AutismKB 2.0

Annotation Detail for GFRA1


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Basic Information Top
Gene Symbol:GFRA1 ( DKFZp313E1012,DKFZp686J0156,FLJ10561,FLJ31546,GDNFR,GDNFRA,GFR-ALPHA-1,MGC23045,RET1L,RETL1,TRNR1 )
Gene Full Name: GDNF family receptor alpha 1
Band: 10q25.3
Quick LinksEntrez ID:2674; OMIM: 601496; Uniprot ID:GFRA1_HUMAN; ENSEMBL ID: ENSG00000151892; HGNC ID: 4243
Relate to Another Database: SFARIGene; denovo-db
Unigene EST Top
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
embryoid body4 / 7076156
blastocyst0 / 623190 
fetus18 / 56401231
neonate0 / 310970 
infant0 / 236200 
juvenile2 / 5555635
adult73 / 193912137
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adrenal tumor0 / 127940 
bladder carcinoma0 / 174750 
breast (mammary gland) tumor20 / 94178212
cervical tumor0 / 343660 
chondrosarcoma4 / 8282348
colorectal tumor0 / 1142460 
esophageal tumor0 / 172900 
gastrointestinal tumor0 / 1193690 
germ cell tumor27 / 263845102
glioma2 / 10688318
head and neck tumor0 / 1363020 
kidney tumor7 / 68959101
leukemia3 / 9584231
liver tumor1 / 9635910
lung tumor0 / 1031270 
lymphoma0 / 717550 
non-neoplasia0 / 972500 
normal90 / 336030726
ovarian tumor0 / 766820 
pancreatic tumor0 / 1046160 
primitive neuroectodermal tumor of the CNS1 / 1256807
prostate cancer0 / 1026800 
retinoblastoma0 / 463560 
skin tumor0 / 1249490 
soft tissue/muscle tissue tumor1 / 1251917
uterine tumor0 / 902570 
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adipose tissue2 / 13106152
adrenal gland0 / 331970 
ascites0 / 400150 
bladder0 / 297570 
blood2 / 12347816
bone1 / 7165513
bone marrow1 / 4880120
brain20 / 110098918
cervix0 / 481710 
connective tissue7 / 14925546
ear2 / 16212123
embryonic tissue5 / 21572223
esophagus0 / 202090 
eye12 / 21105456
heart3 / 8962633
intestine1 / 2344724
kidney13 / 21177761
larynx0 / 241450 
liver3 / 20774314
lung0 / 3369740 
lymph0 / 442700 
lymph node0 / 916100 
mammary gland27 / 153271176
mouth0 / 670520 
muscle2 / 10771518
nerve0 / 157680 
ovary0 / 1020510 
pancreas0 / 2148120 
parathyroid4 / 20539194
pharynx1 / 4132824
pituitary gland0 / 165850 
placenta0 / 2808250 
prostate1 / 1893455
salivary gland0 / 201550 
skin4 / 21057418
spleen3 / 5395255
stomach0 / 966190 
testis25 / 33044275
thymus0 / 811310 
thyroid0 / 474730 
tonsil0 / 169990 
trachea2 / 5241338
umbilical cord0 / 136800 
uterus2 / 2328788
vascular0 / 517800 
Microarray in BioGPS Top
Select probe  
  • Microarray Platform: GeneAtlas U133A, gcrma
  • Affymatrix Probe ID: 205696_s_at
Cell line Expression level Expression bar
721_B_lymphoblasts8.05
Adipocyte7.6
AdrenalCortex9.95
Adrenalgland7.05
Amygdala7.6
Appendix10.2
AtrioventricularNode7.95
BDCA4+_DentriticCells7.45
Bonemarrow8.85
BronchialEpithelialCells7.25
CD105+_Endothelial7.65
CD14+_Monocytes8.2
CD19+_BCells(neg._sel.)8
CD33+_Myeloid9.1
CD34+9.3
CD4+_Tcells7.8
CD56+_NKCells9.2
CD71+_EarlyErythroid7.45
CD8+_Tcells6.85
CardiacMyocytes14.4
Caudatenucleus6.85
Cerebellum6.4
CerebellumPeduncles9.6
CiliaryGanglion7.4
CingulateCortex8.2
Colorectaladenocarcinoma7.55
DorsalRootGanglion7.15
FetalThyroid7.85
Fetalbrain7.2
Fetalliver6.95
Fetallung5.85
GlobusPallidus6.3
Heart13.8
Hypothalamus8.1
Kidney7.3
Leukemia_chronicMyelogenousK-5626.8
Leukemia_promyelocytic-HL-606.8
Leukemialymphoblastic(MOLT-4)5.9
Liver11.9
Lung8.45
Lymphnode6.2
Lymphoma_burkitts(Daudi)10.3
Lymphoma_burkitts(Raji)12.45
MedullaOblongata6.8
OccipitalLobe6.9
OlfactoryBulb5.95
Ovary5.95
Pancreas6.65
PancreaticIslet8.4
ParietalLobe8.75
Pituitary9
Placenta7.65
Pons7.6
PrefrontalCortex9.25
Prostate8.55
Salivarygland6.5
SkeletalMuscle12.75
Skin7.4
SmoothMuscle8.55
Spinalcord8.05
SubthalamicNucleus7.4
SuperiorCervicalGanglion12.6
TemporalLobe7.35
Testis6.5
TestisGermCell6.05
TestisIntersitial6.75
TestisLeydigCell8.05
TestisSeminiferousTubule6.6
Thalamus8.1
Thymus5.75
Thyroid9.2
Tongue9.05
Tonsil7.55
Trachea6.3
TrigeminalGanglion11.25
Uterus5.95
UterusCorpus8.05
WholeBlood8.15
Wholebrain6
colon7.55
pineal_day9.32
pineal_night9.06
retina9.35
small_intestine7.2
Allen Brain Atlas Top
Human Whole Brain Microarrayview in Allen Brain Atlas
  • Probe id     Donor id      
  • Probe name: A_32_P59549
  • Donor H0351.2001
  • Sex: Male     Age: 24 years     Race/Ethnicity: African American     Handedness: Left
  • Tissue Receipt Date: 7/29/2009     Serology: Pass      Tissue pH :6.72     Additional Medical Information :History of asthma
  • Postmortem Interval: 23 hours (estimated time of death to time that tissue is frozen)
  • Toxicology: Positive for atropine and caffeine, at levels usually not toxicologically significant
Tissue Expression(mean ± stddev) Expression Bar
Amygdala4.1 ± 0.74
Basal Forebrain4.44 ± 0.61
Basal Part of Pons3.67 ± 0.87
Cerebellar Cortex3.51 ± 0.65
Cerebellar Nuclei4.13 ± 0.43
Claustrum4.45 ± 0.95
Epithalamus3.84 ± 0.6
Frontal Lobe3.91 ± 0.76
Globus Pallidus4.91 ± 0.78
Hypothalamus4.33 ± 0.62
Insula4.2 ± 0.56
Limbic Lobe4.2 ± 0.92
Mesencephalon4.47 ± 0.97
Myelencephalon4.13 ± 0.81
Occipital Lobe4.5 ± 0.79
Parietal Lobe4.22 ± 0.76
Pontine Tegmentum4.27 ± 0.77
Striatum5.21 ± 0.51
Subthalamus4.04 ± 0.88
Temporal Lobe3.87 ± 0.85
Thalamus4.07 ± 0.76
White Matter4.65 ± 0.87
Mouse Brain ISH
Gene Symbol Brain Structure ID Brain Structure Name Express Desity/Level (Meatured by ISH) Express Bar
Gfra1CBCerebellum8.13
11.41
Gfra1CTXCerebral cortex15.79
16.94
Gfra1HIPHippocampal region35.85
65.05
Gfra1HPFHippocampal formation32.94
54.57
Gfra1HYHypothalamus37.71
43.43
Gfra1LSXLateral septal complex100
100
Gfra1MBMidbrain39.29
53.8
Gfra1MYMedulla25.7
37.51
Gfra1OLFOlfactory bulb7.83
7.22
Gfra1PPons36.52
52.35
Gfra1PALPallidum30.26
35.02
Gfra1RHPRetrohippocampal region28.23
40.76
Gfra1sAMYStriatum-like amygdalar nuclei29.71
31.96
Gfra1STRStriatum30.46
34.11
Gfra1STRdStriatum dorsal region7.05
7.26
Gfra1STRvStriatum ventral region64.51
62.37
Gfra1THThalamus25.56
38.1
Peptide Top

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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