AutismKB 2.0

Annotation Detail for GLS2


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Basic Information Top
Gene Symbol:GLS2 ( GA,GLS,LGA,MGC71567,hLGA )
Gene Full Name: glutaminase 2 (liver, mitochondrial)
Band: 12q13.3
Quick LinksEntrez ID:27165; OMIM: 606365; Uniprot ID:GLSL_HUMAN; ENSEMBL ID: ENSG00000135423; HGNC ID: 29570
Relate to Another Database: SFARIGene; denovo-db
Unigene EST Top
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
embryoid body1 / 7076114
blastocyst0 / 623190 
fetus17 / 56401230
neonate0 / 310970 
infant2 / 2362084
juvenile1 / 5555617
adult25 / 193912112
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adrenal tumor0 / 127940 
bladder carcinoma0 / 174750 
breast (mammary gland) tumor0 / 941780 
cervical tumor0 / 343660 
chondrosarcoma0 / 828230 
colorectal tumor0 / 1142460 
esophageal tumor0 / 172900 
gastrointestinal tumor2 / 11936916
germ cell tumor0 / 2638450 
glioma0 / 1068830 
head and neck tumor0 / 1363020 
kidney tumor3 / 6895943
leukemia1 / 9584210
liver tumor5 / 9635951
lung tumor0 / 1031270 
lymphoma4 / 7175555
non-neoplasia2 / 9725020
normal97 / 336030728
ovarian tumor0 / 766820 
pancreatic tumor0 / 1046160 
primitive neuroectodermal tumor of the CNS0 / 1256800 
prostate cancer1 / 1026809
retinoblastoma0 / 463560 
skin tumor0 / 1249490 
soft tissue/muscle tissue tumor0 / 1251910 
uterine tumor0 / 902570 
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adipose tissue0 / 131060 
adrenal gland0 / 331970 
ascites2 / 4001549
bladder1 / 2975733
blood0 / 1234780 
bone0 / 716550 
bone marrow0 / 488010 
brain55 / 110098949
cervix0 / 481710 
connective tissue0 / 1492550 
ear0 / 162120 
embryonic tissue1 / 2157224
esophagus0 / 202090 
eye5 / 21105423
heart1 / 8962611
intestine0 / 2344720 
kidney6 / 21177728
larynx0 / 241450 
liver17 / 20774381
lung7 / 33697420
lymph0 / 442700 
lymph node0 / 916100 
mammary gland2 / 15327113
mouth0 / 670520 
muscle1 / 1077159
nerve0 / 157680 
ovary0 / 1020510 
pancreas0 / 2148120 
parathyroid4 / 20539194
pharynx0 / 413280 
pituitary gland0 / 165850 
placenta0 / 2808250 
prostate7 / 18934536
salivary gland0 / 201550 
skin1 / 2105744
spleen0 / 539520 
stomach0 / 966190 
testis2 / 3304426
thymus0 / 811310 
thyroid1 / 4747321
tonsil0 / 169990 
trachea1 / 5241319
umbilical cord0 / 136800 
uterus0 / 2328780 
vascular0 / 517800 
Microarray in BioGPS Top
Select probe  
  • Microarray Platform: GeneAtlas U133A, gcrma
  • Affymatrix Probe ID: 205531_s_at
Cell line Expression level Expression bar
721_B_lymphoblasts13.8
Adipocyte33.45
AdrenalCortex44.2
Adrenalgland32.15
Amygdala49.4
Appendix37.65
AtrioventricularNode30.1
BDCA4+_DentriticCells16.95
Bonemarrow42.4
BronchialEpithelialCells28.7
CD105+_Endothelial25.15
CD14+_Monocytes24.3
CD19+_BCells(neg._sel.)23.35
CD33+_Myeloid29
CD34+33.55
CD4+_Tcells33.95
CD56+_NKCells11
CD71+_EarlyErythroid30.8
CD8+_Tcells32.1
CardiacMyocytes57.6
Caudatenucleus84.8
Cerebellum137.95
CerebellumPeduncles102.1
CiliaryGanglion26.65
CingulateCortex70.95
Colorectaladenocarcinoma125.7
DorsalRootGanglion32.15
FetalThyroid31.5
Fetalbrain40.4
Fetalliver200.55
Fetallung78.9
GlobusPallidus60.2
Heart49.85
Hypothalamus46
Kidney31.25
Leukemia_chronicMyelogenousK-56231.25
Leukemia_promyelocytic-HL-6030.4
Leukemialymphoblastic(MOLT-4)27.25
Liver1155.6
Lung37.25
Lymphnode42.65
Lymphoma_burkitts(Daudi)92
Lymphoma_burkitts(Raji)47.4
MedullaOblongata61.25
OccipitalLobe77.65
OlfactoryBulb27
Ovary24.95
Pancreas73.7
PancreaticIslet110
ParietalLobe82.75
Pituitary104.15
Placenta35.05
Pons64.4
PrefrontalCortex74.6
Prostate37.65
Salivarygland27.8
SkeletalMuscle39.35
Skin29.05
SmoothMuscle38.4
Spinalcord38.25
SubthalamicNucleus105.5
SuperiorCervicalGanglion43.15
TemporalLobe45.6
Testis29.8
TestisGermCell27.45
TestisIntersitial28.45
TestisLeydigCell35.1
TestisSeminiferousTubule31.65
Thalamus69.45
Thymus27.1
Thyroid39.9
Tongue36
Tonsil33.6
Trachea36.2
TrigeminalGanglion35.4
Uterus27.55
UterusCorpus22.95
WholeBlood35.1
Wholebrain145.3
colon34.15
pineal_day54.54
pineal_night45.68
retina47.75
small_intestine33
Allen Brain Atlas Top
Human Whole Brain Microarrayview in Allen Brain Atlas
  • Probe id     Donor id      
  • Probe name: CUST_7892_PI416261804
  • Donor H0351.2001
  • Sex: Male     Age: 24 years     Race/Ethnicity: African American     Handedness: Left
  • Tissue Receipt Date: 7/29/2009     Serology: Pass      Tissue pH :6.72     Additional Medical Information :History of asthma
  • Postmortem Interval: 23 hours (estimated time of death to time that tissue is frozen)
  • Toxicology: Positive for atropine and caffeine, at levels usually not toxicologically significant
Tissue Expression(mean ± stddev) Expression Bar
Amygdala6.67 ± 0.53
Basal Forebrain6.36 ± 0.34
Basal Part of Pons7.55 ± 0.21
Cerebellar Cortex7.04 ± 0.24
Cerebellar Nuclei6.84 ± 0.96
Claustrum6.8 ± 0.42
Epithalamus5.9 ± 0.92
Frontal Lobe6.69 ± 0.55
Globus Pallidus5.18 ± 0.47
Hypothalamus6.59 ± 0.85
Insula6.62 ± 0.32
Limbic Lobe6.74 ± 0.57
Mesencephalon6.47 ± 0.67
Myelencephalon6.57 ± 0.71
Occipital Lobe7.09 ± 0.47
Parietal Lobe6.9 ± 0.49
Pontine Tegmentum6.62 ± 0.46
Striatum6.28 ± 0.5
Subthalamus6.54 ± 0.69
Temporal Lobe6.67 ± 0.44
Thalamus6.41 ± 0.5
White Matter3.69 ± 0.79
Mouse Brain ISH
Gene Symbol Brain Structure ID Brain Structure Name Express Desity/Level (Meatured by ISH) Express Bar
Gls2CBCerebellum19.76
23.32
Gls2CTXCerebral cortex49.21
35
Gls2HIPHippocampal region20.93
22.38
Gls2HPFHippocampal formation19.14
17.84
Gls2HYHypothalamus11.91
9.09
Gls2LSXLateral septal complex1.61
1
Gls2MBMidbrain20.69
18.18
Gls2MYMedulla30.75
33.04
Gls2OLFOlfactory bulb30.31
23.33
Gls2PPons20.25
20.76
Gls2PALPallidum12.67
11.97
Gls2RHPRetrohippocampal region15.74
10.95
Gls2sAMYStriatum-like amygdalar nuclei11.78
7.95
Gls2STRStriatum10.58
7.55
Gls2STRdStriatum dorsal region11.82
8.61
Gls2STRvStriatum ventral region7.5
5.43
Gls2THThalamus13.36
11.39
Peptide Top

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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