AutismKB 2.0

Annotation Detail for LAT


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Basic Information Top
Gene Symbol:LAT ( LAT1,pp36 )
Gene Full Name: linker for activation of T cells
Band: 16q13
Quick LinksEntrez ID:27040; OMIM: 602354; Uniprot ID:LAT_HUMAN; ENSEMBL ID: ENSG00000213658; HGNC ID: 18874
Relate to Another Database: SFARIGene; denovo-db
Unigene EST Top
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
embryoid body0 / 707610 
blastocyst0 / 623190 
fetus11 / 56401219
neonate0 / 310970 
infant0 / 236200 
juvenile7 / 55556125
adult47 / 193912124
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adrenal tumor0 / 127940 
bladder carcinoma0 / 174750 
breast (mammary gland) tumor1 / 9417810
cervical tumor0 / 343660 
chondrosarcoma0 / 828230 
colorectal tumor8 / 11424670
esophageal tumor0 / 172900 
gastrointestinal tumor0 / 1193690 
germ cell tumor3 / 26384511
glioma0 / 1068830 
head and neck tumor4 / 13630229
kidney tumor0 / 689590 
leukemia13 / 95842135
liver tumor0 / 963590 
lung tumor0 / 1031270 
lymphoma0 / 717550 
non-neoplasia0 / 972500 
normal61 / 336030718
ovarian tumor1 / 7668213
pancreatic tumor3 / 10461628
primitive neuroectodermal tumor of the CNS0 / 1256800 
prostate cancer1 / 1026809
retinoblastoma0 / 463560 
skin tumor1 / 1249498
soft tissue/muscle tissue tumor0 / 1251910 
uterine tumor2 / 9025722
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adipose tissue0 / 131060 
adrenal gland0 / 331970 
ascites0 / 400150 
bladder0 / 297570 
blood25 / 123478202
bone1 / 7165513
bone marrow0 / 488010 
brain1 / 11009890 
cervix0 / 481710 
connective tissue0 / 1492550 
ear0 / 162120 
embryonic tissue0 / 2157220 
esophagus0 / 202090 
eye5 / 21105423
heart6 / 8962666
intestine10 / 23447242
kidney4 / 21177718
larynx1 / 2414541
liver3 / 20774314
lung4 / 33697411
lymph0 / 442700 
lymph node0 / 916100 
mammary gland1 / 1532716
mouth1 / 6705214
muscle1 / 1077159
nerve1 / 1576863
ovary1 / 1020519
pancreas3 / 21481213
parathyroid0 / 205390 
pharynx0 / 413280 
pituitary gland0 / 165850 
placenta0 / 2808250 
prostate1 / 1893455
salivary gland0 / 201550 
skin2 / 2105749
spleen2 / 5395237
stomach0 / 966190 
testis1 / 3304423
thymus23 / 81131283
thyroid2 / 4747342
tonsil1 / 1699958
trachea0 / 524130 
umbilical cord0 / 136800 
uterus3 / 23287812
vascular0 / 517800 
Microarray in BioGPS Top
Select probe  
  • Microarray Platform: GeneAtlas U133A, gcrma
  • Affymatrix Probe ID: 211005_at
Cell line Expression level Expression bar
721_B_lymphoblasts10.15
Adipocyte12.95
AdrenalCortex11.05
Adrenalgland9.15
Amygdala10.8
Appendix11.1
AtrioventricularNode7.75
BDCA4+_DentriticCells11.65
Bonemarrow14.35
BronchialEpithelialCells8.9
CD105+_Endothelial9.65
CD14+_Monocytes10.5
CD19+_BCells(neg._sel.)9.7
CD33+_Myeloid11.4
CD34+17.95
CD4+_Tcells1364.9
CD56+_NKCells364.45
CD71+_EarlyErythroid8.25
CD8+_Tcells1100.85
CardiacMyocytes14.9
Caudatenucleus9.25
Cerebellum9
CerebellumPeduncles15.35
CiliaryGanglion7.2
CingulateCortex10.4
Colorectaladenocarcinoma29.65
DorsalRootGanglion7.8
FetalThyroid9.95
Fetalbrain9.85
Fetalliver9.05
Fetallung7.9
GlobusPallidus7.5
Heart32.75
Hypothalamus10.6
Kidney9.3
Leukemia_chronicMyelogenousK-5629.2
Leukemia_promyelocytic-HL-608.85
Leukemialymphoblastic(MOLT-4)396.55
Liver16.6
Lung14.85
Lymphnode116.6
Lymphoma_burkitts(Daudi)13.25
Lymphoma_burkitts(Raji)14.9
MedullaOblongata9.5
OccipitalLobe8.85
OlfactoryBulb8
Ovary6.95
Pancreas8.4
PancreaticIslet10.8
ParietalLobe11.05
Pituitary12.05
Placenta8.65
Pons9.8
PrefrontalCortex11.15
Prostate12.1
Salivarygland9.85
SkeletalMuscle23.55
Skin7.8
SmoothMuscle11.15
Spinalcord11.35
SubthalamicNucleus9.45
SuperiorCervicalGanglion13.65
TemporalLobe9.35
Testis8.75
TestisGermCell8.2
TestisIntersitial8.4
TestisLeydigCell10.2
TestisSeminiferousTubule8.45
Thalamus10.45
Thymus399.45
Thyroid12.5
Tongue10.55
Tonsil21.7
Trachea8.4
TrigeminalGanglion10.5
Uterus8.5
UterusCorpus19.8
WholeBlood99.15
Wholebrain8.05
colon10.15
pineal_day12.4
pineal_night11.58
retina12.125
small_intestine10
Allen Brain Atlas Top
Human Whole Brain Microarrayview in Allen Brain Atlas
  • Probe id     Donor id      
  • Probe name: A_23_P60977
  • Donor H0351.2001
  • Sex: Male     Age: 24 years     Race/Ethnicity: African American     Handedness: Left
  • Tissue Receipt Date: 7/29/2009     Serology: Pass      Tissue pH :6.72     Additional Medical Information :History of asthma
  • Postmortem Interval: 23 hours (estimated time of death to time that tissue is frozen)
  • Toxicology: Positive for atropine and caffeine, at levels usually not toxicologically significant
Tissue Expression(mean ± stddev) Expression Bar
Amygdala2.9 ± 0.94
Basal Forebrain2.23 ± 0.42
Basal Part of Pons2.54 ± 0.69
Cerebellar Cortex3.07 ± 0.42
Cerebellar Nuclei2.83 ± 0.72
Claustrum3.25 ± 1.03
Epithalamus2.59 ± 0.55
Frontal Lobe2.62 ± 0.73
Globus Pallidus3.02 ± 0.73
Hypothalamus2.78 ± 0.99
Insula2.27 ± 0.65
Limbic Lobe2.73 ± 0.73
Mesencephalon2.79 ± 0.7
Myelencephalon2.72 ± 0.74
Occipital Lobe2.78 ± 0.65
Parietal Lobe2.76 ± 0.76
Pontine Tegmentum2.66 ± 0.7
Striatum2.56 ± 0.75
Subthalamus2.56 ± 0.44
Temporal Lobe2.59 ± 0.74
Thalamus2.76 ± 0.72
White Matter2.41 ± 0.45
Mouse Brain ISH
Gene Symbol Brain Structure ID Brain Structure Name Express Desity/Level (Meatured by ISH) Express Bar
LatCBCerebellum1.81
1.57
LatCTXCerebral cortex1.77
1.17
LatHIPHippocampal region3.42
2.09
LatHPFHippocampal formation2.92
1.8
LatHYHypothalamus1.66
1.14
LatLSXLateral septal complex0.48
0.42
LatMBMidbrain0.65
0.78
LatMYMedulla0.65
0.83
LatOLFOlfactory bulb5.73
3.39
LatPPons0.86
1.12
LatPALPallidum0.47
0.4
LatRHPRetrohippocampal region1.93
1.33
LatsAMYStriatum-like amygdalar nuclei6.15
3.97
LatSTRStriatum1.44
0.91
LatSTRdStriatum dorsal region0.88
0.52
LatSTRvStriatum ventral region1.05
0.62
LatTHThalamus1.54
1.01
Peptide Top
Peptide Name Peptide Lengh Peptide Start Peptide End Peptide Sequence Source
PAp00035938 16 32 47 LPGSYDSTSSDSLYPR Peptide Atlas

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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