AutismKB 2.0

Annotation Detail for GAD1


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Basic Information Top
Gene Symbol:GAD1 ( FLJ45882,GAD,SCP )
Gene Full Name: glutamate decarboxylase 1 (brain, 67kDa)
Band: 2q31.1
Quick LinksEntrez ID:2571; OMIM: 605363; Uniprot ID:DCE1_HUMAN; ENSEMBL ID: ENSG00000128683; HGNC ID: 4092
Relate to Another Database: SFARIGene; denovo-db
Unigene EST Top
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
embryoid body0 / 707610 
blastocyst3 / 6231948
fetus37 / 56401265
neonate0 / 310970 
infant0 / 236200 
juvenile0 / 555560 
adult110 / 193912156
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adrenal tumor0 / 127940 
bladder carcinoma0 / 174750 
breast (mammary gland) tumor0 / 941780 
cervical tumor0 / 343660 
chondrosarcoma1 / 8282312
colorectal tumor15 / 114246131
esophageal tumor0 / 172900 
gastrointestinal tumor0 / 1193690 
germ cell tumor7 / 26384526
glioma4 / 10688337
head and neck tumor3 / 13630222
kidney tumor9 / 68959130
leukemia1 / 9584210
liver tumor3 / 9635931
lung tumor0 / 1031270 
lymphoma0 / 717550 
non-neoplasia5 / 9725051
normal358 / 3360307106
ovarian tumor2 / 7668226
pancreatic tumor0 / 1046160 
primitive neuroectodermal tumor of the CNS0 / 1256800 
prostate cancer0 / 1026800 
retinoblastoma0 / 463560 
skin tumor0 / 1249490 
soft tissue/muscle tissue tumor0 / 1251910 
uterine tumor1 / 9025711
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adipose tissue0 / 131060 
adrenal gland0 / 331970 
ascites0 / 400150 
bladder0 / 297570 
blood0 / 1234780 
bone1 / 7165513
bone marrow0 / 488010 
brain351 / 1100989318
cervix0 / 481710 
connective tissue0 / 1492550 
ear0 / 162120 
embryonic tissue3 / 21572213
esophagus0 / 202090 
eye9 / 21105442
heart0 / 896260 
intestine15 / 23447263
kidney12 / 21177756
larynx3 / 24145124
liver4 / 20774319
lung0 / 3369740 
lymph0 / 442700 
lymph node0 / 916100 
mammary gland12 / 15327178
mouth0 / 670520 
muscle1 / 1077159
nerve0 / 157680 
ovary2 / 10205119
pancreas0 / 2148120 
parathyroid2 / 2053997
pharynx0 / 413280 
pituitary gland0 / 165850 
placenta15 / 28082553
prostate0 / 1893450 
salivary gland0 / 201550 
skin0 / 2105740 
spleen0 / 539520 
stomach0 / 966190 
testis10 / 33044230
thymus2 / 8113124
thyroid0 / 474730 
tonsil0 / 169990 
trachea1 / 5241319
umbilical cord0 / 136800 
uterus1 / 2328784
vascular0 / 517800 
Microarray in BioGPS Top
Select probe  
  • Microarray Platform: GeneAtlas U133A, gcrma
  • Affymatrix Probe ID: 206670_s_at
Cell line Expression level Expression bar
721_B_lymphoblasts5.1
Adipocyte4.3
AdrenalCortex4.7
Adrenalgland3.7
Amygdala4.6
Appendix4.45
AtrioventricularNode3.55
BDCA4+_DentriticCells4.55
Bonemarrow4.4
BronchialEpithelialCells4.25
CD105+_Endothelial9.4
CD14+_Monocytes4.65
CD19+_BCells(neg._sel.)4.5
CD33+_Myeloid5.4
CD34+5.6
CD4+_Tcells4.55
CD56+_NKCells5.1
CD71+_EarlyErythroid4.15
CD8+_Tcells4
CardiacMyocytes5.55
Caudatenucleus3.9
Cerebellum8.85
CerebellumPeduncles5.3
CiliaryGanglion3.25
CingulateCortex4.45
Colorectaladenocarcinoma10.5
DorsalRootGanglion3.5
FetalThyroid4.2
Fetalbrain4.35
Fetalliver3.8
Fetallung3.6
GlobusPallidus4.25
Heart5.85
Hypothalamus4.7
Kidney3.65
Leukemia_chronicMyelogenousK-56228.45
Leukemia_promyelocytic-HL-603.8
Leukemialymphoblastic(MOLT-4)3.5
Liver5.8
Lung4.65
Lymphnode3.65
Lymphoma_burkitts(Daudi)5.55
Lymphoma_burkitts(Raji)6.1
MedullaOblongata4.65
OccipitalLobe4.15
OlfactoryBulb3.45
Ovary2.95
Pancreas3.55
PancreaticIslet4.65
ParietalLobe4.65
Pituitary5.1
Placenta4.35
Pons4.1
PrefrontalCortex5.3
Prostate4.95
Salivarygland3.55
SkeletalMuscle5.3
Skin3.55
SmoothMuscle4.85
Spinalcord4.65
SubthalamicNucleus5.6
SuperiorCervicalGanglion4.85
TemporalLobe4
Testis3.75
TestisGermCell3.55
TestisIntersitial3.6
TestisLeydigCell4.3
TestisSeminiferousTubule3.7
Thalamus4.45
Thymus3.4
Thyroid5.2
Tongue4.4
Tonsil4.25
Trachea3.65
TrigeminalGanglion4.6
Uterus3.5
UterusCorpus3.95
WholeBlood4.7
Wholebrain9.2
colon4.35
pineal_day5.24
pineal_night5.16
retina5.125
small_intestine4.15
Allen Brain Atlas Top
Human Whole Brain Microarrayview in Allen Brain Atlas
  • Probe id     Donor id      
  • Probe name: A_23_P209578
  • Donor H0351.2001
  • Sex: Male     Age: 24 years     Race/Ethnicity: African American     Handedness: Left
  • Tissue Receipt Date: 7/29/2009     Serology: Pass      Tissue pH :6.72     Additional Medical Information :History of asthma
  • Postmortem Interval: 23 hours (estimated time of death to time that tissue is frozen)
  • Toxicology: Positive for atropine and caffeine, at levels usually not toxicologically significant
Tissue Expression(mean ± stddev) Expression Bar
Amygdala5.67 ± 0.51
Basal Forebrain6.23 ± 0.25
Basal Part of Pons5.23 ± 0.53
Cerebellar Cortex5.48 ± 0.67
Cerebellar Nuclei5.28 ± 0.44
Claustrum5.09 ± 0.86
Epithalamus4.16 ± 0.54
Frontal Lobe5.29 ± 0.51
Globus Pallidus5.74 ± 0.37
Hypothalamus6.03 ± 0.9
Insula5.42 ± 0.43
Limbic Lobe5.27 ± 0.54
Mesencephalon5.44 ± 0.5
Myelencephalon5.35 ± 0.64
Occipital Lobe5.32 ± 0.45
Parietal Lobe5.56 ± 0.59
Pontine Tegmentum5.46 ± 0.66
Striatum6.08 ± 0.56
Subthalamus4.58 ± 0.61
Temporal Lobe5.32 ± 0.55
Thalamus5.59 ± 0.52
White Matter4.16 ± 0.85
Mouse Brain ISH
Gene Symbol Brain Structure ID Brain Structure Name Express Desity/Level (Meatured by ISH) Express Bar
Gad1CBCerebellum95.04
95.07
Gad1CTXCerebral cortex77.46
94.79
Gad1HIPHippocampal region80.78
95.02
Gad1HPFHippocampal formation82.29
95.02
Gad1HYHypothalamus95.04
95.19
Gad1LSXLateral septal complex95
95
Gad1MBMidbrain93.31
95.1
Gad1MYMedulla88.45
95.01
Gad1OLFOlfactory bulb95.04
95.03
Gad1PPons72.47
94.99
Gad1PALPallidum95.02
95.02
Gad1RHPRetrohippocampal region83.81
95.02
Gad1sAMYStriatum-like amygdalar nuclei95.02
95.03
Gad1STRStriatum95.01
95.01
Gad1STRdStriatum dorsal region95.01
95.02
Gad1STRvStriatum ventral region95.01
95
Gad1THThalamus31.17
64.63
Peptide Top
Peptide Name Peptide Lengh Peptide Start Peptide End Peptide Sequence Source
PAp00064492 11 483 493 CLELAEYLYAK Peptide Atlas

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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