AutismKB 2.0

Annotation Detail for PDE7B


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Basic Information Top
Gene Symbol:PDE7B ( MGC88256,bA472E5.1 )
Gene Full Name: phosphodiesterase 7B
Band: 6q23.3
Quick LinksEntrez ID:27115; OMIM: 604645; Uniprot ID:PDE7B_HUMAN; ENSEMBL ID: ENSG00000171408; HGNC ID: 8792
Relate to Another Database: SFARIGene; denovo-db
Unigene EST Top
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
embryoid body0 / 707610 
blastocyst0 / 623190 
fetus6 / 56401210
neonate0 / 310970 
infant0 / 236200 
juvenile0 / 555560 
adult18 / 19391219
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adrenal tumor0 / 127940 
bladder carcinoma0 / 174750 
breast (mammary gland) tumor0 / 941780 
cervical tumor0 / 343660 
chondrosarcoma3 / 8282336
colorectal tumor1 / 1142468
esophageal tumor0 / 172900 
gastrointestinal tumor0 / 1193690 
germ cell tumor5 / 26384518
glioma0 / 1068830 
head and neck tumor0 / 1363020 
kidney tumor0 / 689590 
leukemia0 / 958420 
liver tumor0 / 963590 
lung tumor1 / 1031279
lymphoma0 / 717550 
non-neoplasia0 / 972500 
normal32 / 33603079
ovarian tumor0 / 766820 
pancreatic tumor0 / 1046160 
primitive neuroectodermal tumor of the CNS0 / 1256800 
prostate cancer0 / 1026800 
retinoblastoma0 / 463560 
skin tumor0 / 1249490 
soft tissue/muscle tissue tumor2 / 12519115
uterine tumor2 / 9025722
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adipose tissue0 / 131060 
adrenal gland0 / 331970 
ascites0 / 400150 
bladder0 / 297570 
blood0 / 1234780 
bone0 / 716550 
bone marrow0 / 488010 
brain2 / 11009891
cervix1 / 4817120
connective tissue2 / 14925513
ear2 / 16212123
embryonic tissue0 / 2157220 
esophagus0 / 202090 
eye3 / 21105414
heart0 / 896260 
intestine2 / 2344728
kidney2 / 2117779
larynx0 / 241450 
liver0 / 2077430 
lung5 / 33697414
lymph0 / 442700 
lymph node0 / 916100 
mammary gland0 / 1532710 
mouth0 / 670520 
muscle5 / 10771546
nerve0 / 157680 
ovary0 / 1020510 
pancreas0 / 2148120 
parathyroid0 / 205390 
pharynx0 / 413280 
pituitary gland2 / 16585120
placenta2 / 2808257
prostate3 / 18934515
salivary gland0 / 201550 
skin0 / 2105740 
spleen0 / 539520 
stomach0 / 966190 
testis0 / 3304420 
thymus2 / 8113124
thyroid0 / 474730 
tonsil0 / 169990 
trachea0 / 524130 
umbilical cord0 / 136800 
uterus5 / 23287821
vascular1 / 5178019
Microarray in BioGPS Top
Select probe  
  • Microarray Platform: GeneAtlas U133A, gcrma
  • Affymatrix Probe ID: 220343_at
Cell line Expression level Expression bar
721_B_lymphoblasts11.1
Adipocyte10.45
AdrenalCortex11
Adrenalgland8.75
Amygdala11.2
Appendix10.75
AtrioventricularNode11.9
BDCA4+_DentriticCells10.15
Bonemarrow10.35
BronchialEpithelialCells10.4
CD105+_Endothelial10.55
CD14+_Monocytes10.7
CD19+_BCells(neg._sel.)11.25
CD33+_Myeloid13.4
CD34+12.05
CD4+_Tcells11.65
CD56+_NKCells10.85
CD71+_EarlyErythroid9.8
CD8+_Tcells10.2
CardiacMyocytes12.8
Caudatenucleus9.4
Cerebellum8.55
CerebellumPeduncles13
CiliaryGanglion9.9
CingulateCortex10.9
Colorectaladenocarcinoma9.85
DorsalRootGanglion8.75
FetalThyroid10.4
Fetalbrain10.45
Fetalliver12.45
Fetallung8
GlobusPallidus8
Heart13.45
Hypothalamus10.55
Kidney8.55
Leukemia_chronicMyelogenousK-5629.55
Leukemia_promyelocytic-HL-609.3
Leukemialymphoblastic(MOLT-4)8.5
Liver14.95
Lung10.4
Lymphnode8.9
Lymphoma_burkitts(Daudi)13.45
Lymphoma_burkitts(Raji)14.45
MedullaOblongata9.75
OccipitalLobe9.45
OlfactoryBulb8.3
Ovary6.9
Pancreas8.35
PancreaticIslet11.3
ParietalLobe11.2
Pituitary12.3
Placenta11
Pons11.55
PrefrontalCortex13.45
Prostate12.35
Salivarygland8.7
SkeletalMuscle12.25
Skin8.2
SmoothMuscle12
Spinalcord12.6
SubthalamicNucleus9.55
SuperiorCervicalGanglion12.3
TemporalLobe9.65
Testis9
TestisGermCell11.4
TestisIntersitial8.95
TestisLeydigCell10.45
TestisSeminiferousTubule9.1
Thalamus10.7
Thymus8.3
Thyroid12.5
Tongue10.5
Tonsil10.2
Trachea8.35
TrigeminalGanglion16
Uterus8.75
UterusCorpus11.7
WholeBlood10.5
Wholebrain8.9
colon10.6
pineal_day12.56
pineal_night12.54
retina12.725
small_intestine10.25
Allen Brain Atlas Top
Human Whole Brain Microarrayview in Allen Brain Atlas
  • Probe id     Donor id      
  • Probe name: A_23_P59338
  • Donor H0351.2001
  • Sex: Male     Age: 24 years     Race/Ethnicity: African American     Handedness: Left
  • Tissue Receipt Date: 7/29/2009     Serology: Pass      Tissue pH :6.72     Additional Medical Information :History of asthma
  • Postmortem Interval: 23 hours (estimated time of death to time that tissue is frozen)
  • Toxicology: Positive for atropine and caffeine, at levels usually not toxicologically significant
Tissue Expression(mean ± stddev) Expression Bar
Amygdala6.45 ± 0.7
Basal Forebrain7.16 ± 0.49
Basal Part of Pons5.34 ± 0.71
Cerebellar Cortex5.34 ± 0.49
Cerebellar Nuclei6.37 ± 0.17
Claustrum6.47 ± 0.52
Epithalamus5.52 ± 0.6
Frontal Lobe5.83 ± 0.65
Globus Pallidus6.78 ± 0.22
Hypothalamus6.51 ± 0.71
Insula6.12 ± 0.54
Limbic Lobe5.68 ± 0.71
Mesencephalon6.48 ± 0.76
Myelencephalon6.37 ± 0.77
Occipital Lobe6.71 ± 0.65
Parietal Lobe6.6 ± 0.59
Pontine Tegmentum6.7 ± 0.39
Striatum8.12 ± 0.71
Subthalamus6.12 ± 0.65
Temporal Lobe6.39 ± 0.56
Thalamus6.53 ± 0.44
White Matter4.94 ± 0.5
Mouse Brain ISH
Gene Symbol Brain Structure ID Brain Structure Name Express Desity/Level (Meatured by ISH) Express Bar
Pde7bCBCerebellum1.31
1.26
Pde7bCTXCerebral cortex8.45
6.87
Pde7bHIPHippocampal region3.61
3.2
Pde7bHPFHippocampal formation2.16
1.79
Pde7bHYHypothalamus2.09
2.16
Pde7bLSXLateral septal complex4.2
4.02
Pde7bMBMidbrain0.42
0.38
Pde7bMYMedulla0.91
0.92
Pde7bOLFOlfactory bulb1.21
1.41
Pde7bPPons0.23
0.23
Pde7bPALPallidum8.56
10.89
Pde7bRHPRetrohippocampal region0.19
0.18
Pde7bsAMYStriatum-like amygdalar nuclei9.68
9.54
Pde7bSTRStriatum50
50
Pde7bSTRdStriatum dorsal region50
50
Pde7bSTRvStriatum ventral region50
50
Pde7bTHThalamus15.08
15.63
Peptide Top

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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