AutismKB 2.0

Annotation Detail for TMCO4


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Basic Information Top
Gene Symbol:TMCO4 ( DKFZp686C23231,RP5-1056L3.6 )
Gene Full Name: transmembrane and coiled-coil domains 4
Band: 1p36.13
Quick LinksEntrez ID:255104; OMIM: NA; Uniprot ID:TMCO4_HUMAN; ENSEMBL ID: ENSG00000162542; HGNC ID: 27393
Relate to Another Database: SFARIGene; denovo-db
Unigene EST Top
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
embryoid body2 / 7076128
blastocyst0 / 623190 
fetus6 / 56401210
neonate0 / 310970 
infant0 / 236200 
juvenile1 / 5555617
adult54 / 193912127
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adrenal tumor0 / 127940 
bladder carcinoma0 / 174750 
breast (mammary gland) tumor1 / 9417810
cervical tumor1 / 3436629
chondrosarcoma3 / 8282336
colorectal tumor3 / 11424626
esophageal tumor0 / 172900 
gastrointestinal tumor3 / 11936925
germ cell tumor2 / 2638457
glioma0 / 1068830 
head and neck tumor2 / 13630214
kidney tumor1 / 6895914
leukemia2 / 9584220
liver tumor0 / 963590 
lung tumor7 / 10312767
lymphoma0 / 717550 
non-neoplasia0 / 972500 
normal52 / 336030715
ovarian tumor1 / 7668213
pancreatic tumor3 / 10461628
primitive neuroectodermal tumor of the CNS0 / 1256800 
prostate cancer1 / 1026809
retinoblastoma0 / 463560 
skin tumor3 / 12494924
soft tissue/muscle tissue tumor1 / 1251917
uterine tumor3 / 9025733
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adipose tissue0 / 131060 
adrenal gland0 / 331970 
ascites1 / 4001524
bladder1 / 2975733
blood2 / 12347816
bone3 / 7165541
bone marrow1 / 4880120
brain5 / 11009894
cervix2 / 4817141
connective tissue0 / 1492550 
ear0 / 162120 
embryonic tissue2 / 2157229
esophagus0 / 202090 
eye3 / 21105414
heart0 / 896260 
intestine9 / 23447238
kidney2 / 2117779
larynx0 / 241450 
liver0 / 2077430 
lung10 / 33697429
lymph0 / 442700 
lymph node1 / 9161010
mammary gland3 / 15327119
mouth2 / 6705229
muscle0 / 1077150 
nerve1 / 1576863
ovary1 / 1020519
pancreas5 / 21481223
parathyroid1 / 2053948
pharynx0 / 413280 
pituitary gland0 / 165850 
placenta14 / 28082549
prostate5 / 18934526
salivary gland0 / 201550 
skin3 / 21057414
spleen0 / 539520 
stomach2 / 9661920
testis1 / 3304423
thymus0 / 811310 
thyroid0 / 474730 
tonsil0 / 169990 
trachea0 / 524130 
umbilical cord0 / 136800 
uterus5 / 23287821
vascular1 / 5178019
Microarray in BioGPS Top
Allen Brain Atlas Top
Human Whole Brain Microarrayview in Allen Brain Atlas
  • Probe id     Donor id      
  • Probe name: CUST_6069_PI416261804
  • Donor H0351.2001
  • Sex: Male     Age: 24 years     Race/Ethnicity: African American     Handedness: Left
  • Tissue Receipt Date: 7/29/2009     Serology: Pass      Tissue pH :6.72     Additional Medical Information :History of asthma
  • Postmortem Interval: 23 hours (estimated time of death to time that tissue is frozen)
  • Toxicology: Positive for atropine and caffeine, at levels usually not toxicologically significant
Tissue Expression(mean ± stddev) Expression Bar
Amygdala1.93 ± 0.91
Basal Forebrain1.77 ± 1.06
Basal Part of Pons1.23 ± 0.48
Cerebellar Cortex1.18 ± 0.6
Cerebellar Nuclei1.75 ± 0.84
Claustrum2.27 ± 0.9
Epithalamus1.62 ± 0.83
Frontal Lobe1.3 ± 0.63
Globus Pallidus2.18 ± 0.39
Hypothalamus1.57 ± 0.77
Insula1.26 ± 0.48
Limbic Lobe1.42 ± 0.63
Mesencephalon1.67 ± 0.75
Myelencephalon1.55 ± 0.68
Occipital Lobe1.78 ± 0.98
Parietal Lobe1.46 ± 0.71
Pontine Tegmentum1.51 ± 0.73
Striatum1.97 ± 0.71
Subthalamus1.54 ± 0.7
Temporal Lobe1.45 ± 0.78
Thalamus1.49 ± 0.65
White Matter1.69 ± 0.12
Mouse Brain ISH
Gene Symbol Brain Structure ID Brain Structure Name Express Desity/Level (Meatured by ISH) Express Bar
Tmco4CBCerebellum1.52
2.3
Tmco4CTXCerebral cortex3.6
2.36
Tmco4HIPHippocampal region2.58
2.15
Tmco4HPFHippocampal formation3.84
3.01
Tmco4HYHypothalamus2.2
2.94
Tmco4LSXLateral septal complex0.27
0.22
Tmco4MBMidbrain1.24
3.07
Tmco4MYMedulla3.19
4.61
Tmco4OLFOlfactory bulb9.63
7.11
Tmco4PPons4.35
7.19
Tmco4PALPallidum1.22
1.14
Tmco4RHPRetrohippocampal region7.59
5.02
Tmco4sAMYStriatum-like amygdalar nuclei3.18
2.35
Tmco4STRStriatum2.2
1.85
Tmco4STRdStriatum dorsal region2.18
1.89
Tmco4STRvStriatum ventral region2.39
2.03
Tmco4THThalamus0.71
0.77
Peptide Top

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018