AutismKB 2.0

Annotation Detail for ZNF451


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Basic Information Top
Gene Symbol:ZNF451 ( COASTER,FLJ23421,FLJ53246,FLJ90693,KIAA0576,KIAA1702,MGC26701,dJ417I1.1 )
Gene Full Name: zinc finger protein 451
Band: 6p12.1
Quick LinksEntrez ID:26036; OMIM: NA; Uniprot ID:ZN451_HUMAN; ENSEMBL ID: ENSG00000112200; HGNC ID: 21091
Relate to Another Database: SFARIGene; denovo-db
Unigene EST Top
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
embryoid body5 / 7076170
blastocyst4 / 6231964
fetus32 / 56401256
neonate2 / 3109764
infant0 / 236200 
juvenile3 / 5555653
adult118 / 193912160
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adrenal tumor0 / 127940 
bladder carcinoma0 / 174750 
breast (mammary gland) tumor8 / 9417884
cervical tumor2 / 3436658
chondrosarcoma4 / 8282348
colorectal tumor14 / 114246122
esophageal tumor2 / 17290115
gastrointestinal tumor8 / 11936967
germ cell tumor17 / 26384564
glioma1 / 1068839
head and neck tumor12 / 13630288
kidney tumor1 / 6895914
leukemia1 / 9584210
liver tumor2 / 9635920
lung tumor2 / 10312719
lymphoma1 / 7175513
non-neoplasia1 / 9725010
normal173 / 336030751
ovarian tumor1 / 7668213
pancreatic tumor2 / 10461619
primitive neuroectodermal tumor of the CNS0 / 1256800 
prostate cancer11 / 102680107
retinoblastoma1 / 4635621
skin tumor3 / 12494924
soft tissue/muscle tissue tumor14 / 125191111
uterine tumor2 / 9025722
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adipose tissue0 / 131060 
adrenal gland2 / 3319760
ascites1 / 4001524
bladder2 / 2975767
blood5 / 12347840
bone3 / 7165541
bone marrow1 / 4880120
brain34 / 110098930
cervix4 / 4817183
connective tissue12 / 14925580
ear3 / 16212185
embryonic tissue11 / 21572250
esophagus2 / 2020998
eye11 / 21105452
heart1 / 8962611
intestine17 / 23447272
kidney10 / 21177747
larynx3 / 24145124
liver10 / 20774348
lung9 / 33697426
lymph0 / 442700 
lymph node7 / 9161076
mammary gland12 / 15327178
mouth5 / 6705274
muscle4 / 10771537
nerve3 / 15768190
ovary1 / 1020519
pancreas14 / 21481265
parathyroid2 / 2053997
pharynx0 / 413280 
pituitary gland1 / 1658560
placenta13 / 28082546
prostate17 / 18934589
salivary gland1 / 2015549
skin10 / 21057447
spleen1 / 5395218
stomach8 / 9661982
testis56 / 330442169
thymus4 / 8113149
thyroid4 / 4747384
tonsil0 / 169990 
trachea4 / 5241376
umbilical cord0 / 136800 
uterus13 / 23287855
vascular1 / 5178019
Microarray in BioGPS Top
Select probe  
  • Microarray Platform: GeneAtlas U133A, gcrma
  • Affymatrix Probe ID: 212557_at
Cell line Expression level Expression bar
721_B_lymphoblasts62.6
Adipocyte8.85
AdrenalCortex23.4
Adrenalgland7.55
Amygdala24.4
Appendix8
AtrioventricularNode6.9
BDCA4+_DentriticCells57.55
Bonemarrow8.8
BronchialEpithelialCells10.95
CD105+_Endothelial42.3
CD14+_Monocytes33.15
CD19+_BCells(neg._sel.)69.6
CD33+_Myeloid20.95
CD34+68.3
CD4+_Tcells119.25
CD56+_NKCells49.35
CD71+_EarlyErythroid291.2
CD8+_Tcells156.35
CardiacMyocytes11
Caudatenucleus15.4
Cerebellum6.8
CerebellumPeduncles7.85
CiliaryGanglion5.1
CingulateCortex11.5
Colorectaladenocarcinoma18.45
DorsalRootGanglion6.65
FetalThyroid8.6
Fetalbrain12.7
Fetalliver31
Fetallung62.55
GlobusPallidus8.25
Heart10.5
Hypothalamus64.55
Kidney5.7
Leukemia_chronicMyelogenousK-56285.7
Leukemia_promyelocytic-HL-6021.95
Leukemialymphoblastic(MOLT-4)44
Liver10.7
Lung8.8
Lymphnode36.75
Lymphoma_burkitts(Daudi)15.9
Lymphoma_burkitts(Raji)38.9
MedullaOblongata8.2
OccipitalLobe20.9
OlfactoryBulb8.65
Ovary7.45
Pancreas20.6
PancreaticIslet20.75
ParietalLobe12.95
Pituitary15.05
Placenta8.15
Pons7.45
PrefrontalCortex95.7
Prostate16.7
Salivarygland11
SkeletalMuscle9.9
Skin10.45
SmoothMuscle9.8
Spinalcord44.45
SubthalamicNucleus13.1
SuperiorCervicalGanglion8.9
TemporalLobe7.9
Testis6.55
TestisGermCell15.7
TestisIntersitial8.45
TestisLeydigCell10.25
TestisSeminiferousTubule12.4
Thalamus14.85
Thymus6.8
Thyroid53.45
Tongue9.9
Tonsil11.9
Trachea12.4
TrigeminalGanglion7.9
Uterus23.55
UterusCorpus10.25
WholeBlood30.3
Wholebrain7.5
colon17.15
pineal_day48.6
pineal_night58.22
retina28.65
small_intestine14.6
Allen Brain Atlas Top
Human Whole Brain Microarrayview in Allen Brain Atlas
  • Probe id     Donor id      
  • Probe name: A_24_P320572
  • Donor H0351.2001
  • Sex: Male     Age: 24 years     Race/Ethnicity: African American     Handedness: Left
  • Tissue Receipt Date: 7/29/2009     Serology: Pass      Tissue pH :6.72     Additional Medical Information :History of asthma
  • Postmortem Interval: 23 hours (estimated time of death to time that tissue is frozen)
  • Toxicology: Positive for atropine and caffeine, at levels usually not toxicologically significant
Tissue Expression(mean ± stddev) Expression Bar
Amygdala6.68 ± 0.27
Basal Forebrain6.66 ± 0.14
Basal Part of Pons6.69 ± 0.28
Cerebellar Cortex6.91 ± 0.18
Cerebellar Nuclei6.76 ± 0.18
Claustrum6.77 ± 0.34
Epithalamus6.78 ± 0.21
Frontal Lobe6.56 ± 0.31
Globus Pallidus7.09 ± 0.27
Hypothalamus6.33 ± 0.25
Insula6.53 ± 0.17
Limbic Lobe6.8 ± 0.36
Mesencephalon6.65 ± 0.39
Myelencephalon6.68 ± 0.32
Occipital Lobe6.97 ± 0.34
Parietal Lobe6.71 ± 0.31
Pontine Tegmentum6.66 ± 0.37
Striatum6.69 ± 0.44
Subthalamus6.64 ± 0.12
Temporal Lobe6.6 ± 0.29
Thalamus6.59 ± 0.29
White Matter7.97 ± 0.25
Mouse Brain ISH
Gene Symbol Brain Structure ID Brain Structure Name Express Desity/Level (Meatured by ISH) Express Bar
Zfp451CBCerebellum21.99
24.87
Zfp451CTXCerebral cortex86.9
77.55
Zfp451HIPHippocampal region54.37
90.99
Zfp451HPFHippocampal formation57.13
76.77
Zfp451HYHypothalamus5.6
4.8
Zfp451LSXLateral septal complex12.72
11.28
Zfp451MBMidbrain12.75
11.95
Zfp451MYMedulla22.66
24.65
Zfp451OLFOlfactory bulb52.65
49.33
Zfp451PPons10.1
11.56
Zfp451PALPallidum7.88
7.48
Zfp451RHPRetrohippocampal region61.04
63.3
Zfp451sAMYStriatum-like amygdalar nuclei23.22
18.09
Zfp451STRStriatum14.89
11.81
Zfp451STRdStriatum dorsal region13.78
11.04
Zfp451STRvStriatum ventral region14.68
11.04
Zfp451THThalamus9.9
8.32
Peptide Top
Peptide Name Peptide Lengh Peptide Start Peptide End Peptide Sequence Source
PAp00003238 16 812 827 HCFLQKPSVAHFGSEK Peptide Atlas
ZN451_HUMAN_101 21 101 121 AFREKIDFQHAHGLQELEFIR PRIDE

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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