AutismKB 2.0

Annotation Detail for LHX6


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Basic Information Top
Gene Symbol:LHX6 ( LHX6.1,MGC119542,MGC119544,MGC119545 )
Gene Full Name: LIM homeobox 6
Band: 9q33.2
Quick LinksEntrez ID:26468; OMIM: 608215; Uniprot ID:LHX6_HUMAN; ENSEMBL ID: ENSG00000106852; HGNC ID: 21735
Relate to Another Database: SFARIGene; denovo-db
Unigene EST Top
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
embryoid body1 / 7076114
blastocyst1 / 6231916
fetus36 / 56401263
neonate0 / 310970 
infant0 / 236200 
juvenile0 / 555560 
adult14 / 19391217
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adrenal tumor0 / 127940 
bladder carcinoma1 / 1747557
breast (mammary gland) tumor0 / 941780 
cervical tumor0 / 343660 
chondrosarcoma2 / 8282324
colorectal tumor0 / 1142460 
esophageal tumor0 / 172900 
gastrointestinal tumor1 / 1193698
germ cell tumor3 / 26384511
glioma0 / 1068830 
head and neck tumor0 / 1363020 
kidney tumor0 / 689590 
leukemia0 / 958420 
liver tumor5 / 9635951
lung tumor1 / 1031279
lymphoma0 / 717550 
non-neoplasia0 / 972500 
normal68 / 336030720
ovarian tumor1 / 7668213
pancreatic tumor0 / 1046160 
primitive neuroectodermal tumor of the CNS0 / 1256800 
prostate cancer5 / 10268048
retinoblastoma1 / 4635621
skin tumor0 / 1249490 
soft tissue/muscle tissue tumor0 / 1251910 
uterine tumor1 / 9025711
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adipose tissue0 / 131060 
adrenal gland0 / 331970 
ascites1 / 4001524
bladder0 / 297570 
blood0 / 1234780 
bone1 / 7165513
bone marrow0 / 488010 
brain50 / 110098945
cervix0 / 481710 
connective tissue1 / 1492556
ear0 / 162120 
embryonic tissue2 / 2157229
esophagus0 / 202090 
eye1 / 2110544
heart4 / 8962644
intestine1 / 2344724
kidney1 / 2117774
larynx0 / 241450 
liver5 / 20774324
lung2 / 3369745
lymph0 / 442700 
lymph node0 / 916100 
mammary gland1 / 1532716
mouth0 / 670520 
muscle0 / 1077150 
nerve0 / 157680 
ovary1 / 1020519
pancreas0 / 2148120 
parathyroid0 / 205390 
pharynx0 / 413280 
pituitary gland0 / 165850 
placenta5 / 28082517
prostate6 / 18934531
salivary gland0 / 201550 
skin0 / 2105740 
spleen0 / 539520 
stomach0 / 966190 
testis3 / 3304429
thymus0 / 811310 
thyroid0 / 474730 
tonsil0 / 169990 
trachea0 / 524130 
umbilical cord0 / 136800 
uterus7 / 23287830
vascular0 / 517800 
Microarray in BioGPS Top
Select probe  
  • Microarray Platform: GeneAtlas U133A, gcrma
  • Affymatrix Probe ID: 219884_at
Cell line Expression level Expression bar
721_B_lymphoblasts5.35
Adipocyte4.5
AdrenalCortex5.3
Adrenalgland4
Amygdala5.75
Appendix5.25
AtrioventricularNode4
BDCA4+_DentriticCells4.7
Bonemarrow4.6
BronchialEpithelialCells4.4
CD105+_Endothelial4.5
CD14+_Monocytes4.8
CD19+_BCells(neg._sel.)4.75
CD33+_Myeloid5.65
CD34+5.65
CD4+_Tcells4.8
CD56+_NKCells5.35
CD71+_EarlyErythroid4.2
CD8+_Tcells4.25
CardiacMyocytes6.2
Caudatenucleus4.3
Cerebellum3.75
CerebellumPeduncles5.85
CiliaryGanglion3.55
CingulateCortex6.6
Colorectaladenocarcinoma5.25
DorsalRootGanglion3.9
FetalThyroid5.05
Fetalbrain117.95
Fetalliver3.95
Fetallung4.55
GlobusPallidus3.6
Heart6.25
Hypothalamus5.2
Kidney3.95
Leukemia_chronicMyelogenousK-5624.35
Leukemia_promyelocytic-HL-604.1
Leukemialymphoblastic(MOLT-4)3.7
Liver6.55
Lung5.05
Lymphnode4
Lymphoma_burkitts(Daudi)5.85
Lymphoma_burkitts(Raji)6.55
MedullaOblongata4.85
OccipitalLobe5.4
OlfactoryBulb3.6
Ovary3.9
Pancreas3.7
PancreaticIslet4.9
ParietalLobe5.4
Pituitary5.45
Placenta4.65
Pons4.75
PrefrontalCortex5.95
Prostate5.35
Salivarygland3.85
SkeletalMuscle5.55
Skin3.6
SmoothMuscle5.2
Spinalcord4.95
SubthalamicNucleus4.35
SuperiorCervicalGanglion7.3
TemporalLobe4.65
Testis4.05
TestisGermCell4.2
TestisIntersitial4.9
TestisLeydigCell4.9
TestisSeminiferousTubule4.1
Thalamus4.7
Thymus3.6
Thyroid5.65
Tongue4.8
Tonsil4.5
Trachea3.85
TrigeminalGanglion5.3
Uterus3.7
UterusCorpus4.55
WholeBlood5
Wholebrain17.5
colon4.55
pineal_day5.54
pineal_night5.42
retina5.625
small_intestine4.45
Allen Brain Atlas Top
Human Whole Brain Microarrayview in Allen Brain Atlas
  • Probe id     Donor id      
  • Probe name: A_23_P32177
  • Donor H0351.2001
  • Sex: Male     Age: 24 years     Race/Ethnicity: African American     Handedness: Left
  • Tissue Receipt Date: 7/29/2009     Serology: Pass      Tissue pH :6.72     Additional Medical Information :History of asthma
  • Postmortem Interval: 23 hours (estimated time of death to time that tissue is frozen)
  • Toxicology: Positive for atropine and caffeine, at levels usually not toxicologically significant
Tissue Expression(mean ± stddev) Expression Bar
Amygdala5.43 ± 0.49
Basal Forebrain5.64 ± 1.06
Basal Part of Pons4.14 ± 0.45
Cerebellar Cortex3.72 ± 0.42
Cerebellar Nuclei4.16 ± 0.58
Claustrum4.09 ± 1.23
Epithalamus4.34 ± 0.82
Frontal Lobe5.2 ± 0.7
Globus Pallidus4.14 ± 2.18
Hypothalamus4.33 ± 0.68
Insula5.37 ± 0.64
Limbic Lobe4.9 ± 0.85
Mesencephalon4.66 ± 0.87
Myelencephalon4.67 ± 0.81
Occipital Lobe3.49 ± 0.98
Parietal Lobe4.86 ± 0.68
Pontine Tegmentum4.87 ± 0.85
Striatum4.96 ± 0.9
Subthalamus4.42 ± 0.93
Temporal Lobe4.98 ± 0.64
Thalamus4.19 ± 0.75
White Matter2.37 ± 1.26
Mouse Brain ISH
Peptide Top

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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