AutismKB 2.0

Annotation Detail for TTLL3


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Basic Information Top
Gene Symbol:TTLL3 ( DKFZp434B103,DKFZp686D076,FLJ13898,HOTTL,MGC120529,MGC120530,MGC120532 )
Gene Full Name: tubulin tyrosine ligase-like family, member 3
Band: 3p25.3
Quick LinksEntrez ID:26140; OMIM: NA; Uniprot ID:TTLL3_HUMAN; ENSEMBL ID: ENSG00000214021; HGNC ID: 24483
Relate to Another Database: SFARIGene; denovo-db
Unigene EST Top
Microarray in BioGPS Top
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  • Microarray Platform: GeneAtlas U133A, gcrma
  • Affymatrix Probe ID: 210129_s_at
Cell line Expression level Expression bar
721_B_lymphoblasts13.95
Adipocyte8.2
AdrenalCortex8.45
Adrenalgland7
Amygdala8.95
Appendix8.3
AtrioventricularNode6.15
BDCA4+_DentriticCells19.55
Bonemarrow8.3
BronchialEpithelialCells7.2
CD105+_Endothelial8.2
CD14+_Monocytes9.95
CD19+_BCells(neg._sel.)8.85
CD33+_Myeloid16.25
CD34+11.25
CD4+_Tcells15.2
CD56+_NKCells14.35
CD71+_EarlyErythroid6.8
CD8+_Tcells20.3
CardiacMyocytes10.35
Caudatenucleus7.95
Cerebellum6.7
CerebellumPeduncles9.45
CiliaryGanglion5.05
CingulateCortex8.5
Colorectaladenocarcinoma7.95
DorsalRootGanglion5.5
FetalThyroid11.95
Fetalbrain8.4
Fetalliver7.15
Fetallung8.35
GlobusPallidus5.4
Heart10.5
Hypothalamus9.8
Kidney6.65
Leukemia_chronicMyelogenousK-56212.2
Leukemia_promyelocytic-HL-609.25
Leukemialymphoblastic(MOLT-4)7.4
Liver10.85
Lung9.3
Lymphnode11
Lymphoma_burkitts(Daudi)11.55
Lymphoma_burkitts(Raji)21.7
MedullaOblongata7.65
OccipitalLobe6.9
OlfactoryBulb7.95
Ovary5.55
Pancreas6.45
PancreaticIslet8.9
ParietalLobe8.75
Pituitary9.8
Placenta7.6
Pons7.95
PrefrontalCortex10.85
Prostate9.75
Salivarygland6.6
SkeletalMuscle9.55
Skin6.05
SmoothMuscle9.45
Spinalcord11.55
SubthalamicNucleus7
SuperiorCervicalGanglion9.25
TemporalLobe7.5
Testis14.65
TestisGermCell13.55
TestisIntersitial11.75
TestisLeydigCell12.05
TestisSeminiferousTubule12.05
Thalamus8.45
Thymus6.8
Thyroid10.65
Tongue7.8
Tonsil10.05
Trachea6.95
TrigeminalGanglion8.05
Uterus7.8
UterusCorpus7.5
WholeBlood9.3
Wholebrain7
colon8.35
pineal_day11.36
pineal_night10.26
retina11.15
small_intestine8.05
Allen Brain Atlas Top
Human Whole Brain Microarrayview in Allen Brain Atlas
  • Probe id     Donor id      
  • Probe name: A_24_P37540
  • Donor H0351.2001
  • Sex: Male     Age: 24 years     Race/Ethnicity: African American     Handedness: Left
  • Tissue Receipt Date: 7/29/2009     Serology: Pass      Tissue pH :6.72     Additional Medical Information :History of asthma
  • Postmortem Interval: 23 hours (estimated time of death to time that tissue is frozen)
  • Toxicology: Positive for atropine and caffeine, at levels usually not toxicologically significant
Tissue Expression(mean ± stddev) Expression Bar
Amygdala5.46 ± 0.39
Basal Forebrain5.76 ± 0.37
Basal Part of Pons5.38 ± 0.37
Cerebellar Cortex5.47 ± 0.39
Cerebellar Nuclei5.52 ± 0.49
Claustrum5.25 ± 0.5
Epithalamus6.42 ± 0.44
Frontal Lobe5.33 ± 0.49
Globus Pallidus6.24 ± 0.18
Hypothalamus5.58 ± 0.47
Insula5.42 ± 0.31
Limbic Lobe5.39 ± 0.52
Mesencephalon5.57 ± 0.46
Myelencephalon5.53 ± 0.49
Occipital Lobe5.71 ± 0.45
Parietal Lobe5.45 ± 0.37
Pontine Tegmentum5.45 ± 0.44
Striatum5.87 ± 0.47
Subthalamus4.55 ± 0.66
Temporal Lobe5.42 ± 0.38
Thalamus5.54 ± 0.34
White Matter7.1 ± 0.26
Mouse Brain ISH
Peptide Top

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  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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