AutismKB 2.0

Annotation Detail for GREM1


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Basic Information Top
Gene Symbol:GREM1 ( CKTSF1B1,DAND2,DRM,GREMLIN,IHG-2,MGC126660 )
Gene Full Name: gremlin 1
Band: 15q13.3
Quick LinksEntrez ID:26585; OMIM: 603054; Uniprot ID:GREM1_HUMAN; ENSEMBL ID: ENSG00000166923; HGNC ID: 2001
Relate to Another Database: SFARIGene; denovo-db
Unigene EST Top
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
embryoid body28 / 70761395
blastocyst6 / 6231996
fetus22 / 56401239
neonate11 / 31097353
infant0 / 236200 
juvenile5 / 5555689
adult132 / 193912168
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adrenal tumor0 / 127940 
bladder carcinoma2 / 17475114
breast (mammary gland) tumor2 / 9417821
cervical tumor0 / 343660 
chondrosarcoma29 / 82823350
colorectal tumor10 / 11424687
esophageal tumor1 / 1729057
gastrointestinal tumor28 / 119369234
germ cell tumor12 / 26384545
glioma2 / 10688318
head and neck tumor45 / 136302330
kidney tumor2 / 6895929
leukemia0 / 958420 
liver tumor3 / 9635931
lung tumor1 / 1031279
lymphoma0 / 717550 
non-neoplasia47 / 97250483
normal279 / 336030783
ovarian tumor0 / 766820 
pancreatic tumor4 / 10461638
primitive neuroectodermal tumor of the CNS5 / 12568039
prostate cancer0 / 1026800 
retinoblastoma0 / 463560 
skin tumor0 / 1249490 
soft tissue/muscle tissue tumor2 / 12519115
uterine tumor4 / 9025744
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adipose tissue0 / 131060 
adrenal gland0 / 331970 
ascites0 / 400150 
bladder0 / 297570 
blood0 / 1234780 
bone8 / 71655111
bone marrow42 / 48801860
brain46 / 110098941
cervix0 / 481710 
connective tissue68 / 149255455
ear0 / 162120 
embryonic tissue40 / 215722185
esophagus1 / 2020949
eye0 / 2110540 
heart1 / 8962611
intestine17 / 23447272
kidney3 / 21177714
larynx1 / 2414541
liver7 / 20774333
lung29 / 33697486
lymph0 / 442700 
lymph node0 / 916100 
mammary gland2 / 15327113
mouth44 / 67052656
muscle8 / 10771574
nerve0 / 157680 
ovary0 / 1020510 
pancreas5 / 21481223
parathyroid0 / 205390 
pharynx0 / 413280 
pituitary gland0 / 165850 
placenta0 / 2808250 
prostate0 / 1893450 
salivary gland0 / 201550 
skin97 / 210574460
spleen0 / 539520 
stomach34 / 96619351
testis5 / 33044215
thymus1 / 8113112
thyroid0 / 474730 
tonsil0 / 169990 
trachea5 / 5241395
umbilical cord0 / 136800 
uterus26 / 232878111
vascular20 / 51780386
Microarray in BioGPS Top
Select probe  
  • Microarray Platform: GeneAtlas U133A, gcrma
  • Affymatrix Probe ID: 218469_at
Cell line Expression level Expression bar
721_B_lymphoblasts6.9
Adipocyte54.35
AdrenalCortex8.05
Adrenalgland5.9
Amygdala14.15
Appendix47.5
AtrioventricularNode8.55
BDCA4+_DentriticCells5.95
Bonemarrow7.15
BronchialEpithelialCells5.95
CD105+_Endothelial6.3
CD14+_Monocytes7.1
CD19+_BCells(neg._sel.)6.55
CD33+_Myeloid7.55
CD34+7.35
CD4+_Tcells6.15
CD56+_NKCells7.1
CD71+_EarlyErythroid6.45
CD8+_Tcells5.6
CardiacMyocytes11.45
Caudatenucleus11.8
Cerebellum5.6
CerebellumPeduncles8.1
CiliaryGanglion7.6
CingulateCortex16.3
Colorectaladenocarcinoma6.5
DorsalRootGanglion5.65
FetalThyroid9.5
Fetalbrain16.55
Fetalliver5.9
Fetallung5.45
GlobusPallidus5.9
Heart10.9
Hypothalamus12.7
Kidney6
Leukemia_chronicMyelogenousK-5625.7
Leukemia_promyelocytic-HL-605.55
Leukemialymphoblastic(MOLT-4)4.7
Liver9.9
Lung7.45
Lymphnode46.5
Lymphoma_burkitts(Daudi)8.75
Lymphoma_burkitts(Raji)10.2
MedullaOblongata31.45
OccipitalLobe12.1
OlfactoryBulb5
Ovary5.55
Pancreas6.85
PancreaticIslet79.9
ParietalLobe8.2
Pituitary7.7
Placenta6.1
Pons7
PrefrontalCortex21.4
Prostate8.1
Salivarygland5.6
SkeletalMuscle12.2
Skin7.45
SmoothMuscle2623
Spinalcord7.15
SubthalamicNucleus7.05
SuperiorCervicalGanglion13.85
TemporalLobe7.1
Testis5.75
TestisGermCell5
TestisIntersitial5.8
TestisLeydigCell7.15
TestisSeminiferousTubule5.55
Thalamus8.45
Thymus4.55
Thyroid7.6
Tongue7.25
Tonsil6.75
Trachea5.7
TrigeminalGanglion10.25
Uterus34.35
UterusCorpus133.3
WholeBlood7
Wholebrain5.3
colon156.65
pineal_day7.74
pineal_night7.46
retina7.8
small_intestine155.45
Allen Brain Atlas Top
Human Whole Brain Microarrayview in Allen Brain Atlas
  • Probe id     Donor id      
  • Probe name: CUST_11492_PI416261804
  • Donor H0351.2001
  • Sex: Male     Age: 24 years     Race/Ethnicity: African American     Handedness: Left
  • Tissue Receipt Date: 7/29/2009     Serology: Pass      Tissue pH :6.72     Additional Medical Information :History of asthma
  • Postmortem Interval: 23 hours (estimated time of death to time that tissue is frozen)
  • Toxicology: Positive for atropine and caffeine, at levels usually not toxicologically significant
Tissue Expression(mean ± stddev) Expression Bar
Amygdala6.31 ± 0.69
Basal Forebrain6.16 ± 0.53
Basal Part of Pons6.28 ± 0.47
Cerebellar Cortex5.74 ± 0.74
Cerebellar Nuclei6.35 ± 0.41
Claustrum6.42 ± 0.51
Epithalamus5.34 ± 0.64
Frontal Lobe6.21 ± 0.79
Globus Pallidus6.65 ± 0.4
Hypothalamus5.74 ± 0.55
Insula6.16 ± 0.75
Limbic Lobe6.14 ± 0.77
Mesencephalon6.09 ± 0.49
Myelencephalon6.18 ± 0.72
Occipital Lobe6.02 ± 0.73
Parietal Lobe6.06 ± 0.61
Pontine Tegmentum5.98 ± 0.7
Striatum6.38 ± 0.65
Subthalamus5.66 ± 0.2
Temporal Lobe6.06 ± 0.82
Thalamus6.18 ± 0.55
White Matter6.97 ± 0.71
Mouse Brain ISH
Gene Symbol Brain Structure ID Brain Structure Name Express Desity/Level (Meatured by ISH) Express Bar
Grem1CBCerebellum62.35
89.92
Grem1CTXCerebral cortex84.91
68.05
Grem1HIPHippocampal region69.62
100
Grem1HPFHippocampal formation72.11
93.08
Grem1HYHypothalamus56.24
48.6
Grem1LSXLateral septal complex64.55
54.61
Grem1MBMidbrain56.64
52.55
Grem1MYMedulla54.36
57.43
Grem1OLFOlfactory bulb88.7
98.05
Grem1PPons50.94
53.82
Grem1PALPallidum52.36
55.45
Grem1RHPRetrohippocampal region80.16
65.36
Grem1sAMYStriatum-like amygdalar nuclei34.91
27.67
Grem1STRStriatum45.45
36.48
Grem1STRdStriatum dorsal region37.77
28.69
Grem1STRvStriatum ventral region63.7
52.4
Grem1THThalamus49.59
43.93
Peptide Top
Peptide Name Peptide Lengh Peptide Start Peptide End Peptide Sequence Source
GREM1_HUMAN_116 13 116 128 FCYGQCNSFYIPR PRIDE
GREM1_HUMAN_132 15 132 146 KEEGSFQSCSFCKPK PRIDE
GREM1_HUMAN_65 22 65 86 GTAMPGEEVLESSQEALHVTER PRIDE
GREM1_HUMAN_95 16 95 110 TQPLKQTIHEEGCNSR PRIDE

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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