AutismKB 2.0

Annotation Detail for GAP43


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Basic Information Top
Gene Symbol:GAP43 ( B-50,PP46 )
Gene Full Name: growth associated protein 43
Band: 3q13.31
Quick LinksEntrez ID:2596; OMIM: 162060; Uniprot ID:NEUM_HUMAN; ENSEMBL ID: ENSG00000172020; HGNC ID: 4140
Relate to Another Database: SFARIGene; denovo-db
Unigene EST Top
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
embryoid body1 / 7076114
blastocyst4 / 6231964
fetus43 / 56401276
neonate0 / 310970 
infant1 / 2362042
juvenile6 / 55556107
adult107 / 193912155
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adrenal tumor0 / 127940 
bladder carcinoma0 / 174750 
breast (mammary gland) tumor0 / 941780 
cervical tumor0 / 343660 
chondrosarcoma1 / 8282312
colorectal tumor0 / 1142460 
esophageal tumor0 / 172900 
gastrointestinal tumor0 / 1193690 
germ cell tumor20 / 26384575
glioma23 / 106883215
head and neck tumor2 / 13630214
kidney tumor0 / 689590 
leukemia0 / 958420 
liver tumor0 / 963590 
lung tumor1 / 1031279
lymphoma0 / 717550 
non-neoplasia6 / 9725061
normal151 / 336030744
ovarian tumor0 / 766820 
pancreatic tumor0 / 1046160 
primitive neuroectodermal tumor of the CNS10 / 12568079
prostate cancer0 / 1026800 
retinoblastoma0 / 463560 
skin tumor0 / 1249490 
soft tissue/muscle tissue tumor36 / 125191287
uterine tumor0 / 902570 
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adipose tissue0 / 131060 
adrenal gland0 / 331970 
ascites0 / 400150 
bladder0 / 297570 
blood0 / 1234780 
bone2 / 7165527
bone marrow0 / 488010 
brain187 / 1100989169
cervix0 / 481710 
connective tissue37 / 149255247
ear0 / 162120 
embryonic tissue19 / 21572288
esophagus0 / 202090 
eye16 / 21105475
heart0 / 896260 
intestine0 / 2344720 
kidney0 / 2117770 
larynx0 / 241450 
liver0 / 2077430 
lung6 / 33697417
lymph0 / 442700 
lymph node0 / 916100 
mammary gland0 / 1532710 
mouth2 / 6705229
muscle0 / 1077150 
nerve3 / 15768190
ovary0 / 1020510 
pancreas3 / 21481213
parathyroid0 / 205390 
pharynx0 / 413280 
pituitary gland0 / 165850 
placenta1 / 2808253
prostate0 / 1893450 
salivary gland0 / 201550 
skin0 / 2105740 
spleen0 / 539520 
stomach0 / 966190 
testis18 / 33044254
thymus0 / 811310 
thyroid0 / 474730 
tonsil0 / 169990 
trachea0 / 524130 
umbilical cord0 / 136800 
uterus0 / 2328780 
vascular0 / 517800 
Microarray in BioGPS Top
Select probe  
  • Microarray Platform: GeneAtlas U133A, gcrma
  • Affymatrix Probe ID: 204471_at
Cell line Expression level Expression bar
721_B_lymphoblasts9.45
Adipocyte8.65
AdrenalCortex15.1
Adrenalgland8.1
Amygdala2756.7
Appendix17.45
AtrioventricularNode17.65
BDCA4+_DentriticCells8.05
Bonemarrow10.6
BronchialEpithelialCells8.6
CD105+_Endothelial9.05
CD14+_Monocytes12.1
CD19+_BCells(neg._sel.)10.85
CD33+_Myeloid10.9
CD34+11.2
CD4+_Tcells9.25
CD56+_NKCells9.9
CD71+_EarlyErythroid8.65
CD8+_Tcells7.5
CardiacMyocytes25.85
Caudatenucleus372.8
Cerebellum506.05
CerebellumPeduncles339.65
CiliaryGanglion16.3
CingulateCortex1467.4
Colorectaladenocarcinoma9
DorsalRootGanglion48.65
FetalThyroid9.3
Fetalbrain3319.7
Fetalliver8.5
Fetallung6.6
GlobusPallidus558.7
Heart22.65
Hypothalamus2480.9
Kidney8.65
Leukemia_chronicMyelogenousK-5627.9
Leukemia_promyelocytic-HL-608.1
Leukemialymphoblastic(MOLT-4)6.85
Liver17.9
Lung10.2
Lymphnode7.05
Lymphoma_burkitts(Daudi)11.85
Lymphoma_burkitts(Raji)14.65
MedullaOblongata520.25
OccipitalLobe1301.75
OlfactoryBulb21.15
Ovary7.15
Pancreas7.85
PancreaticIslet9.9
ParietalLobe943.05
Pituitary12.15
Placenta9.05
Pons458.55
PrefrontalCortex1710.1
Prostate10.45
Salivarygland8.4
SkeletalMuscle16.3
Skin12.5
SmoothMuscle10.7
Spinalcord95.8
SubthalamicNucleus909.45
SuperiorCervicalGanglion19.9
TemporalLobe827.3
Testis7.65
TestisGermCell7.15
TestisIntersitial9.25
TestisLeydigCell10.1
TestisSeminiferousTubule7.7
Thalamus1766.05
Thymus6.4
Thyroid10.7
Tongue11.2
Tonsil8.95
Trachea7.5
TrigeminalGanglion20.15
Uterus6.95
UterusCorpus12.8
WholeBlood9.85
Wholebrain2519.6
colon9.25
pineal_day652.6
pineal_night623.48
retina126.525
small_intestine8.95
Allen Brain Atlas Top
Human Whole Brain Microarrayview in Allen Brain Atlas
  • Probe id     Donor id      
  • Probe name: CUST_282_PI416408490
  • Donor H0351.2001
  • Sex: Male     Age: 24 years     Race/Ethnicity: African American     Handedness: Left
  • Tissue Receipt Date: 7/29/2009     Serology: Pass      Tissue pH :6.72     Additional Medical Information :History of asthma
  • Postmortem Interval: 23 hours (estimated time of death to time that tissue is frozen)
  • Toxicology: Positive for atropine and caffeine, at levels usually not toxicologically significant
Tissue Expression(mean ± stddev) Expression Bar
Amygdala11.05 ± 0.39
Basal Forebrain10.7 ± 0.18
Basal Part of Pons10.68 ± 0.47
Cerebellar Cortex10.72 ± 0.22
Cerebellar Nuclei8.67 ± 0.67
Claustrum11.2 ± 0.25
Epithalamus9.89 ± 0.97
Frontal Lobe11.13 ± 0.46
Globus Pallidus8.72 ± 1.16
Hypothalamus10.86 ± 1.25
Insula11.08 ± 0.32
Limbic Lobe11.01 ± 0.4
Mesencephalon10.91 ± 0.87
Myelencephalon10.74 ± 0.9
Occipital Lobe10.18 ± 0.82
Parietal Lobe10.94 ± 0.67
Pontine Tegmentum10.64 ± 0.81
Striatum9.86 ± 0.92
Subthalamus10.69 ± 0.4
Temporal Lobe11.03 ± 0.41
Thalamus11.42 ± 0.49
White Matter8.61 ± 0.42
Mouse Brain ISH
Gene Symbol Brain Structure ID Brain Structure Name Express Desity/Level (Meatured by ISH) Express Bar
Gap43CBCerebellum100
100
Gap43CTXCerebral cortex100
100
Gap43HIPHippocampal region61.09
100
Gap43HPFHippocampal formation100
100
Gap43HYHypothalamus100
100
Gap43LSXLateral septal complex100
100
Gap43MBMidbrain100
100
Gap43MYMedulla98.2
100
Gap43OLFOlfactory bulb100
100
Gap43PPons100
100
Gap43PALPallidum100
100
Gap43RHPRetrohippocampal region100
100
Gap43sAMYStriatum-like amygdalar nuclei100
100
Gap43STRStriatum100
100
Gap43STRdStriatum dorsal region100
100
Gap43STRvStriatum ventral region100
100
Gap43THThalamus100
100
Peptide Top
Peptide Name Peptide Lengh Peptide Start Peptide End Peptide Sequence Source
NEUM_HUMAN_223 16 223 238 QDEGKEEEPEADQEHA PRIDE
PAp00137428 28 191 218 ATAQPPTETGESSQAEENIEAVDETKPK Peptide Atlas

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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