AutismKB 2.0

Annotation Detail for TMEM186


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Basic Information Top
Gene Symbol:TMEM186 ( C16orf51,DKFZp564K2062 )
Gene Full Name: transmembrane protein 186
Band: 16p13.2
Quick LinksEntrez ID:25880; OMIM: NA; Uniprot ID:TM186_HUMAN; ENSEMBL ID: ENSG00000184857; HGNC ID: 24530
Relate to Another Database: SFARIGene; denovo-db
Unigene EST Top
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
embryoid body1 / 7076114
blastocyst0 / 623190 
fetus14 / 56401224
neonate0 / 310970 
infant0 / 236200 
juvenile0 / 555560 
adult38 / 193912119
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adrenal tumor1 / 1279478
bladder carcinoma0 / 174750 
breast (mammary gland) tumor7 / 9417874
cervical tumor0 / 343660 
chondrosarcoma1 / 8282312
colorectal tumor2 / 11424617
esophageal tumor0 / 172900 
gastrointestinal tumor6 / 11936950
germ cell tumor4 / 26384515
glioma5 / 10688346
head and neck tumor2 / 13630214
kidney tumor0 / 689590 
leukemia3 / 9584231
liver tumor0 / 963590 
lung tumor1 / 1031279
lymphoma0 / 717550 
non-neoplasia0 / 972500 
normal53 / 336030715
ovarian tumor3 / 7668239
pancreatic tumor2 / 10461619
primitive neuroectodermal tumor of the CNS0 / 1256800 
prostate cancer5 / 10268048
retinoblastoma2 / 4635643
skin tumor4 / 12494932
soft tissue/muscle tissue tumor1 / 1251917
uterine tumor2 / 9025722
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adipose tissue0 / 131060 
adrenal gland1 / 3319730
ascites0 / 400150 
bladder0 / 297570 
blood2 / 12347816
bone0 / 716550 
bone marrow1 / 4880120
brain14 / 110098912
cervix0 / 481710 
connective tissue2 / 14925513
ear0 / 162120 
embryonic tissue1 / 2157224
esophagus0 / 202090 
eye6 / 21105428
heart0 / 896260 
intestine7 / 23447229
kidney3 / 21177714
larynx0 / 241450 
liver1 / 2077434
lung4 / 33697411
lymph0 / 442700 
lymph node0 / 916100 
mammary gland7 / 15327145
mouth2 / 6705229
muscle0 / 1077150 
nerve0 / 157680 
ovary3 / 10205129
pancreas2 / 2148129
parathyroid0 / 205390 
pharynx2 / 4132848
pituitary gland0 / 165850 
placenta6 / 28082521
prostate11 / 18934558
salivary gland0 / 201550 
skin4 / 21057418
spleen2 / 5395237
stomach5 / 9661951
testis5 / 33044215
thymus1 / 8113112
thyroid0 / 474730 
tonsil0 / 169990 
trachea0 / 524130 
umbilical cord0 / 136800 
uterus3 / 23287812
vascular0 / 517800 
Microarray in BioGPS Top
Select probe  
  • Microarray Platform: GeneAtlas U133A, gcrma
  • Affymatrix Probe ID: 204676_at
Cell line Expression level Expression bar
721_B_lymphoblasts29.65
Adipocyte6.65
AdrenalCortex7.3
Adrenalgland6.2
Amygdala6.85
Appendix7.3
AtrioventricularNode5.9
BDCA4+_DentriticCells7.15
Bonemarrow7.05
BronchialEpithelialCells7.1
CD105+_Endothelial7.15
CD14+_Monocytes7.4
CD19+_BCells(neg._sel.)9.25
CD33+_Myeloid8.55
CD34+12.15
CD4+_Tcells8.5
CD56+_NKCells7.85
CD71+_EarlyErythroid6.4
CD8+_Tcells7.95
CardiacMyocytes8.5
Caudatenucleus6.05
Cerebellum5.45
CerebellumPeduncles9
CiliaryGanglion5.35
CingulateCortex7.05
Colorectaladenocarcinoma6.9
DorsalRootGanglion5.65
FetalThyroid7.3
Fetalbrain8
Fetalliver5.95
Fetallung5.1
GlobusPallidus5
Heart9.95
Hypothalamus8.05
Kidney5.85
Leukemia_chronicMyelogenousK-56210.8
Leukemia_promyelocytic-HL-608.95
Leukemialymphoblastic(MOLT-4)7.2
Liver9.2
Lung7.5
Lymphnode6
Lymphoma_burkitts(Daudi)15.95
Lymphoma_burkitts(Raji)9.95
MedullaOblongata6.3
OccipitalLobe6.15
OlfactoryBulb5.35
Ovary6.2
Pancreas6.1
PancreaticIslet7.4
ParietalLobe7.3
Pituitary10.85
Placenta6.8
Pons7.55
PrefrontalCortex8.05
Prostate8
Salivarygland5.4
SkeletalMuscle8.75
Skin5.7
SmoothMuscle7.75
Spinalcord7.25
SubthalamicNucleus6.15
SuperiorCervicalGanglion7.5
TemporalLobe6.7
Testis5.85
TestisGermCell5.3
TestisIntersitial5.7
TestisLeydigCell6.85
TestisSeminiferousTubule5.65
Thalamus6.9
Thymus5.5
Thyroid8.65
Tongue7.1
Tonsil6.65
Trachea5.55
TrigeminalGanglion7.55
Uterus5.65
UterusCorpus6.1
WholeBlood7.3
Wholebrain7.75
colon7.35
pineal_day8
pineal_night7.8
retina8.375
small_intestine6.6
Allen Brain Atlas Top
Human Whole Brain Microarrayview in Allen Brain Atlas
  • Probe id     Donor id      
  • Probe name: CUST_55_PI416383280
  • Donor H0351.2001
  • Sex: Male     Age: 24 years     Race/Ethnicity: African American     Handedness: Left
  • Tissue Receipt Date: 7/29/2009     Serology: Pass      Tissue pH :6.72     Additional Medical Information :History of asthma
  • Postmortem Interval: 23 hours (estimated time of death to time that tissue is frozen)
  • Toxicology: Positive for atropine and caffeine, at levels usually not toxicologically significant
Tissue Expression(mean ± stddev) Expression Bar
Amygdala5.5 ± 0.5
Basal Forebrain5.63 ± 0.65
Basal Part of Pons5.97 ± 0.44
Cerebellar Cortex5.74 ± 0.34
Cerebellar Nuclei5.63 ± 0.46
Claustrum5.16 ± 1
Epithalamus5.95 ± 0.46
Frontal Lobe5.99 ± 0.41
Globus Pallidus5.74 ± 0.29
Hypothalamus6.04 ± 0.51
Insula6.04 ± 0.3
Limbic Lobe5.48 ± 0.66
Mesencephalon5.75 ± 0.55
Myelencephalon5.68 ± 0.64
Occipital Lobe5.22 ± 0.62
Parietal Lobe5.78 ± 0.56
Pontine Tegmentum5.84 ± 0.55
Striatum5.49 ± 0.61
Subthalamus6.18 ± 0.38
Temporal Lobe5.95 ± 0.43
Thalamus5.83 ± 0.47
White Matter5.51 ± 0.56
Mouse Brain ISH
Gene Symbol Brain Structure ID Brain Structure Name Express Desity/Level (Meatured by ISH) Express Bar
4432406C05RikCBCerebellum4.05
4.79
4432406C05RikCTXCerebral cortex5.71
3.84
4432406C05RikHIPHippocampal region6.3
5.24
4432406C05RikHPFHippocampal formation6.23
4.96
4432406C05RikHYHypothalamus10.32
7.43
4432406C05RikLSXLateral septal complex4.21
2.72
4432406C05RikMBMidbrain5.38
4.92
4432406C05RikMYMedulla9.48
11.22
4432406C05RikOLFOlfactory bulb9.89
7.47
4432406C05RikPPons7.88
8.35
4432406C05RikPALPallidum8.59
6.82
4432406C05RikRHPRetrohippocampal region6.28
4.5
4432406C05RiksAMYStriatum-like amygdalar nuclei4.5
3.43
4432406C05RikSTRStriatum4.62
3.17
4432406C05RikSTRdStriatum dorsal region2.41
1.66
4432406C05RikSTRvStriatum ventral region10.64
6.66
4432406C05RikTHThalamus9.76
9.04
Peptide Top

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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