Annotation Detail for PLEKHG4
Basic Information Top
| Gene Symbol: | PLEKHG4 ( ARHGEF44,DKFZp434I216,PRTPHN1,SCA4 ) |
|---|---|
| Gene Full Name: | pleckstrin homology domain containing, family G (with RhoGef domain) member 4 |
| Band: | 16q22.1 |
| Quick Links | Entrez ID:25894; OMIM: 609526; Uniprot ID:PKHG4_HUMAN; ENSEMBL ID: ENSG00000196155; HGNC ID: 24501 |
| Relate to Another Database: | SFARIGene; denovo-db |
- Unigene ID: Hs.188781
| Pool Name | Gene EST/Total EST in pool | Transcripts per million(TPM) | Bar based on TPM |
|---|---|---|---|
 | |||
| embryoid body | 0 / 70761 | 0 | |
| blastocyst | 0 / 62319 | 0 | |
| fetus | 11 / 564012 | 19 |  |
| neonate | 0 / 31097 | 0 | |
| infant | 0 / 23620 | 0 | |
| juvenile | 1 / 55556 | 17 | |
| adult | 22 / 1939121 | 11 | |
| Pool Name | Gene EST/Total EST in pool | Transcripts per million(TPM) | Bar based on TPM |
|---|---|---|---|
| |||
| adrenal tumor | 0 / 12794 | 0 | |
| bladder carcinoma | 2 / 17475 | 114 |  |
| breast (mammary gland) tumor | 0 / 94178 | 0 | |
| cervical tumor | 2 / 34366 | 58 | |
| chondrosarcoma | 0 / 82823 | 0 | |
| colorectal tumor | 3 / 114246 | 26 | |
| esophageal tumor | 0 / 17290 | 0 | |
| gastrointestinal tumor | 0 / 119369 | 0 | |
| germ cell tumor | 5 / 263845 | 18 | |
| glioma | 0 / 106883 | 0 | |
| head and neck tumor | 4 / 136302 | 29 | |
| kidney tumor | 2 / 68959 | 29 | |
| leukemia | 6 / 95842 | 62 | |
| liver tumor | 0 / 96359 | 0 | |
| lung tumor | 2 / 103127 | 19 | |
| lymphoma | 0 / 71755 | 0 | |
| non-neoplasia | 1 / 97250 | 10 |  |
| normal | 62 / 3360307 | 18 | |
| ovarian tumor | 1 / 76682 | 13 | |
| pancreatic tumor | 1 / 104616 | 9 | |
| primitive neuroectodermal tumor of the CNS | 1 / 125680 | 7 | |
| prostate cancer | 0 / 102680 | 0 | |
| retinoblastoma | 2 / 46356 | 43 | |
| skin tumor | 11 / 124949 | 88 | |
| soft tissue/muscle tissue tumor | 0 / 125191 | 0 | |
| uterine tumor | 1 / 90257 | 11 | |
| Pool Name | Gene EST/Total EST in pool | Transcripts per million(TPM) | Bar based on TPM |
|---|---|---|---|
| |||
| adipose tissue | 0 / 13106 | 0 | |
| adrenal gland | 0 / 33197 | 0 | |
| ascites | 0 / 40015 | 0 | |
| bladder | 0 / 29757 | 0 | |
| blood | 11 / 123478 | 89 | |
| bone | 1 / 71655 | 13 | |
| bone marrow | 1 / 48801 | 20 | |
| brain | 9 / 1100989 | 8 | |
| cervix | 2 / 48171 | 41 | |
| connective tissue | 0 / 149255 | 0 | |
| ear | 0 / 16212 | 0 | |
| embryonic tissue | 1 / 215722 | 4 | |
| esophagus | 0 / 20209 | 0 | |
| eye | 7 / 211054 | 33 | |
| heart | 5 / 89626 | 55 | |
| intestine | 3 / 234472 | 12 | |
| kidney | 3 / 211777 | 14 | |
| larynx | 2 / 24145 | 82 | |
| liver | 0 / 207743 | 0 | |
| lung | 3 / 336974 | 8 | |
| lymph | 0 / 44270 | 0 | |
| lymph node | 0 / 91610 | 0 | |
| mammary gland | 0 / 153271 | 0 | |
| mouth | 1 / 67052 | 14 | |
| muscle | 1 / 107715 | 9 | |
| nerve | 0 / 15768 | 0 | |
| ovary | 3 / 102051 | 29 | |
| pancreas | 1 / 214812 | 4 | |
| parathyroid | 0 / 20539 | 0 | |
| pharynx | 0 / 41328 | 0 | |
| pituitary gland | 0 / 16585 | 0 | |
| placenta | 5 / 280825 | 17 | |
| prostate | 0 / 189345 | 0 | |
| salivary gland | 0 / 20155 | 0 | |
| skin | 17 / 210574 | 80 | |
| spleen | 1 / 53952 | 18 | |
| stomach | 0 / 96619 | 0 | |
| testis | 51 / 330442 | 154 | |
| thymus | 2 / 81131 | 24 | |
| thyroid | 1 / 47473 | 21 | |
| tonsil | 1 / 16999 | 58 | |
| trachea | 0 / 52413 | 0 | |
| umbilical cord | 0 / 13680 | 0 | |
| uterus | 6 / 232878 | 25 | |
| vascular | 1 / 51780 | 19 | |
Microarray in - Probe name: A_23_P345460
- Donor H0351.2001
- Sex: Male Age: 24 years Race/Ethnicity: African American Handedness: Left
- Tissue Receipt Date: 7/29/2009 Serology: Pass Tissue pH :6.72 Additional Medical Information :History of asthma
- Postmortem Interval: 23 hours (estimated time of death to time that tissue is frozen)
- Toxicology: Positive for atropine and caffeine, at levels usually not toxicologically significant
| Tissue | Expression(mean ± stddev) | Expression Bar |
|---|---|---|
| Amygdala | 2.84 ± 0.94 | ![](../"images/bar_3.png"){kind=small}   |
| Basal Forebrain | 2.71 ± 0.29 | |
| Basal Part of Pons | 2.77 ± 0.65 | |
| Cerebellar Cortex | 2.65 ± 0.44 | |
| Cerebellar Nuclei | 3.3 ± 0.68 | |
| Claustrum | 2.66 ± 0.67 | |
| Epithalamus | 2.45 ± 0.81 | |
| Frontal Lobe | 2.71 ± 0.75 | |
| Globus Pallidus | 4.18 ± 0.81 | |
| Hypothalamus | 3.29 ± 0.64 | |
| Insula | 2.47 ± 0.5 | |
| Limbic Lobe | 2.59 ± 0.79 | |
| Mesencephalon | 2.92 ± 0.8 | |
| Myelencephalon | 2.75 ± 0.77 | |
| Occipital Lobe | 2.68 ± 0.8 | |
| Parietal Lobe | 2.78 ± 0.75 | |
| Pontine Tegmentum | 2.78 ± 0.62 | |
| Striatum | 2.95 ± 0.6 | |
| Subthalamus | 3.62 ± 1.35 | |
| Temporal Lobe | 2.42 ± 0.7 | |
| Thalamus | 2.66 ± 0.67 | |
| White Matter | 5.19 ± 0.28 | |
Mouse Brain ISH 
| Gene Symbol | Brain Structure ID | Brain Structure Name | Express Desity/Level (Meatured by ISH) | Express Bar |
|---|---|---|---|---|
| Plekhg4 | CB | Cerebellum | 5.44 | |
| 7.02 | | |||
| Plekhg4 | CTX | Cerebral cortex | 3.27 | |
| 2.57 | | |||
| Plekhg4 | HIP | Hippocampal region | 1.71 | |
| 1.55 | | |||
| Plekhg4 | HPF | Hippocampal formation | 1.4 | |
| 1.24 | | |||
| Plekhg4 | HY | Hypothalamus | 1.02 | |
| 1.35 | | |||
| Plekhg4 | LSX | Lateral septal complex | 0.35 | |
| 0.19 | | |||
| Plekhg4 | MB | Midbrain | 1.72 | |
| 1.65 | | |||
| Plekhg4 | MY | Medulla | 4.24 | |
| 4.48 | | |||
| Plekhg4 | OLF | Olfactory bulb | 5.37 | |
| 3.7 | | |||
| Plekhg4 | P | Pons | 1.7 | |
| 1.92 | | |||
| Plekhg4 | PAL | Pallidum | 0.72 | |
| 0.82 | | |||
| Plekhg4 | RHP | Retrohippocampal region | 0.84 | |
| 0.82 | | |||
| Plekhg4 | sAMY | Striatum-like amygdalar nuclei | 3 | |
| 1.94 | | |||
| Plekhg4 | STR | Striatum | 1.96 | |
| 1.42 | | |||
| Plekhg4 | STRd | Striatum dorsal region | 1.41 | |
| 1.14 | | |||
| Plekhg4 | STRv | Striatum ventral region | 3.9 | |
| 2.46 | | |||
| Plekhg4 | TH | Thalamus | 1.32 | |
| 1.33 | |