AutismKB 2.0

Annotation Detail for PRKD2


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Basic Information Top
Gene Symbol:PRKD2 ( PKD2 )
Gene Full Name: protein kinase D2
Band: 19q13.2
Quick LinksEntrez ID:25865; OMIM: 607074; Uniprot ID:KPCD2_HUMAN; ENSEMBL ID: ENSG00000105287; HGNC ID: 17293
Relate to Another Database: SFARIGene; denovo-db
Unigene EST Top
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
embryoid body5 / 7076170
blastocyst3 / 6231948
fetus25 / 56401244
neonate2 / 3109764
infant1 / 2362042
juvenile2 / 5555635
adult137 / 193912170
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adrenal tumor1 / 1279478
bladder carcinoma0 / 174750 
breast (mammary gland) tumor10 / 94178106
cervical tumor0 / 343660 
chondrosarcoma6 / 8282372
colorectal tumor7 / 11424661
esophageal tumor2 / 17290115
gastrointestinal tumor9 / 11936975
germ cell tumor26 / 26384598
glioma5 / 10688346
head and neck tumor14 / 136302102
kidney tumor4 / 6895958
leukemia8 / 9584283
liver tumor6 / 9635962
lung tumor6 / 10312758
lymphoma5 / 7175569
non-neoplasia8 / 9725082
normal203 / 336030760
ovarian tumor13 / 76682169
pancreatic tumor6 / 10461657
primitive neuroectodermal tumor of the CNS8 / 12568063
prostate cancer1 / 1026809
retinoblastoma1 / 4635621
skin tumor7 / 12494956
soft tissue/muscle tissue tumor6 / 12519147
uterine tumor4 / 9025744
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adipose tissue1 / 1310676
adrenal gland1 / 3319730
ascites2 / 4001549
bladder2 / 2975767
blood7 / 12347856
bone5 / 7165569
bone marrow3 / 4880161
brain40 / 110098936
cervix0 / 481710 
connective tissue9 / 14925560
ear0 / 162120 
embryonic tissue11 / 21572250
esophagus2 / 2020998
eye7 / 21105433
heart1 / 8962611
intestine17 / 23447272
kidney10 / 21177747
larynx0 / 241450 
liver8 / 20774338
lung15 / 33697444
lymph2 / 4427045
lymph node16 / 91610174
mammary gland21 / 153271137
mouth9 / 67052134
muscle1 / 1077159
nerve3 / 15768190
ovary17 / 102051166
pancreas9 / 21481241
parathyroid0 / 205390 
pharynx3 / 4132872
pituitary gland0 / 165850 
placenta21 / 28082574
prostate13 / 18934568
salivary gland0 / 201550 
skin17 / 21057480
spleen24 / 53952444
stomach7 / 9661972
testis20 / 33044260
thymus46 / 81131566
thyroid6 / 47473126
tonsil4 / 16999235
trachea13 / 52413248
umbilical cord1 / 1368073
uterus21 / 23287890
vascular4 / 5178077
Microarray in BioGPS Top
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  • Microarray Platform: GeneAtlas U133A, gcrma
  • Affymatrix Probe ID: 38269_at
Cell line Expression level Expression bar
721_B_lymphoblasts183.9
Adipocyte10.85
AdrenalCortex12
Adrenalgland10.4
Amygdala11.5
Appendix12.45
AtrioventricularNode8.85
BDCA4+_DentriticCells57.35
Bonemarrow15.15
BronchialEpithelialCells21.65
CD105+_Endothelial13.85
CD14+_Monocytes30.7
CD19+_BCells(neg._sel.)270.45
CD33+_Myeloid18.4
CD34+26.85
CD4+_Tcells272.5
CD56+_NKCells203.45
CD71+_EarlyErythroid15.65
CD8+_Tcells267.55
CardiacMyocytes20.7
Caudatenucleus9.4
Cerebellum8.9
CerebellumPeduncles11.6
CiliaryGanglion8
CingulateCortex10.5
Colorectaladenocarcinoma85.35
DorsalRootGanglion8.3
FetalThyroid41.7
Fetalbrain11.15
Fetalliver9.1
Fetallung43.8
GlobusPallidus8.15
Heart54.4
Hypothalamus11.75
Kidney10.3
Leukemia_chronicMyelogenousK-56216.7
Leukemia_promyelocytic-HL-6010.65
Leukemialymphoblastic(MOLT-4)52.15
Liver39.65
Lung169.6
Lymphnode84.75
Lymphoma_burkitts(Daudi)54.5
Lymphoma_burkitts(Raji)55.55
MedullaOblongata9.75
OccipitalLobe10
OlfactoryBulb9.7
Ovary7.45
Pancreas22.6
PancreaticIslet42.75
ParietalLobe11.35
Pituitary19.2
Placenta54.15
Pons10.8
PrefrontalCortex13.75
Prostate150.25
Salivarygland9.2
SkeletalMuscle13.3
Skin9.9
SmoothMuscle31.2
Spinalcord11.8
SubthalamicNucleus10
SuperiorCervicalGanglion12.4
TemporalLobe9.95
Testis12.65
TestisGermCell9.85
TestisIntersitial9.45
TestisLeydigCell11.35
TestisSeminiferousTubule10.85
Thalamus10.6
Thymus180.55
Thyroid49.6
Tongue13.8
Tonsil87
Trachea12.65
TrigeminalGanglion11.05
Uterus44.35
UterusCorpus10.7
WholeBlood250.7
Wholebrain9.4
colon11.35
pineal_day16.6
pineal_night16.22
retina23.1
small_intestine11
Allen Brain Atlas Top
Human Whole Brain Microarrayview in Allen Brain Atlas
  • Probe id     Donor id      
  • Probe name: A_23_P78802
  • Donor H0351.2001
  • Sex: Male     Age: 24 years     Race/Ethnicity: African American     Handedness: Left
  • Tissue Receipt Date: 7/29/2009     Serology: Pass      Tissue pH :6.72     Additional Medical Information :History of asthma
  • Postmortem Interval: 23 hours (estimated time of death to time that tissue is frozen)
  • Toxicology: Positive for atropine and caffeine, at levels usually not toxicologically significant
Tissue Expression(mean ± stddev) Expression Bar
Amygdala4.22 ± 0.4
Basal Forebrain4.08 ± 0.39
Basal Part of Pons3.85 ± 0.45
Cerebellar Cortex3.86 ± 0.52
Cerebellar Nuclei4.06 ± 0.35
Claustrum3.73 ± 0.7
Epithalamus4.79 ± 0.56
Frontal Lobe4.25 ± 0.49
Globus Pallidus4.36 ± 0.39
Hypothalamus4.04 ± 0.55
Insula4.33 ± 0.26
Limbic Lobe4.26 ± 0.46
Mesencephalon4.23 ± 0.48
Myelencephalon4.21 ± 0.54
Occipital Lobe4.24 ± 0.46
Parietal Lobe4.17 ± 0.41
Pontine Tegmentum4.22 ± 0.5
Striatum4.52 ± 0.45
Subthalamus3.71 ± 0.35
Temporal Lobe4.24 ± 0.41
Thalamus4.16 ± 0.41
White Matter4.08 ± 0.32
Mouse Brain ISH
Gene Symbol Brain Structure ID Brain Structure Name Express Desity/Level (Meatured by ISH) Express Bar
Prkd2HYHypothalamus0.21
0.39
Peptide Top
Peptide Name Peptide Lengh Peptide Start Peptide End Peptide Sequence Source
KPCD2_HUMAN_506 21 506 526 QALMPVILQDAPSAPGHAPHR PRIDE
KPCD2_HUMAN_597 10 597 606 NEVAILQSLR PRIDE
PAp00005830 24 669 692 NIVHCDLKPENVLLASADPFPQVK Peptide Atlas

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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