AutismKB 2.0

Annotation Detail for USP21


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Basic Information Top
Gene Symbol:USP21 ( MGC3394,USP16,USP23 )
Gene Full Name: ubiquitin specific peptidase 21
Band: 1q23.3
Quick LinksEntrez ID:27005; OMIM: 604729; Uniprot ID:UBP21_HUMAN; ENSEMBL ID: ENSG00000143258; HGNC ID: 12620
Relate to Another Database: SFARIGene; denovo-db
Unigene EST Top
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
embryoid body2 / 7076128
blastocyst2 / 6231932
fetus37 / 56401265
neonate3 / 3109796
infant2 / 2362084
juvenile1 / 5555617
adult110 / 193912156
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adrenal tumor0 / 127940 
bladder carcinoma0 / 174750 
breast (mammary gland) tumor6 / 9417863
cervical tumor3 / 3436687
chondrosarcoma5 / 8282360
colorectal tumor2 / 11424617
esophageal tumor0 / 172900 
gastrointestinal tumor11 / 11936992
germ cell tumor16 / 26384560
glioma6 / 10688356
head and neck tumor8 / 13630258
kidney tumor6 / 6895987
leukemia4 / 9584241
liver tumor3 / 9635931
lung tumor2 / 10312719
lymphoma3 / 7175541
non-neoplasia4 / 9725041
normal163 / 336030748
ovarian tumor6 / 7668278
pancreatic tumor5 / 10461647
primitive neuroectodermal tumor of the CNS9 / 12568071
prostate cancer0 / 1026800 
retinoblastoma0 / 463560 
skin tumor4 / 12494932
soft tissue/muscle tissue tumor6 / 12519147
uterine tumor6 / 9025766
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adipose tissue0 / 131060 
adrenal gland1 / 3319730
ascites10 / 40015249
bladder0 / 297570 
blood5 / 12347840
bone2 / 7165527
bone marrow0 / 488010 
brain61 / 110098955
cervix3 / 4817162
connective tissue5 / 14925533
ear0 / 162120 
embryonic tissue6 / 21572227
esophagus0 / 202090 
eye8 / 21105437
heart4 / 8962644
intestine4 / 23447217
kidney6 / 21177728
larynx1 / 2414541
liver5 / 20774324
lung15 / 33697444
lymph0 / 442700 
lymph node3 / 9161032
mammary gland11 / 15327171
mouth2 / 6705229
muscle3 / 10771527
nerve1 / 1576863
ovary6 / 10205158
pancreas6 / 21481227
parathyroid0 / 205390 
pharynx6 / 41328145
pituitary gland0 / 165850 
placenta20 / 28082571
prostate4 / 18934521
salivary gland0 / 201550 
skin9 / 21057442
spleen3 / 5395255
stomach1 / 9661910
testis28 / 33044284
thymus4 / 8113149
thyroid0 / 474730 
tonsil0 / 169990 
trachea2 / 5241338
umbilical cord0 / 136800 
uterus15 / 23287864
vascular1 / 5178019
Microarray in BioGPS Top
Select probe  
  • Microarray Platform: GeneAtlas U133A, gcrma
  • Affymatrix Probe ID: 218367_x_at
Cell line Expression level Expression bar
721_B_lymphoblasts54.25
Adipocyte30.1
AdrenalCortex29.85
Adrenalgland24.05
Amygdala38.35
Appendix30.35
AtrioventricularNode28.95
BDCA4+_DentriticCells44.1
Bonemarrow29.7
BronchialEpithelialCells25.6
CD105+_Endothelial50.95
CD14+_Monocytes43.35
CD19+_BCells(neg._sel.)53.05
CD33+_Myeloid56.4
CD34+117.3
CD4+_Tcells82.4
CD56+_NKCells51.25
CD71+_EarlyErythroid61.65
CD8+_Tcells65.8
CardiacMyocytes38.4
Caudatenucleus25.3
Cerebellum33.9
CerebellumPeduncles38.9
CiliaryGanglion20.95
CingulateCortex31
Colorectaladenocarcinoma32.75
DorsalRootGanglion22.3
FetalThyroid30.45
Fetalbrain37.65
Fetalliver26.15
Fetallung26
GlobusPallidus20.9
Heart51.15
Hypothalamus29.25
Kidney28.45
Leukemia_chronicMyelogenousK-56244.3
Leukemia_promyelocytic-HL-6026.3
Leukemialymphoblastic(MOLT-4)37.7
Liver39.7
Lung38.1
Lymphnode32.7
Lymphoma_burkitts(Daudi)33.6
Lymphoma_burkitts(Raji)67.15
MedullaOblongata41.05
OccipitalLobe27.95
OlfactoryBulb25.55
Ovary20.15
Pancreas21.9
PancreaticIslet31.55
ParietalLobe33.5
Pituitary34.6
Placenta36.7
Pons35
PrefrontalCortex61.15
Prostate40.9
Salivarygland23.7
SkeletalMuscle34.55
Skin23
SmoothMuscle33.5
Spinalcord31.65
SubthalamicNucleus24.2
SuperiorCervicalGanglion33.5
TemporalLobe26.75
Testis49.1
TestisGermCell41.9
TestisIntersitial30.55
TestisLeydigCell36.8
TestisSeminiferousTubule28
Thalamus28.25
Thymus42
Thyroid39.3
Tongue29.45
Tonsil33.45
Trachea23.7
TrigeminalGanglion30.3
Uterus38.25
UterusCorpus28.45
WholeBlood48.95
Wholebrain42.65
colon27.7
pineal_day52.88
pineal_night39.98
retina42.1
small_intestine27.5
Allen Brain Atlas Top
Human Whole Brain Microarrayview in Allen Brain Atlas
  • Probe id     Donor id      
  • Probe name: A_24_P139620
  • Donor H0351.2001
  • Sex: Male     Age: 24 years     Race/Ethnicity: African American     Handedness: Left
  • Tissue Receipt Date: 7/29/2009     Serology: Pass      Tissue pH :6.72     Additional Medical Information :History of asthma
  • Postmortem Interval: 23 hours (estimated time of death to time that tissue is frozen)
  • Toxicology: Positive for atropine and caffeine, at levels usually not toxicologically significant
Tissue Expression(mean ± stddev) Expression Bar
Amygdala5.21 ± 0.48
Basal Forebrain5.06 ± 0.38
Basal Part of Pons5.03 ± 0.27
Cerebellar Cortex4.98 ± 0.51
Cerebellar Nuclei4.95 ± 0.53
Claustrum5.45 ± 0.54
Epithalamus5.25 ± 0.55
Frontal Lobe4.97 ± 0.43
Globus Pallidus5.3 ± 0.5
Hypothalamus4.42 ± 0.64
Insula4.9 ± 0.4
Limbic Lobe5.24 ± 0.52
Mesencephalon4.99 ± 0.58
Myelencephalon5.04 ± 0.54
Occipital Lobe5.3 ± 0.66
Parietal Lobe5.17 ± 0.44
Pontine Tegmentum5.07 ± 0.51
Striatum5.02 ± 0.47
Subthalamus4.92 ± 0.69
Temporal Lobe5.03 ± 0.53
Thalamus5 ± 0.47
White Matter5.57 ± 0.76
Mouse Brain ISH
Gene Symbol Brain Structure ID Brain Structure Name Express Desity/Level (Meatured by ISH) Express Bar
Usp21CBCerebellum43.23
26.16
Usp21CTXCerebral cortex62.96
33.94
Usp21HIPHippocampal region61.72
43.23
Usp21HPFHippocampal formation64.68
41.9
Usp21HYHypothalamus32.01
20.5
Usp21LSXLateral septal complex36.47
19.55
Usp21MBMidbrain29.98
18.91
Usp21MYMedulla30.03
22.81
Usp21OLFOlfactory bulb87.28
52.05
Usp21PPons30.84
23.84
Usp21PALPallidum37.85
23.55
Usp21RHPRetrohippocampal region69.3
39.12
Usp21sAMYStriatum-like amygdalar nuclei41.85
22.31
Usp21STRStriatum41.17
21.35
Usp21STRdStriatum dorsal region38.62
19.37
Usp21STRvStriatum ventral region55.7
29.68
Usp21THThalamus26.61
16.29
Peptide Top

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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