AutismKB 2.0

Annotation Detail for FBXO5


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Basic Information Top
Gene Symbol:FBXO5 ( EMI1,FBX5,Fbxo31 )
Gene Full Name: F-box protein 5
Band: 6q25.2
Quick LinksEntrez ID:26271; OMIM: 606013; Uniprot ID:FBX5_HUMAN; ENSEMBL ID: ENSG00000112029; HGNC ID: 13584
Relate to Another Database: SFARIGene; denovo-db
Unigene EST Top
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
embryoid body9 / 70761127
blastocyst2 / 6231932
fetus13 / 56401223
neonate2 / 3109764
infant3 / 23620127
juvenile7 / 55556125
adult25 / 193912112
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adrenal tumor0 / 127940 
bladder carcinoma0 / 174750 
breast (mammary gland) tumor1 / 9417810
cervical tumor1 / 3436629
chondrosarcoma0 / 828230 
colorectal tumor4 / 11424635
esophageal tumor3 / 17290173
gastrointestinal tumor1 / 1193698
germ cell tumor15 / 26384556
glioma2 / 10688318
head and neck tumor1 / 1363027
kidney tumor1 / 6895914
leukemia3 / 9584231
liver tumor4 / 9635941
lung tumor1 / 1031279
lymphoma3 / 7175541
non-neoplasia0 / 972500 
normal78 / 336030723
ovarian tumor3 / 7668239
pancreatic tumor4 / 10461638
primitive neuroectodermal tumor of the CNS8 / 12568063
prostate cancer1 / 1026809
retinoblastoma0 / 463560 
skin tumor2 / 12494916
soft tissue/muscle tissue tumor2 / 12519115
uterine tumor1 / 9025711
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adipose tissue0 / 131060 
adrenal gland0 / 331970 
ascites0 / 400150 
bladder0 / 297570 
blood7 / 12347856
bone0 / 716550 
bone marrow2 / 4880140
brain20 / 110098918
cervix1 / 4817120
connective tissue1 / 1492556
ear0 / 162120 
embryonic tissue19 / 21572288
esophagus3 / 20209148
eye3 / 21105414
heart0 / 896260 
intestine7 / 23447229
kidney4 / 21177718
larynx0 / 241450 
liver5 / 20774324
lung7 / 33697420
lymph2 / 4427045
lymph node11 / 91610120
mammary gland1 / 1532716
mouth0 / 670520 
muscle1 / 1077159
nerve1 / 1576863
ovary2 / 10205119
pancreas4 / 21481218
parathyroid0 / 205390 
pharynx1 / 4132824
pituitary gland0 / 165850 
placenta6 / 28082521
prostate3 / 18934515
salivary gland0 / 201550 
skin4 / 21057418
spleen0 / 539520 
stomach1 / 9661910
testis6 / 33044218
thymus4 / 8113149
thyroid0 / 474730 
tonsil1 / 1699958
trachea0 / 524130 
umbilical cord0 / 136800 
uterus4 / 23287817
vascular3 / 5178057
Microarray in BioGPS Top
Select probe  
  • Microarray Platform: GeneAtlas U133A, gcrma
  • Affymatrix Probe ID: 218875_s_at
Cell line Expression level Expression bar
721_B_lymphoblasts128.85
Adipocyte8.15
AdrenalCortex15.6
Adrenalgland7.65
Amygdala8.3
Appendix13.15
AtrioventricularNode15.25
BDCA4+_DentriticCells28.4
Bonemarrow10.7
BronchialEpithelialCells7.95
CD105+_Endothelial93.25
CD14+_Monocytes10.15
CD19+_BCells(neg._sel.)12.2
CD33+_Myeloid13.75
CD34+55.1
CD4+_Tcells8.55
CD56+_NKCells31.55
CD71+_EarlyErythroid166.1
CD8+_Tcells11.95
CardiacMyocytes21.55
Caudatenucleus7.65
Cerebellum6.9
CerebellumPeduncles11.55
CiliaryGanglion12.5
CingulateCortex9.3
Colorectaladenocarcinoma51.15
DorsalRootGanglion10.9
FetalThyroid9.25
Fetalbrain8.1
Fetalliver32.8
Fetallung6.3
GlobusPallidus7.75
Heart17.55
Hypothalamus8.5
Kidney8.5
Leukemia_chronicMyelogenousK-56214.9
Leukemia_promyelocytic-HL-6053
Leukemialymphoblastic(MOLT-4)74.35
Liver15.6
Lung9.2
Lymphnode6.95
Lymphoma_burkitts(Daudi)60.35
Lymphoma_burkitts(Raji)14.95
MedullaOblongata7.5
OccipitalLobe7.4
OlfactoryBulb6.4
Ovary7.2
Pancreas7.85
PancreaticIslet9.2
ParietalLobe10.25
Pituitary10.15
Placenta8.1
Pons8.8
PrefrontalCortex10
Prostate9.75
Salivarygland7.65
SkeletalMuscle17.35
Skin17.8
SmoothMuscle9.5
Spinalcord8.7
SubthalamicNucleus8.9
SuperiorCervicalGanglion22.35
TemporalLobe8.4
Testis7.25
TestisGermCell6.7
TestisIntersitial8.5
TestisLeydigCell9.4
TestisSeminiferousTubule7.25
Thalamus9
Thymus7.9
Thyroid10.25
Tongue12
Tonsil9.15
Trachea6.9
TrigeminalGanglion16.75
Uterus6.7
UterusCorpus9.95
WholeBlood9.2
Wholebrain6.6
colon14.15
pineal_day10.52
pineal_night9.94
retina10.075
small_intestine8.1
Allen Brain Atlas Top
Human Whole Brain Microarrayview in Allen Brain Atlas
  • Probe id     Donor id      
  • Probe name: A_23_P8241
  • Donor H0351.2001
  • Sex: Male     Age: 24 years     Race/Ethnicity: African American     Handedness: Left
  • Tissue Receipt Date: 7/29/2009     Serology: Pass      Tissue pH :6.72     Additional Medical Information :History of asthma
  • Postmortem Interval: 23 hours (estimated time of death to time that tissue is frozen)
  • Toxicology: Positive for atropine and caffeine, at levels usually not toxicologically significant
Tissue Expression(mean ± stddev) Expression Bar
Amygdala3.26 ± 0.76
Basal Forebrain2.84 ± 0.37
Basal Part of Pons3.12 ± 0.56
Cerebellar Cortex3.7 ± 0.29
Cerebellar Nuclei3.18 ± 0.69
Claustrum3.01 ± 0.85
Epithalamus2.76 ± 0.73
Frontal Lobe3.09 ± 0.55
Globus Pallidus3.08 ± 0.47
Hypothalamus2.95 ± 0.57
Insula3.15 ± 0.55
Limbic Lobe3.04 ± 0.55
Mesencephalon3.17 ± 0.63
Myelencephalon3.12 ± 0.56
Occipital Lobe3 ± 0.54
Parietal Lobe3.15 ± 0.66
Pontine Tegmentum3.11 ± 0.59
Striatum3.07 ± 0.61
Subthalamus2.9 ± 0.57
Temporal Lobe3.1 ± 0.53
Thalamus3.03 ± 0.51
White Matter3.53 ± 0.56
Mouse Brain ISH
Peptide Top

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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