
Leukemialymphoblastic(MOLT-4)159.1
Liver44.4
Lung33.15
Lymphnode32.5
Lymphoma_burkitts(Daudi)22.85
Lymphoma_burkitts(Raji)41.55
MedullaOblongata110.45
OccipitalLobe199.55
OlfactoryBulb35.95
Ovary22.5
Pancreas70.55
PancreaticIslet67.1
ParietalLobe117.25
Pituitary108.3
Placenta24.75
Pons67.75
PrefrontalCortex275.05
Prostate61.85
Salivarygland27.15
SkeletalMuscle37.7
Skin52.4
SmoothMuscle31.25
Spinalcord43.9
SubthalamicNucleus124.4
SuperiorCervicalGanglion55.1
TemporalLobe124.4
Testis24.75
TestisGermCell82.35
TestisIntersitial22.4
TestisLeydigCell33.75
TestisSeminiferousTubule40
Thalamus82.1
Thymus76.15
Thyroid135.8
Tongue47.45
Tonsil33.3
Trachea33.45
TrigeminalGanglion40.1
Uterus98.85
UterusCorpus40.3
WholeBlood42.15
Wholebrain120.65
colon139.5
pineal_day461.98
pineal_night501.36
retina84.975
small_intestine156.45
Allen Brain Atlas Top
Human Whole Brain Microarrayview in Allen Brain Atlas
  • Probe id     Donor id      
  • Probe name: A_24_P289366
  • Donor H0351.2001
  • Sex: Male     Age: 24 years     Race/Ethnicity: African American     Handedness: Left
  • Tissue Receipt Date: 7/29/2009     Serology: Pass      Tissue pH :6.72     Additional Medical Information :History of asthma
  • Postmortem Interval: 23 hours (estimated time of death to time that tissue is frozen)
  • Toxicology: Positive for atropine and caffeine, at levels usually not toxicologically significant
Tissue Expression(mean ± stddev) Expression Bar
Amygdala6.4 ± 0.7
Basal Forebrain6.45 ± 0.3
Basal Part of Pons6.54 ± 0.4
Cerebellar Cortex6.62 ± 0.22
Cerebellar Nuclei5.76 ± 0.67
Claustrum6.58 ± 0.46
Epithalamus5.8 ± 0.41
Frontal Lobe6.53 ± 0.43
Globus Pallidus4.82 ± 0.46
Hypothalamus6.63 ± 0.51
Insula6.55 ± 0.27
Limbic Lobe6.52 ± 0.68
Mesencephalon6.37 ± 0.82
Myelencephalon6.21 ± 0.73
Occipital Lobe6.06 ± 0.81
Parietal Lobe6.51 ± 0.49
Pontine Tegmentum6.33 ± 0.56
Striatum5.41 ± 0.9
Subthalamus6.05 ± 0.76
Temporal Lobe6.53 ± 0.34
Thalamus6.27 ± 0.59
White Matter3.86 ± 0.39
Mouse Brain ISH
Gene Symbol Brain Structure ID Brain Structure Name Express Desity/Level (Meatured by ISH) Express Bar
Lass6CBCerebellum6.26
6.8
Lass6CTXCerebral cortex14.07
9.56
Lass6HIPHippocampal region24.52
32.32
Lass6HPFHippocampal formation19
22.46
Lass6HYHypothalamus1.18
0.98
Lass6LSXLateral septal complex2.66
2
Lass6MBMidbrain2.39
2.68
Lass6MYMedulla5.4
5.98
Lass6OLFOlfactory bulb32.41
27.06
Lass6PPons2.82
3.9
Lass6PALPallidum4.25
3.8
Lass6RHPRetrohippocampal region7.3
6.07
Lass6sAMYStriatum-like amygdalar nuclei11.05
7.95
Lass6STRStriatum5.52
3.95
Lass6STRdStriatum dorsal region3.74
2.78
Lass6STRvStriatum ventral region9.3
5.9
Lass6THThalamus8.38
9.81
Peptide Top
Peptide Name Peptide Lengh Peptide Start Peptide End Peptide Sequence Source
PAp00097180 20 230 249 VGTLVLCLHDSADALLEAAK Peptide Atlas

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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