AutismKB 2.0

Annotation Detail for FBXL5


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Basic Information Top
Gene Symbol:FBXL5 ( FBL4,FBL5,FLR1 )
Gene Full Name: F-box and leucine-rich repeat protein 5
Band: 4p15.32
Quick LinksEntrez ID:26234; OMIM: 605655; Uniprot ID:FBXL5_HUMAN; ENSEMBL ID: ENSG00000118564; HGNC ID: 13602
Relate to Another Database: SFARIGene; denovo-db
Unigene EST Top
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
embryoid body2 / 7076128
blastocyst5 / 6231980
fetus72 / 564012127
neonate5 / 31097160
infant2 / 2362084
juvenile1 / 5555617
adult128 / 193912166
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adrenal tumor3 / 12794234
bladder carcinoma1 / 1747557
breast (mammary gland) tumor7 / 9417874
cervical tumor0 / 343660 
chondrosarcoma10 / 82823120
colorectal tumor1 / 1142468
esophageal tumor4 / 17290231
gastrointestinal tumor1 / 1193698
germ cell tumor33 / 263845125
glioma5 / 10688346
head and neck tumor8 / 13630258
kidney tumor4 / 6895958
leukemia8 / 9584283
liver tumor3 / 9635931
lung tumor1 / 1031279
lymphoma1 / 7175513
non-neoplasia2 / 9725020
normal392 / 3360307116
ovarian tumor0 / 766820 
pancreatic tumor4 / 10461638
primitive neuroectodermal tumor of the CNS2 / 12568015
prostate cancer3 / 10268029
retinoblastoma1 / 4635621
skin tumor3 / 12494924
soft tissue/muscle tissue tumor6 / 12519147
uterine tumor7 / 9025777
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adipose tissue3 / 13106228
adrenal gland5 / 33197150
ascites0 / 400150 
bladder2 / 2975767
blood18 / 123478145
bone5 / 7165569
bone marrow3 / 4880161
brain168 / 1100989152
cervix1 / 4817120
connective tissue9 / 14925560
ear4 / 16212246
embryonic tissue11 / 21572250
esophagus5 / 20209247
eye12 / 21105456
heart5 / 8962655
intestine7 / 23447229
kidney23 / 211777108
larynx0 / 241450 
liver9 / 20774343
lung13 / 33697438
lymph0 / 442700 
lymph node13 / 91610141
mammary gland12 / 15327178
mouth9 / 67052134
muscle9 / 10771583
nerve1 / 1576863
ovary0 / 1020510 
pancreas8 / 21481237
parathyroid3 / 20539146
pharynx4 / 4132896
pituitary gland8 / 16585482
placenta17 / 28082560
prostate10 / 18934552
salivary gland1 / 2015549
skin14 / 21057466
spleen10 / 53952185
stomach4 / 9661941
testis86 / 330442260
thymus16 / 81131197
thyroid3 / 4747363
tonsil0 / 169990 
trachea10 / 52413190
umbilical cord0 / 136800 
uterus22 / 23287894
vascular4 / 5178077
Microarray in BioGPS Top
Select probe  
  • Microarray Platform: GeneAtlas U133A, gcrma
  • Affymatrix Probe ID: 209005_at
Cell line Expression level Expression bar
721_B_lymphoblasts7.95
Adipocyte7.25
AdrenalCortex8.6
Adrenalgland7.2
Amygdala12.05
Appendix7.7
AtrioventricularNode6.1
BDCA4+_DentriticCells9.35
Bonemarrow8.5
BronchialEpithelialCells7.15
CD105+_Endothelial7.6
CD14+_Monocytes32
CD19+_BCells(neg._sel.)8.65
CD33+_Myeloid37
CD34+8.85
CD4+_Tcells8.2
CD56+_NKCells13.25
CD71+_EarlyErythroid7.1
CD8+_Tcells7.2
CardiacMyocytes9.65
Caudatenucleus10
Cerebellum6.1
CerebellumPeduncles9.2
CiliaryGanglion5.3
CingulateCortex7.8
Colorectaladenocarcinoma6.95
DorsalRootGanglion5.95
FetalThyroid7.25
Fetalbrain9.4
Fetalliver6.55
Fetallung6.55
GlobusPallidus5.6
Heart9.55
Hypothalamus12.5
Kidney6.2
Leukemia_chronicMyelogenousK-5626.7
Leukemia_promyelocytic-HL-606.6
Leukemialymphoblastic(MOLT-4)6
Liver9.9
Lung8
Lymphnode6.4
Lymphoma_burkitts(Daudi)9.6
Lymphoma_burkitts(Raji)10.05
MedullaOblongata8.75
OccipitalLobe8.75
OlfactoryBulb6.4
Ovary5.45
Pancreas5.95
PancreaticIslet8
ParietalLobe7.9
Pituitary11.75
Placenta7.1
Pons7.15
PrefrontalCortex16.05
Prostate8.65
Salivarygland6.1
SkeletalMuscle8.55
Skin5.8
SmoothMuscle8.45
Spinalcord10.95
SubthalamicNucleus6.95
SuperiorCervicalGanglion8.55
TemporalLobe6.9
Testis8.2
TestisGermCell6.4
TestisIntersitial6.25
TestisLeydigCell7.45
TestisSeminiferousTubule6.4
Thalamus7.85
Thymus5.85
Thyroid9.8
Tongue7.25
Tonsil7.25
Trachea6.25
TrigeminalGanglion7.45
Uterus6.55
UterusCorpus6.7
WholeBlood29.9
Wholebrain6.4
colon7.45
pineal_day13.5
pineal_night17.68
retina9.375
small_intestine7.1
Allen Brain Atlas Top
Human Whole Brain Microarrayview in Allen Brain Atlas
  • Probe id     Donor id      
  • Probe name: CUST_7155_PI416261804
  • Donor H0351.2001
  • Sex: Male     Age: 24 years     Race/Ethnicity: African American     Handedness: Left
  • Tissue Receipt Date: 7/29/2009     Serology: Pass      Tissue pH :6.72     Additional Medical Information :History of asthma
  • Postmortem Interval: 23 hours (estimated time of death to time that tissue is frozen)
  • Toxicology: Positive for atropine and caffeine, at levels usually not toxicologically significant
Tissue Expression(mean ± stddev) Expression Bar
Amygdala6.55 ± 0.43
Basal Forebrain6.96 ± 0.22
Basal Part of Pons6.97 ± 0.19
Cerebellar Cortex7.24 ± 0.15
Cerebellar Nuclei7 ± 0.36
Claustrum6.44 ± 0.46
Epithalamus6.99 ± 0.44
Frontal Lobe6.85 ± 0.37
Globus Pallidus6.98 ± 0.33
Hypothalamus6.91 ± 0.54
Insula6.93 ± 0.34
Limbic Lobe6.76 ± 0.32
Mesencephalon6.87 ± 0.3
Myelencephalon6.87 ± 0.37
Occipital Lobe7.01 ± 0.4
Parietal Lobe6.83 ± 0.32
Pontine Tegmentum6.92 ± 0.39
Striatum6.77 ± 0.32
Subthalamus7.13 ± 0.25
Temporal Lobe6.91 ± 0.35
Thalamus6.93 ± 0.38
White Matter7.66 ± 0.26
Mouse Brain ISH
Gene Symbol Brain Structure ID Brain Structure Name Express Desity/Level (Meatured by ISH) Express Bar
Fbxl5CBCerebellum100
100
Fbxl5CTXCerebral cortex100
100
Fbxl5HIPHippocampal region84.6
100
Fbxl5HPFHippocampal formation100
100
Fbxl5HYHypothalamus87.76
68.8
Fbxl5LSXLateral septal complex100
72.36
Fbxl5MBMidbrain81.27
67.55
Fbxl5MYMedulla82.36
78.39
Fbxl5OLFOlfactory bulb100
100
Fbxl5PPons67.18
61.21
Fbxl5PALPallidum83.02
65.07
Fbxl5RHPRetrohippocampal region100
100
Fbxl5sAMYStriatum-like amygdalar nuclei100
67.53
Fbxl5STRStriatum90.46
65.44
Fbxl5STRdStriatum dorsal region84.13
60.58
Fbxl5STRvStriatum ventral region95.46
72.53
Fbxl5THThalamus82.68
71.15
Peptide Top

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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