AutismKB 2.0

Annotation Detail for HERC4


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Basic Information Top
Gene Symbol:HERC4 ( DKFZp564G092,KIAA1593 )
Gene Full Name: hect domain and RLD 4
Band: 10q21.3
Quick LinksEntrez ID:26091; OMIM: 609248; Uniprot ID:HERC4_HUMAN; ENSEMBL ID: ENSG00000148634; HGNC ID: 24521
Relate to Another Database: SFARIGene; denovo-db
Unigene EST Top
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
embryoid body6 / 7076184
blastocyst2 / 6231932
fetus41 / 56401272
neonate2 / 3109764
infant0 / 236200 
juvenile1 / 5555617
adult92 / 193912147
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adrenal tumor0 / 127940 
bladder carcinoma3 / 17475171
breast (mammary gland) tumor2 / 9417821
cervical tumor0 / 343660 
chondrosarcoma3 / 8282336
colorectal tumor9 / 11424678
esophageal tumor0 / 172900 
gastrointestinal tumor9 / 11936975
germ cell tumor5 / 26384518
glioma0 / 1068830 
head and neck tumor3 / 13630222
kidney tumor0 / 689590 
leukemia1 / 9584210
liver tumor4 / 9635941
lung tumor3 / 10312729
lymphoma0 / 717550 
non-neoplasia7 / 9725071
normal165 / 336030749
ovarian tumor1 / 7668213
pancreatic tumor0 / 1046160 
primitive neuroectodermal tumor of the CNS5 / 12568039
prostate cancer8 / 10268077
retinoblastoma0 / 463560 
skin tumor2 / 12494916
soft tissue/muscle tissue tumor3 / 12519123
uterine tumor5 / 9025755
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adipose tissue1 / 1310676
adrenal gland0 / 331970 
ascites2 / 4001549
bladder2 / 2975767
blood4 / 12347832
bone3 / 7165541
bone marrow6 / 48801122
brain53 / 110098948
cervix5 / 48171103
connective tissue9 / 14925560
ear3 / 16212185
embryonic tissue12 / 21572255
esophagus0 / 202090 
eye6 / 21105428
heart4 / 8962644
intestine15 / 23447263
kidney7 / 21177733
larynx1 / 2414541
liver11 / 20774352
lung11 / 33697432
lymph0 / 442700 
lymph node6 / 9161065
mammary gland7 / 15327145
mouth2 / 6705229
muscle5 / 10771546
nerve1 / 1576863
ovary2 / 10205119
pancreas11 / 21481251
parathyroid0 / 205390 
pharynx1 / 4132824
pituitary gland0 / 165850 
placenta20 / 28082571
prostate8 / 18934542
salivary gland0 / 201550 
skin4 / 21057418
spleen1 / 5395218
stomach5 / 9661951
testis19 / 33044257
thymus3 / 8113136
thyroid0 / 474730 
tonsil0 / 169990 
trachea9 / 52413171
umbilical cord0 / 136800 
uterus10 / 23287842
vascular3 / 5178057
Microarray in BioGPS Top
Select probe  
  • Microarray Platform: GeneAtlas U133A, gcrma
  • Affymatrix Probe ID: 208055_s_at
Cell line Expression level Expression bar
721_B_lymphoblasts13
Adipocyte13.4
AdrenalCortex22.35
Adrenalgland12.7
Amygdala11.25
Appendix18.45
AtrioventricularNode34.5
BDCA4+_DentriticCells11.8
Bonemarrow17.05
BronchialEpithelialCells11.4
CD105+_Endothelial13
CD14+_Monocytes20.85
CD19+_BCells(neg._sel.)13
CD33+_Myeloid15.95
CD34+14.5
CD4+_Tcells19.55
CD56+_NKCells13.6
CD71+_EarlyErythroid13.3
CD8+_Tcells22.4
CardiacMyocytes36.3
Caudatenucleus13
Cerebellum10.4
CerebellumPeduncles20.35
CiliaryGanglion24.45
CingulateCortex17.2
Colorectaladenocarcinoma11.55
DorsalRootGanglion17.5
FetalThyroid15.6
Fetalbrain12
Fetalliver11
Fetallung9.05
GlobusPallidus14
Heart25.1
Hypothalamus12.1
Kidney13.55
Leukemia_chronicMyelogenousK-56211.1
Leukemia_promyelocytic-HL-6010.9
Leukemialymphoblastic(MOLT-4)9.5
Liver20.05
Lung12.7
Lymphnode10.1
Lymphoma_burkitts(Daudi)19.85
Lymphoma_burkitts(Raji)21.75
MedullaOblongata10.7
OccipitalLobe11.55
OlfactoryBulb10.6
Ovary12.2
Pancreas12.15
PancreaticIslet14.45
ParietalLobe16.4
Pituitary16.15
Placenta12.4
Pons14.05
PrefrontalCortex12.55
Prostate12.25
Salivarygland13.75
SkeletalMuscle23.65
Skin22.25
SmoothMuscle15.65
Spinalcord13.4
SubthalamicNucleus19.8
SuperiorCervicalGanglion30.3
TemporalLobe13.75
Testis9.7
TestisGermCell10.05
TestisIntersitial12.35
TestisLeydigCell15.75
TestisSeminiferousTubule11.45
Thalamus14.1
Thymus8
Thyroid12.35
Tongue18.8
Tonsil14.8
Trachea10.5
TrigeminalGanglion24.4
Uterus9.05
UterusCorpus15.95
WholeBlood12.25
Wholebrain8.65
colon12.7
pineal_day15.28
pineal_night17.52
retina15.225
small_intestine10.95
Allen Brain Atlas Top
Human Whole Brain Microarrayview in Allen Brain Atlas
  • Probe id     Donor id      
  • Probe name: A_23_P202408
  • Donor H0351.2001
  • Sex: Male     Age: 24 years     Race/Ethnicity: African American     Handedness: Left
  • Tissue Receipt Date: 7/29/2009     Serology: Pass      Tissue pH :6.72     Additional Medical Information :History of asthma
  • Postmortem Interval: 23 hours (estimated time of death to time that tissue is frozen)
  • Toxicology: Positive for atropine and caffeine, at levels usually not toxicologically significant
Tissue Expression(mean ± stddev) Expression Bar
Amygdala6.79 ± 0.42
Basal Forebrain6.75 ± 0.12
Basal Part of Pons6.5 ± 0.21
Cerebellar Cortex6.72 ± 0.28
Cerebellar Nuclei6.5 ± 0.46
Claustrum6.9 ± 0.44
Epithalamus6.83 ± 0.24
Frontal Lobe6.73 ± 0.31
Globus Pallidus6.86 ± 0.34
Hypothalamus6.75 ± 0.27
Insula6.84 ± 0.23
Limbic Lobe6.93 ± 0.32
Mesencephalon6.74 ± 0.36
Myelencephalon6.71 ± 0.35
Occipital Lobe6.7 ± 0.36
Parietal Lobe6.76 ± 0.3
Pontine Tegmentum6.8 ± 0.42
Striatum6.63 ± 0.42
Subthalamus6.61 ± 0.16
Temporal Lobe6.79 ± 0.28
Thalamus6.52 ± 0.31
White Matter7.66 ± 0.17
Mouse Brain ISH
Gene Symbol Brain Structure ID Brain Structure Name Express Desity/Level (Meatured by ISH) Express Bar
Herc4CBCerebellum15.57
16.38
Herc4CTXCerebral cortex73.98
53.86
Herc4HIPHippocampal region30.37
31.22
Herc4HPFHippocampal formation42.5
39.76
Herc4HYHypothalamus17.01
11.41
Herc4LSXLateral septal complex18.6
14.5
Herc4MBMidbrain23.61
18.13
Herc4MYMedulla33.46
31.06
Herc4OLFOlfactory bulb52.92
42.79
Herc4PPons21.5
18.15
Herc4PALPallidum13.04
9.78
Herc4RHPRetrohippocampal region65.59
53.87
Herc4sAMYStriatum-like amygdalar nuclei8.24
5.56
Herc4STRStriatum18.78
13.47
Herc4STRdStriatum dorsal region17.83
13.31
Herc4STRvStriatum ventral region26.31
16.43
Herc4THThalamus14.86
10.5
Peptide Top
Peptide Name Peptide Lengh Peptide Start Peptide End Peptide Sequence Source
PAp00026768 27 999 1025 LVIQSTGGGEEYLPVSHTCFNLLDLPK Peptide Atlas

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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