AutismKB 2.0

Annotation Detail for TBC1D10B


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Basic Information Top
Gene Symbol:TBC1D10B ( DKFZp434P1750 )
Gene Full Name: TBC1 domain family, member 10B
Band: 16p11.2
Quick LinksEntrez ID:26000; OMIM: 613620; Uniprot ID:TB10B_HUMAN; ENSEMBL ID: ENSG00000169221; HGNC ID: 24510
Relate to Another Database: SFARIGene; denovo-db
Unigene EST Top
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
embryoid body4 / 7076156
blastocyst1 / 6231916
fetus4 / 5640127
neonate0 / 310970 
infant1 / 2362042
juvenile1 / 5555617
adult69 / 193912135
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adrenal tumor2 / 12794156
bladder carcinoma2 / 17475114
breast (mammary gland) tumor5 / 9417853
cervical tumor0 / 343660 
chondrosarcoma1 / 8282312
colorectal tumor3 / 11424626
esophageal tumor0 / 172900 
gastrointestinal tumor2 / 11936916
germ cell tumor9 / 26384534
glioma3 / 10688328
head and neck tumor8 / 13630258
kidney tumor0 / 689590 
leukemia3 / 9584231
liver tumor10 / 96359103
lung tumor13 / 103127126
lymphoma4 / 7175555
non-neoplasia2 / 9725020
normal76 / 336030722
ovarian tumor13 / 76682169
pancreatic tumor6 / 10461657
primitive neuroectodermal tumor of the CNS13 / 125680103
prostate cancer3 / 10268029
retinoblastoma1 / 4635621
skin tumor2 / 12494916
soft tissue/muscle tissue tumor6 / 12519147
uterine tumor3 / 9025733
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adipose tissue1 / 1310676
adrenal gland3 / 3319790
ascites0 / 400150 
bladder3 / 29757100
blood9 / 12347872
bone3 / 7165541
bone marrow0 / 488010 
brain23 / 110098920
cervix0 / 481710 
connective tissue1 / 1492556
ear0 / 162120 
embryonic tissue7 / 21572232
esophagus0 / 202090 
eye11 / 21105452
heart0 / 896260 
intestine6 / 23447225
kidney3 / 21177714
larynx2 / 2414582
liver11 / 20774352
lung15 / 33697444
lymph4 / 4427090
lymph node2 / 9161021
mammary gland8 / 15327152
mouth0 / 670520 
muscle3 / 10771527
nerve1 / 1576863
ovary14 / 102051137
pancreas8 / 21481237
parathyroid1 / 2053948
pharynx0 / 413280 
pituitary gland0 / 165850 
placenta4 / 28082514
prostate3 / 18934515
salivary gland4 / 20155198
skin4 / 21057418
spleen1 / 5395218
stomach6 / 9661962
testis6 / 33044218
thymus3 / 8113136
thyroid5 / 47473105
tonsil2 / 16999117
trachea1 / 5241319
umbilical cord0 / 136800 
uterus10 / 23287842
vascular0 / 517800 
Microarray in BioGPS Top
Select probe  
  • Microarray Platform: GeneAtlas U133A, gcrma
  • Affymatrix Probe ID: 220947_s_at
Cell line Expression level Expression bar
721_B_lymphoblasts17.8
Adipocyte12.15
AdrenalCortex12.95
Adrenalgland13.25
Amygdala29.95
Appendix18.1
AtrioventricularNode7.3
BDCA4+_DentriticCells25.7
Bonemarrow26.25
BronchialEpithelialCells11.85
CD105+_Endothelial15
CD14+_Monocytes43.7
CD19+_BCells(neg._sel.)11.1
CD33+_Myeloid30.7
CD34+30.8
CD4+_Tcells12.7
CD56+_NKCells51.85
CD71+_EarlyErythroid21.25
CD8+_Tcells10.9
CardiacMyocytes14.4
Caudatenucleus13.8
Cerebellum20.25
CerebellumPeduncles16.3
CiliaryGanglion6.85
CingulateCortex10.5
Colorectaladenocarcinoma11.95
DorsalRootGanglion7.3
FetalThyroid12.25
Fetalbrain12.95
Fetalliver15.75
Fetallung9.45
GlobusPallidus5.55
Heart22.1
Hypothalamus12.85
Kidney11.35
Leukemia_chronicMyelogenousK-56213.2
Leukemia_promyelocytic-HL-6011.65
Leukemialymphoblastic(MOLT-4)17.8
Liver28.95
Lung18.75
Lymphnode11.6
Lymphoma_burkitts(Daudi)16.8
Lymphoma_burkitts(Raji)16.75
MedullaOblongata11.45
OccipitalLobe12.7
OlfactoryBulb7.8
Ovary7.35
Pancreas10.3
PancreaticIslet14.35
ParietalLobe10.95
Pituitary13.1
Placenta22.9
Pons14.8
PrefrontalCortex22.3
Prostate13.8
Salivarygland8
SkeletalMuscle12.35
Skin8.2
SmoothMuscle13.55
Spinalcord17.15
SubthalamicNucleus10.8
SuperiorCervicalGanglion12.35
TemporalLobe11.4
Testis51.55
TestisGermCell27.8
TestisIntersitial13.75
TestisLeydigCell14
TestisSeminiferousTubule18.05
Thalamus13.15
Thymus30.15
Thyroid20.75
Tongue10.55
Tonsil10.05
Trachea10
TrigeminalGanglion11
Uterus10.5
UterusCorpus11.75
WholeBlood35.25
Wholebrain24.5
colon11.2
pineal_day19.06
pineal_night17.94
retina39.2
small_intestine10.9
Allen Brain Atlas Top
Human Whole Brain Microarrayview in Allen Brain Atlas
  • Probe id     Donor id      
  • Probe name: CUST_11178_PI416261804
  • Donor H0351.2001
  • Sex: Male     Age: 24 years     Race/Ethnicity: African American     Handedness: Left
  • Tissue Receipt Date: 7/29/2009     Serology: Pass      Tissue pH :6.72     Additional Medical Information :History of asthma
  • Postmortem Interval: 23 hours (estimated time of death to time that tissue is frozen)
  • Toxicology: Positive for atropine and caffeine, at levels usually not toxicologically significant
Tissue Expression(mean ± stddev) Expression Bar
Amygdala4.01 ± 0.71
Basal Forebrain3.76 ± 0.56
Basal Part of Pons3.75 ± 0.66
Cerebellar Cortex3.98 ± 0.51
Cerebellar Nuclei3.79 ± 0.69
Claustrum4.12 ± 0.84
Epithalamus3.39 ± 0.51
Frontal Lobe3.65 ± 0.66
Globus Pallidus3.78 ± 0.64
Hypothalamus3.2 ± 0.62
Insula3.4 ± 0.66
Limbic Lobe3.96 ± 0.61
Mesencephalon3.78 ± 0.62
Myelencephalon3.79 ± 0.58
Occipital Lobe3.96 ± 0.7
Parietal Lobe3.66 ± 0.57
Pontine Tegmentum3.61 ± 0.71
Striatum3.59 ± 0.65
Subthalamus3.53 ± 1.07
Temporal Lobe3.75 ± 0.63
Thalamus3.57 ± 0.68
White Matter4.99 ± 0.3
Mouse Brain ISH
Gene Symbol Brain Structure ID Brain Structure Name Express Desity/Level (Meatured by ISH) Express Bar
Tbc1d10bCBCerebellum20.95
30.81
Tbc1d10bCTXCerebral cortex71.8
63.84
Tbc1d10bHIPHippocampal region57.26
97.73
Tbc1d10bHPFHippocampal formation65.84
90.77
Tbc1d10bHYHypothalamus49.33
44.48
Tbc1d10bLSXLateral septal complex32.2
27.91
Tbc1d10bMBMidbrain38.34
43.03
Tbc1d10bMYMedulla41.25
55.45
Tbc1d10bOLFOlfactory bulb65.61
64.61
Tbc1d10bPPons50.55
65.32
Tbc1d10bPALPallidum45.29
50.76
Tbc1d10bRHPRetrohippocampal region89.93
84.64
Tbc1d10bsAMYStriatum-like amygdalar nuclei81.19
73.01
Tbc1d10bSTRStriatum48.99
41.1
Tbc1d10bSTRdStriatum dorsal region44.6
36.26
Tbc1d10bSTRvStriatum ventral region49.18
40.61
Tbc1d10bTHThalamus39.65
37.16
Peptide Top
Peptide Name Peptide Lengh Peptide Start Peptide End Peptide Sequence Source
PAp00041948 28 585 612 NLPQQCMQEDFLVHEVTNLPVTEALIER Peptide Atlas

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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