AutismKB 2.0

Annotation Detail for GCA


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Basic Information Top
Gene Symbol:GCA ( GCL )
Gene Full Name: grancalcin, EF-hand calcium binding protein
Band: 2q24.2
Quick LinksEntrez ID:25801; OMIM: 607030; Uniprot ID:GRAN_HUMAN; ENSEMBL ID: ENSG00000115271; HGNC ID: 15990
Relate to Another Database: SFARIGene; denovo-db
Unigene EST Top
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
embryoid body2 / 7076128
blastocyst4 / 6231964
fetus8 / 56401214
neonate2 / 3109764
infant0 / 236200 
juvenile0 / 555560 
adult84 / 193912143
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adrenal tumor1 / 1279478
bladder carcinoma4 / 17475228
breast (mammary gland) tumor1 / 9417810
cervical tumor0 / 343660 
chondrosarcoma1 / 8282312
colorectal tumor1 / 1142468
esophageal tumor0 / 172900 
gastrointestinal tumor2 / 11936916
germ cell tumor4 / 26384515
glioma1 / 1068839
head and neck tumor0 / 1363020 
kidney tumor4 / 6895958
leukemia7 / 9584273
liver tumor0 / 963590 
lung tumor0 / 1031270 
lymphoma3 / 7175541
non-neoplasia7 / 9725071
normal149 / 336030744
ovarian tumor1 / 7668213
pancreatic tumor2 / 10461619
primitive neuroectodermal tumor of the CNS0 / 1256800 
prostate cancer1 / 1026809
retinoblastoma0 / 463560 
skin tumor1 / 1249498
soft tissue/muscle tissue tumor5 / 12519139
uterine tumor4 / 9025744
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adipose tissue0 / 131060 
adrenal gland1 / 3319730
ascites0 / 400150 
bladder4 / 29757134
blood19 / 123478153
bone1 / 7165513
bone marrow7 / 48801143
brain61 / 110098955
cervix1 / 4817120
connective tissue6 / 14925540
ear0 / 162120 
embryonic tissue9 / 21572241
esophagus0 / 202090 
eye0 / 2110540 
heart1 / 8962611
intestine1 / 2344724
kidney9 / 21177742
larynx0 / 241450 
liver0 / 2077430 
lung11 / 33697432
lymph1 / 4427022
lymph node12 / 91610130
mammary gland5 / 15327132
mouth0 / 670520 
muscle1 / 1077159
nerve2 / 15768126
ovary2 / 10205119
pancreas6 / 21481227
parathyroid2 / 2053997
pharynx3 / 4132872
pituitary gland1 / 1658560
placenta20 / 28082571
prostate2 / 18934510
salivary gland0 / 201550 
skin2 / 2105749
spleen3 / 5395255
stomach3 / 9661931
testis7 / 33044221
thymus4 / 8113149
thyroid1 / 4747321
tonsil0 / 169990 
trachea1 / 5241319
umbilical cord2 / 13680146
uterus5 / 23287821
vascular3 / 5178057
Microarray in BioGPS Top
Select probe  
  • Microarray Platform: GeneAtlas U133A, gcrma
  • Affymatrix Probe ID: 203765_at
Cell line Expression level Expression bar
721_B_lymphoblasts46.25
Adipocyte13
AdrenalCortex21.35
Adrenalgland14.25
Amygdala72.25
Appendix24.7
AtrioventricularNode16.6
BDCA4+_DentriticCells73.95
Bonemarrow679.05
BronchialEpithelialCells9.35
CD105+_Endothelial36.1
CD14+_Monocytes795.25
CD19+_BCells(neg._sel.)54.3
CD33+_Myeloid1016.2
CD34+120.2
CD4+_Tcells14.2
CD56+_NKCells20.7
CD71+_EarlyErythroid17.55
CD8+_Tcells15.3
CardiacMyocytes22.35
Caudatenucleus29.25
Cerebellum14.5
CerebellumPeduncles21.6
CiliaryGanglion12.7
CingulateCortex27.5
Colorectaladenocarcinoma19.75
DorsalRootGanglion17
FetalThyroid17.2
Fetalbrain20.15
Fetalliver16.5
Fetallung25.5
GlobusPallidus18.5
Heart23.25
Hypothalamus47.65
Kidney14
Leukemia_chronicMyelogenousK-56216
Leukemia_promyelocytic-HL-6016.1
Leukemialymphoblastic(MOLT-4)12.35
Liver24.7
Lung17
Lymphnode28.65
Lymphoma_burkitts(Daudi)23.95
Lymphoma_burkitts(Raji)25.5
MedullaOblongata25.75
OccipitalLobe26.3
OlfactoryBulb15.55
Ovary13.3
Pancreas15.85
PancreaticIslet26.7
ParietalLobe21.2
Pituitary17.25
Placenta22.65
Pons19.15
PrefrontalCortex62.05
Prostate19
Salivarygland14.7
SkeletalMuscle23.9
Skin15.8
SmoothMuscle18.8
Spinalcord30.6
SubthalamicNucleus21.75
SuperiorCervicalGanglion29.95
TemporalLobe22.25
Testis14.7
TestisGermCell14.6
TestisIntersitial15.7
TestisLeydigCell17.85
TestisSeminiferousTubule14.55
Thalamus21.25
Thymus13.95
Thyroid26.85
Tongue18.85
Tonsil17.7
Trachea15.5
TrigeminalGanglion20.1
Uterus13.65
UterusCorpus16.75
WholeBlood3366.9
Wholebrain27.2
colon34.25
pineal_day40.9
pineal_night42.34
retina24.55
small_intestine79.15
Allen Brain Atlas Top
Human Whole Brain Microarrayview in Allen Brain Atlas
  • Probe id     Donor id      
  • Probe name: CUST_11297_PI416261804
  • Donor H0351.2001
  • Sex: Male     Age: 24 years     Race/Ethnicity: African American     Handedness: Left
  • Tissue Receipt Date: 7/29/2009     Serology: Pass      Tissue pH :6.72     Additional Medical Information :History of asthma
  • Postmortem Interval: 23 hours (estimated time of death to time that tissue is frozen)
  • Toxicology: Positive for atropine and caffeine, at levels usually not toxicologically significant
Tissue Expression(mean ± stddev) Expression Bar
Amygdala5.24 ± 0.54
Basal Forebrain5.46 ± 0.42
Basal Part of Pons5.73 ± 0.39
Cerebellar Cortex5.16 ± 0.45
Cerebellar Nuclei5.92 ± 0.59
Claustrum4.65 ± 0.98
Epithalamus5.63 ± 0.44
Frontal Lobe5.56 ± 0.48
Globus Pallidus6.08 ± 0.29
Hypothalamus5.64 ± 0.38
Insula5.18 ± 0.52
Limbic Lobe5.05 ± 0.53
Mesencephalon5.34 ± 0.58
Myelencephalon5.39 ± 0.54
Occipital Lobe5.18 ± 0.62
Parietal Lobe5.4 ± 0.51
Pontine Tegmentum5.49 ± 0.39
Striatum5.16 ± 0.59
Subthalamus5.95 ± 0.45
Temporal Lobe5.38 ± 0.45
Thalamus5.54 ± 0.57
White Matter7.58 ± 0.36
Mouse Brain ISH
Gene Symbol Brain Structure ID Brain Structure Name Express Desity/Level (Meatured by ISH) Express Bar
GcaCBCerebellum2.19
3.75
GcaCTXCerebral cortex28.11
20.45
GcaHIPHippocampal region6.78
6.77
GcaHPFHippocampal formation7.38
6.73
GcaHYHypothalamus1.5
1.76
GcaLSXLateral septal complex0.5
0.42
GcaMBMidbrain2.44
2.59
GcaMYMedulla1.64
3.22
GcaOLFOlfactory bulb11.23
7.95
GcaPPons1.8
2.59
GcaPALPallidum0.84
0.82
GcaRHPRetrohippocampal region8.49
6.81
GcasAMYStriatum-like amygdalar nuclei1.2
0.74
GcaSTRStriatum3.5
2.51
GcaSTRdStriatum dorsal region4.63
3.35
GcaSTRvStriatum ventral region0.59
0.55
GcaTHThalamus2.55
2.14
Peptide Top
Peptide Name Peptide Lengh Peptide Start Peptide End Peptide Sequence Source
GRAN_HUMAN_145 9 145 153 QAIGLMGYR PRIDE
GRAN_HUMAN_146 9 146 154 QAIGLMGYR PRIDE
GRAN_HUMAN_154 11 154 164 LSPQTLTTIVK PRIDE
GRAN_HUMAN_172 12 172 183 IFFDDYVACCVK PRIDE
PAp00033609 20 126 145 ENFMTVDQDGSGTVEHHELR Peptide Atlas

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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