Annotation Detail for GCHFR
Basic Information Top
| Gene Symbol: | GCHFR ( GFRP,HsT16933,MGC138467,MGC138469,P35 ) |
|---|---|
| Gene Full Name: | GTP cyclohydrolase I feedback regulator |
| Band: | 15q15.1 |
| Quick Links | Entrez ID:2644; OMIM: 602437; Uniprot ID:GFRP_HUMAN; ENSEMBL ID: ENSG00000137880; HGNC ID: 4194 |
| Relate to Another Database: | SFARIGene; denovo-db |
- Unigene ID: Hs.631717
| Pool Name | Gene EST/Total EST in pool | Transcripts per million(TPM) | Bar based on TPM |
|---|---|---|---|
 | |||
| embryoid body | 1 / 70761 | 14 |  |
| blastocyst | 0 / 62319 | 0 | |
| fetus | 3 / 564012 | 5 |  |
| neonate | 0 / 31097 | 0 | |
| infant | 0 / 23620 | 0 | |
| juvenile | 0 / 55556 | 0 | |
| adult | 27 / 1939121 | 13 | |
| Pool Name | Gene EST/Total EST in pool | Transcripts per million(TPM) | Bar based on TPM |
|---|---|---|---|
| |||
| adrenal tumor | 0 / 12794 | 0 | |
| bladder carcinoma | 0 / 17475 | 0 | |
| breast (mammary gland) tumor | 1 / 94178 | 10 | |
| cervical tumor | 2 / 34366 | 58 |  |
| chondrosarcoma | 1 / 82823 | 12 | |
| colorectal tumor | 1 / 114246 | 8 | |
| esophageal tumor | 0 / 17290 | 0 | |
| gastrointestinal tumor | 0 / 119369 | 0 | |
| germ cell tumor | 5 / 263845 | 18 | |
| glioma | 0 / 106883 | 0 | |
| head and neck tumor | 0 / 136302 | 0 | |
| kidney tumor | 1 / 68959 | 14 | |
| leukemia | 0 / 95842 | 0 | |
| liver tumor | 3 / 96359 | 31 | |
| lung tumor | 0 / 103127 | 0 | |
| lymphoma | 4 / 71755 | 55 | |
| non-neoplasia | 1 / 97250 | 10 | |
| normal | 52 / 3360307 | 15 | |
| ovarian tumor | 1 / 76682 | 13 | |
| pancreatic tumor | 7 / 104616 | 66 | |
| primitive neuroectodermal tumor of the CNS | 2 / 125680 | 15 | |
| prostate cancer | 8 / 102680 | 77 | |
| retinoblastoma | 0 / 46356 | 0 | |
| skin tumor | 0 / 124949 | 0 | |
| soft tissue/muscle tissue tumor | 6 / 125191 | 47 | |
| uterine tumor | 0 / 90257 | 0 |
| Pool Name | Gene EST/Total EST in pool | Transcripts per million(TPM) | Bar based on TPM |
|---|---|---|---|
| |||
| adipose tissue | 0 / 13106 | 0 | |
| adrenal gland | 0 / 33197 | 0 | |
| ascites | 0 / 40015 | 0 | |
| bladder | 0 / 29757 | 0 | |
| blood | 1 / 123478 | 8 | |
| bone | 2 / 71655 | 27 | |
| bone marrow | 0 / 48801 | 0 | |
| brain | 7 / 1100989 | 6 | |
| cervix | 2 / 48171 | 41 | |
| connective tissue | 4 / 149255 | 26 | |
| ear | 0 / 16212 | 0 | |
| embryonic tissue | 2 / 215722 | 9 | |
| esophagus | 0 / 20209 | 0 | |
| eye | 4 / 211054 | 18 | |
| heart | 0 / 89626 | 0 | |
| intestine | 4 / 234472 | 17 | |
| kidney | 8 / 211777 | 37 | |
| larynx | 0 / 24145 | 0 | |
| liver | 7 / 207743 | 33 | |
| lung | 9 / 336974 | 26 | |
| lymph | 4 / 44270 | 90 | |
| lymph node | 3 / 91610 | 32 | |
| mammary gland | 1 / 153271 | 6 | |
| mouth | 0 / 67052 | 0 | |
| muscle | 1 / 107715 | 9 | |
| nerve | 0 / 15768 | 0 | |
| ovary | 1 / 102051 | 9 | |
| pancreas | 7 / 214812 | 32 | |
| parathyroid | 0 / 20539 | 0 | |
| pharynx | 0 / 41328 | 0 | |
| pituitary gland | 0 / 16585 | 0 | |
| placenta | 4 / 280825 | 14 | |
| prostate | 8 / 189345 | 42 | |
| salivary gland | 0 / 20155 | 0 | |
| skin | 0 / 210574 | 0 | |
| spleen | 2 / 53952 | 37 | |
| stomach | 0 / 96619 | 0 | |
| testis | 0 / 330442 | 0 | |
| thymus | 0 / 81131 | 0 | |
| thyroid | 0 / 47473 | 0 | |
| tonsil | 3 / 16999 | 176 | |
| trachea | 0 / 52413 | 0 | |
| umbilical cord | 0 / 13680 | 0 | |
| uterus | 1 / 232878 | 4 | |
| vascular | 0 / 51780 | 0 |
- Microarray Platform: GeneAtlas U133A, gcrma
- Affymatrix Probe ID: 204867_at
| Cell line | Expression level | Expression bar |
|---|---|---|
| ||
| 721_B_lymphoblasts | 55.35 | |
| Adipocyte | 18.2 | |
| AdrenalCortex | 6.35 | |
| Adrenalgland | 4.55 | |
| Amygdala | 5.3 | |
| Appendix | 5.25 | |
| AtrioventricularNode | 4 | |
| BDCA4+_DentriticCells | 14.8 | |
| Bonemarrow | 5.5 | |
| BronchialEpithelialCells | 5.15 | |
| CD105+_Endothelial | 8.5 | |
| CD14+_Monocytes | 11.4 | |
| CD19+_BCells(neg._sel.) | 9.6 | |
| CD33+_Myeloid | 16.6 | |
| CD34+ | 8.95 | |
| CD4+_Tcells | 11.8 | |
| CD56+_NKCells | 62.5 | |
| CD71+_EarlyErythroid | 5.2 | |
| CD8+_Tcells | 11.35 | |
| CardiacMyocytes | 6.3 | |
| Caudatenucleus | 4.6 | |
| Cerebellum | 5.75 | |
| CerebellumPeduncles | 6.35 | |
| CiliaryGanglion | 3.9 | |
| CingulateCortex | 5.35 | |
| Colorectaladenocarcinoma | 39.15 | |
| DorsalRootGanglion | 3.9 | |
| FetalThyroid | 6.2 | |
| Fetalbrain | 5.05 | |
| Fetalliver | 6.25 | |
| Fetallung | 4.8 | |
| GlobusPallidus | 3.75 | |
| Heart | 7.3 | |
| Hypothalamus | 5.75 | |
| Kidney | 62.4 | |
| Leukemia_chronicMyelogenousK-562 | 4.8 | |
| Leukemia_promyelocytic-HL-60 | 34.85 | |
| Leukemialymphoblastic(MOLT-4) | 6.8 | |
| Liver | 1027.95 |  |
| Lung | 668.8 |  |
| Lymphnode | 9.65 | |
| Lymphoma_burkitts(Daudi) | 44.35 | |
| Lymphoma_burkitts(Raji) | 87.1 | |
| MedullaOblongata | 4.9 | |
| OccipitalLobe | 4.45 | |
| OlfactoryBulb | 4.1 | |
| Ovary | 3.5 | |
| Pancreas | 4.45 | |
| PancreaticIslet | 5.55 | |
| ParietalLobe | 5.7 | |
| Pituitary | 6.1 | |
| Placenta | 5.3 | |
| Pons | 4.95 | |
| PrefrontalCortex | 6.45 | |
| Prostate | 35.65 | |
| Salivarygland | 4.25 | |
| SkeletalMuscle | 6 | |
| Skin | 3.9 | |
| SmoothMuscle | 5.95 | |
| Spinalcord | 5.5 | |
| SubthalamicNucleus | 4.75 | |
| SuperiorCervicalGanglion | 5.85 | |
| TemporalLobe | 4.8 | |
| Testis | 4.75 | |
| TestisGermCell | 4.45 | |
| TestisIntersitial | 4.45 | |
| TestisLeydigCell | 5.4 | |
| TestisSeminiferousTubule | 4.4 | |
| Thalamus | 5.25 | |
| Thymus | 36.75 | |
| Thyroid | 6.9 | |
| Tongue | 5.25 | |
| Tonsil | 5.25 | |
| Trachea | 4.5 | |
| TrigeminalGanglion | 5.4 | |
| Uterus | 4.2 | |
| UterusCorpus | 4.55 | |
| WholeBlood | 6.15 | |
| Wholebrain | 4.2 | |
| colon | 14.5 | |
| pineal_day | 6.44 | |
| pineal_night | 6.3 | |
| retina | 6.375 | |
| small_intestine | 55.8 | |
- Probe name: CUST_6922_PI416261804
- Donor H0351.2001
- Sex: Male Age: 24 years Race/Ethnicity: African American Handedness: Left
- Tissue Receipt Date: 7/29/2009 Serology: Pass Tissue pH :6.72 Additional Medical Information :History of asthma
- Postmortem Interval: 23 hours (estimated time of death to time that tissue is frozen)
- Toxicology: Positive for atropine and caffeine, at levels usually not toxicologically significant
| Tissue | Expression(mean ± stddev) | Expression Bar |
|---|---|---|
| Amygdala | 5.41 ± 0.82 | ![](../"images/bar_3.png"){kind=small}   |
| Basal Forebrain | 5.78 ± 0.34 | |
| Basal Part of Pons | 6.35 ± 0.35 | |
| Cerebellar Cortex | 6.18 ± 0.38 | |
| Cerebellar Nuclei | 5.96 ± 0.54 | |
| Claustrum | 5.09 ± 0.79 | |
| Epithalamus | 6.03 ± 0.47 | |
| Frontal Lobe | 5.52 ± 0.61 | |
| Globus Pallidus | 4.5 ± 0.43 | |
| Hypothalamus | 5.96 ± 0.54 | |
| Insula | 5.54 ± 0.52 | |
| Limbic Lobe | 5.37 ± 0.69 | |
| Mesencephalon | 5.16 ± 1.05 | |
| Myelencephalon | 5.46 ± 0.82 | |
| Occipital Lobe | 5.02 ± 0.62 | |
| Parietal Lobe | 5.62 ± 0.71 | |
| Pontine Tegmentum | 5.16 ± 0.6 | |
| Striatum | 4.36 ± 0.61 | |
| Subthalamus | 5.99 ± 0.89 | |
| Temporal Lobe | 5.41 ± 0.6 | |
| Thalamus | 5.31 ± 0.79 | |
| White Matter | 2.94 ± 1.45 | |
Mouse Brain ISH 
| Gene Symbol | Brain Structure ID | Brain Structure Name | Express Desity/Level (Meatured by ISH) | Express Bar |
|---|---|---|---|---|
| Gchfr | CB | Cerebellum | 3.31 | |
| 3.6 | | |||
| Gchfr | CTX | Cerebral cortex | 0.47 | |
| 0.68 | | |||
| Gchfr | HIP | Hippocampal region | 0.25 | |
| 0.31 | | |||
| Gchfr | HPF | Hippocampal formation | 0.23 | |
| 0.28 | | |||
| Gchfr | HY | Hypothalamus | 0.2 | |
| 0.26 | | |||
| Gchfr | LSX | Lateral septal complex | 0.32 | |
| 0.25 | | |||
| Gchfr | MB | Midbrain | 1.5 | |
| 2.89 | | |||
| Gchfr | MY | Medulla | 1.26 | |
| 1.5 | | |||
| Gchfr | OLF | Olfactory bulb | 0.35 | |
| 1.16 | | |||
| Gchfr | P | Pons | 2.7 | |
| 4.07 | | |||
| Gchfr | PAL | Pallidum | 0.28 | |
| 0.37 | | |||
| Gchfr | RHP | Retrohippocampal region | 0.2 | |
| 0.25 | | |||
| Gchfr | sAMY | Striatum-like amygdalar nuclei | 0.13 | |
| 0.3 | | |||
| Gchfr | STR | Striatum | 0.19 | |
| 0.22 | | |||
| Gchfr | STRd | Striatum dorsal region | 0.15 | |
| 0.18 | | |||
| Gchfr | STRv | Striatum ventral region | 0.29 | |
| 0.28 | | |||
| Gchfr | TH | Thalamus | 0.2 | |
| 0.36 | |
| Peptide Name | Peptide Lengh | Peptide Start | Peptide End | Peptide Sequence | Source |
|---|---|---|---|---|---|
| PAp00074626 | 25 | 12 | 36 | MEVGPTMVGDEQSDPELMQHLGASK | Peptide Atlas |