Annotation Detail for EIF2AK1
Basic Information Top
| Gene Symbol: | EIF2AK1 ( HCR,HRI,KIAA1369 ) |
|---|---|
| Gene Full Name: | eukaryotic translation initiation factor 2-alpha kinase 1 |
| Band: | 7p22.1 |
| Quick Links | Entrez ID:27102; OMIM: NA; Uniprot ID:E2AK1_HUMAN; ENSEMBL ID: ENSG00000086232; HGNC ID: 24921 |
| Relate to Another Database: | SFARIGene; denovo-db |
Unigene EST- Microarray Platform: GeneAtlas U133A, gcrma
- Affymatrix Probe ID: 217735_s_at
| Cell line | Expression level | Expression bar |
|---|---|---|
 | ||
| 721_B_lymphoblasts | 6.65 |  |
| Adipocyte | 5.5 | |
| AdrenalCortex | 5.55 | |
| Adrenalgland | 4.65 | |
| Amygdala | 5.85 | |
| Appendix | 5.45 | |
| AtrioventricularNode | 4.05 | |
| BDCA4+_DentriticCells | 6.15 | |
| Bonemarrow | 5.45 | |
| BronchialEpithelialCells | 5.3 | |
| CD105+_Endothelial | 5.55 | |
| CD14+_Monocytes | 5.9 | |
| CD19+_BCells(neg._sel.) | 5.7 | |
| CD33+_Myeloid | 6.85 | |
| CD34+ | 6.95 | |
| CD4+_Tcells | 5.75 | |
| CD56+_NKCells | 6.4 | |
| CD71+_EarlyErythroid | 123.7 |  |
| CD8+_Tcells | 5.15 | |
| CardiacMyocytes | 6.85 | |
| Caudatenucleus | 4.95 | |
| Cerebellum | 4.5 | |
| CerebellumPeduncles | 6.25 | |
| CiliaryGanglion | 4.1 | |
| CingulateCortex | 5.6 | |
| Colorectaladenocarcinoma | 5.5 | |
| DorsalRootGanglion | 4.4 | |
| FetalThyroid | 5.25 | |
| Fetalbrain | 8.95 | |
| Fetalliver | 4.95 | |
| Fetallung | 4.55 | |
| GlobusPallidus | 3.95 | |
| Heart | 6.9 | |
| Hypothalamus | 6.2 | |
| Kidney | 4.45 | |
| Leukemia_chronicMyelogenousK-562 | 5.05 | |
| Leukemia_promyelocytic-HL-60 | 4.8 | |
| Leukemialymphoblastic(MOLT-4) | 4.35 | |
| Liver | 7.2 | |
| Lung | 6 | |
| Lymphnode | 4.7 | |
| Lymphoma_burkitts(Daudi) | 7.05 | |
| Lymphoma_burkitts(Raji) | 7.5 | |
| MedullaOblongata | 5.05 | |
| OccipitalLobe | 5.15 | |
| OlfactoryBulb | 4.3 | |
| Ovary | 3.6 | |
| Pancreas | 4.35 | |
| PancreaticIslet | 5.85 | |
| ParietalLobe | 5.85 | |
| Pituitary | 6.45 | |
| Placenta | 5.75 | |
| Pons | 5.25 | |
| PrefrontalCortex | 7 | |
| Prostate | 6.45 | |
| Salivarygland | 4.35 | |
| SkeletalMuscle | 6.25 | |
| Skin | 4.15 | |
| SmoothMuscle | 6.2 | |
| Spinalcord | 6.65 | |
| SubthalamicNucleus | 5.1 | |
| SuperiorCervicalGanglion | 6.1 | |
| TemporalLobe | 5.05 | |
| Testis | 4.7 | |
| TestisGermCell | 4.55 | |
| TestisIntersitial | 4.55 | |
| TestisLeydigCell | 5.4 | |
| TestisSeminiferousTubule | 4.65 | |
| Thalamus | 5.65 | |
| Thymus | 4.3 | |
| Thyroid | 6.85 | |
| Tongue | 5.2 | |
| Tonsil | 5.3 | |
| Trachea | 4.55 | |
| TrigeminalGanglion | 5.35 | |
| Uterus | 4.45 | |
| UterusCorpus | 4.9 | |
| WholeBlood | 6.45 | |
| Wholebrain | 6 | |
| colon | 5.5 | |
| pineal_day | 6.86 | |
| pineal_night | 6.78 | |
| retina | 6.6 | |
| small_intestine | 5.25 | |
- Probe name: A_23_P251173
- Donor H0351.2001
- Sex: Male Age: 24 years Race/Ethnicity: African American Handedness: Left
- Tissue Receipt Date: 7/29/2009 Serology: Pass Tissue pH :6.72 Additional Medical Information :History of asthma
- Postmortem Interval: 23 hours (estimated time of death to time that tissue is frozen)
- Toxicology: Positive for atropine and caffeine, at levels usually not toxicologically significant
| Tissue | Expression(mean ± stddev) | Expression Bar |
|---|---|---|
| Amygdala | 8.98 ± 0.32 | ![](../"images/bar_3.png"){kind=small}   |
| Basal Forebrain | 9.04 ± 0.12 | |
| Basal Part of Pons | 9.14 ± 0.21 | |
| Cerebellar Cortex | 8.69 ± 0.15 | |
| Cerebellar Nuclei | 9.27 ± 0.19 | |
| Claustrum | 9.37 ± 0.39 | |
| Epithalamus | 8.78 ± 0.15 | |
| Frontal Lobe | 8.93 ± 0.3 | |
| Globus Pallidus | 9.14 ± 0.19 | |
| Hypothalamus | 8.86 ± 0.28 | |
| Insula | 8.86 ± 0.21 | |
| Limbic Lobe | 8.9 ± 0.27 | |
| Mesencephalon | 9.08 ± 0.22 | |
| Myelencephalon | 8.97 ± 0.24 | |
| Occipital Lobe | 9.12 ± 0.25 | |
| Parietal Lobe | 9.02 ± 0.22 | |
| Pontine Tegmentum | 8.88 ± 0.27 | |
| Striatum | 9.02 ± 0.31 | |
| Subthalamus | 9.06 ± 0.24 | |
| Temporal Lobe | 8.87 ± 0.21 | |
| Thalamus | 9.08 ± 0.19 | |
| White Matter | 9.04 ± 0.2 | |
Mouse Brain ISH 
| Gene Symbol | Brain Structure ID | Brain Structure Name | Express Desity/Level (Meatured by ISH) | Express Bar |
|---|---|---|---|---|
| Eif2ak1 | CB | Cerebellum | 27.91 | |
| 41.98 | | |||
| Eif2ak1 | CTX | Cerebral cortex | 68.85 | |
| 59.54 | | |||
| Eif2ak1 | HIP | Hippocampal region | 44.04 | |
| 73.17 | | |||
| Eif2ak1 | HPF | Hippocampal formation | 50.64 | |
| 65.15 | | |||
| Eif2ak1 | HY | Hypothalamus | 25.34 | |
| 22.9 | | |||
| Eif2ak1 | LSX | Lateral septal complex | 18.18 | |
| 14.46 | | |||
| Eif2ak1 | MB | Midbrain | 34.96 | |
| 37.14 | | |||
| Eif2ak1 | MY | Medulla | 47.55 | |
| 61.97 | | |||
| Eif2ak1 | OLF | Olfactory bulb | 40.67 | |
| 35.57 | | |||
| Eif2ak1 | P | Pons | 34.85 | |
| 45.26 | | |||
| Eif2ak1 | PAL | Pallidum | 27.98 | |
| 29.08 | | |||
| Eif2ak1 | RHP | Retrohippocampal region | 62.28 | |
| 57.24 | | |||
| Eif2ak1 | sAMY | Striatum-like amygdalar nuclei | 30.15 | |
| 23.86 | | |||
| Eif2ak1 | STR | Striatum | 24.35 | |
| 18.59 | | |||
| Eif2ak1 | STRd | Striatum dorsal region | 25.41 | |
| 19.64 | | |||
| Eif2ak1 | STRv | Striatum ventral region | 22.13 | |
| 15.64 | | |||
| Eif2ak1 | TH | Thalamus | 36.67 | |
| 34.92 | |
| Peptide Name | Peptide Lengh | Peptide Start | Peptide End | Peptide Sequence | Source |
|---|---|---|---|---|---|
| E2AK1_HUMAN_1 | 9 | 1 | 9 | MQGGNSGVR | PRIDE |