AutismKB 2.0

Annotation Detail for OSBPL3


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Basic Information Top
Gene Symbol:OSBPL3 ( DKFZp667P1518,KIAA0704,MGC21526,ORP-3,ORP3,OSBP3 )
Gene Full Name: oxysterol binding protein-like 3
Band: 7p15.3
Quick LinksEntrez ID:26031; OMIM: 606732; Uniprot ID:OSBL3_HUMAN; ENSEMBL ID: ENSG00000070882; HGNC ID: 16370
Relate to Another Database: SFARIGene; denovo-db
Unigene EST Top
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
embryoid body2 / 7076128
blastocyst2 / 6231932
fetus16 / 56401228
neonate2 / 3109764
infant2 / 2362084
juvenile0 / 555560 
adult68 / 193912135
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adrenal tumor0 / 127940 
bladder carcinoma1 / 1747557
breast (mammary gland) tumor5 / 9417853
cervical tumor0 / 343660 
chondrosarcoma3 / 8282336
colorectal tumor13 / 114246113
esophageal tumor0 / 172900 
gastrointestinal tumor4 / 11936933
germ cell tumor6 / 26384522
glioma4 / 10688337
head and neck tumor11 / 13630280
kidney tumor0 / 689590 
leukemia5 / 9584252
liver tumor0 / 963590 
lung tumor0 / 1031270 
lymphoma1 / 7175513
non-neoplasia4 / 9725041
normal86 / 336030725
ovarian tumor1 / 7668213
pancreatic tumor6 / 10461657
primitive neuroectodermal tumor of the CNS4 / 12568031
prostate cancer0 / 1026800 
retinoblastoma0 / 463560 
skin tumor3 / 12494924
soft tissue/muscle tissue tumor6 / 12519147
uterine tumor3 / 9025733
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adipose tissue0 / 131060 
adrenal gland0 / 331970 
ascites3 / 4001574
bladder2 / 2975767
blood2 / 12347816
bone2 / 7165527
bone marrow1 / 4880120
brain20 / 110098918
cervix0 / 481710 
connective tissue4 / 14925526
ear0 / 162120 
embryonic tissue7 / 21572232
esophagus0 / 202090 
eye3 / 21105414
heart0 / 896260 
intestine16 / 23447268
kidney8 / 21177737
larynx4 / 24145165
liver0 / 2077430 
lung6 / 33697417
lymph0 / 442700 
lymph node12 / 91610130
mammary gland5 / 15327132
mouth6 / 6705289
muscle1 / 1077159
nerve0 / 157680 
ovary3 / 10205129
pancreas6 / 21481227
parathyroid0 / 205390 
pharynx0 / 413280 
pituitary gland0 / 165850 
placenta6 / 28082521
prostate5 / 18934526
salivary gland0 / 201550 
skin8 / 21057437
spleen0 / 539520 
stomach2 / 9661920
testis7 / 33044221
thymus3 / 8113136
thyroid4 / 4747384
tonsil0 / 169990 
trachea7 / 52413133
umbilical cord0 / 136800 
uterus7 / 23287830
vascular3 / 5178057
Microarray in BioGPS Top
Select probe  
  • Microarray Platform: GeneAtlas U133A, gcrma
  • Affymatrix Probe ID: 209627_s_at
Cell line Expression level Expression bar
721_B_lymphoblasts8.2
Adipocyte5
AdrenalCortex5.5
Adrenalgland4.3
Amygdala5.3
Appendix5.8
AtrioventricularNode3.9
BDCA4+_DentriticCells5.8
Bonemarrow5.1
BronchialEpithelialCells6.95
CD105+_Endothelial5.1
CD14+_Monocytes5.3
CD19+_BCells(neg._sel.)5.1
CD33+_Myeloid6.7
CD34+6.25
CD4+_Tcells5.8
CD56+_NKCells16
CD71+_EarlyErythroid4.65
CD8+_Tcells5.4
CardiacMyocytes6.85
Caudatenucleus4.5
Cerebellum4.15
CerebellumPeduncles5.7
CiliaryGanglion3.6
CingulateCortex5.2
Colorectaladenocarcinoma27.25
DorsalRootGanglion4
FetalThyroid5
Fetalbrain4.8
Fetalliver4.4
Fetallung3.9
GlobusPallidus3.7
Heart6.85
Hypothalamus5.3
Kidney4.25
Leukemia_chronicMyelogenousK-5625.7
Leukemia_promyelocytic-HL-604.55
Leukemialymphoblastic(MOLT-4)4.15
Liver6.8
Lung5.4
Lymphnode4.55
Lymphoma_burkitts(Daudi)17.5
Lymphoma_burkitts(Raji)8.1
MedullaOblongata7.15
OccipitalLobe4.9
OlfactoryBulb3.85
Ovary3.4
Pancreas4.1
PancreaticIslet5.35
ParietalLobe6.05
Pituitary5.8
Placenta5.25
Pons5.05
PrefrontalCortex7.7
Prostate5.75
Salivarygland4.05
SkeletalMuscle6.7
Skin3.9
SmoothMuscle5.6
Spinalcord5.25
SubthalamicNucleus4.6
SuperiorCervicalGanglion5.85
TemporalLobe5.75
Testis4.65
TestisGermCell4.35
TestisIntersitial4.15
TestisLeydigCell4.95
TestisSeminiferousTubule4.2
Thalamus5.15
Thymus3.95
Thyroid7.15
Tongue5
Tonsil5.35
Trachea4.25
TrigeminalGanglion5.25
Uterus4
UterusCorpus4.65
WholeBlood5.55
Wholebrain4.4
colon5
pineal_day6.14
pineal_night5.96
retina6.05
small_intestine4.95
Allen Brain Atlas Top
Human Whole Brain Microarrayview in Allen Brain Atlas
  • Probe id     Donor id      
  • Probe name: A_24_P599340
  • Donor H0351.2001
  • Sex: Male     Age: 24 years     Race/Ethnicity: African American     Handedness: Left
  • Tissue Receipt Date: 7/29/2009     Serology: Pass      Tissue pH :6.72     Additional Medical Information :History of asthma
  • Postmortem Interval: 23 hours (estimated time of death to time that tissue is frozen)
  • Toxicology: Positive for atropine and caffeine, at levels usually not toxicologically significant
Tissue Expression(mean ± stddev) Expression Bar
Amygdala2.29 ± 1.05
Basal Forebrain1.61 ± 0.19
Basal Part of Pons1.55 ± 0.39
Cerebellar Cortex1.36 ± 0.38
Cerebellar Nuclei1.88 ± 0.65
Claustrum2.43 ± 0.63
Epithalamus2.59 ± 0.26
Frontal Lobe2.21 ± 0.65
Globus Pallidus2.02 ± 0.73
Hypothalamus1.94 ± 0.88
Insula1.7 ± 0.85
Limbic Lobe1.96 ± 0.65
Mesencephalon2.12 ± 0.8
Myelencephalon1.96 ± 0.75
Occipital Lobe2.21 ± 0.91
Parietal Lobe2.19 ± 0.71
Pontine Tegmentum1.96 ± 0.67
Striatum1.37 ± 0.97
Subthalamus1.84 ± 0.67
Temporal Lobe1.75 ± 0.81
Thalamus1.9 ± 0.69
White Matter1.25 ± 0.29
Mouse Brain ISH
Gene Symbol Brain Structure ID Brain Structure Name Express Desity/Level (Meatured by ISH) Express Bar
Osbpl3CBCerebellum18.16
20.08
Osbpl3CTXCerebral cortex100
98.36
Osbpl3HIPHippocampal region37.43
49.02
Osbpl3HPFHippocampal formation49.92
56.11
Osbpl3HYHypothalamus16.61
14.67
Osbpl3LSXLateral septal complex23.22
16.96
Osbpl3MBMidbrain22.98
21.3
Osbpl3MYMedulla17.44
18.16
Osbpl3OLFOlfactory bulb76.47
75.49
Osbpl3PPons17.28
17.61
Osbpl3PALPallidum16.13
14.38
Osbpl3RHPRetrohippocampal region72.27
67
Osbpl3sAMYStriatum-like amygdalar nuclei19.57
15.17
Osbpl3STRStriatum63.27
50.52
Osbpl3STRdStriatum dorsal region76.53
62.02
Osbpl3STRvStriatum ventral region61.35
47.7
Osbpl3THThalamus95.57
100
Peptide Top
Peptide Name Peptide Lengh Peptide Start Peptide End Peptide Sequence Source
OSBL3_HUMAN_543 16 543 558 VAMPVELNEPLNTLQR PRIDE
PAp00076193 19 363 381 QLMEQDASSSPSAQVIGLK Peptide Atlas

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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