AutismKB 2.0

Annotation Detail for ARHGEF26


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Basic Information Top
Gene Symbol:ARHGEF26 ( CSGEF,DKFZp434D146,HMFN1864,SGEF )
Gene Full Name: Rho guanine nucleotide exchange factor (GEF) 26
Band: 3q25.2
Quick LinksEntrez ID:26084; OMIM: NA; Uniprot ID:ARHGQ_HUMAN; ENSEMBL ID: ENSG00000114790; HGNC ID: 24490
Relate to Another Database: SFARIGene; denovo-db
Unigene EST Top
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
embryoid body1 / 7076114
blastocyst0 / 623190 
fetus15 / 56401226
neonate0 / 310970 
infant0 / 236200 
juvenile0 / 555560 
adult50 / 193912125
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adrenal tumor0 / 127940 
bladder carcinoma0 / 174750 
breast (mammary gland) tumor0 / 941780 
cervical tumor0 / 343660 
chondrosarcoma0 / 828230 
colorectal tumor0 / 1142460 
esophageal tumor0 / 172900 
gastrointestinal tumor2 / 11936916
germ cell tumor10 / 26384537
glioma2 / 10688318
head and neck tumor2 / 13630214
kidney tumor0 / 689590 
leukemia0 / 958420 
liver tumor5 / 9635951
lung tumor1 / 1031279
lymphoma0 / 717550 
non-neoplasia6 / 9725061
normal78 / 336030723
ovarian tumor1 / 7668213
pancreatic tumor0 / 1046160 
primitive neuroectodermal tumor of the CNS0 / 1256800 
prostate cancer16 / 102680155
retinoblastoma0 / 463560 
skin tumor0 / 1249490 
soft tissue/muscle tissue tumor0 / 1251910 
uterine tumor0 / 902570 
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adipose tissue0 / 131060 
adrenal gland1 / 3319730
ascites1 / 4001524
bladder0 / 297570 
blood0 / 1234780 
bone0 / 716550 
bone marrow0 / 488010 
brain29 / 110098926
cervix0 / 481710 
connective tissue1 / 1492556
ear0 / 162120 
embryonic tissue3 / 21572213
esophagus0 / 202090 
eye7 / 21105433
heart2 / 8962622
intestine1 / 2344724
kidney3 / 21177714
larynx0 / 241450 
liver8 / 20774338
lung4 / 33697411
lymph0 / 442700 
lymph node0 / 916100 
mammary gland1 / 1532716
mouth1 / 6705214
muscle0 / 1077150 
nerve0 / 157680 
ovary1 / 1020519
pancreas0 / 2148120 
parathyroid1 / 2053948
pharynx0 / 413280 
pituitary gland0 / 165850 
placenta5 / 28082517
prostate17 / 18934589
salivary gland0 / 201550 
skin6 / 21057428
spleen0 / 539520 
stomach1 / 9661910
testis19 / 33044257
thymus0 / 811310 
thyroid1 / 4747321
tonsil0 / 169990 
trachea1 / 5241319
umbilical cord0 / 136800 
uterus3 / 23287812
vascular0 / 517800 
Microarray in BioGPS Top
Select probe  
  • Microarray Platform: GeneAtlas U133A, gcrma
  • Affymatrix Probe ID: 222121_at
Cell line Expression level Expression bar
721_B_lymphoblasts9.35
Adipocyte9.45
AdrenalCortex13.1
Adrenalgland8.5
Amygdala9.6
Appendix13.8
AtrioventricularNode12.6
BDCA4+_DentriticCells8.7
Bonemarrow11
BronchialEpithelialCells8.3
CD105+_Endothelial9
CD14+_Monocytes11.75
CD19+_BCells(neg._sel.)10.2
CD33+_Myeloid11.05
CD34+11.7
CD4+_Tcells8.7
CD56+_NKCells10.9
CD71+_EarlyErythroid9.05
CD8+_Tcells7.7
CardiacMyocytes17.2
Caudatenucleus8.6
Cerebellum7.7
CerebellumPeduncles12.35
CiliaryGanglion12.85
CingulateCortex10.25
Colorectaladenocarcinoma9.2
DorsalRootGanglion12.75
FetalThyroid10.85
Fetalbrain8.8
Fetalliver8.45
Fetallung7.45
GlobusPallidus7.85
Heart15.75
Hypothalamus9.65
Kidney9.2
Leukemia_chronicMyelogenousK-5628.2
Leukemia_promyelocytic-HL-607.95
Leukemialymphoblastic(MOLT-4)7
Liver15.7
Lung9.95
Lymphnode7.5
Lymphoma_burkitts(Daudi)12.7
Lymphoma_burkitts(Raji)15.1
MedullaOblongata8.25
OccipitalLobe8.5
OlfactoryBulb7.3
Ovary7.5
Pancreas8.05
PancreaticIslet10.1
ParietalLobe11.4
Pituitary10.5
Placenta9.05
Pons9.55
PrefrontalCortex10.75
Prostate10.4
Salivarygland7.9
SkeletalMuscle19
Skin13.05
SmoothMuscle10.9
Spinalcord10.2
SubthalamicNucleus9.1
SuperiorCervicalGanglion19.8
TemporalLobe9.1
Testis7.55
TestisGermCell7.25
TestisIntersitial8.5
TestisLeydigCell10
TestisSeminiferousTubule7.95
Thalamus9.8
Thymus6.5
Thyroid10.35
Tongue12.2
Tonsil9.55
Trachea7.8
TrigeminalGanglion16.25
Uterus7.25
UterusCorpus9.6
WholeBlood9.85
Wholebrain6.95
colon9.05
pineal_day11.12
pineal_night10.84
retina11.225
small_intestine8.75
Allen Brain Atlas Top
Human Whole Brain Microarrayview in Allen Brain Atlas
  • Probe id     Donor id      
  • Probe name: A_32_P5276
  • Donor H0351.2001
  • Sex: Male     Age: 24 years     Race/Ethnicity: African American     Handedness: Left
  • Tissue Receipt Date: 7/29/2009     Serology: Pass      Tissue pH :6.72     Additional Medical Information :History of asthma
  • Postmortem Interval: 23 hours (estimated time of death to time that tissue is frozen)
  • Toxicology: Positive for atropine and caffeine, at levels usually not toxicologically significant
Tissue Expression(mean ± stddev) Expression Bar
Amygdala6.53 ± 0.38
Basal Forebrain6.84 ± 0.12
Basal Part of Pons5.34 ± 0.41
Cerebellar Cortex5.67 ± 0.26
Cerebellar Nuclei5.02 ± 0.52
Claustrum5.92 ± 0.69
Epithalamus7.08 ± 0.43
Frontal Lobe6.14 ± 0.54
Globus Pallidus7.46 ± 0.45
Hypothalamus6.48 ± 0.31
Insula6.27 ± 0.2
Limbic Lobe6.01 ± 0.62
Mesencephalon6.57 ± 0.5
Myelencephalon6.32 ± 0.63
Occipital Lobe6.65 ± 0.57
Parietal Lobe6.25 ± 0.56
Pontine Tegmentum6.34 ± 0.45
Striatum6.97 ± 0.35
Subthalamus5.51 ± 0.79
Temporal Lobe6.09 ± 0.45
Thalamus6.5 ± 0.38
White Matter5.18 ± 0.19
Mouse Brain ISH
Peptide Top

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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