AutismKB 2.0

Annotation Detail for TJP3


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Basic Information Top
Gene Symbol:TJP3 ( MGC119546,ZO-3,ZO3 )
Gene Full Name: tight junction protein 3 (zona occludens 3)
Band: 19p13.3
Quick LinksEntrez ID:27134; OMIM: 612689; Uniprot ID:ZO3_HUMAN; ENSEMBL ID: ENSG00000105289; HGNC ID: 11829
Relate to Another Database: SFARIGene; denovo-db
Unigene EST Top
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
embryoid body3 / 7076142
blastocyst2 / 6231932
fetus9 / 56401215
neonate0 / 310970 
infant0 / 236200 
juvenile1 / 5555617
adult49 / 193912125
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adrenal tumor0 / 127940 
bladder carcinoma1 / 1747557
breast (mammary gland) tumor3 / 9417831
cervical tumor0 / 343660 
chondrosarcoma2 / 8282324
colorectal tumor10 / 11424687
esophageal tumor1 / 1729057
gastrointestinal tumor4 / 11936933
germ cell tumor10 / 26384537
glioma0 / 1068830 
head and neck tumor8 / 13630258
kidney tumor0 / 689590 
leukemia0 / 958420 
liver tumor1 / 9635910
lung tumor1 / 1031279
lymphoma1 / 7175513
non-neoplasia1 / 9725010
normal47 / 336030713
ovarian tumor15 / 76682195
pancreatic tumor1 / 1046169
primitive neuroectodermal tumor of the CNS0 / 1256800 
prostate cancer2 / 10268019
retinoblastoma9 / 46356194
skin tumor0 / 1249490 
soft tissue/muscle tissue tumor0 / 1251910 
uterine tumor5 / 9025755
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adipose tissue0 / 131060 
adrenal gland0 / 331970 
ascites1 / 4001524
bladder3 / 29757100
blood0 / 1234780 
bone1 / 7165513
bone marrow0 / 488010 
brain2 / 11009891
cervix2 / 4817141
connective tissue1 / 1492556
ear0 / 162120 
embryonic tissue7 / 21572232
esophagus2 / 2020998
eye10 / 21105447
heart0 / 896260 
intestine17 / 23447272
kidney0 / 2117770 
larynx0 / 241450 
liver2 / 2077439
lung7 / 33697420
lymph1 / 4427022
lymph node0 / 916100 
mammary gland6 / 15327139
mouth8 / 67052119
muscle0 / 1077150 
nerve0 / 157680 
ovary19 / 102051186
pancreas2 / 2148129
parathyroid0 / 205390 
pharynx0 / 413280 
pituitary gland0 / 165850 
placenta8 / 28082528
prostate4 / 18934521
salivary gland0 / 201550 
skin0 / 2105740 
spleen1 / 5395218
stomach3 / 9661931
testis16 / 33044248
thymus0 / 811310 
thyroid2 / 4747342
tonsil0 / 169990 
trachea12 / 52413228
umbilical cord0 / 136800 
uterus5 / 23287821
vascular0 / 517800 
Microarray in BioGPS Top
Select probe  
  • Microarray Platform: GeneAtlas U133A, gcrma
  • Affymatrix Probe ID: 35148_at
Cell line Expression level Expression bar
721_B_lymphoblasts9.35
Adipocyte8.25
AdrenalCortex11.15
Adrenalgland7.55
Amygdala8.5
Appendix9.8
AtrioventricularNode8.3
BDCA4+_DentriticCells8.2
Bonemarrow9.15
BronchialEpithelialCells7.95
CD105+_Endothelial8.2
CD14+_Monocytes8.9
CD19+_BCells(neg._sel.)8.45
CD33+_Myeloid10.25
CD34+9.8
CD4+_Tcells8.9
CD56+_NKCells9.8
CD71+_EarlyErythroid8
CD8+_Tcells8.1
CardiacMyocytes13.9
Caudatenucleus7.6
Cerebellum7.1
CerebellumPeduncles10.45
CiliaryGanglion7.1
CingulateCortex8.9
Colorectaladenocarcinoma9.6
DorsalRootGanglion7.45
FetalThyroid8.9
Fetalbrain8.05
Fetalliver8
Fetallung8.35
GlobusPallidus6.75
Heart16.6
Hypothalamus8.85
Kidney9.65
Leukemia_chronicMyelogenousK-5627.6
Leukemia_promyelocytic-HL-607.45
Leukemialymphoblastic(MOLT-4)6.25
Liver13.9
Lung15
Lymphnode6.75
Lymphoma_burkitts(Daudi)11.15
Lymphoma_burkitts(Raji)13.6
MedullaOblongata7.55
OccipitalLobe7.3
OlfactoryBulb6.5
Ovary6.5
Pancreas7.15
PancreaticIslet9.25
ParietalLobe9.6
Pituitary10.25
Placenta8.65
Pons8.6
PrefrontalCortex10.15
Prostate9.85
Salivarygland10
SkeletalMuscle13.6
Skin7.7
SmoothMuscle9.55
Spinalcord9
SubthalamicNucleus8.15
SuperiorCervicalGanglion11.65
TemporalLobe9.25
Testis38.3
TestisGermCell39.4
TestisIntersitial29.4
TestisLeydigCell20.3
TestisSeminiferousTubule16.5
Thalamus8.85
Thymus6.2
Thyroid27.65
Tongue9.35
Tonsil8.55
Trachea8.95
TrigeminalGanglion10.15
Uterus6.65
UterusCorpus22.5
WholeBlood9.25
Wholebrain6.6
colon40.8
pineal_day13.46
pineal_night13.12
retina10.4
small_intestine10.45
Allen Brain Atlas Top
Human Whole Brain Microarrayview in Allen Brain Atlas
  • Probe id     Donor id      
  • Probe name: CUST_13687_PI416261804
  • Donor H0351.2001
  • Sex: Male     Age: 24 years     Race/Ethnicity: African American     Handedness: Left
  • Tissue Receipt Date: 7/29/2009     Serology: Pass      Tissue pH :6.72     Additional Medical Information :History of asthma
  • Postmortem Interval: 23 hours (estimated time of death to time that tissue is frozen)
  • Toxicology: Positive for atropine and caffeine, at levels usually not toxicologically significant
Tissue Expression(mean ± stddev) Expression Bar
Amygdala5.4 ± 0.77
Basal Forebrain4.76 ± 0.32
Basal Part of Pons4.74 ± 0.34
Cerebellar Cortex4.43 ± 0.53
Cerebellar Nuclei4.56 ± 0.54
Claustrum5.21 ± 0.65
Epithalamus3.86 ± 0.57
Frontal Lobe4.66 ± 0.57
Globus Pallidus5.06 ± 0.45
Hypothalamus4.48 ± 0.51
Insula4.47 ± 0.35
Limbic Lobe4.82 ± 0.62
Mesencephalon4.73 ± 0.52
Myelencephalon4.73 ± 0.63
Occipital Lobe4.82 ± 0.59
Parietal Lobe4.6 ± 0.66
Pontine Tegmentum4.62 ± 0.6
Striatum4.69 ± 0.72
Subthalamus4.41 ± 0.48
Temporal Lobe4.66 ± 0.65
Thalamus4.64 ± 0.52
White Matter4.46 ± 0.42
Mouse Brain ISH
Gene Symbol Brain Structure ID Brain Structure Name Express Desity/Level (Meatured by ISH) Express Bar
Tjp3CBCerebellum8.46
10.55
Tjp3CTXCerebral cortex4.8
4.28
Tjp3HIPHippocampal region2.47
2.82
Tjp3HPFHippocampal formation2.24
2.4
Tjp3HYHypothalamus6.03
4.55
Tjp3LSXLateral septal complex4.6
3.37
Tjp3MBMidbrain6.31
5.86
Tjp3MYMedulla18.47
18.46
Tjp3OLFOlfactory bulb8.85
6.86
Tjp3PPons10.52
10.78
Tjp3PALPallidum4.49
3.63
Tjp3RHPRetrohippocampal region1.72
1.66
Tjp3sAMYStriatum-like amygdalar nuclei1.05
1.78
Tjp3STRStriatum2.68
2.36
Tjp3STRdStriatum dorsal region1.33
1.34
Tjp3STRvStriatum ventral region6.18
4.38
Tjp3THThalamus5.2
4.57
Peptide Top
Peptide Name Peptide Lengh Peptide Start Peptide End Peptide Sequence Source
ZO3_HUMAN_738 9 738 746 LYAQAQKLR PRIDE

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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