AutismKB 2.0

Annotation Detail for GBP2


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Basic Information Top
Gene Symbol:GBP2 ( - )
Gene Full Name: guanylate binding protein 2, interferon-inducible
Band: 1p22.2
Quick LinksEntrez ID:2634; OMIM: 600412; Uniprot ID:GBP2_HUMAN; ENSEMBL ID: ENSG00000162645; HGNC ID: 4183
Relate to Another Database: SFARIGene; denovo-db
Unigene EST Top
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
embryoid body0 / 707610 
blastocyst0 / 623190 
fetus4 / 5640127
neonate3 / 3109796
infant0 / 236200 
juvenile4 / 5555671
adult158 / 193912181
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adrenal tumor0 / 127940 
bladder carcinoma4 / 17475228
breast (mammary gland) tumor14 / 94178148
cervical tumor0 / 343660 
chondrosarcoma6 / 8282372
colorectal tumor5 / 11424643
esophageal tumor2 / 17290115
gastrointestinal tumor9 / 11936975
germ cell tumor13 / 26384549
glioma4 / 10688337
head and neck tumor4 / 13630229
kidney tumor11 / 68959159
leukemia6 / 9584262
liver tumor12 / 96359124
lung tumor1 / 1031279
lymphoma2 / 7175527
non-neoplasia19 / 97250195
normal262 / 336030777
ovarian tumor6 / 7668278
pancreatic tumor4 / 10461638
primitive neuroectodermal tumor of the CNS4 / 12568031
prostate cancer1 / 1026809
retinoblastoma0 / 463560 
skin tumor3 / 12494924
soft tissue/muscle tissue tumor7 / 12519155
uterine tumor14 / 90257155
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adipose tissue2 / 13106152
adrenal gland10 / 33197301
ascites0 / 400150 
bladder7 / 29757235
blood37 / 123478299
bone2 / 7165527
bone marrow6 / 48801122
brain43 / 110098939
cervix2 / 4817141
connective tissue30 / 149255200
ear0 / 162120 
embryonic tissue0 / 2157220 
esophagus5 / 20209247
eye2 / 2110549
heart4 / 8962644
intestine33 / 234472140
kidney19 / 21177789
larynx0 / 241450 
liver14 / 20774367
lung26 / 33697477
lymph0 / 442700 
lymph node3 / 9161032
mammary gland23 / 153271150
mouth3 / 6705244
muscle4 / 10771537
nerve0 / 157680 
ovary7 / 10205168
pancreas4 / 21481218
parathyroid2 / 2053997
pharynx0 / 413280 
pituitary gland0 / 165850 
placenta16 / 28082556
prostate17 / 18934589
salivary gland0 / 201550 
skin3 / 21057414
spleen30 / 53952556
stomach20 / 96619206
testis5 / 33044215
thymus22 / 81131271
thyroid1 / 4747321
tonsil1 / 1699958
trachea7 / 52413133
umbilical cord0 / 136800 
uterus51 / 232878218
vascular5 / 5178096
Microarray in BioGPS Top
Select probe  
  • Microarray Platform: GeneAtlas U133A, gcrma
  • Affymatrix Probe ID: 202748_at
Cell line Expression level Expression bar
721_B_lymphoblasts19.5
Adipocyte25.6
AdrenalCortex36.75
Adrenalgland43.1
Amygdala16.75
Appendix45.55
AtrioventricularNode18.2
BDCA4+_DentriticCells69.35
Bonemarrow18.25
BronchialEpithelialCells16.3
CD105+_Endothelial16.6
CD14+_Monocytes305.4
CD19+_BCells(neg._sel.)21.25
CD33+_Myeloid66.6
CD34+19.3
CD4+_Tcells449
CD56+_NKCells759.2
CD71+_EarlyErythroid12.3
CD8+_Tcells593.8
CardiacMyocytes29.65
Caudatenucleus18.6
Cerebellum16.75
CerebellumPeduncles22.9
CiliaryGanglion33.5
CingulateCortex21.35
Colorectaladenocarcinoma17.55
DorsalRootGanglion32.35
FetalThyroid18.8
Fetalbrain18.45
Fetalliver15.85
Fetallung42.65
GlobusPallidus15.7
Heart26
Hypothalamus18.9
Kidney16.5
Leukemia_chronicMyelogenousK-56217.9
Leukemia_promyelocytic-HL-6015.5
Leukemialymphoblastic(MOLT-4)14.75
Liver26.5
Lung22.75
Lymphnode100.55
Lymphoma_burkitts(Daudi)23.75
Lymphoma_burkitts(Raji)23.65
MedullaOblongata22.4
OccipitalLobe16.95
OlfactoryBulb52.35
Ovary115.2
Pancreas17.35
PancreaticIslet144.4
ParietalLobe23.55
Pituitary23.15
Placenta28.95
Pons18.3
PrefrontalCortex23.85
Prostate20.3
Salivarygland36.2
SkeletalMuscle30.05
Skin26.45
SmoothMuscle31.8
Spinalcord21.45
SubthalamicNucleus19.65
SuperiorCervicalGanglion36.7
TemporalLobe19
Testis17.35
TestisGermCell21.2
TestisIntersitial18
TestisLeydigCell22.3
TestisSeminiferousTubule31.9
Thalamus19.3
Thymus21.35
Thyroid24.15
Tongue33.1
Tonsil41.65
Trachea22.65
TrigeminalGanglion54.15
Uterus86.8
UterusCorpus50.85
WholeBlood895.85
Wholebrain14.95
colon35.7
pineal_day27.28
pineal_night23.22
retina27.6
small_intestine26.9
Allen Brain Atlas Top
Human Whole Brain Microarrayview in Allen Brain Atlas
  • Probe id     Donor id      
  • Probe name: CUST_9990_PI416261804
  • Donor H0351.2001
  • Sex: Male     Age: 24 years     Race/Ethnicity: African American     Handedness: Left
  • Tissue Receipt Date: 7/29/2009     Serology: Pass      Tissue pH :6.72     Additional Medical Information :History of asthma
  • Postmortem Interval: 23 hours (estimated time of death to time that tissue is frozen)
  • Toxicology: Positive for atropine and caffeine, at levels usually not toxicologically significant
Tissue Expression(mean ± stddev) Expression Bar
Amygdala2.33 ± 0.85
Basal Forebrain2.44 ± 0.97
Basal Part of Pons2.38 ± 0.49
Cerebellar Cortex1.85 ± 0.45
Cerebellar Nuclei3.54 ± 0.52
Claustrum2.49 ± 0.62
Epithalamus2.59 ± 0.59
Frontal Lobe2.33 ± 0.84
Globus Pallidus4.08 ± 0.29
Hypothalamus2.35 ± 1
Insula2.65 ± 0.88
Limbic Lobe2.18 ± 0.72
Mesencephalon2.53 ± 0.79
Myelencephalon2.55 ± 0.79
Occipital Lobe2.51 ± 0.71
Parietal Lobe2.34 ± 0.78
Pontine Tegmentum2.4 ± 0.85
Striatum3.29 ± 0.56
Subthalamus2.95 ± 0.25
Temporal Lobe2.22 ± 0.74
Thalamus2.64 ± 0.66
White Matter3.82 ± 0.81
Mouse Brain ISH
Peptide Top
Peptide Name Peptide Lengh Peptide Start Peptide End Peptide Sequence Source
GBP2_HUMAN_340 16 340 355 VQLPTETLQELLDLHR PRIDE
GBP2_HUMAN_373 8 373 380 DVDQMFQR PRIDE
PAp00009459 10 233 242 CFVFDWPAPK Peptide Atlas

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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