AutismKB 2.0

Annotation Detail for ZNF521


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Basic Information Top
Gene Symbol:ZNF521 ( DKFZp564D0764,EHZF,Evi3,MGC142182,MGC142208 )
Gene Full Name: zinc finger protein 521
Band: 18q11.2
Quick LinksEntrez ID:25925; OMIM: 610974; Uniprot ID:ZN521_HUMAN; ENSEMBL ID: ENSG00000198795; HGNC ID: 24605
Relate to Another Database: SFARIGene; denovo-db
Unigene EST Top
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
embryoid body6 / 7076184
blastocyst4 / 6231964
fetus26 / 56401246
neonate4 / 31097128
infant0 / 236200 
juvenile1 / 5555617
adult25 / 193912112
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adrenal tumor0 / 127940 
bladder carcinoma0 / 174750 
breast (mammary gland) tumor0 / 941780 
cervical tumor0 / 343660 
chondrosarcoma2 / 8282324
colorectal tumor0 / 1142460 
esophageal tumor0 / 172900 
gastrointestinal tumor0 / 1193690 
germ cell tumor6 / 26384522
glioma1 / 1068839
head and neck tumor1 / 1363027
kidney tumor2 / 6895929
leukemia0 / 958420 
liver tumor0 / 963590 
lung tumor2 / 10312719
lymphoma1 / 7175513
non-neoplasia5 / 9725051
normal139 / 336030741
ovarian tumor0 / 766820 
pancreatic tumor3 / 10461628
primitive neuroectodermal tumor of the CNS0 / 1256800 
prostate cancer0 / 1026800 
retinoblastoma0 / 463560 
skin tumor1 / 1249498
soft tissue/muscle tissue tumor6 / 12519147
uterine tumor0 / 902570 
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adipose tissue0 / 131060 
adrenal gland0 / 331970 
ascites0 / 400150 
bladder0 / 297570 
blood0 / 1234780 
bone1 / 7165513
bone marrow0 / 488010 
brain74 / 110098967
cervix0 / 481710 
connective tissue8 / 14925553
ear4 / 16212246
embryonic tissue16 / 21572274
esophagus0 / 202090 
eye3 / 21105414
heart2 / 8962622
intestine1 / 2344724
kidney8 / 21177737
larynx0 / 241450 
liver0 / 2077430 
lung10 / 33697429
lymph0 / 442700 
lymph node1 / 9161010
mammary gland0 / 1532710 
mouth1 / 6705214
muscle3 / 10771527
nerve0 / 157680 
ovary0 / 1020510 
pancreas3 / 21481213
parathyroid0 / 205390 
pharynx0 / 413280 
pituitary gland2 / 16585120
placenta3 / 28082510
prostate0 / 1893450 
salivary gland0 / 201550 
skin2 / 2105749
spleen1 / 5395218
stomach0 / 966190 
testis5 / 33044215
thymus0 / 811310 
thyroid0 / 474730 
tonsil0 / 169990 
trachea3 / 5241357
umbilical cord4 / 13680292
uterus5 / 23287821
vascular2 / 5178038
Microarray in BioGPS Top
Allen Brain Atlas Top
Human Whole Brain Microarrayview in Allen Brain Atlas
  • Probe id     Donor id      
  • Probe name: CUST_15143_PI416261804
  • Donor H0351.2001
  • Sex: Male     Age: 24 years     Race/Ethnicity: African American     Handedness: Left
  • Tissue Receipt Date: 7/29/2009     Serology: Pass      Tissue pH :6.72     Additional Medical Information :History of asthma
  • Postmortem Interval: 23 hours (estimated time of death to time that tissue is frozen)
  • Toxicology: Positive for atropine and caffeine, at levels usually not toxicologically significant
Tissue Expression(mean ± stddev) Expression Bar
Amygdala5.67 ± 0.57
Basal Forebrain6.47 ± 0.33
Basal Part of Pons6.39 ± 0.43
Cerebellar Cortex6.61 ± 0.48
Cerebellar Nuclei6.07 ± 0.49
Claustrum5.09 ± 0.99
Epithalamus6.23 ± 0.54
Frontal Lobe5.69 ± 0.65
Globus Pallidus6.04 ± 0.77
Hypothalamus6.37 ± 0.28
Insula5.63 ± 0.38
Limbic Lobe5.3 ± 0.63
Mesencephalon5.82 ± 0.58
Myelencephalon5.84 ± 0.6
Occipital Lobe5.61 ± 0.55
Parietal Lobe5.58 ± 0.56
Pontine Tegmentum5.69 ± 0.46
Striatum5.75 ± 0.68
Subthalamus5.88 ± 0.07
Temporal Lobe5.92 ± 0.59
Thalamus6.09 ± 0.46
White Matter6.12 ± 0.32
Mouse Brain ISH
Gene Symbol Brain Structure ID Brain Structure Name Express Desity/Level (Meatured by ISH) Express Bar
Zfp521CBCerebellum65.49
88.75
Zfp521CTXCerebral cortex2.71
2.2
Zfp521HIPHippocampal region2.85
2.74
Zfp521HPFHippocampal formation2.52
2.27
Zfp521HYHypothalamus10.17
8.74
Zfp521LSXLateral septal complex74.19
68.88
Zfp521MBMidbrain11.46
11.34
Zfp521MYMedulla20.41
24.61
Zfp521OLFOlfactory bulb3.7
2.82
Zfp521PPons17.28
21.36
Zfp521PALPallidum17.25
18.62
Zfp521RHPRetrohippocampal region2
1.63
Zfp521sAMYStriatum-like amygdalar nuclei6.13
5.16
Zfp521STRStriatum12.41
11.15
Zfp521STRdStriatum dorsal region8.34
7.98
Zfp521STRvStriatum ventral region7.76
5.74
Zfp521THThalamus7.11
6.08
Peptide Top

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018