AutismKB 2.0

Annotation Detail for PPP1R16B


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Basic Information Top
Gene Symbol:PPP1R16B ( ANKRD4,KIAA0823,TIMAP )
Gene Full Name: protein phosphatase 1, regulatory (inhibitor) subunit 16B
Band: 20q11.23
Quick LinksEntrez ID:26051; OMIM: 613275; Uniprot ID:PP16B_HUMAN; ENSEMBL ID: ENSG00000101445; HGNC ID: 15850
Relate to Another Database: SFARIGene; denovo-db
Unigene EST Top
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
embryoid body0 / 707610 
blastocyst2 / 6231932
fetus16 / 56401228
neonate0 / 310970 
infant1 / 2362042
juvenile0 / 555560 
adult74 / 193912138
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adrenal tumor1 / 1279478
bladder carcinoma1 / 1747557
breast (mammary gland) tumor0 / 941780 
cervical tumor0 / 343660 
chondrosarcoma4 / 8282348
colorectal tumor0 / 1142460 
esophageal tumor0 / 172900 
gastrointestinal tumor1 / 1193698
germ cell tumor2 / 2638457
glioma9 / 10688384
head and neck tumor2 / 13630214
kidney tumor0 / 689590 
leukemia1 / 9584210
liver tumor0 / 963590 
lung tumor4 / 10312738
lymphoma18 / 71755250
non-neoplasia3 / 9725030
normal221 / 336030765
ovarian tumor0 / 766820 
pancreatic tumor1 / 1046169
primitive neuroectodermal tumor of the CNS6 / 12568047
prostate cancer2 / 10268019
retinoblastoma0 / 463560 
skin tumor0 / 1249490 
soft tissue/muscle tissue tumor0 / 1251910 
uterine tumor1 / 9025711
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adipose tissue0 / 131060 
adrenal gland1 / 3319730
ascites0 / 400150 
bladder1 / 2975733
blood5 / 12347840
bone2 / 7165527
bone marrow1 / 4880120
brain89 / 110098980
cervix0 / 481710 
connective tissue3 / 14925520
ear0 / 162120 
embryonic tissue2 / 2157229
esophagus0 / 202090 
eye0 / 2110540 
heart3 / 8962633
intestine1 / 2344724
kidney14 / 21177766
larynx0 / 241450 
liver0 / 2077430 
lung14 / 33697441
lymph15 / 44270338
lymph node53 / 91610578
mammary gland15 / 15327197
mouth0 / 670520 
muscle0 / 1077150 
nerve0 / 157680 
ovary1 / 1020519
pancreas6 / 21481227
parathyroid0 / 205390 
pharynx4 / 4132896
pituitary gland2 / 16585120
placenta2 / 2808257
prostate2 / 18934510
salivary gland0 / 201550 
skin0 / 2105740 
spleen7 / 53952129
stomach1 / 9661910
testis4 / 33044212
thymus4 / 8113149
thyroid2 / 4747342
tonsil7 / 16999411
trachea1 / 5241319
umbilical cord0 / 136800 
uterus4 / 23287817
vascular1 / 5178019
Microarray in BioGPS Top
Select probe  
  • Microarray Platform: GeneAtlas U133A, gcrma
  • Affymatrix Probe ID: 212750_at
Cell line Expression level Expression bar
721_B_lymphoblasts76.7
Adipocyte8.45
AdrenalCortex9.55
Adrenalgland8
Amygdala62.65
Appendix9.45
AtrioventricularNode7.15
BDCA4+_DentriticCells125.5
Bonemarrow9.55
BronchialEpithelialCells9.3
CD105+_Endothelial8.25
CD14+_Monocytes8.05
CD19+_BCells(neg._sel.)258.95
CD33+_Myeloid12.35
CD34+11.25
CD4+_Tcells54
CD56+_NKCells146.65
CD71+_EarlyErythroid7.25
CD8+_Tcells40.7
CardiacMyocytes12.35
Caudatenucleus388.75
Cerebellum69.5
CerebellumPeduncles38.55
CiliaryGanglion6.55
CingulateCortex102.2
Colorectaladenocarcinoma9.4
DorsalRootGanglion7.25
FetalThyroid8.4
Fetalbrain12.6
Fetalliver8.1
Fetallung8.2
GlobusPallidus63.65
Heart12.3
Hypothalamus24.15
Kidney21.2
Leukemia_chronicMyelogenousK-5628.7
Leukemia_promyelocytic-HL-6035.7
Leukemialymphoblastic(MOLT-4)15.35
Liver12.35
Lung12.25
Lymphnode27.4
Lymphoma_burkitts(Daudi)155.35
Lymphoma_burkitts(Raji)59.4
MedullaOblongata132
OccipitalLobe74
OlfactoryBulb7.7
Ovary6.2
Pancreas7.6
PancreaticIslet11
ParietalLobe104.15
Pituitary11.35
Placenta10
Pons42.85
PrefrontalCortex113.45
Prostate10.55
Salivarygland7.6
SkeletalMuscle10.6
Skin6.85
SmoothMuscle10.75
Spinalcord50.1
SubthalamicNucleus71.2
SuperiorCervicalGanglion10.7
TemporalLobe65.7
Testis8.25
TestisGermCell6
TestisIntersitial6.45
TestisLeydigCell8.9
TestisSeminiferousTubule8.3
Thalamus36.25
Thymus17.6
Thyroid11.75
Tongue8.6
Tonsil20.2
Trachea8
TrigeminalGanglion9.2
Uterus7.8
UterusCorpus8.5
WholeBlood18.65
Wholebrain312.95
colon8.95
pineal_day11.66
pineal_night13.7
retina29.9
small_intestine9.45
Allen Brain Atlas Top
Human Whole Brain Microarrayview in Allen Brain Atlas
  • Probe id     Donor id      
  • Probe name: A_32_P97763
  • Donor H0351.2001
  • Sex: Male     Age: 24 years     Race/Ethnicity: African American     Handedness: Left
  • Tissue Receipt Date: 7/29/2009     Serology: Pass      Tissue pH :6.72     Additional Medical Information :History of asthma
  • Postmortem Interval: 23 hours (estimated time of death to time that tissue is frozen)
  • Toxicology: Positive for atropine and caffeine, at levels usually not toxicologically significant
Tissue Expression(mean ± stddev) Expression Bar
Amygdala2.24 ± 1.12
Basal Forebrain1.61 ± 0.27
Basal Part of Pons1.61 ± 0.84
Cerebellar Cortex1.42 ± 0.52
Cerebellar Nuclei2.31 ± 1.17
Claustrum2.39 ± 0.63
Epithalamus1.4 ± 0.73
Frontal Lobe1.59 ± 0.73
Globus Pallidus1.63 ± 0.35
Hypothalamus1.71 ± 0.7
Insula1.84 ± 0.7
Limbic Lobe1.74 ± 0.69
Mesencephalon1.88 ± 0.76
Myelencephalon1.85 ± 0.7
Occipital Lobe2.08 ± 0.77
Parietal Lobe1.89 ± 0.71
Pontine Tegmentum1.99 ± 0.89
Striatum2.92 ± 0.72
Subthalamus1.88 ± 0.69
Temporal Lobe1.76 ± 0.74
Thalamus1.69 ± 0.7
White Matter2.5 ± 0.91
Mouse Brain ISH
Gene Symbol Brain Structure ID Brain Structure Name Express Desity/Level (Meatured by ISH) Express Bar
Ppp1r16bCBCerebellum32.32
94.94
Ppp1r16bCTXCerebral cortex100
84.42
Ppp1r16bHIPHippocampal region69.65
89.26
Ppp1r16bHPFHippocampal formation68.56
74.28
Ppp1r16bHYHypothalamus34.43
28.19
Ppp1r16bLSXLateral septal complex43.77
28.46
Ppp1r16bMBMidbrain44.28
38.52
Ppp1r16bMYMedulla32.7
33.45
Ppp1r16bOLFOlfactory bulb88.11
82.14
Ppp1r16bPPons28.2
27.03
Ppp1r16bPALPallidum49.85
43.18
Ppp1r16bRHPRetrohippocampal region65.45
52.47
Ppp1r16bsAMYStriatum-like amygdalar nuclei55.86
39.97
Ppp1r16bSTRStriatum100
91.28
Ppp1r16bSTRdStriatum dorsal region100
100
Ppp1r16bSTRvStriatum ventral region98.46
74.18
Ppp1r16bTHThalamus46.7
42.05
Peptide Top
Peptide Name Peptide Lengh Peptide Start Peptide End Peptide Sequence Source
PP16B_HUMAN_422 8 422 429 MPVENGLR PRIDE

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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