AutismKB 2.0

Annotation Detail for PVRL3


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Basic Information Top
Gene Symbol:PVRL3 ( CD113,CDw113,DKFZp566B0846,FLJ90624,PPR3,PRR3,PVRR3,nectin-3 )
Gene Full Name: poliovirus receptor-related 3
Band: 3q13
Quick LinksEntrez ID:25945; OMIM: 607147; Uniprot ID:PVRL3_HUMAN; ENSEMBL ID: ENSG00000177707; HGNC ID:
Relate to Another Database: SFARIGene; denovo-db
Unigene EST Top
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
embryoid body5 / 7076170
blastocyst4 / 6231964
fetus12 / 56401221
neonate0 / 310970 
infant0 / 236200 
juvenile1 / 5555617
adult59 / 193912130
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adrenal tumor0 / 127940 
bladder carcinoma0 / 174750 
breast (mammary gland) tumor0 / 941780 
cervical tumor1 / 3436629
chondrosarcoma1 / 8282312
colorectal tumor2 / 11424617
esophageal tumor0 / 172900 
gastrointestinal tumor1 / 1193698
germ cell tumor4 / 26384515
glioma2 / 10688318
head and neck tumor1 / 1363027
kidney tumor2 / 6895929
leukemia0 / 958420 
liver tumor1 / 9635910
lung tumor3 / 10312729
lymphoma0 / 717550 
non-neoplasia0 / 972500 
normal111 / 336030733
ovarian tumor0 / 766820 
pancreatic tumor0 / 1046160 
primitive neuroectodermal tumor of the CNS3 / 12568023
prostate cancer0 / 1026800 
retinoblastoma0 / 463560 
skin tumor0 / 1249490 
soft tissue/muscle tissue tumor4 / 12519131
uterine tumor1 / 9025711
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adipose tissue0 / 131060 
adrenal gland0 / 331970 
ascites0 / 400150 
bladder1 / 2975733
blood1 / 1234788
bone2 / 7165527
bone marrow1 / 4880120
brain16 / 110098914
cervix1 / 4817120
connective tissue5 / 14925533
ear0 / 162120 
embryonic tissue11 / 21572250
esophagus0 / 202090 
eye2 / 2110549
heart1 / 8962611
intestine3 / 23447212
kidney3 / 21177714
larynx1 / 2414541
liver6 / 20774328
lung4 / 33697411
lymph0 / 442700 
lymph node0 / 916100 
mammary gland0 / 1532710 
mouth0 / 670520 
muscle0 / 1077150 
nerve1 / 1576863
ovary0 / 1020510 
pancreas3 / 21481213
parathyroid0 / 205390 
pharynx0 / 413280 
pituitary gland0 / 165850 
placenta39 / 280825138
prostate3 / 18934515
salivary gland0 / 201550 
skin0 / 2105740 
spleen0 / 539520 
stomach1 / 9661910
testis27 / 33044281
thymus0 / 811310 
thyroid0 / 474730 
tonsil0 / 169990 
trachea0 / 524130 
umbilical cord0 / 136800 
uterus1 / 2328784
vascular3 / 5178057
Microarray in BioGPS Top
Select probe  
  • Microarray Platform: GeneAtlas U133A, gcrma
  • Affymatrix Probe ID: 213325_at
Cell line Expression level Expression bar
721_B_lymphoblasts7.65
Adipocyte8.95
AdrenalCortex8.95
Adrenalgland6.25
Amygdala13.55
Appendix11.1
AtrioventricularNode7.55
BDCA4+_DentriticCells6.7
Bonemarrow7.7
BronchialEpithelialCells7.1
CD105+_Endothelial6.9
CD14+_Monocytes7.55
CD19+_BCells(neg._sel.)7.2
CD33+_Myeloid8.65
CD34+8.45
CD4+_Tcells6.6
CD56+_NKCells7.45
CD71+_EarlyErythroid6.8
CD8+_Tcells5.9
CardiacMyocytes11.9
Caudatenucleus6.4
Cerebellum6
CerebellumPeduncles9
CiliaryGanglion7.85
CingulateCortex7.65
Colorectaladenocarcinoma7
DorsalRootGanglion6.8
FetalThyroid27.05
Fetalbrain36.85
Fetalliver17.65
Fetallung8.95
GlobusPallidus5.9
Heart10.85
Hypothalamus7.8
Kidney6.2
Leukemia_chronicMyelogenousK-5626.55
Leukemia_promyelocytic-HL-606.15
Leukemialymphoblastic(MOLT-4)5.65
Liver10.65
Lung8
Lymphnode5.8
Lymphoma_burkitts(Daudi)9.25
Lymphoma_burkitts(Raji)10.55
MedullaOblongata8.7
OccipitalLobe6.65
OlfactoryBulb5.55
Ovary5.75
Pancreas6.15
PancreaticIslet9.05
ParietalLobe8.4
Pituitary8.2
Placenta240.3
Pons7.3
PrefrontalCortex8.5
Prostate8.45
Salivarygland6
SkeletalMuscle10.35
Skin7.35
SmoothMuscle11.05
Spinalcord7.5
SubthalamicNucleus6.95
SuperiorCervicalGanglion12.95
TemporalLobe8
Testis19.15
TestisGermCell34.85
TestisIntersitial46.95
TestisLeydigCell61.1
TestisSeminiferousTubule19.95
Thalamus7.65
Thymus5
Thyroid48.7
Tongue8.35
Tonsil7.3
Trachea5.85
TrigeminalGanglion19.6
Uterus5.75
UterusCorpus8
WholeBlood7.65
Wholebrain10.6
colon32.2
pineal_day12.12
pineal_night8.76
retina9.9
small_intestine22.8
Allen Brain Atlas Top
Human Whole Brain Microarrayview in Allen Brain Atlas
  • Probe id     Donor id      
  • Probe name: CUST_9340_PI416261804
  • Donor H0351.2001
  • Sex: Male     Age: 24 years     Race/Ethnicity: African American     Handedness: Left
  • Tissue Receipt Date: 7/29/2009     Serology: Pass      Tissue pH :6.72     Additional Medical Information :History of asthma
  • Postmortem Interval: 23 hours (estimated time of death to time that tissue is frozen)
  • Toxicology: Positive for atropine and caffeine, at levels usually not toxicologically significant
Tissue Expression(mean ± stddev) Expression Bar
Amygdala7.83 ± 0.43
Basal Forebrain7.87 ± 0.17
Basal Part of Pons7.15 ± 0.5
Cerebellar Cortex7.11 ± 0.4
Cerebellar Nuclei7.74 ± 0.37
Claustrum7.3 ± 0.49
Epithalamus8.28 ± 0.21
Frontal Lobe8.18 ± 0.46
Globus Pallidus8.14 ± 0.41
Hypothalamus7.92 ± 0.15
Insula8.15 ± 0.43
Limbic Lobe7.81 ± 0.78
Mesencephalon7.93 ± 0.39
Myelencephalon7.83 ± 0.53
Occipital Lobe7.3 ± 0.45
Parietal Lobe7.75 ± 0.51
Pontine Tegmentum7.96 ± 0.5
Striatum7.05 ± 0.94
Subthalamus8.1 ± 0.31
Temporal Lobe7.93 ± 0.4
Thalamus7.7 ± 0.32
White Matter8.25 ± 0.24
Mouse Brain ISH
Gene Symbol Brain Structure ID Brain Structure Name Express Desity/Level (Meatured by ISH) Express Bar
Pvrl3CBCerebellum1.96
2.97
Pvrl3CTXCerebral cortex39.45
42.14
Pvrl3HIPHippocampal region34.86
62.16
Pvrl3HPFHippocampal formation21.34
34.13
Pvrl3HYHypothalamus4.21
3.5
Pvrl3LSXLateral septal complex3.16
2.13
Pvrl3MBMidbrain3.15
3.22
Pvrl3MYMedulla2.27
2.3
Pvrl3OLFOlfactory bulb21.96
21.2
Pvrl3PPons3.03
3.13
Pvrl3PALPallidum1.3
0.96
Pvrl3RHPRetrohippocampal region4.47
4.73
Pvrl3sAMYStriatum-like amygdalar nuclei2.98
2.28
Pvrl3STRStriatum0.95
0.78
Pvrl3STRdStriatum dorsal region0.38
0.42
Pvrl3STRvStriatum ventral region0.93
0.73
Pvrl3THThalamus7.21
10.12
Peptide Top
Peptide Name Peptide Lengh Peptide Start Peptide End Peptide Sequence Source
PAp01362046 8 340 347 VTNSLGQR Peptide Atlas

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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