Annotation Detail for GAK
Basic Information Top
| Gene Symbol: | GAK ( FLJ16629,FLJ40395,MGC99654 ) |
|---|---|
| Gene Full Name: | cyclin G associated kinase |
| Band: | 4p16.3 |
| Quick Links | Entrez ID:2580; OMIM: 602052; Uniprot ID:GAK_HUMAN; ENSEMBL ID: ENSG00000178950; HGNC ID: 4113 |
| Relate to Another Database: | SFARIGene; denovo-db |
- Unigene ID: Hs.369607
| Pool Name | Gene EST/Total EST in pool | Transcripts per million(TPM) | Bar based on TPM |
|---|---|---|---|
 | |||
| embryoid body | 4 / 70761 | 56 |  |
| blastocyst | 6 / 62319 | 96 | |
| fetus | 27 / 564012 | 47 |  |
| neonate | 0 / 31097 | 0 | |
| infant | 0 / 23620 | 0 | |
| juvenile | 2 / 55556 | 35 | |
| adult | 135 / 1939121 | 69 | |
| Pool Name | Gene EST/Total EST in pool | Transcripts per million(TPM) | Bar based on TPM |
|---|---|---|---|
| |||
| adrenal tumor | 2 / 12794 | 156 | |
| bladder carcinoma | 1 / 17475 | 57 | |
| breast (mammary gland) tumor | 4 / 94178 | 42 | |
| cervical tumor | 2 / 34366 | 58 | |
| chondrosarcoma | 5 / 82823 | 60 | |
| colorectal tumor | 16 / 114246 | 140 | |
| esophageal tumor | 0 / 17290 | 0 | |
| gastrointestinal tumor | 8 / 119369 | 67 | |
| germ cell tumor | 15 / 263845 | 56 | |
| glioma | 9 / 106883 | 84 | |
| head and neck tumor | 11 / 136302 | 80 | |
| kidney tumor | 6 / 68959 | 87 | |
| leukemia | 11 / 95842 | 114 | |
| liver tumor | 0 / 96359 | 0 | |
| lung tumor | 7 / 103127 | 67 | |
| lymphoma | 3 / 71755 | 41 | |
| non-neoplasia | 3 / 97250 | 30 | |
| normal | 191 / 3360307 | 56 | |
| ovarian tumor | 10 / 76682 | 130 | |
| pancreatic tumor | 9 / 104616 | 86 | |
| primitive neuroectodermal tumor of the CNS | 7 / 125680 | 55 | |
| prostate cancer | 6 / 102680 | 58 | |
| retinoblastoma | 3 / 46356 | 64 | |
| skin tumor | 7 / 124949 | 56 | |
| soft tissue/muscle tissue tumor | 2 / 125191 | 15 | |
| uterine tumor | 6 / 90257 | 66 | |
| Pool Name | Gene EST/Total EST in pool | Transcripts per million(TPM) | Bar based on TPM |
|---|---|---|---|
| |||
| adipose tissue | 2 / 13106 | 152 | |
| adrenal gland | 2 / 33197 | 60 | |
| ascites | 4 / 40015 | 99 | |
| bladder | 2 / 29757 | 67 | |
| blood | 12 / 123478 | 97 | |
| bone | 4 / 71655 | 55 | |
| bone marrow | 0 / 48801 | 0 | |
| brain | 82 / 1100989 | 74 | |
| cervix | 2 / 48171 | 41 | |
| connective tissue | 5 / 149255 | 33 | |
| ear | 0 / 16212 | 0 | |
| embryonic tissue | 14 / 215722 | 64 | |
| esophagus | 0 / 20209 | 0 | |
| eye | 9 / 211054 | 42 | |
| heart | 2 / 89626 | 22 | |
| intestine | 32 / 234472 | 136 | |
| kidney | 13 / 211777 | 61 | |
| larynx | 0 / 24145 | 0 | |
| liver | 4 / 207743 | 19 | |
| lung | 25 / 336974 | 74 | |
| lymph | 1 / 44270 | 22 | |
| lymph node | 13 / 91610 | 141 | |
| mammary gland | 9 / 153271 | 58 | |
| mouth | 4 / 67052 | 59 | |
| muscle | 4 / 107715 | 37 | |
| nerve | 2 / 15768 | 126 | |
| ovary | 14 / 102051 | 137 | |
| pancreas | 10 / 214812 | 46 | |
| parathyroid | 5 / 20539 | 243 |  |
| pharynx | 0 / 41328 | 0 | |
| pituitary gland | 3 / 16585 | 180 | |
| placenta | 23 / 280825 | 81 | |
| prostate | 10 / 189345 | 52 | |
| salivary gland | 6 / 20155 | 297 | |
| skin | 9 / 210574 | 42 | |
| spleen | 2 / 53952 | 37 | |
| stomach | 4 / 96619 | 41 | |
| testis | 29 / 330442 | 87 | |
| thymus | 10 / 81131 | 123 | |
| thyroid | 2 / 47473 | 42 | |
| tonsil | 0 / 16999 | 0 | |
| trachea | 6 / 52413 | 114 | |
| umbilical cord | 0 / 13680 | 0 | |
| uterus | 8 / 232878 | 34 | |
| vascular | 0 / 51780 | 0 |
- Microarray Platform: GeneAtlas U133A, gcrma
- Affymatrix Probe ID: 202281_at
| Cell line | Expression level | Expression bar |
|---|---|---|
| ||
| 721_B_lymphoblasts | 43 | |
| Adipocyte | 17.3 | |
| AdrenalCortex | 39.15 | |
| Adrenalgland | 28.75 | |
| Amygdala | 44.05 | |
| Appendix | 22.4 | |
| AtrioventricularNode | 11.4 | |
| BDCA4+_DentriticCells | 98.15 | |
| Bonemarrow | 25.95 | |
| BronchialEpithelialCells | 34.95 | |
| CD105+_Endothelial | 43.3 | |
| CD14+_Monocytes | 103.5 | |
| CD19+_BCells(neg._sel.) | 44 | |
| CD33+_Myeloid | 78.85 | |
| CD34+ | 68.55 | |
| CD4+_Tcells | 96.15 | |
| CD56+_NKCells | 102.45 | |
| CD71+_EarlyErythroid | 33 | |
| CD8+_Tcells | 109.35 | |
| CardiacMyocytes | 29.85 | |
| Caudatenucleus | 32.1 | |
| Cerebellum | 27.35 | |
| CerebellumPeduncles | 38.7 | |
| CiliaryGanglion | 15.35 | |
| CingulateCortex | 36.35 | |
| Colorectaladenocarcinoma | 37.8 | |
| DorsalRootGanglion | 14.95 | |
| FetalThyroid | 39.95 | |
| Fetalbrain | 35.85 | |
| Fetalliver | 16.55 | |
| Fetallung | 33.55 | |
| GlobusPallidus | 15.5 | |
| Heart | 34.9 | |
| Hypothalamus | 41.65 | |
| Kidney | 29.5 | |
| Leukemia_chronicMyelogenousK-562 | 30.35 | |
| Leukemia_promyelocytic-HL-60 | 32.55 | |
| Leukemialymphoblastic(MOLT-4) | 57.85 | |
| Liver | 31.5 | |
| Lung | 61.9 | |
| Lymphnode | 53.65 | |
| Lymphoma_burkitts(Daudi) | 45.45 | |
| Lymphoma_burkitts(Raji) | 143.95 | |
| MedullaOblongata | 28.45 | |
| OccipitalLobe | 25.45 | |
| OlfactoryBulb | 28.7 | |
| Ovary | 14.95 | |
| Pancreas | 23.65 | |
| PancreaticIslet | 43.3 | |
| ParietalLobe | 21.65 | |
| Pituitary | 19.1 | |
| Placenta | 40.6 | |
| Pons | 23.35 | |
| PrefrontalCortex | 51.25 | |
| Prostate | 55.8 | |
| Salivarygland | 44.1 | |
| SkeletalMuscle | 32.3 | |
| Skin | 16.9 | |
| SmoothMuscle | 32.55 | |
| Spinalcord | 38.1 | |
| SubthalamicNucleus | 25.15 | |
| SuperiorCervicalGanglion | 25 | |
| TemporalLobe | 23.75 | |
| Testis | 72.6 | |
| TestisGermCell | 52.7 | |
| TestisIntersitial | 65.2 | |
| TestisLeydigCell | 44.15 | |
| TestisSeminiferousTubule | 60.1 | |
| Thalamus | 27.7 | |
| Thymus | 43.05 | |
| Thyroid | 47.65 | |
| Tongue | 34.4 | |
| Tonsil | 34.75 | |
| Trachea | 30.15 | |
| TrigeminalGanglion | 26.1 | |
| Uterus | 44.05 | |
| UterusCorpus | 28.15 | |
| WholeBlood | 39.55 | |
| Wholebrain | 33.9 | |
| colon | 31.3 | |
| pineal_day | 47.08 | |
| pineal_night | 44.36 | |
| retina | 34.65 | |
| small_intestine | 29.4 | |
- Probe name: A_23_P155700
- Donor H0351.2001
- Sex: Male Age: 24 years Race/Ethnicity: African American Handedness: Left
- Tissue Receipt Date: 7/29/2009 Serology: Pass Tissue pH :6.72 Additional Medical Information :History of asthma
- Postmortem Interval: 23 hours (estimated time of death to time that tissue is frozen)
- Toxicology: Positive for atropine and caffeine, at levels usually not toxicologically significant
| Tissue | Expression(mean ± stddev) | Expression Bar |
|---|---|---|
| Amygdala | 5.05 ± 0.42 | ![](../"images/bar_3.png"){kind=small}   |
| Basal Forebrain | 4.98 ± 0.46 | |
| Basal Part of Pons | 5.62 ± 0.37 | |
| Cerebellar Cortex | 5.58 ± 0.43 | |
| Cerebellar Nuclei | 5.07 ± 0.47 | |
| Claustrum | 5.01 ± 0.71 | |
| Epithalamus | 5.19 ± 0.6 | |
| Frontal Lobe | 5.43 ± 0.46 | |
| Globus Pallidus | 4.78 ± 0.27 | |
| Hypothalamus | 5.23 ± 0.47 | |
| Insula | 5.45 ± 0.42 | |
| Limbic Lobe | 5.3 ± 0.44 | |
| Mesencephalon | 5.24 ± 0.41 | |
| Myelencephalon | 5.28 ± 0.52 | |
| Occipital Lobe | 5 ± 0.45 | |
| Parietal Lobe | 5.27 ± 0.41 | |
| Pontine Tegmentum | 5.23 ± 0.55 | |
| Striatum | 5.02 ± 0.46 | |
| Subthalamus | 5.48 ± 0.29 | |
| Temporal Lobe | 5.49 ± 0.42 | |
| Thalamus | 5.28 ± 0.47 | |
| White Matter | 4.98 ± 0.35 | |
Mouse Brain ISH 
| Gene Symbol | Brain Structure ID | Brain Structure Name | Express Desity/Level (Meatured by ISH) | Express Bar |
|---|---|---|---|---|
| Gak | CB | Cerebellum | 100 | |
| 100 | | |||
| Gak | CTX | Cerebral cortex | 100 | |
| 100 | | |||
| Gak | HIP | Hippocampal region | 100 | |
| 100 | | |||
| Gak | HPF | Hippocampal formation | 100 | |
| 100 | | |||
| Gak | HY | Hypothalamus | 100 | |
| 100 | | |||
| Gak | LSX | Lateral septal complex | 100 | |
| 100 | | |||
| Gak | MB | Midbrain | 100 | |
| 100 | | |||
| Gak | MY | Medulla | 100 | |
| 100 | | |||
| Gak | OLF | Olfactory bulb | 100 | |
| 100 | | |||
| Gak | P | Pons | 86.96 | |
| 100 | | |||
| Gak | PAL | Pallidum | 95.32 | |
| 100 | | |||
| Gak | RHP | Retrohippocampal region | 100 | |
| 100 | | |||
| Gak | sAMY | Striatum-like amygdalar nuclei | 100 | |
| 100 | | |||
| Gak | STR | Striatum | 100 | |
| 100 | | |||
| Gak | STRd | Striatum dorsal region | 100 | |
| 100 | | |||
| Gak | STRv | Striatum ventral region | 100 | |
| 100 | | |||
| Gak | TH | Thalamus | 100 | |
| 100 | |
| Peptide Name | Peptide Lengh | Peptide Start | Peptide End | Peptide Sequence | Source |
|---|---|---|---|---|---|
| GAK_HUMAN_0 | 0 | 0 | 0 | LSIAEVVHQLQEIAAAR | PRIDE |
| GAK_HUMAN_165 | 8 | 165 | 172 | QKPPIIHR | PRIDE |
| GAK_HUMAN_498 | 10 | 498 | 507 | QDHKNVCVVH | PRIDE |
| PAp00039320 | 19 | 1141 | 1159 | ACTQPRPNYASNFSVIGAR | Peptide Atlas |