AutismKB 2.0

Annotation Detail for FBXL6


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Basic Information Top
Gene Symbol:FBXL6 ( FBL6,FBL6A,PP14630 )
Gene Full Name: F-box and leucine-rich repeat protein 6
Band: 8q24.3
Quick LinksEntrez ID:26233; OMIM: 609076; Uniprot ID:FBXL6_HUMAN; ENSEMBL ID: ENSG00000182325; HGNC ID: 13603
Relate to Another Database: SFARIGene; denovo-db
Unigene EST Top
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
embryoid body2 / 7076128
blastocyst2 / 6231932
fetus3 / 5640125
neonate0 / 310970 
infant0 / 236200 
juvenile0 / 555560 
adult32 / 193912116
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adrenal tumor0 / 127940 
bladder carcinoma0 / 174750 
breast (mammary gland) tumor1 / 9417810
cervical tumor0 / 343660 
chondrosarcoma3 / 8282336
colorectal tumor5 / 11424643
esophageal tumor1 / 1729057
gastrointestinal tumor22 / 119369184
germ cell tumor8 / 26384530
glioma1 / 1068839
head and neck tumor0 / 1363020 
kidney tumor0 / 689590 
leukemia2 / 9584220
liver tumor0 / 963590 
lung tumor2 / 10312719
lymphoma1 / 7175513
non-neoplasia0 / 972500 
normal47 / 336030713
ovarian tumor5 / 7668265
pancreatic tumor6 / 10461657
primitive neuroectodermal tumor of the CNS0 / 1256800 
prostate cancer2 / 10268019
retinoblastoma0 / 463560 
skin tumor8 / 12494964
soft tissue/muscle tissue tumor1 / 1251917
uterine tumor1 / 9025711
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adipose tissue0 / 131060 
adrenal gland0 / 331970 
ascites0 / 400150 
bladder0 / 297570 
blood3 / 12347824
bone2 / 7165527
bone marrow0 / 488010 
brain11 / 11009899
cervix1 / 4817120
connective tissue2 / 14925513
ear0 / 162120 
embryonic tissue5 / 21572223
esophagus1 / 2020949
eye3 / 21105414
heart0 / 896260 
intestine15 / 23447263
kidney2 / 2117779
larynx0 / 241450 
liver0 / 2077430 
lung3 / 3369748
lymph0 / 442700 
lymph node10 / 91610109
mammary gland3 / 15327119
mouth0 / 670520 
muscle0 / 1077150 
nerve0 / 157680 
ovary7 / 10205168
pancreas6 / 21481227
parathyroid0 / 205390 
pharynx0 / 413280 
pituitary gland1 / 1658560
placenta2 / 2808257
prostate7 / 18934536
salivary gland0 / 201550 
skin10 / 21057447
spleen0 / 539520 
stomach16 / 96619165
testis1 / 3304423
thymus1 / 8113112
thyroid0 / 474730 
tonsil0 / 169990 
trachea0 / 524130 
umbilical cord0 / 136800 
uterus2 / 2328788
vascular1 / 5178019
Microarray in BioGPS Top
Select probe  
  • Microarray Platform: GeneAtlas U133A, gcrma
  • Affymatrix Probe ID: 219189_at
Cell line Expression level Expression bar
721_B_lymphoblasts30.55
Adipocyte6.4
AdrenalCortex7.05
Adrenalgland5.35
Amygdala6.3
Appendix6.45
AtrioventricularNode6.65
BDCA4+_DentriticCells13.35
Bonemarrow6.25
BronchialEpithelialCells6.5
CD105+_Endothelial6.65
CD14+_Monocytes13.5
CD19+_BCells(neg._sel.)6.9
CD33+_Myeloid8.75
CD34+26.95
CD4+_Tcells7.9
CD56+_NKCells16.55
CD71+_EarlyErythroid7.85
CD8+_Tcells8.75
CardiacMyocytes8.15
Caudatenucleus7.15
Cerebellum5.3
CerebellumPeduncles7.4
CiliaryGanglion4.6
CingulateCortex7.5
Colorectaladenocarcinoma16.1
DorsalRootGanglion6.35
FetalThyroid6.4
Fetalbrain6.6
Fetalliver5.6
Fetallung5.4
GlobusPallidus7.4
Heart8.2
Hypothalamus7
Kidney5.25
Leukemia_chronicMyelogenousK-5629.05
Leukemia_promyelocytic-HL-605.8
Leukemialymphoblastic(MOLT-4)14.05
Liver8.5
Lung7.3
Lymphnode6.2
Lymphoma_burkitts(Daudi)8.35
Lymphoma_burkitts(Raji)9.1
MedullaOblongata5.95
OccipitalLobe5.85
OlfactoryBulb5.1
Ovary4.35
Pancreas21.55
PancreaticIslet6.7
ParietalLobe6.85
Pituitary10.25
Placenta6.6
Pons6.25
PrefrontalCortex8.1
Prostate7.45
Salivarygland5.1
SkeletalMuscle7.7
Skin5.05
SmoothMuscle7.1
Spinalcord7
SubthalamicNucleus9.75
SuperiorCervicalGanglion7.35
TemporalLobe9.25
Testis5.65
TestisGermCell5.55
TestisIntersitial5.5
TestisLeydigCell6.3
TestisSeminiferousTubule5.6
Thalamus6.65
Thymus5.2
Thyroid8.35
Tongue6.35
Tonsil6.35
Trachea5.35
TrigeminalGanglion11.15
Uterus5
UterusCorpus5.8
WholeBlood7.05
Wholebrain5.55
colon6.65
pineal_day9.84
pineal_night7.78
retina7.5
small_intestine6.4
Allen Brain Atlas Top
Human Whole Brain Microarrayview in Allen Brain Atlas
  • Probe id     Donor id      
  • Probe name: CUST_6131_PI416261804
  • Donor H0351.2001
  • Sex: Male     Age: 24 years     Race/Ethnicity: African American     Handedness: Left
  • Tissue Receipt Date: 7/29/2009     Serology: Pass      Tissue pH :6.72     Additional Medical Information :History of asthma
  • Postmortem Interval: 23 hours (estimated time of death to time that tissue is frozen)
  • Toxicology: Positive for atropine and caffeine, at levels usually not toxicologically significant
Tissue Expression(mean ± stddev) Expression Bar
Amygdala4.34 ± 0.71
Basal Forebrain4.22 ± 0.58
Basal Part of Pons4.1 ± 0.65
Cerebellar Cortex4.7 ± 0.4
Cerebellar Nuclei4.26 ± 0.44
Claustrum4.61 ± 0.96
Epithalamus4.13 ± 0.49
Frontal Lobe4.13 ± 0.55
Globus Pallidus3.75 ± 0.68
Hypothalamus3.75 ± 0.58
Insula4.07 ± 0.21
Limbic Lobe4.33 ± 0.57
Mesencephalon4.16 ± 0.62
Myelencephalon4.24 ± 0.61
Occipital Lobe4.47 ± 0.61
Parietal Lobe4.25 ± 0.52
Pontine Tegmentum4.11 ± 0.56
Striatum4.12 ± 0.61
Subthalamus4.25 ± 0.16
Temporal Lobe4.19 ± 0.61
Thalamus4.2 ± 0.53
White Matter4.31 ± 0.2
Mouse Brain ISH
Peptide Top

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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