Annotation Detail for TPK1
Basic Information Top
| Gene Symbol: | TPK1 ( HTPK1,PP20 ) |
|---|---|
| Gene Full Name: | thiamin pyrophosphokinase 1 |
| Band: | 7q35 |
| Quick Links | Entrez ID:27010; OMIM: 606370; Uniprot ID:TPK1_HUMAN; ENSEMBL ID: ENSG00000196511; HGNC ID: 17358 |
| Relate to Another Database: | SFARIGene; denovo-db |
- Unigene ID: Hs.660232
| Pool Name | Gene EST/Total EST in pool | Transcripts per million(TPM) | Bar based on TPM |
|---|---|---|---|
 | |||
| embryoid body | 0 / 70761 | 0 | |
| blastocyst | 0 / 62319 | 0 | |
| fetus | 7 / 564012 | 12 |  |
| neonate | 0 / 31097 | 0 | |
| infant | 0 / 23620 | 0 | |
| juvenile | 2 / 55556 | 35 | |
| adult | 14 / 1939121 | 7 |  |
| Pool Name | Gene EST/Total EST in pool | Transcripts per million(TPM) | Bar based on TPM |
|---|---|---|---|
| |||
| adrenal tumor | 0 / 12794 | 0 | |
| bladder carcinoma | 0 / 17475 | 0 | |
| breast (mammary gland) tumor | 0 / 94178 | 0 | |
| cervical tumor | 1 / 34366 | 29 | |
| chondrosarcoma | 1 / 82823 | 12 | |
| colorectal tumor | 0 / 114246 | 0 | |
| esophageal tumor | 0 / 17290 | 0 | |
| gastrointestinal tumor | 2 / 119369 | 16 | |
| germ cell tumor | 11 / 263845 | 41 | |
| glioma | 0 / 106883 | 0 | |
| head and neck tumor | 0 / 136302 | 0 | |
| kidney tumor | 1 / 68959 | 14 | |
| leukemia | 0 / 95842 | 0 | |
| liver tumor | 2 / 96359 | 20 | |
| lung tumor | 0 / 103127 | 0 | |
| lymphoma | 0 / 71755 | 0 | |
| non-neoplasia | 1 / 97250 | 10 | |
| normal | 32 / 3360307 | 9 | |
| ovarian tumor | 0 / 76682 | 0 | |
| pancreatic tumor | 3 / 104616 | 28 | |
| primitive neuroectodermal tumor of the CNS | 2 / 125680 | 15 | |
| prostate cancer | 0 / 102680 | 0 | |
| retinoblastoma | 0 / 46356 | 0 | |
| skin tumor | 1 / 124949 | 8 | |
| soft tissue/muscle tissue tumor | 1 / 125191 | 7 | |
| uterine tumor | 1 / 90257 | 11 | |
| Pool Name | Gene EST/Total EST in pool | Transcripts per million(TPM) | Bar based on TPM |
|---|---|---|---|
| |||
| adipose tissue | 0 / 13106 | 0 | |
| adrenal gland | 0 / 33197 | 0 | |
| ascites | 0 / 40015 | 0 | |
| bladder | 0 / 29757 | 0 | |
| blood | 0 / 123478 | 0 | |
| bone | 1 / 71655 | 13 | |
| bone marrow | 1 / 48801 | 20 | |
| brain | 4 / 1100989 | 3 | |
| cervix | 1 / 48171 | 20 | |
| connective tissue | 1 / 149255 | 6 | |
| ear | 0 / 16212 | 0 | |
| embryonic tissue | 0 / 215722 | 0 | |
| esophagus | 0 / 20209 | 0 | |
| eye | 0 / 211054 | 0 | |
| heart | 2 / 89626 | 22 | |
| intestine | 1 / 234472 | 4 | |
| kidney | 3 / 211777 | 14 | |
| larynx | 0 / 24145 | 0 | |
| liver | 2 / 207743 | 9 | |
| lung | 0 / 336974 | 0 | |
| lymph | 0 / 44270 | 0 | |
| lymph node | 0 / 91610 | 0 | |
| mammary gland | 0 / 153271 | 0 | |
| mouth | 0 / 67052 | 0 | |
| muscle | 0 / 107715 | 0 | |
| nerve | 0 / 15768 | 0 | |
| ovary | 0 / 102051 | 0 | |
| pancreas | 3 / 214812 | 13 | |
| parathyroid | 0 / 20539 | 0 | |
| pharynx | 0 / 41328 | 0 | |
| pituitary gland | 0 / 16585 | 0 | |
| placenta | 7 / 280825 | 24 | |
| prostate | 0 / 189345 | 0 | |
| salivary gland | 0 / 20155 | 0 | |
| skin | 1 / 210574 | 4 | |
| spleen | 0 / 53952 | 0 | |
| stomach | 2 / 96619 | 20 | |
| testis | 9 / 330442 | 27 | |
| thymus | 0 / 81131 | 0 | |
| thyroid | 0 / 47473 | 0 | |
| tonsil | 0 / 16999 | 0 | |
| trachea | 1 / 52413 | 19 | |
| umbilical cord | 0 / 13680 | 0 | |
| uterus | 2 / 232878 | 8 | |
| vascular | 1 / 51780 | 19 | |
- Microarray Platform: GeneAtlas U133A, gcrma
- Affymatrix Probe ID: 221218_s_at
| Cell line | Expression level | Expression bar |
|---|---|---|
| ||
| 721_B_lymphoblasts | 3.9 | |
| Adipocyte | 3.05 | |
| AdrenalCortex | 3.1 | |
| Adrenalgland | 2.55 | |
| Amygdala | 3.25 | |
| Appendix | 3 | |
| AtrioventricularNode | 2.25 | |
| BDCA4+_DentriticCells | 19.3 | |
| Bonemarrow | 3 | |
| BronchialEpithelialCells | 3.05 | |
| CD105+_Endothelial | 3.1 | |
| CD14+_Monocytes | 28.8 | |
| CD19+_BCells(neg._sel.) | 14.6 | |
| CD33+_Myeloid | 15.3 | |
| CD34+ | 4.1 | |
| CD4+_Tcells | 12.25 | |
| CD56+_NKCells | 18.15 | |
| CD71+_EarlyErythroid | 2.8 | |
| CD8+_Tcells | 12.45 | |
| CardiacMyocytes | 3.9 | |
| Caudatenucleus | 2.7 | |
| Cerebellum | 2.45 | |
| CerebellumPeduncles | 3.4 | |
| CiliaryGanglion | 2.1 | |
| CingulateCortex | 3.1 | |
| Colorectaladenocarcinoma | 3.05 | |
| DorsalRootGanglion | 2.25 | |
| FetalThyroid | 2.95 | |
| Fetalbrain | 3.05 | |
| Fetalliver | 2.6 | |
| Fetallung | 2.55 | |
| GlobusPallidus | 2.2 | |
| Heart | 3.85 | |
| Hypothalamus | 3.35 | |
| Kidney | 2.4 | |
| Leukemia_chronicMyelogenousK-562 | 2.75 | |
| Leukemia_promyelocytic-HL-60 | 2.7 | |
| Leukemialymphoblastic(MOLT-4) | 2.45 | |
| Liver | 3.95 | |
| Lung | 3.4 | |
| Lymphnode | 2.7 | |
| Lymphoma_burkitts(Daudi) | 3.85 | |
| Lymphoma_burkitts(Raji) | 4.2 | |
| MedullaOblongata | 2.8 | |
| OccipitalLobe | 2.75 | |
| OlfactoryBulb | 2.4 | |
| Ovary | 2 | |
| Pancreas | 2.4 | |
| PancreaticIslet | 3.25 | |
| ParietalLobe | 3.2 | |
| Pituitary | 3.6 | |
| Placenta | 3.25 | |
| Pons | 2.9 | |
| PrefrontalCortex | 3.9 | |
| Prostate | 3.6 | |
| Salivarygland | 2.4 | |
| SkeletalMuscle | 3.4 | |
| Skin | 2.3 | |
| SmoothMuscle | 3.45 | |
| Spinalcord | 3.25 | |
| SubthalamicNucleus | 2.75 | |
| SuperiorCervicalGanglion | 3.35 | |
| TemporalLobe | 2.75 | |
| Testis | 2.65 | |
| TestisGermCell | 2.6 | |
| TestisIntersitial | 2.55 | |
| TestisLeydigCell | 3 | |
| TestisSeminiferousTubule | 2.6 | |
| Thalamus | 3.1 | |
| Thymus | 2.45 | |
| Thyroid | 3.9 | |
| Tongue | 2.95 | |
| Tonsil | 2.95 | |
| Trachea | 2.55 | |
| TrigeminalGanglion | 2.95 | |
| Uterus | 2.55 | |
| UterusCorpus | 2.65 | |
| WholeBlood | 11.1 | |
| Wholebrain | 2.65 | |
| colon | 3.05 | |
| pineal_day | 6.36 | |
| pineal_night | 6.12 | |
| retina | 4.325 | |
| small_intestine | 3.05 | |
- Probe name: CUST_8331_PI416261804
- Donor H0351.2001
- Sex: Male Age: 24 years Race/Ethnicity: African American Handedness: Left
- Tissue Receipt Date: 7/29/2009 Serology: Pass Tissue pH :6.72 Additional Medical Information :History of asthma
- Postmortem Interval: 23 hours (estimated time of death to time that tissue is frozen)
- Toxicology: Positive for atropine and caffeine, at levels usually not toxicologically significant
| Tissue | Expression(mean ± stddev) | Expression Bar |
|---|---|---|
| Amygdala | 4.87 ± 0.56 | ![](../"images/bar_3.png"){kind=small}   |
| Basal Forebrain | 4.75 ± 0.64 | |
| Basal Part of Pons | 4.53 ± 0.61 | |
| Cerebellar Cortex | 4.38 ± 0.54 | |
| Cerebellar Nuclei | 4.5 ± 0.43 | |
| Claustrum | 4.41 ± 0.72 | |
| Epithalamus | 4.33 ± 0.53 | |
| Frontal Lobe | 4.82 ± 0.5 | |
| Globus Pallidus | 4.23 ± 0.49 | |
| Hypothalamus | 4.88 ± 0.48 | |
| Insula | 4.74 ± 0.34 | |
| Limbic Lobe | 4.56 ± 0.47 | |
| Mesencephalon | 4.83 ± 0.65 | |
| Myelencephalon | 4.61 ± 0.55 | |
| Occipital Lobe | 4.27 ± 0.62 | |
| Parietal Lobe | 4.89 ± 0.5 | |
| Pontine Tegmentum | 4.64 ± 0.67 | |
| Striatum | 4.29 ± 0.61 | |
| Subthalamus | 4.63 ± 0.42 | |
| Temporal Lobe | 4.7 ± 0.48 | |
| Thalamus | 4.6 ± 0.54 | |
| White Matter | 5.34 ± 0.55 | |
Mouse Brain ISH 
| Gene Symbol | Brain Structure ID | Brain Structure Name | Express Desity/Level (Meatured by ISH) | Express Bar |
|---|---|---|---|---|
| Tpk1 | CB | Cerebellum | 55.51 |  |
| 100 | | |||
| Tpk1 | CTX | Cerebral cortex | 93.49 | |
| 100 | | |||
| Tpk1 | HIP | Hippocampal region | 73.29 | |
| 100 | | |||
| Tpk1 | HPF | Hippocampal formation | 83.93 | |
| 100 | | |||
| Tpk1 | HY | Hypothalamus | 11.16 | |
| 11.66 | | |||
| Tpk1 | LSX | Lateral septal complex | 0.04 | |
| 0 | | |||
| Tpk1 | MB | Midbrain | 14.45 | |
| 17.5 | | |||
| Tpk1 | MY | Medulla | 25.03 | |
| 35.55 | | |||
| Tpk1 | OLF | Olfactory bulb | 70.7 | |
| 83.5 | | |||
| Tpk1 | P | Pons | 17.02 | |
| 23.2 | | |||
| Tpk1 | PAL | Pallidum | 35.17 | |
| 46.43 | | |||
| Tpk1 | RHP | Retrohippocampal region | 100 | |
| 100 | | |||
| Tpk1 | sAMY | Striatum-like amygdalar nuclei | 54.07 | |
| 50.78 | | |||
| Tpk1 | STR | Striatum | 48.49 | |
| 44.88 | | |||
| Tpk1 | STRd | Striatum dorsal region | 60.24 | |
| 56.63 | | |||
| Tpk1 | STRv | Striatum ventral region | 20.28 | |
| 17.57 | | |||
| Tpk1 | TH | Thalamus | 23.34 | |
| 27.17 | |
| Peptide Name | Peptide Lengh | Peptide Start | Peptide End | Peptide Sequence | Source |
|---|---|---|---|---|---|
| PAp00002692 | 17 | 87 | 103 | GCELISTPDQDHTDFTK | Peptide Atlas |