Annotation Detail for PCSK9
Basic Information Top
| Gene Symbol: | PCSK9 ( FH3,HCHOLA3,LDLCQ1,NARC-1,NARC1,PC9 ) |
|---|---|
| Gene Full Name: | proprotein convertase subtilisin/kexin type 9 |
| Band: | 1p32.3 |
| Quick Links | Entrez ID:255738; OMIM: 607786; Uniprot ID:PCSK9_HUMAN; ENSEMBL ID: ENSG00000169174; HGNC ID: 20001 |
| Relate to Another Database: | SFARIGene; denovo-db |
- Unigene ID: Hs.18844
| Pool Name | Gene EST/Total EST in pool | Transcripts per million(TPM) | Bar based on TPM |
|---|---|---|---|
 | |||
| embryoid body | 0 / 70761 | 0 | |
| blastocyst | 3 / 62319 | 48 |  |
| fetus | 20 / 564012 | 35 | |
| neonate | 1 / 31097 | 32 | |
| infant | 0 / 23620 | 0 | |
| juvenile | 1 / 55556 | 17 | |
| adult | 40 / 1939121 | 20 | |
| Pool Name | Gene EST/Total EST in pool | Transcripts per million(TPM) | Bar based on TPM |
|---|---|---|---|
| |||
| adrenal tumor | 0 / 12794 | 0 | |
| bladder carcinoma | 0 / 17475 | 0 | |
| breast (mammary gland) tumor | 0 / 94178 | 0 | |
| cervical tumor | 2 / 34366 | 58 |  |
| chondrosarcoma | 2 / 82823 | 24 | |
| colorectal tumor | 3 / 114246 | 26 | |
| esophageal tumor | 0 / 17290 | 0 | |
| gastrointestinal tumor | 5 / 119369 | 41 | |
| germ cell tumor | 22 / 263845 | 83 | |
| glioma | 0 / 106883 | 0 | |
| head and neck tumor | 25 / 136302 | 183 | |
| kidney tumor | 0 / 68959 | 0 | |
| leukemia | 2 / 95842 | 20 | |
| liver tumor | 3 / 96359 | 31 | |
| lung tumor | 0 / 103127 | 0 | |
| lymphoma | 0 / 71755 | 0 | |
| non-neoplasia | 0 / 97250 | 0 | |
| normal | 45 / 3360307 | 13 | |
| ovarian tumor | 0 / 76682 | 0 | |
| pancreatic tumor | 2 / 104616 | 19 | |
| primitive neuroectodermal tumor of the CNS | 1 / 125680 | 7 |  |
| prostate cancer | 0 / 102680 | 0 | |
| retinoblastoma | 0 / 46356 | 0 | |
| skin tumor | 0 / 124949 | 0 | |
| soft tissue/muscle tissue tumor | 1 / 125191 | 7 | |
| uterine tumor | 1 / 90257 | 11 | |
| Pool Name | Gene EST/Total EST in pool | Transcripts per million(TPM) | Bar based on TPM |
|---|---|---|---|
| |||
| adipose tissue | 0 / 13106 | 0 | |
| adrenal gland | 0 / 33197 | 0 | |
| ascites | 4 / 40015 | 99 | |
| bladder | 0 / 29757 | 0 | |
| blood | 0 / 123478 | 0 | |
| bone | 1 / 71655 | 13 | |
| bone marrow | 0 / 48801 | 0 | |
| brain | 29 / 1100989 | 26 | |
| cervix | 7 / 48171 | 145 | |
| connective tissue | 1 / 149255 | 6 | |
| ear | 0 / 16212 | 0 | |
| embryonic tissue | 3 / 215722 | 13 | |
| esophagus | 0 / 20209 | 0 | |
| eye | 0 / 211054 | 0 | |
| heart | 0 / 89626 | 0 | |
| intestine | 6 / 234472 | 25 | |
| kidney | 0 / 211777 | 0 | |
| larynx | 0 / 24145 | 0 | |
| liver | 6 / 207743 | 28 | |
| lung | 0 / 336974 | 0 | |
| lymph | 0 / 44270 | 0 | |
| lymph node | 0 / 91610 | 0 | |
| mammary gland | 2 / 153271 | 13 | |
| mouth | 25 / 67052 | 372 |  |
| muscle | 0 / 107715 | 0 | |
| nerve | 0 / 15768 | 0 | |
| ovary | 2 / 102051 | 19 | |
| pancreas | 2 / 214812 | 9 | |
| parathyroid | 0 / 20539 | 0 | |
| pharynx | 0 / 41328 | 0 | |
| pituitary gland | 0 / 16585 | 0 | |
| placenta | 0 / 280825 | 0 | |
| prostate | 0 / 189345 | 0 | |
| salivary gland | 1 / 20155 | 49 | |
| skin | 1 / 210574 | 4 | |
| spleen | 0 / 53952 | 0 | |
| stomach | 1 / 96619 | 10 | |
| testis | 19 / 330442 | 57 | |
| thymus | 0 / 81131 | 0 | |
| thyroid | 0 / 47473 | 0 | |
| tonsil | 0 / 16999 | 0 | |
| trachea | 0 / 52413 | 0 | |
| umbilical cord | 0 / 13680 | 0 | |
| uterus | 2 / 232878 | 8 | |
| vascular | 0 / 51780 | 0 |
Microarray in - Probe name: CUST_16798_PI416261804
- Donor H0351.2001
- Sex: Male Age: 24 years Race/Ethnicity: African American Handedness: Left
- Tissue Receipt Date: 7/29/2009 Serology: Pass Tissue pH :6.72 Additional Medical Information :History of asthma
- Postmortem Interval: 23 hours (estimated time of death to time that tissue is frozen)
- Toxicology: Positive for atropine and caffeine, at levels usually not toxicologically significant
| Tissue | Expression(mean ± stddev) | Expression Bar |
|---|---|---|
| Amygdala | 4.41 ± 0.66 | ![](../"images/bar_3.png"){kind=small}   |
| Basal Forebrain | 4.04 ± 0.63 | |
| Basal Part of Pons | 4.17 ± 0.35 | |
| Cerebellar Cortex | 4.45 ± 0.36 | |
| Cerebellar Nuclei | 4.22 ± 0.5 | |
| Claustrum | 4.71 ± 0.64 | |
| Epithalamus | 3.76 ± 0.43 | |
| Frontal Lobe | 4.03 ± 0.62 | |
| Globus Pallidus | 4.1 ± 0.71 | |
| Hypothalamus | 3.65 ± 0.98 | |
| Insula | 3.83 ± 0.64 | |
| Limbic Lobe | 4.13 ± 0.55 | |
| Mesencephalon | 3.97 ± 0.56 | |
| Myelencephalon | 4.14 ± 0.56 | |
| Occipital Lobe | 4.17 ± 0.51 | |
| Parietal Lobe | 4.16 ± 0.56 | |
| Pontine Tegmentum | 4.04 ± 0.64 | |
| Striatum | 3.91 ± 0.61 | |
| Subthalamus | 4.51 ± 0.3 | |
| Temporal Lobe | 4 ± 0.59 | |
| Thalamus | 4.18 ± 0.49 | |
| White Matter | 4.1 ± 0.71 | |
Mouse Brain ISH 
| Gene Symbol | Brain Structure ID | Brain Structure Name | Express Desity/Level (Meatured by ISH) | Express Bar |
|---|---|---|---|---|
| Pcsk9 | CB | Cerebellum | 2.26 | |
| 3.23 | | |||
| Pcsk9 | CTX | Cerebral cortex | 6.76 | |
| 4.1 | | |||
| Pcsk9 | HIP | Hippocampal region | 0.43 | |
| 0.42 | | |||
| Pcsk9 | HPF | Hippocampal formation | 1.95 | |
| 1.51 | | |||
| Pcsk9 | HY | Hypothalamus | 0.59 | |
| 0.33 | | |||
| Pcsk9 | LSX | Lateral septal complex | 0.08 | |
| 0 | | |||
| Pcsk9 | MB | Midbrain | 0.52 | |
| 0.26 | | |||
| Pcsk9 | MY | Medulla | 1.82 | |
| 1.85 | | |||
| Pcsk9 | OLF | Olfactory bulb | 19.29 | |
| 14.93 | | |||
| Pcsk9 | P | Pons | 1.62 | |
| 1.28 | | |||
| Pcsk9 | PAL | Pallidum | 1.06 | |
| 0.47 | | |||
| Pcsk9 | RHP | Retrohippocampal region | 4.63 | |
| 3.15 | | |||
| Pcsk9 | sAMY | Striatum-like amygdalar nuclei | 12.16 | |
| 4.92 | | |||
| Pcsk9 | STR | Striatum | 2.27 | |
| 1.17 | | |||
| Pcsk9 | STRd | Striatum dorsal region | 1.53 | |
| 0.86 | | |||
| Pcsk9 | STRv | Striatum ventral region | 2.16 | |
| 1.16 | | |||
| Pcsk9 | TH | Thalamus | 0.96 | |
| 1.69 | |
| Peptide Name | Peptide Lengh | Peptide Start | Peptide End | Peptide Sequence | Source |
|---|---|---|---|---|---|
| PAp00037495 | 20 | 47 | 66 | SEEDGLAEAPEHGTTATFHR | Peptide Atlas |
| PCSK9_HUMAN_110 | 15 | 110 | 124 | ILHVFHGLLPGFLVK | PRIDE |