AutismKB 2.0

Annotation Detail for TRMT2A


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Basic Information Top
Gene Symbol:TRMT2A ( HTF9C,MGC102728 )
Gene Full Name: TRM2 tRNA methyltransferase 2 homolog A (S. cerevisiae)
Band: 22q11.21
Quick LinksEntrez ID:27037; OMIM: 611151; Uniprot ID:TRM2A_HUMAN; ENSEMBL ID: ENSG00000099899; HGNC ID: 24974
Relate to Another Database: SFARIGene; denovo-db
Unigene EST Top
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
embryoid body1 / 7076114
blastocyst3 / 6231948
fetus35 / 56401262
neonate2 / 3109764
infant0 / 236200 
juvenile11 / 55556197
adult139 / 193912171
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adrenal tumor0 / 127940 
bladder carcinoma0 / 174750 
breast (mammary gland) tumor7 / 9417874
cervical tumor2 / 3436658
chondrosarcoma11 / 82823132
colorectal tumor6 / 11424652
esophageal tumor1 / 1729057
gastrointestinal tumor7 / 11936958
germ cell tumor41 / 263845155
glioma22 / 106883205
head and neck tumor14 / 136302102
kidney tumor5 / 6895972
leukemia18 / 95842187
liver tumor5 / 9635951
lung tumor7 / 10312767
lymphoma10 / 71755139
non-neoplasia6 / 9725061
normal227 / 336030767
ovarian tumor11 / 76682143
pancreatic tumor3 / 10461628
primitive neuroectodermal tumor of the CNS63 / 125680501
prostate cancer2 / 10268019
retinoblastoma2 / 4635643
skin tumor8 / 12494964
soft tissue/muscle tissue tumor6 / 12519147
uterine tumor6 / 9025766
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adipose tissue1 / 1310676
adrenal gland8 / 33197240
ascites3 / 4001574
bladder0 / 297570 
blood23 / 123478186
bone4 / 7165555
bone marrow10 / 48801204
brain97 / 110098988
cervix10 / 48171207
connective tissue10 / 14925566
ear0 / 162120 
embryonic tissue6 / 21572227
esophagus2 / 2020998
eye12 / 21105456
heart4 / 8962644
intestine28 / 234472119
kidney11 / 21177751
larynx0 / 241450 
liver6 / 20774328
lung14 / 33697441
lymph0 / 442700 
lymph node8 / 9161087
mammary gland13 / 15327184
mouth13 / 67052193
muscle5 / 10771546
nerve1 / 1576863
ovary15 / 102051146
pancreas4 / 21481218
parathyroid0 / 205390 
pharynx0 / 413280 
pituitary gland1 / 1658560
placenta28 / 28082599
prostate6 / 18934531
salivary gland0 / 201550 
skin16 / 21057475
spleen13 / 53952240
stomach7 / 9661972
testis33 / 33044299
thymus14 / 81131172
thyroid2 / 4747342
tonsil2 / 16999117
trachea6 / 52413114
umbilical cord0 / 136800 
uterus11 / 23287847
vascular2 / 5178038
Microarray in BioGPS Top
Select probe  
  • Microarray Platform: GeneAtlas U133A, gcrma
  • Affymatrix Probe ID: 218475_at
Cell line Expression level Expression bar
721_B_lymphoblasts24
Adipocyte18.3
AdrenalCortex18.6
Adrenalgland18.55
Amygdala15.15
Appendix18.2
AtrioventricularNode13.5
BDCA4+_DentriticCells22.55
Bonemarrow17.9
BronchialEpithelialCells13.95
CD105+_Endothelial16.7
CD14+_Monocytes25.25
CD19+_BCells(neg._sel.)19.5
CD33+_Myeloid43.55
CD34+24.05
CD4+_Tcells26.1
CD56+_NKCells21.65
CD71+_EarlyErythroid17.2
CD8+_Tcells22.25
CardiacMyocytes22.4
Caudatenucleus16.6
Cerebellum16.5
CerebellumPeduncles30.9
CiliaryGanglion12.5
CingulateCortex20.8
Colorectaladenocarcinoma15.2
DorsalRootGanglion13.75
FetalThyroid18.9
Fetalbrain18.65
Fetalliver15.75
Fetallung15.25
GlobusPallidus13.25
Heart22.95
Hypothalamus20.35
Kidney14.65
Leukemia_chronicMyelogenousK-56224.45
Leukemia_promyelocytic-HL-6017.6
Leukemialymphoblastic(MOLT-4)19.55
Liver23.6
Lung20.7
Lymphnode21.1
Lymphoma_burkitts(Daudi)25.8
Lymphoma_burkitts(Raji)28.85
MedullaOblongata17.5
OccipitalLobe16.7
OlfactoryBulb15.25
Ovary11.95
Pancreas14.6
PancreaticIslet19.7
ParietalLobe21.3
Pituitary23.3
Placenta17.65
Pons19.1
PrefrontalCortex23.4
Prostate25.55
Salivarygland14.5
SkeletalMuscle20.3
Skin13.7
SmoothMuscle17.25
Spinalcord20.65
SubthalamicNucleus16.55
SuperiorCervicalGanglion20.25
TemporalLobe16.75
Testis20.1
TestisGermCell16.9
TestisIntersitial15.45
TestisLeydigCell22.25
TestisSeminiferousTubule16
Thalamus21.35
Thymus15.35
Thyroid26.55
Tongue20.55
Tonsil19.6
Trachea18.2
TrigeminalGanglion17.6
Uterus14.95
UterusCorpus16.5
WholeBlood21.25
Wholebrain13.9
colon18.5
pineal_day20.86
pineal_night20.32
retina22.35
small_intestine17.85
Allen Brain Atlas Top
Human Whole Brain Microarrayview in Allen Brain Atlas
  • Probe id     Donor id      
  • Probe name: A_24_P305662
  • Donor H0351.2001
  • Sex: Male     Age: 24 years     Race/Ethnicity: African American     Handedness: Left
  • Tissue Receipt Date: 7/29/2009     Serology: Pass      Tissue pH :6.72     Additional Medical Information :History of asthma
  • Postmortem Interval: 23 hours (estimated time of death to time that tissue is frozen)
  • Toxicology: Positive for atropine and caffeine, at levels usually not toxicologically significant
Tissue Expression(mean ± stddev) Expression Bar
Amygdala3.81 ± 0.72
Basal Forebrain3.68 ± 0.55
Basal Part of Pons4.54 ± 0.73
Cerebellar Cortex4.43 ± 0.51
Cerebellar Nuclei3.72 ± 0.58
Claustrum3.59 ± 0.86
Epithalamus4.24 ± 0.69
Frontal Lobe4.25 ± 0.58
Globus Pallidus3.55 ± 0.44
Hypothalamus3.91 ± 0.51
Insula4.25 ± 0.54
Limbic Lobe3.87 ± 0.68
Mesencephalon3.93 ± 0.6
Myelencephalon4.05 ± 0.62
Occipital Lobe3.61 ± 0.63
Parietal Lobe4.02 ± 0.59
Pontine Tegmentum3.92 ± 0.54
Striatum3.58 ± 0.47
Subthalamus3.68 ± 0.33
Temporal Lobe4.15 ± 0.53
Thalamus4.13 ± 0.56
White Matter3.96 ± 0.84
Mouse Brain ISH
Gene Symbol Brain Structure ID Brain Structure Name Express Desity/Level (Meatured by ISH) Express Bar
Htf9cCBCerebellum23.68
22.61
Htf9cCTXCerebral cortex45.01
28.45
Htf9cHIPHippocampal region47
56.01
Htf9cHPFHippocampal formation48.08
48.36
Htf9cHYHypothalamus39.83
26.58
Htf9cLSXLateral septal complex19.89
12.14
Htf9cMBMidbrain21.35
15.72
Htf9cMYMedulla26.08
23.82
Htf9cOLFOlfactory bulb57.2
42.25
Htf9cPPons26.49
23.25
Htf9cPALPallidum21.9
16.04
Htf9cRHPRetrohippocampal region51.18
37.92
Htf9csAMYStriatum-like amygdalar nuclei35.88
22.91
Htf9cSTRStriatum26.05
16.62
Htf9cSTRdStriatum dorsal region22.13
14.2
Htf9cSTRvStriatum ventral region34.09
20.84
Htf9cTHThalamus25.42
17.58
Peptide Top
Peptide Name Peptide Lengh Peptide Start Peptide End Peptide Sequence Source
PAp00068261 20 267 286 GGTCAVAAPFDTVHIPEATK Peptide Atlas

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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