AutismKB 2.0

Annotation Detail for SOSTDC1


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Basic Information Top
Gene Symbol:SOSTDC1 ( DKFZp564D206,ECTODIN,USAG1 )
Gene Full Name: sclerostin domain containing 1
Band: 7p21.2
Quick LinksEntrez ID:25928; OMIM: 609675; Uniprot ID:SOSD1_HUMAN; ENSEMBL ID: ENSG00000171243; HGNC ID: 21748
Relate to Another Database: SFARIGene; denovo-db
Unigene EST Top
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
embryoid body0 / 707610 
blastocyst0 / 623190 
fetus20 / 56401235
neonate0 / 310970 
infant0 / 236200 
juvenile1 / 5555617
adult37 / 193912119
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adrenal tumor1 / 1279478
bladder carcinoma0 / 174750 
breast (mammary gland) tumor0 / 941780 
cervical tumor0 / 343660 
chondrosarcoma1 / 8282312
colorectal tumor2 / 11424617
esophageal tumor0 / 172900 
gastrointestinal tumor7 / 11936958
germ cell tumor1 / 2638453
glioma0 / 1068830 
head and neck tumor2 / 13630214
kidney tumor1 / 6895914
leukemia3 / 9584231
liver tumor0 / 963590 
lung tumor0 / 1031270 
lymphoma0 / 717550 
non-neoplasia3 / 9725030
normal90 / 336030726
ovarian tumor0 / 766820 
pancreatic tumor0 / 1046160 
primitive neuroectodermal tumor of the CNS1 / 1256807
prostate cancer0 / 1026800 
retinoblastoma0 / 463560 
skin tumor0 / 1249490 
soft tissue/muscle tissue tumor0 / 1251910 
uterine tumor1 / 9025711
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adipose tissue0 / 131060 
adrenal gland1 / 3319730
ascites6 / 40015149
bladder0 / 297570 
blood0 / 1234780 
bone0 / 716550 
bone marrow3 / 4880161
brain26 / 110098923
cervix0 / 481710 
connective tissue1 / 1492556
ear2 / 16212123
embryonic tissue4 / 21572218
esophagus0 / 202090 
eye11 / 21105452
heart3 / 8962633
intestine2 / 2344728
kidney11 / 21177751
larynx0 / 241450 
liver0 / 2077430 
lung4 / 33697411
lymph0 / 442700 
lymph node0 / 916100 
mammary gland0 / 1532710 
mouth2 / 6705229
muscle0 / 1077150 
nerve0 / 157680 
ovary0 / 1020510 
pancreas0 / 2148120 
parathyroid0 / 205390 
pharynx5 / 41328120
pituitary gland0 / 165850 
placenta1 / 2808253
prostate1 / 1893455
salivary gland0 / 201550 
skin2 / 2105749
spleen0 / 539520 
stomach3 / 9661931
testis4 / 33044212
thymus0 / 811310 
thyroid0 / 474730 
tonsil0 / 169990 
trachea0 / 524130 
umbilical cord0 / 136800 
uterus1 / 2328784
vascular1 / 5178019
Microarray in BioGPS Top
Select probe  
  • Microarray Platform: GeneAtlas U133A, gcrma
  • Affymatrix Probe ID: 213456_at
Cell line Expression level Expression bar
721_B_lymphoblasts5.4
Adipocyte4.4
AdrenalCortex4.85
Adrenalgland3.8
Amygdala4.85
Appendix4.6
AtrioventricularNode3.6
BDCA4+_DentriticCells5
Bonemarrow4.45
BronchialEpithelialCells4.4
CD105+_Endothelial4.4
CD14+_Monocytes4.8
CD19+_BCells(neg._sel.)4.7
CD33+_Myeloid5.6
CD34+5.55
CD4+_Tcells4.75
CD56+_NKCells5.35
CD71+_EarlyErythroid4.2
CD8+_Tcells4.3
CardiacMyocytes6.15
Caudatenucleus4
Cerebellum3.65
CerebellumPeduncles5.55
CiliaryGanglion3.25
CingulateCortex4.6
Colorectaladenocarcinoma4.5
DorsalRootGanglion3.5
FetalThyroid4.4
Fetalbrain5.75
Fetalliver3.95
Fetallung7.55
GlobusPallidus3.35
Heart6.4
Hypothalamus4.9
Kidney4
Leukemia_chronicMyelogenousK-5624
Leukemia_promyelocytic-HL-603.95
Leukemialymphoblastic(MOLT-4)3.65
Liver6.15
Lung5.45
Lymphnode3.85
Lymphoma_burkitts(Daudi)5.75
Lymphoma_burkitts(Raji)6.5
MedullaOblongata4.05
OccipitalLobe4.05
OlfactoryBulb3.5
Ovary3
Pancreas3.6
PancreaticIslet4.75
ParietalLobe4.85
Pituitary5.2
Placenta4.5
Pons4.3
PrefrontalCortex5.65
Prostate5.25
Salivarygland3.65
SkeletalMuscle5.35
Skin4
SmoothMuscle5.1
Spinalcord4.75
SubthalamicNucleus4.15
SuperiorCervicalGanglion5.2
TemporalLobe4.1
Testis3.85
TestisGermCell3.7
TestisIntersitial3.75
TestisLeydigCell4.45
TestisSeminiferousTubule3.85
Thalamus4.6
Thymus3.55
Thyroid5.6
Tongue4.45
Tonsil4.45
Trachea3.8
TrigeminalGanglion4.7
Uterus3.6
UterusCorpus4.15
WholeBlood4.85
Wholebrain4.15
colon10.3
pineal_day5.48
pineal_night8.88
retina170.525
small_intestine19.65
Allen Brain Atlas Top
Human Whole Brain Microarrayview in Allen Brain Atlas
  • Probe id     Donor id      
  • Probe name: CUST_9105_PI416261804
  • Donor H0351.2001
  • Sex: Male     Age: 24 years     Race/Ethnicity: African American     Handedness: Left
  • Tissue Receipt Date: 7/29/2009     Serology: Pass      Tissue pH :6.72     Additional Medical Information :History of asthma
  • Postmortem Interval: 23 hours (estimated time of death to time that tissue is frozen)
  • Toxicology: Positive for atropine and caffeine, at levels usually not toxicologically significant
Tissue Expression(mean ± stddev) Expression Bar
Amygdala3.12 ± 0.99
Basal Forebrain2.42 ± 0.39
Basal Part of Pons2.18 ± 0.33
Cerebellar Cortex2.33 ± 0.65
Cerebellar Nuclei2.57 ± 0.53
Claustrum3.36 ± 0.95
Epithalamus2.35 ± 0.75
Frontal Lobe2.57 ± 0.75
Globus Pallidus3.04 ± 0.49
Hypothalamus2.41 ± 0.63
Insula2.13 ± 0.48
Limbic Lobe2.75 ± 0.85
Mesencephalon2.68 ± 0.7
Myelencephalon2.58 ± 0.79
Occipital Lobe2.96 ± 0.71
Parietal Lobe2.53 ± 0.87
Pontine Tegmentum2.62 ± 0.78
Striatum2.4 ± 0.89
Subthalamus2.65 ± 0.62
Temporal Lobe2.5 ± 0.74
Thalamus2.41 ± 0.77
White Matter2.4 ± 0.17
Mouse Brain ISH
Gene Symbol Brain Structure ID Brain Structure Name Express Desity/Level (Meatured by ISH) Express Bar
Sostdc1CBCerebellum8.03
9.06
Sostdc1CTXCerebral cortex23.82
16.84
Sostdc1HIPHippocampal region23.56
29.42
Sostdc1HPFHippocampal formation24.24
25.16
Sostdc1HYHypothalamus10.67
8.7
Sostdc1LSXLateral septal complex20.99
16
Sostdc1MBMidbrain11.99
11.16
Sostdc1MYMedulla24.17
32.44
Sostdc1OLFOlfactory bulb27.9
21.16
Sostdc1PPons15.01
15.43
Sostdc1PALPallidum13.54
12.53
Sostdc1RHPRetrohippocampal region25.34
20.44
Sostdc1sAMYStriatum-like amygdalar nuclei15.55
11.65
Sostdc1STRStriatum14.15
10.47
Sostdc1STRdStriatum dorsal region11.11
7.94
Sostdc1STRvStriatum ventral region19.71
13.52
Sostdc1THThalamus22.15
20.22
Peptide Top

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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