AutismKB 2.0

Annotation Detail for INTS1


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Basic Information Top
Gene Symbol:INTS1 ( DKFZp586J0619,FLJ46624,INT1,KIAA1440,NET28 )
Gene Full Name: integrator complex subunit 1
Band: 7p22.3
Quick LinksEntrez ID:26173; OMIM: 611345; Uniprot ID:INT1_HUMAN; ENSEMBL ID: ENSG00000164880; HGNC ID: 24555
Relate to Another Database: SFARIGene; denovo-db
Unigene EST Top
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
embryoid body12 / 70761169
blastocyst5 / 6231980
fetus46 / 56401281
neonate2 / 3109764
infant0 / 236200 
juvenile2 / 5555635
adult144 / 193912174
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adrenal tumor0 / 127940 
bladder carcinoma2 / 17475114
breast (mammary gland) tumor3 / 9417831
cervical tumor5 / 34366145
chondrosarcoma6 / 8282372
colorectal tumor19 / 114246166
esophageal tumor1 / 1729057
gastrointestinal tumor5 / 11936941
germ cell tumor16 / 26384560
glioma23 / 106883215
head and neck tumor5 / 13630236
kidney tumor7 / 68959101
leukemia15 / 95842156
liver tumor2 / 9635920
lung tumor16 / 103127155
lymphoma8 / 71755111
non-neoplasia3 / 9725030
normal219 / 336030765
ovarian tumor10 / 76682130
pancreatic tumor7 / 10461666
primitive neuroectodermal tumor of the CNS28 / 125680222
prostate cancer3 / 10268029
retinoblastoma2 / 4635643
skin tumor26 / 124949208
soft tissue/muscle tissue tumor6 / 12519147
uterine tumor3 / 9025733
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adipose tissue3 / 13106228
adrenal gland0 / 331970 
ascites1 / 4001524
bladder3 / 29757100
blood15 / 123478121
bone4 / 7165555
bone marrow0 / 488010 
brain74 / 110098967
cervix7 / 48171145
connective tissue4 / 14925526
ear0 / 162120 
embryonic tissue26 / 215722120
esophagus1 / 2020949
eye22 / 211054104
heart0 / 896260 
intestine26 / 234472110
kidney9 / 21177742
larynx0 / 241450 
liver2 / 2077439
lung24 / 33697471
lymph8 / 44270180
lymph node31 / 91610338
mammary gland9 / 15327158
mouth1 / 6705214
muscle4 / 10771537
nerve1 / 1576863
ovary13 / 102051127
pancreas19 / 21481288
parathyroid0 / 205390 
pharynx3 / 4132872
pituitary gland0 / 165850 
placenta12 / 28082542
prostate5 / 18934526
salivary gland0 / 201550 
skin27 / 210574128
spleen0 / 539520 
stomach3 / 9661931
testis10 / 33044230
thymus12 / 81131147
thyroid1 / 4747321
tonsil3 / 16999176
trachea0 / 524130 
umbilical cord2 / 13680146
uterus7 / 23287830
vascular0 / 517800 
Microarray in BioGPS Top
Select probe  
  • Microarray Platform: GeneAtlas U133A, gcrma
  • Affymatrix Probe ID: 212212_s_at
Cell line Expression level Expression bar
721_B_lymphoblasts24.75
Adipocyte6.1
AdrenalCortex6.9
Adrenalgland5.1
Amygdala10.85
Appendix6.1
AtrioventricularNode5
BDCA4+_DentriticCells15.2
Bonemarrow6.7
BronchialEpithelialCells6.65
CD105+_Endothelial27.9
CD14+_Monocytes19.2
CD19+_BCells(neg._sel.)19.2
CD33+_Myeloid16.5
CD34+30.2
CD4+_Tcells24.85
CD56+_NKCells17.7
CD71+_EarlyErythroid10.3
CD8+_Tcells21.2
CardiacMyocytes10.9
Caudatenucleus5.45
Cerebellum4.9
CerebellumPeduncles7.5
CiliaryGanglion4.3
CingulateCortex9.4
Colorectaladenocarcinoma29.05
DorsalRootGanglion4.65
FetalThyroid16.65
Fetalbrain7.15
Fetalliver5.35
Fetallung5.4
GlobusPallidus4.95
Heart12.4
Hypothalamus7.25
Kidney5
Leukemia_chronicMyelogenousK-56214.3
Leukemia_promyelocytic-HL-605.55
Leukemialymphoblastic(MOLT-4)8
Liver8.55
Lung31.45
Lymphnode6.9
Lymphoma_burkitts(Daudi)8
Lymphoma_burkitts(Raji)45.9
MedullaOblongata5.6
OccipitalLobe5.8
OlfactoryBulb5.35
Ovary4.1
Pancreas5.3
PancreaticIslet7.25
ParietalLobe7.15
Pituitary7.05
Placenta8.75
Pons5.85
PrefrontalCortex9.8
Prostate28.25
Salivarygland4.9
SkeletalMuscle8.35
Skin4.9
SmoothMuscle11.2
Spinalcord8
SubthalamicNucleus5.85
SuperiorCervicalGanglion6.85
TemporalLobe5.7
Testis22.3
TestisGermCell16.2
TestisIntersitial12.55
TestisLeydigCell6.75
TestisSeminiferousTubule7.55
Thalamus6.65
Thymus23.4
Thyroid17.85
Tongue6.55
Tonsil6.55
Trachea5.1
TrigeminalGanglion6.05
Uterus12.75
UterusCorpus5.65
WholeBlood7.3
Wholebrain6
colon5.1
pineal_day14.56
pineal_night8.5
retina7.825
small_intestine5.35
Allen Brain Atlas Top
Human Whole Brain Microarrayview in Allen Brain Atlas
  • Probe id     Donor id      
  • Probe name: A_24_P66672
  • Donor H0351.2001
  • Sex: Male     Age: 24 years     Race/Ethnicity: African American     Handedness: Left
  • Tissue Receipt Date: 7/29/2009     Serology: Pass      Tissue pH :6.72     Additional Medical Information :History of asthma
  • Postmortem Interval: 23 hours (estimated time of death to time that tissue is frozen)
  • Toxicology: Positive for atropine and caffeine, at levels usually not toxicologically significant
Tissue Expression(mean ± stddev) Expression Bar
Amygdala4.22 ± 0.77
Basal Forebrain3.68 ± 0.75
Basal Part of Pons3.8 ± 0.6
Cerebellar Cortex3.99 ± 0.5
Cerebellar Nuclei3.45 ± 0.37
Claustrum4.45 ± 0.66
Epithalamus3.52 ± 0.45
Frontal Lobe3.83 ± 0.59
Globus Pallidus4.03 ± 0.3
Hypothalamus3.43 ± 0.55
Insula3.93 ± 0.62
Limbic Lobe4.09 ± 0.58
Mesencephalon3.9 ± 0.66
Myelencephalon3.94 ± 0.6
Occipital Lobe4.05 ± 0.52
Parietal Lobe4.04 ± 0.55
Pontine Tegmentum3.94 ± 0.56
Striatum3.52 ± 0.88
Subthalamus3.63 ± 1
Temporal Lobe3.97 ± 0.53
Thalamus3.87 ± 0.57
White Matter4.21 ± 0.92
Mouse Brain ISH
Gene Symbol Brain Structure ID Brain Structure Name Express Desity/Level (Meatured by ISH) Express Bar
Ints1CBCerebellum56.53
72.98
Ints1CTXCerebral cortex100
100
Ints1HIPHippocampal region65.44
100
Ints1HPFHippocampal formation77.65
100
Ints1HYHypothalamus78.7
68.99
Ints1LSXLateral septal complex84.28
64.45
Ints1MBMidbrain82.6
79.45
Ints1MYMedulla87.49
100
Ints1OLFOlfactory bulb100
100
Ints1PPons78.98
98.12
Ints1PALPallidum81.54
83.19
Ints1RHPRetrohippocampal region100
100
Ints1sAMYStriatum-like amygdalar nuclei100
84.97
Ints1STRStriatum87.61
69.24
Ints1STRdStriatum dorsal region83.42
65.87
Ints1STRvStriatum ventral region96.42
74.69
Ints1THThalamus98.6
91.33
Peptide Top
Peptide Name Peptide Lengh Peptide Start Peptide End Peptide Sequence Source
PAp00040960 20 170 189 IKPNIFATEGVIEALCSLLR Peptide Atlas

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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