AutismKB 2.0

Annotation Detail for INTS6


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Basic Information Top
Gene Symbol:INTS6 ( DBI-1,DDX26,DDX26A,DICE1,DKFZp434B105,HDB,INT6,Notchl2 )
Gene Full Name: integrator complex subunit 6
Band: 13q14.3
Quick LinksEntrez ID:26512; OMIM: 604331; Uniprot ID:INT6_HUMAN; ENSEMBL ID: ENSG00000102786; HGNC ID: 14879
Relate to Another Database: SFARIGene; denovo-db
Unigene EST Top
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
embryoid body3 / 7076142
blastocyst3 / 6231948
fetus30 / 56401253
neonate1 / 3109732
infant4 / 23620169
juvenile0 / 555560 
adult67 / 193912134
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adrenal tumor0 / 127940 
bladder carcinoma0 / 174750 
breast (mammary gland) tumor2 / 9417821
cervical tumor1 / 3436629
chondrosarcoma5 / 8282360
colorectal tumor3 / 11424626
esophageal tumor2 / 17290115
gastrointestinal tumor3 / 11936925
germ cell tumor8 / 26384530
glioma7 / 10688365
head and neck tumor9 / 13630266
kidney tumor2 / 6895929
leukemia9 / 9584293
liver tumor3 / 9635931
lung tumor3 / 10312729
lymphoma0 / 717550 
non-neoplasia3 / 9725030
normal154 / 336030745
ovarian tumor1 / 7668213
pancreatic tumor2 / 10461619
primitive neuroectodermal tumor of the CNS6 / 12568047
prostate cancer0 / 1026800 
retinoblastoma0 / 463560 
skin tumor1 / 1249498
soft tissue/muscle tissue tumor2 / 12519115
uterine tumor5 / 9025755
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adipose tissue2 / 13106152
adrenal gland1 / 3319730
ascites1 / 4001524
bladder0 / 297570 
blood9 / 12347872
bone4 / 7165555
bone marrow1 / 4880120
brain28 / 110098925
cervix2 / 4817141
connective tissue5 / 14925533
ear2 / 16212123
embryonic tissue6 / 21572227
esophagus2 / 2020998
eye12 / 21105456
heart6 / 8962666
intestine6 / 23447225
kidney7 / 21177733
larynx0 / 241450 
liver8 / 20774338
lung6 / 33697417
lymph0 / 442700 
lymph node10 / 91610109
mammary gland4 / 15327126
mouth5 / 6705274
muscle6 / 10771555
nerve1 / 1576863
ovary3 / 10205129
pancreas4 / 21481218
parathyroid0 / 205390 
pharynx0 / 413280 
pituitary gland0 / 165850 
placenta12 / 28082542
prostate3 / 18934515
salivary gland0 / 201550 
skin2 / 2105749
spleen1 / 5395218
stomach3 / 9661931
testis80 / 330442242
thymus5 / 8113161
thyroid4 / 4747384
tonsil0 / 169990 
trachea12 / 52413228
umbilical cord0 / 136800 
uterus12 / 23287851
vascular1 / 5178019
Microarray in BioGPS Top
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  • Microarray Platform: GeneAtlas U133A, gcrma
  • Affymatrix Probe ID: 218819_at
Cell line Expression level Expression bar
721_B_lymphoblasts11.95
Adipocyte4.6
AdrenalCortex4.85
Adrenalgland4
Amygdala5.05
Appendix5
AtrioventricularNode3.85
BDCA4+_DentriticCells26.65
Bonemarrow4.65
BronchialEpithelialCells8.05
CD105+_Endothelial21.9
CD14+_Monocytes6.55
CD19+_BCells(neg._sel.)9.15
CD33+_Myeloid9.35
CD34+15.5
CD4+_Tcells24.15
CD56+_NKCells29.65
CD71+_EarlyErythroid6.95
CD8+_Tcells22.85
CardiacMyocytes5.9
Caudatenucleus4.25
Cerebellum3.95
CerebellumPeduncles5.4
CiliaryGanglion3.45
CingulateCortex4.7
Colorectaladenocarcinoma4.7
DorsalRootGanglion3.6
FetalThyroid4.7
Fetalbrain4.75
Fetalliver4.05
Fetallung4.65
GlobusPallidus3.45
Heart5.8
Hypothalamus5.3
Kidney4
Leukemia_chronicMyelogenousK-5624.2
Leukemia_promyelocytic-HL-604.15
Leukemialymphoblastic(MOLT-4)5.8
Liver6.05
Lung5.15
Lymphnode5.05
Lymphoma_burkitts(Daudi)5.9
Lymphoma_burkitts(Raji)6.5
MedullaOblongata4.35
OccipitalLobe4.25
OlfactoryBulb3.8
Ovary3.15
Pancreas3.85
PancreaticIslet5
ParietalLobe5
Pituitary9.75
Placenta4.8
Pons4.5
PrefrontalCortex6.85
Prostate5.65
Salivarygland3.85
SkeletalMuscle5.3
Skin3.8
SmoothMuscle7.5
Spinalcord5.2
SubthalamicNucleus4.3
SuperiorCervicalGanglion5.3
TemporalLobe4.3
Testis8.75
TestisGermCell13.95
TestisIntersitial9
TestisLeydigCell8.85
TestisSeminiferousTubule26.6
Thalamus4.8
Thymus4.3
Thyroid6.15
Tongue4.6
Tonsil5.15
Trachea3.95
TrigeminalGanglion4.65
Uterus6.5
UterusCorpus4.2
WholeBlood18.15
Wholebrain4.15
colon4.8
pineal_day21.28
pineal_night19.92
retina6.15
small_intestine4.55
Allen Brain Atlas Top
Human Whole Brain Microarrayview in Allen Brain Atlas
  • Probe id     Donor id      
  • Probe name: A_24_P167614
  • Donor H0351.2001
  • Sex: Male     Age: 24 years     Race/Ethnicity: African American     Handedness: Left
  • Tissue Receipt Date: 7/29/2009     Serology: Pass      Tissue pH :6.72     Additional Medical Information :History of asthma
  • Postmortem Interval: 23 hours (estimated time of death to time that tissue is frozen)
  • Toxicology: Positive for atropine and caffeine, at levels usually not toxicologically significant
Tissue Expression(mean ± stddev) Expression Bar
Amygdala6.78 ± 0.28
Basal Forebrain6.52 ± 0.11
Basal Part of Pons6.44 ± 0.28
Cerebellar Cortex6.69 ± 0.47
Cerebellar Nuclei6.32 ± 0.21
Claustrum6.8 ± 0.35
Epithalamus6.64 ± 0.23
Frontal Lobe6.49 ± 0.31
Globus Pallidus6.51 ± 0.15
Hypothalamus6.34 ± 0.2
Insula6.43 ± 0.22
Limbic Lobe6.77 ± 0.39
Mesencephalon6.51 ± 0.4
Myelencephalon6.57 ± 0.31
Occipital Lobe7.11 ± 0.39
Parietal Lobe6.69 ± 0.28
Pontine Tegmentum6.63 ± 0.32
Striatum6.78 ± 0.24
Subthalamus6.44 ± 0.21
Temporal Lobe6.55 ± 0.29
Thalamus6.49 ± 0.25
White Matter6.99 ± 0.07
Mouse Brain ISH
Gene Symbol Brain Structure ID Brain Structure Name Express Desity/Level (Meatured by ISH) Express Bar
Ints6CBCerebellum35.96
38.26
Ints6CTXCerebral cortex16.89
11.15
Ints6HIPHippocampal region32.2
39.36
Ints6HPFHippocampal formation25.3
26.8
Ints6HYHypothalamus2.25
1.91
Ints6LSXLateral septal complex9.07
5.78
Ints6MBMidbrain5.41
5.03
Ints6MYMedulla14.1
13.42
Ints6OLFOlfactory bulb30.26
24.26
Ints6PPons6.94
7.06
Ints6PALPallidum3.36
2.61
Ints6RHPRetrohippocampal region13.69
9.88
Ints6sAMYStriatum-like amygdalar nuclei6.61
3.95
Ints6STRStriatum7.14
4.9
Ints6STRdStriatum dorsal region5.34
3.75
Ints6STRvStriatum ventral region11.82
7.69
Ints6THThalamus8.03
5.69
Peptide Top

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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