AutismKB 2.0

Annotation Detail for NKX2-8


View Evidences View Variants View Annotations
Basic Information Top
Gene Symbol:NKX2-8 ( NKX2.8,NKX2H,Nkx2-9 )
Gene Full Name: NK2 homeobox 8
Band: 14q13.3
Quick LinksEntrez ID:26257; OMIM: 603245; Uniprot ID:NKX28_HUMAN; ENSEMBL ID: ENSG00000136327; HGNC ID: 16364
Relate to Another Database: SFARIGene; denovo-db
Unigene EST Top
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
embryoid body0 / 707610 
blastocyst0 / 623190 
fetus0 / 5640120 
neonate0 / 310970 
infant0 / 236200 
juvenile0 / 555560 
adult1 / 19391210 
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adrenal tumor0 / 127940 
bladder carcinoma0 / 174750 
breast (mammary gland) tumor0 / 941780 
cervical tumor0 / 343660 
chondrosarcoma0 / 828230 
colorectal tumor0 / 1142460 
esophageal tumor0 / 172900 
gastrointestinal tumor0 / 1193690 
germ cell tumor0 / 2638450 
glioma0 / 1068830 
head and neck tumor1 / 1363027
kidney tumor0 / 689590 
leukemia0 / 958420 
liver tumor0 / 963590 
lung tumor0 / 1031270 
lymphoma0 / 717550 
non-neoplasia0 / 972500 
normal3 / 33603070 
ovarian tumor0 / 766820 
pancreatic tumor0 / 1046160 
primitive neuroectodermal tumor of the CNS0 / 1256800 
prostate cancer0 / 1026800 
retinoblastoma0 / 463560 
skin tumor0 / 1249490 
soft tissue/muscle tissue tumor0 / 1251910 
uterine tumor1 / 9025711
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adipose tissue0 / 131060 
adrenal gland0 / 331970 
ascites0 / 400150 
bladder0 / 297570 
blood0 / 1234780 
bone0 / 716550 
bone marrow0 / 488010 
brain0 / 11009890 
cervix0 / 481710 
connective tissue0 / 1492550 
ear0 / 162120 
embryonic tissue0 / 2157220 
esophagus0 / 202090 
eye0 / 2110540 
heart0 / 896260 
intestine0 / 2344720 
kidney0 / 2117770 
larynx0 / 241450 
liver0 / 2077430 
lung4 / 33697411
lymph0 / 442700 
lymph node0 / 916100 
mammary gland0 / 1532710 
mouth2 / 6705229
muscle0 / 1077150 
nerve0 / 157680 
ovary0 / 1020510 
pancreas0 / 2148120 
parathyroid0 / 205390 
pharynx0 / 413280 
pituitary gland0 / 165850 
placenta0 / 2808250 
prostate0 / 1893450 
salivary gland0 / 201550 
skin0 / 2105740 
spleen0 / 539520 
stomach0 / 966190 
testis1 / 3304423
thymus0 / 811310 
thyroid0 / 474730 
tonsil0 / 169990 
trachea0 / 524130 
umbilical cord0 / 136800 
uterus1 / 2328784
vascular0 / 517800 
Microarray in BioGPS Top
Select probe  
  • Microarray Platform: GeneAtlas U133A, gcrma
  • Affymatrix Probe ID: 207451_at
Cell line Expression level Expression bar
721_B_lymphoblasts5.05
Adipocyte3.85
AdrenalCortex4.3
Adrenalgland3.3
Amygdala4.05
Appendix3.9
AtrioventricularNode3.2
BDCA4+_DentriticCells4.25
Bonemarrow3.9
BronchialEpithelialCells3.9
CD105+_Endothelial4.1
CD14+_Monocytes4.15
CD19+_BCells(neg._sel.)4.2
CD33+_Myeloid4.9
CD34+4.95
CD4+_Tcells4.2
CD56+_NKCells4.65
CD71+_EarlyErythroid3.6
CD8+_Tcells3.7
CardiacMyocytes5.25
Caudatenucleus3.45
Cerebellum3.15
CerebellumPeduncles4.4
CiliaryGanglion3
CingulateCortex4
Colorectaladenocarcinoma4
DorsalRootGanglion3
FetalThyroid3.8
Fetalbrain3.85
Fetalliver3.35
Fetallung3.2
GlobusPallidus2.85
Heart5.1
Hypothalamus4.25
Kidney3.2
Leukemia_chronicMyelogenousK-5623.5
Leukemia_promyelocytic-HL-603.45
Leukemialymphoblastic(MOLT-4)3.1
Liver5.45
Lung4.35
Lymphnode3.3
Lymphoma_burkitts(Daudi)5
Lymphoma_burkitts(Raji)5.55
MedullaOblongata3.55
OccipitalLobe3.45
OlfactoryBulb3.1
Ovary2.6
Pancreas3.1
PancreaticIslet4.15
ParietalLobe4.1
Pituitary4.55
Placenta4.1
Pons3.7
PrefrontalCortex4.85
Prostate4.7
Salivarygland3.15
SkeletalMuscle4.55
Skin3.25
SmoothMuscle4.55
Spinalcord4.2
SubthalamicNucleus3.6
SuperiorCervicalGanglion4.6
TemporalLobe3.55
Testis3.45
TestisGermCell3.3
TestisIntersitial3.25
TestisLeydigCell3.95
TestisSeminiferousTubule3.4
Thalamus4
Thymus3
Thyroid4.95
Tongue3.8
Tonsil3.8
Trachea3.3
TrigeminalGanglion4.65
Uterus3.25
UterusCorpus3.5
WholeBlood4.3
Wholebrain3.35
colon3.95
pineal_day5.46
pineal_night4.76
retina4.8
small_intestine3.8
Allen Brain Atlas Top
Human Whole Brain Microarrayview in Allen Brain Atlas
  • Probe id     Donor id      
  • Probe name: CUST_16261_PI416261804
  • Donor H0351.2001
  • Sex: Male     Age: 24 years     Race/Ethnicity: African American     Handedness: Left
  • Tissue Receipt Date: 7/29/2009     Serology: Pass      Tissue pH :6.72     Additional Medical Information :History of asthma
  • Postmortem Interval: 23 hours (estimated time of death to time that tissue is frozen)
  • Toxicology: Positive for atropine and caffeine, at levels usually not toxicologically significant
Tissue Expression(mean ± stddev) Expression Bar
Amygdala2.26 ± 0.99
Basal Forebrain1.83 ± 0.33
Basal Part of Pons1.44 ± 0.34
Cerebellar Cortex1.73 ± 0.77
Cerebellar Nuclei2.2 ± 0.81
Claustrum2.68 ± 0.85
Epithalamus1.45 ± 0.65
Frontal Lobe1.63 ± 0.58
Globus Pallidus2.48 ± 0.35
Hypothalamus1.87 ± 0.51
Insula1.61 ± 0.45
Limbic Lobe1.84 ± 0.79
Mesencephalon1.98 ± 0.71
Myelencephalon1.87 ± 0.77
Occipital Lobe1.88 ± 0.56
Parietal Lobe1.81 ± 0.8
Pontine Tegmentum1.87 ± 0.7
Striatum1.98 ± 0.58
Subthalamus1.96 ± 0.6
Temporal Lobe1.79 ± 0.81
Thalamus1.81 ± 0.61
White Matter3.01 ± 1.24
Mouse Brain ISH
Gene Symbol Brain Structure ID Brain Structure Name Express Desity/Level (Meatured by ISH) Express Bar
Nkx2-9CBCerebellum1.66
2.66
Nkx2-9CTXCerebral cortex0.69
0.51
Nkx2-9HIPHippocampal region0.52
0.5
Nkx2-9HPFHippocampal formation0.56
0.51
Nkx2-9HYHypothalamus0.29
0.19
Nkx2-9LSXLateral septal complex0
0
Nkx2-9MBMidbrain0.85
0.78
Nkx2-9MYMedulla1.01
0.62
Nkx2-9OLFOlfactory bulb0.37
0.26
Nkx2-9PPons0.61
0.36
Nkx2-9PALPallidum0.4
0.35
Nkx2-9RHPRetrohippocampal region0.54
0.49
Nkx2-9sAMYStriatum-like amygdalar nuclei0.26
0.19
Nkx2-9STRStriatum0.51
0.33
Nkx2-9STRdStriatum dorsal region0.54
0.32
Nkx2-9STRvStriatum ventral region0.63
0.38
Nkx2-9THThalamus1.03
0.6
Peptide Top

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


Copyright © 2017, Center for Bioinformatics , Peking University | All Rights Reserved