AutismKB 2.0

Annotation Detail for GFRA2


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Basic Information Top
Gene Symbol:GFRA2 ( GDNFRB,NRTNR-ALPHA,NTNRA,RETL2,TRNR2 )
Gene Full Name: GDNF family receptor alpha 2
Band: 8p21.3
Quick LinksEntrez ID:2675; OMIM: 601956; Uniprot ID:GFRA2_HUMAN; ENSEMBL ID: ENSG00000168546; HGNC ID: 4244
Relate to Another Database: SFARIGene; denovo-db
Unigene EST Top
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
embryoid body0 / 707610 
blastocyst0 / 623190 
fetus12 / 56401221
neonate0 / 310970 
infant4 / 23620169
juvenile0 / 555560 
adult21 / 193912110
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adrenal tumor0 / 127940 
bladder carcinoma0 / 174750 
breast (mammary gland) tumor0 / 941780 
cervical tumor0 / 343660 
chondrosarcoma1 / 8282312
colorectal tumor0 / 1142460 
esophageal tumor0 / 172900 
gastrointestinal tumor0 / 1193690 
germ cell tumor0 / 2638450 
glioma2 / 10688318
head and neck tumor0 / 1363020 
kidney tumor0 / 689590 
leukemia0 / 958420 
liver tumor0 / 963590 
lung tumor0 / 1031270 
lymphoma0 / 717550 
non-neoplasia0 / 972500 
normal49 / 336030714
ovarian tumor2 / 7668226
pancreatic tumor0 / 1046160 
primitive neuroectodermal tumor of the CNS19 / 125680151
prostate cancer0 / 1026800 
retinoblastoma0 / 463560 
skin tumor0 / 1249490 
soft tissue/muscle tissue tumor1 / 1251917
uterine tumor0 / 902570 
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adipose tissue0 / 131060 
adrenal gland0 / 331970 
ascites0 / 400150 
bladder0 / 297570 
blood0 / 1234780 
bone2 / 7165527
bone marrow0 / 488010 
brain22 / 110098919
cervix0 / 481710 
connective tissue1 / 1492556
ear0 / 162120 
embryonic tissue1 / 2157224
esophagus0 / 202090 
eye12 / 21105456
heart2 / 8962622
intestine1 / 2344724
kidney1 / 2117774
larynx0 / 241450 
liver0 / 2077430 
lung0 / 3369740 
lymph0 / 442700 
lymph node0 / 916100 
mammary gland0 / 1532710 
mouth0 / 670520 
muscle1 / 1077159
nerve0 / 157680 
ovary1 / 1020519
pancreas0 / 2148120 
parathyroid0 / 205390 
pharynx0 / 413280 
pituitary gland0 / 165850 
placenta9 / 28082532
prostate1 / 1893455
salivary gland0 / 201550 
skin0 / 2105740 
spleen0 / 539520 
stomach0 / 966190 
testis2 / 3304426
thymus0 / 811310 
thyroid0 / 474730 
tonsil0 / 169990 
trachea0 / 524130 
umbilical cord0 / 136800 
uterus0 / 2328780 
vascular0 / 517800 
Microarray in BioGPS Top
Select probe  
  • Microarray Platform: GeneAtlas U133A, gcrma
  • Affymatrix Probe ID: 205722_s_at
Cell line Expression level Expression bar
721_B_lymphoblasts4.45
Adipocyte3.5
AdrenalCortex3.7
Adrenalgland3
Amygdala3.8
Appendix3.55
AtrioventricularNode2.7
BDCA4+_DentriticCells3.95
Bonemarrow3.5
BronchialEpithelialCells3.55
CD105+_Endothelial3.6
CD14+_Monocytes3.8
CD19+_BCells(neg._sel.)3.85
CD33+_Myeloid4.65
CD34+4.65
CD4+_Tcells3.9
CD56+_NKCells4.35
CD71+_EarlyErythroid3.35
CD8+_Tcells3.45
CardiacMyocytes4.6
Caudatenucleus3.2
Cerebellum2.9
CerebellumPeduncles4.05
CiliaryGanglion2.55
CingulateCortex4.3
Colorectaladenocarcinoma3.55
DorsalRootGanglion2.65
FetalThyroid3.45
Fetalbrain3.6
Fetalliver3.05
Fetallung3.05
GlobusPallidus3.15
Heart4.55
Hypothalamus3.95
Kidney2.9
Leukemia_chronicMyelogenousK-5623.25
Leukemia_promyelocytic-HL-603.15
Leukemialymphoblastic(MOLT-4)2.9
Liver4.65
Lung3.95
Lymphnode3.05
Lymphoma_burkitts(Daudi)4.55
Lymphoma_burkitts(Raji)4.95
MedullaOblongata3.55
OccipitalLobe3.25
OlfactoryBulb2.85
Ovary2.35
Pancreas2.85
PancreaticIslet3.8
ParietalLobe3.75
Pituitary4.1
Placenta3.7
Pons3.4
PrefrontalCortex4.5
Prostate4.2
Salivarygland2.85
SkeletalMuscle4.2
Skin2.7
SmoothMuscle4.05
Spinalcord3.8
SubthalamicNucleus3.35
SuperiorCervicalGanglion4
TemporalLobe3.3
Testis3.1
TestisGermCell3.05
TestisIntersitial3
TestisLeydigCell3.6
TestisSeminiferousTubule3.1
Thalamus3.65
Thymus2.8
Thyroid4.55
Tongue3.5
Tonsil3.45
Trachea3
TrigeminalGanglion3.5
Uterus2.95
UterusCorpus3.2
WholeBlood3.95
Wholebrain4.3
colon3.6
pineal_day4.48
pineal_night4.36
retina4.325
small_intestine3.45
Allen Brain Atlas Top
Human Whole Brain Microarrayview in Allen Brain Atlas
  • Probe id     Donor id      
  • Probe name: A_32_P162507
  • Donor H0351.2001
  • Sex: Male     Age: 24 years     Race/Ethnicity: African American     Handedness: Left
  • Tissue Receipt Date: 7/29/2009     Serology: Pass      Tissue pH :6.72     Additional Medical Information :History of asthma
  • Postmortem Interval: 23 hours (estimated time of death to time that tissue is frozen)
  • Toxicology: Positive for atropine and caffeine, at levels usually not toxicologically significant
Tissue Expression(mean ± stddev) Expression Bar
Amygdala6.66 ± 0.45
Basal Forebrain6.72 ± 0.3
Basal Part of Pons6.67 ± 0.37
Cerebellar Cortex6.6 ± 0.56
Cerebellar Nuclei6.75 ± 0.38
Claustrum6.4 ± 0.63
Epithalamus6.5 ± 0.61
Frontal Lobe6.89 ± 0.46
Globus Pallidus6.9 ± 0.67
Hypothalamus6.58 ± 0.37
Insula6.66 ± 0.66
Limbic Lobe6.82 ± 0.61
Mesencephalon6.74 ± 0.45
Myelencephalon6.79 ± 0.54
Occipital Lobe6.89 ± 0.6
Parietal Lobe6.72 ± 0.53
Pontine Tegmentum6.59 ± 0.63
Striatum6.55 ± 0.61
Subthalamus6.18 ± 0.38
Temporal Lobe6.66 ± 0.53
Thalamus6.67 ± 0.56
White Matter6.24 ± 0.63
Mouse Brain ISH
Gene Symbol Brain Structure ID Brain Structure Name Express Desity/Level (Meatured by ISH) Express Bar
Gfra2CBCerebellum33.83
59.6
Gfra2CTXCerebral cortex100
100
Gfra2HIPHippocampal region45.73
68.64
Gfra2HPFHippocampal formation56.91
68.81
Gfra2HYHypothalamus69.11
65.77
Gfra2LSXLateral septal complex93.39
93.19
Gfra2MBMidbrain56.19
55.73
Gfra2MYMedulla61.62
74.96
Gfra2OLFOlfactory bulb79.23
73.12
Gfra2PPons54.97
61.46
Gfra2PALPallidum55.08
53.32
Gfra2RHPRetrohippocampal region73.94
68.79
Gfra2sAMYStriatum-like amygdalar nuclei73.05
64.6
Gfra2STRStriatum53.67
43.03
Gfra2STRdStriatum dorsal region47.42
36.46
Gfra2STRvStriatum ventral region45.34
32.72
Gfra2THThalamus39.08
34.72
Peptide Top

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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