AutismKB 2.0

Annotation Detail for SERINC5


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Basic Information Top
Gene Symbol:SERINC5 ( C5orf12,TPO1 )
Gene Full Name: serine incorporator 5
Band: 5q14.1
Quick LinksEntrez ID:256987; OMIM: NA; Uniprot ID:SERC5_HUMAN; ENSEMBL ID: ENSG00000164300; HGNC ID: 18825
Relate to Another Database: SFARIGene; denovo-db
Unigene EST Top
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
embryoid body3 / 7076142
blastocyst1 / 6231916
fetus12 / 56401221
neonate0 / 310970 
infant0 / 236200 
juvenile2 / 5555635
adult78 / 193912140
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adrenal tumor4 / 12794312
bladder carcinoma1 / 1747557
breast (mammary gland) tumor1 / 9417810
cervical tumor0 / 343660 
chondrosarcoma4 / 8282348
colorectal tumor3 / 11424626
esophageal tumor0 / 172900 
gastrointestinal tumor1 / 1193698
germ cell tumor8 / 26384530
glioma6 / 10688356
head and neck tumor2 / 13630214
kidney tumor0 / 689590 
leukemia4 / 9584241
liver tumor3 / 9635931
lung tumor4 / 10312738
lymphoma0 / 717550 
non-neoplasia0 / 972500 
normal95 / 336030728
ovarian tumor4 / 7668252
pancreatic tumor1 / 1046169
primitive neuroectodermal tumor of the CNS1 / 1256807
prostate cancer11 / 102680107
retinoblastoma0 / 463560 
skin tumor4 / 12494932
soft tissue/muscle tissue tumor0 / 1251910 
uterine tumor5 / 9025755
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adipose tissue0 / 131060 
adrenal gland4 / 33197120
ascites0 / 400150 
bladder0 / 297570 
blood5 / 12347840
bone3 / 7165541
bone marrow0 / 488010 
brain17 / 110098915
cervix0 / 481710 
connective tissue2 / 14925513
ear2 / 16212123
embryonic tissue8 / 21572237
esophagus0 / 202090 
eye6 / 21105428
heart2 / 8962622
intestine6 / 23447225
kidney2 / 2117779
larynx0 / 241450 
liver8 / 20774338
lung13 / 33697438
lymph0 / 442700 
lymph node3 / 9161032
mammary gland5 / 15327132
mouth1 / 6705214
muscle1 / 1077159
nerve1 / 1576863
ovary5 / 10205148
pancreas7 / 21481232
parathyroid0 / 205390 
pharynx1 / 4132824
pituitary gland0 / 165850 
placenta15 / 28082553
prostate17 / 18934589
salivary gland0 / 201550 
skin4 / 21057418
spleen0 / 539520 
stomach4 / 9661941
testis11 / 33044233
thymus0 / 811310 
thyroid0 / 474730 
tonsil0 / 169990 
trachea0 / 524130 
umbilical cord0 / 136800 
uterus5 / 23287821
vascular1 / 5178019
Microarray in BioGPS Top
Allen Brain Atlas Top
Human Whole Brain Microarrayview in Allen Brain Atlas
  • Probe id     Donor id      
  • Probe name: A_23_P423457
  • Donor H0351.2001
  • Sex: Male     Age: 24 years     Race/Ethnicity: African American     Handedness: Left
  • Tissue Receipt Date: 7/29/2009     Serology: Pass      Tissue pH :6.72     Additional Medical Information :History of asthma
  • Postmortem Interval: 23 hours (estimated time of death to time that tissue is frozen)
  • Toxicology: Positive for atropine and caffeine, at levels usually not toxicologically significant
Tissue Expression(mean ± stddev) Expression Bar
Amygdala6.28 ± 0.38
Basal Forebrain6.91 ± 0.4
Basal Part of Pons6.52 ± 0.46
Cerebellar Cortex6.29 ± 0.21
Cerebellar Nuclei7.39 ± 0.47
Claustrum6.24 ± 0.48
Epithalamus6.77 ± 0.71
Frontal Lobe6.66 ± 0.53
Globus Pallidus7.9 ± 0.25
Hypothalamus6.5 ± 0.35
Insula6.41 ± 0.37
Limbic Lobe6.43 ± 0.53
Mesencephalon6.85 ± 0.47
Myelencephalon6.78 ± 0.56
Occipital Lobe6.72 ± 0.5
Parietal Lobe6.61 ± 0.53
Pontine Tegmentum6.85 ± 0.51
Striatum7.22 ± 0.46
Subthalamus6.69 ± 0.14
Temporal Lobe6.65 ± 0.41
Thalamus7.17 ± 0.36
White Matter9.11 ± 0.33
Mouse Brain ISH
Gene Symbol Brain Structure ID Brain Structure Name Express Desity/Level (Meatured by ISH) Express Bar
Serinc5CBCerebellum54.43
64.74
Serinc5CTXCerebral cortex81.48
65.56
Serinc5HIPHippocampal region72.24
98.7
Serinc5HPFHippocampal formation78.19
89.57
Serinc5HYHypothalamus80.34
71.83
Serinc5LSXLateral septal complex100
100
Serinc5MBMidbrain100
90.12
Serinc5MYMedulla100
96.31
Serinc5OLFOlfactory bulb100
100
Serinc5PPons100
98.99
Serinc5PALPallidum83.33
78.57
Serinc5RHPRetrohippocampal region90.96
78.1
Serinc5sAMYStriatum-like amygdalar nuclei68.19
57.85
Serinc5STRStriatum84.44
73.79
Serinc5STRdStriatum dorsal region82.15
71.86
Serinc5STRvStriatum ventral region74.64
60.65
Serinc5THThalamus72.99
61.58
Peptide Top

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018