AutismKB 2.0

Annotation Detail for FBXL4


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Basic Information Top
Gene Symbol:FBXL4 ( FBL4,FBL5 )
Gene Full Name: F-box and leucine-rich repeat protein 4
Band: 6q16.1-q16.2
Quick LinksEntrez ID:26235; OMIM: 605654; Uniprot ID:FBXL4_HUMAN; ENSEMBL ID: ENSG00000112234; HGNC ID: 13601
Relate to Another Database: SFARIGene; denovo-db
Unigene EST Top
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
embryoid body0 / 707610 
blastocyst1 / 6231916
fetus20 / 56401235
neonate3 / 3109796
infant0 / 236200 
juvenile2 / 5555635
adult38 / 193912119
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adrenal tumor0 / 127940 
bladder carcinoma1 / 1747557
breast (mammary gland) tumor0 / 941780 
cervical tumor0 / 343660 
chondrosarcoma2 / 8282324
colorectal tumor1 / 1142468
esophageal tumor0 / 172900 
gastrointestinal tumor2 / 11936916
germ cell tumor1 / 2638453
glioma1 / 1068839
head and neck tumor3 / 13630222
kidney tumor0 / 689590 
leukemia5 / 9584252
liver tumor2 / 9635920
lung tumor0 / 1031270 
lymphoma1 / 7175513
non-neoplasia0 / 972500 
normal65 / 336030719
ovarian tumor1 / 7668213
pancreatic tumor0 / 1046160 
primitive neuroectodermal tumor of the CNS6 / 12568047
prostate cancer0 / 1026800 
retinoblastoma2 / 4635643
skin tumor2 / 12494916
soft tissue/muscle tissue tumor6 / 12519147
uterine tumor1 / 9025711
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adipose tissue0 / 131060 
adrenal gland0 / 331970 
ascites0 / 400150 
bladder0 / 297570 
blood2 / 12347816
bone1 / 7165513
bone marrow3 / 4880161
brain19 / 110098917
cervix6 / 48171124
connective tissue3 / 14925520
ear0 / 162120 
embryonic tissue1 / 2157224
esophagus0 / 202090 
eye3 / 21105414
heart2 / 8962622
intestine3 / 23447212
kidney9 / 21177742
larynx0 / 241450 
liver2 / 2077439
lung3 / 3369748
lymph1 / 4427022
lymph node6 / 9161065
mammary gland1 / 1532716
mouth2 / 6705229
muscle2 / 10771518
nerve0 / 157680 
ovary1 / 1020519
pancreas3 / 21481213
parathyroid1 / 2053948
pharynx1 / 4132824
pituitary gland0 / 165850 
placenta2 / 2808257
prostate5 / 18934526
salivary gland0 / 201550 
skin7 / 21057433
spleen2 / 5395237
stomach2 / 9661920
testis5 / 33044215
thymus3 / 8113136
thyroid1 / 4747321
tonsil0 / 169990 
trachea3 / 5241357
umbilical cord0 / 136800 
uterus1 / 2328784
vascular1 / 5178019
Microarray in BioGPS Top
Select probe  
  • Microarray Platform: GeneAtlas U133A, gcrma
  • Affymatrix Probe ID: 209943_at
Cell line Expression level Expression bar
721_B_lymphoblasts14.1
Adipocyte8.3
AdrenalCortex11.85
Adrenalgland8
Amygdala8
Appendix14.1
AtrioventricularNode10.8
BDCA4+_DentriticCells10.6
Bonemarrow10.55
BronchialEpithelialCells9.75
CD105+_Endothelial13.15
CD14+_Monocytes16.1
CD19+_BCells(neg._sel.)18.3
CD33+_Myeloid13.1
CD34+17.55
CD4+_Tcells9.45
CD56+_NKCells20.15
CD71+_EarlyErythroid50.95
CD8+_Tcells9.55
CardiacMyocytes17.9
Caudatenucleus7.95
Cerebellum7.25
CerebellumPeduncles10.9
CiliaryGanglion10.9
CingulateCortex9.05
Colorectaladenocarcinoma8.6
DorsalRootGanglion9.95
FetalThyroid9.85
Fetalbrain8.05
Fetalliver7.6
Fetallung6.65
GlobusPallidus8.35
Heart15
Hypothalamus8.5
Kidney7.95
Leukemia_chronicMyelogenousK-5627.75
Leukemia_promyelocytic-HL-6016.8
Leukemialymphoblastic(MOLT-4)6.2
Liver15.15
Lung9.3
Lymphnode6.75
Lymphoma_burkitts(Daudi)12.05
Lymphoma_burkitts(Raji)14.85
MedullaOblongata7.75
OccipitalLobe7.25
OlfactoryBulb15.2
Ovary8.4
Pancreas12.1
PancreaticIslet10.55
ParietalLobe9.75
Pituitary10.5
Placenta8.3
Pons8.8
PrefrontalCortex10.15
Prostate10.25
Salivarygland7.65
SkeletalMuscle14.45
Skin8.65
SmoothMuscle9.9
Spinalcord9
SubthalamicNucleus9
SuperiorCervicalGanglion14.9
TemporalLobe8.35
Testis7.15
TestisGermCell6.4
TestisIntersitial7.3
TestisLeydigCell9.15
TestisSeminiferousTubule7.4
Thalamus9.35
Thymus6.1
Thyroid11
Tongue9.8
Tonsil8.55
Trachea7.05
TrigeminalGanglion13.9
Uterus7.45
UterusCorpus9.35
WholeBlood9.75
Wholebrain6.25
colon8.35
pineal_day10.78
pineal_night10.7
retina10.2
small_intestine8.1
Allen Brain Atlas Top
Human Whole Brain Microarrayview in Allen Brain Atlas
  • Probe id     Donor id      
  • Probe name: A_24_P129205
  • Donor H0351.2001
  • Sex: Male     Age: 24 years     Race/Ethnicity: African American     Handedness: Left
  • Tissue Receipt Date: 7/29/2009     Serology: Pass      Tissue pH :6.72     Additional Medical Information :History of asthma
  • Postmortem Interval: 23 hours (estimated time of death to time that tissue is frozen)
  • Toxicology: Positive for atropine and caffeine, at levels usually not toxicologically significant
Tissue Expression(mean ± stddev) Expression Bar
Amygdala5.28 ± 0.51
Basal Forebrain5.66 ± 0.2
Basal Part of Pons5.27 ± 0.3
Cerebellar Cortex5.79 ± 0.24
Cerebellar Nuclei5.26 ± 0.4
Claustrum4.78 ± 0.54
Epithalamus5.74 ± 0.35
Frontal Lobe5.21 ± 0.36
Globus Pallidus5.74 ± 0.44
Hypothalamus5.32 ± 0.49
Insula5.33 ± 0.43
Limbic Lobe5.35 ± 0.41
Mesencephalon5.44 ± 0.49
Myelencephalon5.38 ± 0.45
Occipital Lobe5.83 ± 0.4
Parietal Lobe5.44 ± 0.42
Pontine Tegmentum5.39 ± 0.47
Striatum5.59 ± 0.49
Subthalamus5.44 ± 0.79
Temporal Lobe5.31 ± 0.36
Thalamus5.52 ± 0.35
White Matter6.37 ± 0.33
Mouse Brain ISH
Gene Symbol Brain Structure ID Brain Structure Name Express Desity/Level (Meatured by ISH) Express Bar
Fbxl4CBCerebellum6.15
6.78
Fbxl4CTXCerebral cortex4.53
3.32
Fbxl4HIPHippocampal region9.74
8.76
Fbxl4HPFHippocampal formation9.69
8.08
Fbxl4HYHypothalamus22.38
18.87
Fbxl4LSXLateral septal complex3.21
2.46
Fbxl4MBMidbrain8.23
8.69
Fbxl4MYMedulla13.14
16.32
Fbxl4OLFOlfactory bulb23.7
18.54
Fbxl4PPons16.28
19.81
Fbxl4PALPallidum12.67
11.38
Fbxl4RHPRetrohippocampal region9.73
7.34
Fbxl4sAMYStriatum-like amygdalar nuclei2.72
2.05
Fbxl4STRStriatum5
4.09
Fbxl4STRdStriatum dorsal region2.41
1.98
Fbxl4STRvStriatum ventral region14.72
11.35
Fbxl4THThalamus6.61
5.18
Peptide Top

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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