AutismKB 2.0

Annotation Detail for HSPB8


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Basic Information Top
Gene Symbol:HSPB8 ( CMT2L,DHMN2,E2IG1,H11,HMN2,HMN2A,HSP22 )
Gene Full Name: heat shock 22kDa protein 8
Band: 12q24.23
Quick LinksEntrez ID:26353; OMIM: 608014; Uniprot ID:HSPB8_HUMAN; ENSEMBL ID: ENSG00000152137; HGNC ID: 30171
Relate to Another Database: SFARIGene; denovo-db
Unigene EST Top
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
embryoid body4 / 7076156
blastocyst2 / 6231932
fetus34 / 56401260
neonate2 / 3109764
infant0 / 236200 
juvenile2 / 5555635
adult239 / 1939121123
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adrenal tumor0 / 127940 
bladder carcinoma0 / 174750 
breast (mammary gland) tumor3 / 9417831
cervical tumor1 / 3436629
chondrosarcoma7 / 8282384
colorectal tumor0 / 1142460 
esophageal tumor0 / 172900 
gastrointestinal tumor1 / 1193698
germ cell tumor3 / 26384511
glioma22 / 106883205
head and neck tumor7 / 13630251
kidney tumor7 / 68959101
leukemia0 / 958420 
liver tumor0 / 963590 
lung tumor3 / 10312729
lymphoma1 / 7175513
non-neoplasia11 / 97250113
normal399 / 3360307118
ovarian tumor0 / 766820 
pancreatic tumor2 / 10461619
primitive neuroectodermal tumor of the CNS1 / 1256807
prostate cancer0 / 1026800 
retinoblastoma0 / 463560 
skin tumor4 / 12494932
soft tissue/muscle tissue tumor5 / 12519139
uterine tumor5 / 9025755
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adipose tissue1 / 1310676
adrenal gland2 / 3319760
ascites0 / 400150 
bladder1 / 2975733
blood0 / 1234780 
bone6 / 7165583
bone marrow0 / 488010 
brain127 / 1100989115
cervix6 / 48171124
connective tissue6 / 14925540
ear0 / 162120 
embryonic tissue6 / 21572227
esophagus2 / 2020998
eye39 / 211054184
heart34 / 89626379
intestine11 / 23447246
kidney16 / 21177775
larynx0 / 241450 
liver1 / 2077434
lung7 / 33697420
lymph0 / 442700 
lymph node1 / 9161010
mammary gland3 / 15327119
mouth7 / 67052104
muscle16 / 107715148
nerve3 / 15768190
ovary1 / 1020519
pancreas7 / 21481232
parathyroid7 / 20539340
pharynx1 / 4132824
pituitary gland0 / 165850 
placenta117 / 280825416
prostate5 / 18934526
salivary gland3 / 20155148
skin8 / 21057437
spleen3 / 5395255
stomach7 / 9661972
testis2 / 3304426
thymus0 / 811310 
thyroid3 / 4747363
tonsil0 / 169990 
trachea1 / 5241319
umbilical cord2 / 13680146
uterus20 / 23287885
vascular3 / 5178057
Microarray in BioGPS Top
Select probe  
  • Microarray Platform: GeneAtlas U133A, gcrma
  • Affymatrix Probe ID: 221667_s_at
Cell line Expression level Expression bar
721_B_lymphoblasts12.85
Adipocyte60.35
AdrenalCortex17.9
Adrenalgland13.5
Amygdala301.7
Appendix110.8
AtrioventricularNode10.9
BDCA4+_DentriticCells9.9
Bonemarrow10.35
BronchialEpithelialCells10.65
CD105+_Endothelial9.75
CD14+_Monocytes9.7
CD19+_BCells(neg._sel.)9.8
CD33+_Myeloid13.4
CD34+11.75
CD4+_Tcells12.05
CD56+_NKCells12.6
CD71+_EarlyErythroid11.35
CD8+_Tcells8.3
CardiacMyocytes27.9
Caudatenucleus222.45
Cerebellum44.85
CerebellumPeduncles67.25
CiliaryGanglion29.25
CingulateCortex83.15
Colorectaladenocarcinoma9.7
DorsalRootGanglion10.8
FetalThyroid49.45
Fetalbrain12.95
Fetalliver9.7
Fetallung68.75
GlobusPallidus136.25
Heart2808.5
Hypothalamus643.65
Kidney31.7
Leukemia_chronicMyelogenousK-5628.75
Leukemia_promyelocytic-HL-608.65
Leukemialymphoblastic(MOLT-4)7.4
Liver12.35
Lung416.9
Lymphnode29.2
Lymphoma_burkitts(Daudi)12.45
Lymphoma_burkitts(Raji)14.55
MedullaOblongata89
OccipitalLobe183.4
OlfactoryBulb445.45
Ovary9.65
Pancreas10.85
PancreaticIslet12.85
ParietalLobe180.9
Pituitary25.7
Placenta3395.05
Pons89.55
PrefrontalCortex767.65
Prostate523.55
Salivarygland44.5
SkeletalMuscle479.1
Skin17.65
SmoothMuscle44.05
Spinalcord1683.1
SubthalamicNucleus119.25
SuperiorCervicalGanglion56.3
TemporalLobe135.35
Testis29.95
TestisGermCell61.1
TestisIntersitial12.3
TestisLeydigCell13.5
TestisSeminiferousTubule15.3
Thalamus344.2
Thymus139.6
Thyroid146.9
Tongue403.6
Tonsil139.1
Trachea87.4
TrigeminalGanglion21.75
Uterus369.55
UterusCorpus18.5
WholeBlood10.2
Wholebrain538.4
colon397.25
pineal_day2414.7
pineal_night2696.6
retina1655.525
small_intestine66.65
Allen Brain Atlas Top
Human Whole Brain Microarrayview in Allen Brain Atlas
  • Probe id     Donor id      
  • Probe name: A_23_P162579
  • Donor H0351.2001
  • Sex: Male     Age: 24 years     Race/Ethnicity: African American     Handedness: Left
  • Tissue Receipt Date: 7/29/2009     Serology: Pass      Tissue pH :6.72     Additional Medical Information :History of asthma
  • Postmortem Interval: 23 hours (estimated time of death to time that tissue is frozen)
  • Toxicology: Positive for atropine and caffeine, at levels usually not toxicologically significant
Tissue Expression(mean ± stddev) Expression Bar
Amygdala8.24 ± 0.59
Basal Forebrain8.96 ± 0.54
Basal Part of Pons8.24 ± 0.35
Cerebellar Cortex7.68 ± 0.45
Cerebellar Nuclei9.05 ± 0.57
Claustrum8.56 ± 0.37
Epithalamus9.86 ± 0.44
Frontal Lobe8.65 ± 0.58
Globus Pallidus10.39 ± 0.59
Hypothalamus8.86 ± 0.87
Insula7.95 ± 0.55
Limbic Lobe8.15 ± 0.93
Mesencephalon8.78 ± 0.65
Myelencephalon8.63 ± 0.58
Occipital Lobe8.44 ± 0.84
Parietal Lobe8.56 ± 0.58
Pontine Tegmentum8.5 ± 0.4
Striatum8.8 ± 0.64
Subthalamus8.06 ± 0.34
Temporal Lobe7.93 ± 0.53
Thalamus8.81 ± 0.37
White Matter9.93 ± 0.64
Mouse Brain ISH
Gene Symbol Brain Structure ID Brain Structure Name Express Desity/Level (Meatured by ISH) Express Bar
Hspb8CBCerebellum4.76
10.39
Hspb8CTXCerebral cortex3.88
3.91
Hspb8HIPHippocampal region6.8
7.53
Hspb8HPFHippocampal formation6.07
7.22
Hspb8HYHypothalamus8.6
10.49
Hspb8LSXLateral septal complex1.48
1.55
Hspb8MBMidbrain2.8
5.77
Hspb8MYMedulla4.8
12.58
Hspb8OLFOlfactory bulb3.42
4.14
Hspb8PPons8.42
18.51
Hspb8PALPallidum14.7
21.24
Hspb8RHPRetrohippocampal region4.69
7.04
Hspb8sAMYStriatum-like amygdalar nuclei13.52
17.99
Hspb8STRStriatum6.08
6.96
Hspb8STRdStriatum dorsal region4.95
5
Hspb8STRvStriatum ventral region8.35
9.66
Hspb8THThalamus5.92
7.51
Peptide Top
Peptide Name Peptide Lengh Peptide Start Peptide End Peptide Sequence Source
PAp00512534 11 87 97 TPPPFPGEPWK Peptide Atlas

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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