AutismKB 2.0

Annotation Detail for GCDH


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Basic Information Top
Gene Symbol:GCDH ( ACAD5,GCD )
Gene Full Name: glutaryl-CoA dehydrogenase
Band: 19p13.13
Quick LinksEntrez ID:2639; OMIM: 608801; Uniprot ID:GCDH_HUMAN; ENSEMBL ID: ENSG00000105607; HGNC ID: 4189
Relate to Another Database: SFARIGene; denovo-db
Unigene EST Top
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
embryoid body0 / 707610 
blastocyst3 / 6231948
fetus19 / 56401233
neonate1 / 3109732
infant2 / 2362084
juvenile6 / 55556107
adult79 / 193912140
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adrenal tumor0 / 127940 
bladder carcinoma0 / 174750 
breast (mammary gland) tumor1 / 9417810
cervical tumor1 / 3436629
chondrosarcoma4 / 8282348
colorectal tumor3 / 11424626
esophageal tumor1 / 1729057
gastrointestinal tumor5 / 11936941
germ cell tumor10 / 26384537
glioma4 / 10688337
head and neck tumor0 / 1363020 
kidney tumor7 / 68959101
leukemia11 / 95842114
liver tumor6 / 9635962
lung tumor9 / 10312787
lymphoma9 / 71755125
non-neoplasia7 / 9725071
normal183 / 336030754
ovarian tumor3 / 7668239
pancreatic tumor0 / 1046160 
primitive neuroectodermal tumor of the CNS30 / 125680238
prostate cancer1 / 1026809
retinoblastoma2 / 4635643
skin tumor0 / 1249490 
soft tissue/muscle tissue tumor1 / 1251917
uterine tumor1 / 9025711
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adipose tissue0 / 131060 
adrenal gland0 / 331970 
ascites5 / 40015124
bladder0 / 297570 
blood12 / 12347897
bone3 / 7165541
bone marrow4 / 4880181
brain61 / 110098955
cervix3 / 4817162
connective tissue3 / 14925520
ear0 / 162120 
embryonic tissue7 / 21572232
esophagus1 / 2020949
eye5 / 21105423
heart7 / 8962678
intestine11 / 23447246
kidney18 / 21177784
larynx0 / 241450 
liver12 / 20774357
lung21 / 33697462
lymph5 / 44270112
lymph node4 / 9161043
mammary gland2 / 15327113
mouth1 / 6705214
muscle1 / 1077159
nerve0 / 157680 
ovary8 / 10205178
pancreas0 / 2148120 
parathyroid0 / 205390 
pharynx0 / 413280 
pituitary gland0 / 165850 
placenta16 / 28082556
prostate8 / 18934542
salivary gland0 / 201550 
skin4 / 21057418
spleen5 / 5395292
stomach8 / 9661982
testis5 / 33044215
thymus6 / 8113173
thyroid0 / 474730 
tonsil2 / 16999117
trachea0 / 524130 
umbilical cord0 / 136800 
uterus4 / 23287817
vascular1 / 5178019
Microarray in BioGPS Top
Select probe  
  • Microarray Platform: GeneAtlas U133A, gcrma
  • Affymatrix Probe ID: 208369_s_at
Cell line Expression level Expression bar
721_B_lymphoblasts50.6
Adipocyte6.25
AdrenalCortex6.25
Adrenalgland7.2
Amygdala5.2
Appendix5.6
AtrioventricularNode4.4
BDCA4+_DentriticCells17.85
Bonemarrow5.45
BronchialEpithelialCells4.75
CD105+_Endothelial21.35
CD14+_Monocytes8
CD19+_BCells(neg._sel.)13.1
CD33+_Myeloid7.05
CD34+51.15
CD4+_Tcells11.85
CD56+_NKCells14.45
CD71+_EarlyErythroid39.45
CD8+_Tcells12.55
CardiacMyocytes6.95
Caudatenucleus5
Cerebellum6.1
CerebellumPeduncles6.25
CiliaryGanglion4.2
CingulateCortex5.35
Colorectaladenocarcinoma5.45
DorsalRootGanglion4
FetalThyroid5.9
Fetalbrain4.85
Fetalliver12.35
Fetallung4.85
GlobusPallidus4.35
Heart33.9
Hypothalamus6.05
Kidney15.35
Leukemia_chronicMyelogenousK-5625.75
Leukemia_promyelocytic-HL-605
Leukemialymphoblastic(MOLT-4)8.4
Liver186.6
Lung6.05
Lymphnode4.9
Lymphoma_burkitts(Daudi)14.45
Lymphoma_burkitts(Raji)7.25
MedullaOblongata6.9
OccipitalLobe4.55
OlfactoryBulb4.5
Ovary3.45
Pancreas4.05
PancreaticIslet6.4
ParietalLobe7.05
Pituitary6.4
Placenta4.65
Pons5.3
PrefrontalCortex6.7
Prostate6.25
Salivarygland4.05
SkeletalMuscle6.6
Skin4.5
SmoothMuscle5.6
Spinalcord6.5
SubthalamicNucleus7.05
SuperiorCervicalGanglion6.4
TemporalLobe5.05
Testis4.45
TestisGermCell3.95
TestisIntersitial4
TestisLeydigCell5.2
TestisSeminiferousTubule4.4
Thalamus5.7
Thymus12.85
Thyroid7.9
Tongue5.4
Tonsil5.45
Trachea4.5
TrigeminalGanglion4.95
Uterus4.25
UterusCorpus4.9
WholeBlood5.45
Wholebrain5.2
colon5
pineal_day7.88
pineal_night6.58
retina6.2
small_intestine4.7
Allen Brain Atlas Top
Human Whole Brain Microarrayview in Allen Brain Atlas
  • Probe id     Donor id      
  • Probe name: CUST_9177_PI416261804
  • Donor H0351.2001
  • Sex: Male     Age: 24 years     Race/Ethnicity: African American     Handedness: Left
  • Tissue Receipt Date: 7/29/2009     Serology: Pass      Tissue pH :6.72     Additional Medical Information :History of asthma
  • Postmortem Interval: 23 hours (estimated time of death to time that tissue is frozen)
  • Toxicology: Positive for atropine and caffeine, at levels usually not toxicologically significant
Tissue Expression(mean ± stddev) Expression Bar
Amygdala4.31 ± 0.42
Basal Forebrain4.58 ± 0.28
Basal Part of Pons4.32 ± 0.42
Cerebellar Cortex4.41 ± 0.65
Cerebellar Nuclei4.21 ± 0.5
Claustrum3.68 ± 0.76
Epithalamus4.52 ± 0.7
Frontal Lobe4.52 ± 0.53
Globus Pallidus4.84 ± 0.27
Hypothalamus4.47 ± 0.57
Insula4.48 ± 0.44
Limbic Lobe4.22 ± 0.62
Mesencephalon4.56 ± 0.6
Myelencephalon4.45 ± 0.53
Occipital Lobe4.26 ± 0.44
Parietal Lobe4.35 ± 0.55
Pontine Tegmentum4.38 ± 0.5
Striatum4.65 ± 0.42
Subthalamus4.37 ± 0.02
Temporal Lobe4.43 ± 0.49
Thalamus4.67 ± 0.43
White Matter4.72 ± 0.28
Mouse Brain ISH
Gene Symbol Brain Structure ID Brain Structure Name Express Desity/Level (Meatured by ISH) Express Bar
GcdhCBCerebellum10.18
10.45
GcdhCTXCerebral cortex15.19
10.16
GcdhHIPHippocampal region12.92
13.61
GcdhHPFHippocampal formation11.86
10.64
GcdhHYHypothalamus4.57
3.42
GcdhLSXLateral septal complex1.55
1.15
GcdhMBMidbrain8.84
7.3
GcdhMYMedulla11.84
11.38
GcdhOLFOlfactory bulb19.43
15.11
GcdhPPons7.31
6.85
GcdhPALPallidum8
6.17
GcdhRHPRetrohippocampal region10.3
6.99
GcdhsAMYStriatum-like amygdalar nuclei6.97
5
GcdhSTRStriatum7.13
4.79
GcdhSTRdStriatum dorsal region4.83
3.29
GcdhSTRvStriatum ventral region18.15
11.16
GcdhTHThalamus14.79
10.8
Peptide Top
Peptide Name Peptide Lengh Peptide Start Peptide End Peptide Sequence Source
GCDH_HUMAN_139 23 139 161 SAMSVQSSLVMHPIYAYGSEEQR PRIDE
GCDH_HUMAN_24 12 24 35 VSSAAQTEKGGR PRIDE
PAp00003203 17 112 128 GYGCAGVSSVAYGLLAR Peptide Atlas

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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