AutismKB 2.0

Annotation Detail for GPC3


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Basic Information Top
Gene Symbol:GPC3 ( DGSX,GTR2-2,MXR7,OCI-5,SDYS,SGB,SGBS,SGBS1 )
Gene Full Name: glypican 3
Band: Xq26.2
Quick LinksEntrez ID:2719; OMIM: 300037; Uniprot ID:GPC3_HUMAN; ENSEMBL ID: ENSG00000147257; HGNC ID: 4451
Relate to Another Database: SFARIGene; denovo-db
Unigene EST Top
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
embryoid body18 / 70761254
blastocyst2 / 6231932
fetus124 / 564012219
neonate19 / 31097610
infant0 / 236200 
juvenile70 / 555561259
adult312 / 1939121160
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adrenal tumor0 / 127940 
bladder carcinoma1 / 1747557
breast (mammary gland) tumor16 / 94178169
cervical tumor0 / 343660 
chondrosarcoma3 / 8282336
colorectal tumor1 / 1142468
esophageal tumor0 / 172900 
gastrointestinal tumor0 / 1193690 
germ cell tumor48 / 263845181
glioma0 / 1068830 
head and neck tumor19 / 136302139
kidney tumor5 / 6895972
leukemia3 / 9584231
liver tumor100 / 963591037
lung tumor2 / 10312719
lymphoma0 / 717550 
non-neoplasia0 / 972500 
normal468 / 3360307139
ovarian tumor3 / 7668239
pancreatic tumor1 / 1046169
primitive neuroectodermal tumor of the CNS0 / 1256800 
prostate cancer0 / 1026800 
retinoblastoma0 / 463560 
skin tumor0 / 1249490 
soft tissue/muscle tissue tumor6 / 12519147
uterine tumor0 / 902570 
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adipose tissue0 / 131060 
adrenal gland1 / 3319730
ascites0 / 400150 
bladder0 / 297570 
blood3 / 12347824
bone1 / 7165513
bone marrow0 / 488010 
brain5 / 11009894
cervix0 / 481710 
connective tissue9 / 14925560
ear1 / 1621261
embryonic tissue48 / 215722222
esophagus0 / 202090 
eye8 / 21105437
heart21 / 89626234
intestine1 / 2344724
kidney33 / 211777155
larynx0 / 241450 
liver112 / 207743539
lung37 / 336974109
lymph0 / 442700 
lymph node0 / 916100 
mammary gland17 / 153271110
mouth19 / 67052283
muscle5 / 10771546
nerve0 / 157680 
ovary10 / 10205197
pancreas3 / 21481213
parathyroid0 / 205390 
pharynx1 / 4132824
pituitary gland3 / 16585180
placenta213 / 280825758
prostate1 / 1893455
salivary gland0 / 201550 
skin5 / 21057423
spleen3 / 5395255
stomach0 / 966190 
testis28 / 33044284
thymus4 / 8113149
thyroid2 / 4747342
tonsil0 / 169990 
trachea1 / 5241319
umbilical cord14 / 136801023
uterus5 / 23287821
vascular1 / 5178019
Microarray in BioGPS Top
Select probe  
  • Microarray Platform: GeneAtlas U133A, gcrma
  • Affymatrix Probe ID: 209220_at
Cell line Expression level Expression bar
721_B_lymphoblasts6.2
Adipocyte30.85
AdrenalCortex5.25
Adrenalgland4.2
Amygdala5.15
Appendix5.2
AtrioventricularNode4.55
BDCA4+_DentriticCells5.25
Bonemarrow4.95
BronchialEpithelialCells4.95
CD105+_Endothelial4.85
CD14+_Monocytes5.1
CD19+_BCells(neg._sel.)5.1
CD33+_Myeloid6.1
CD34+6.15
CD4+_Tcells5.5
CD56+_NKCells5.3
CD71+_EarlyErythroid4.65
CD8+_Tcells4.8
CardiacMyocytes6.4
Caudatenucleus4.45
Cerebellum4
CerebellumPeduncles5.65
CiliaryGanglion3.55
CingulateCortex5.1
Colorectaladenocarcinoma4.95
DorsalRootGanglion6.45
FetalThyroid7.2
Fetalbrain4.95
Fetalliver1071.75
Fetallung296.5
GlobusPallidus3.7
Heart6.9
Hypothalamus5.4
Kidney6.1
Leukemia_chronicMyelogenousK-5624.5
Leukemia_promyelocytic-HL-604.45
Leukemialymphoblastic(MOLT-4)4.05
Liver9.45
Lung45.05
Lymphnode4.65
Lymphoma_burkitts(Daudi)6
Lymphoma_burkitts(Raji)7.05
MedullaOblongata4.35
OccipitalLobe4.15
OlfactoryBulb38.7
Ovary3.95
Pancreas5.1
PancreaticIslet8.35
ParietalLobe5.05
Pituitary43
Placenta2479
Pons4.75
PrefrontalCortex6.2
Prostate5.8
Salivarygland4.15
SkeletalMuscle6.7
Skin5.25
SmoothMuscle5.35
Spinalcord5.3
SubthalamicNucleus4.6
SuperiorCervicalGanglion6.75
TemporalLobe4.35
Testis5
TestisGermCell4.3
TestisIntersitial4.2
TestisLeydigCell4.95
TestisSeminiferousTubule4.05
Thalamus4.95
Thymus4
Thyroid6.55
Tongue17.6
Tonsil4.95
Trachea4.3
TrigeminalGanglion5.05
Uterus4.1
UterusCorpus4.6
WholeBlood5.45
Wholebrain3.75
colon5.05
pineal_day6.24
pineal_night6.08
retina18.45
small_intestine4.9
Allen Brain Atlas Top
Human Whole Brain Microarrayview in Allen Brain Atlas
  • Probe id     Donor id      
  • Probe name: CUST_14672_PI416261804
  • Donor H0351.2001
  • Sex: Male     Age: 24 years     Race/Ethnicity: African American     Handedness: Left
  • Tissue Receipt Date: 7/29/2009     Serology: Pass      Tissue pH :6.72     Additional Medical Information :History of asthma
  • Postmortem Interval: 23 hours (estimated time of death to time that tissue is frozen)
  • Toxicology: Positive for atropine and caffeine, at levels usually not toxicologically significant
Tissue Expression(mean ± stddev) Expression Bar
Amygdala2.76 ± 1.06
Basal Forebrain2.57 ± 0.43
Basal Part of Pons2 ± 0.31
Cerebellar Cortex2.25 ± 0.7
Cerebellar Nuclei2.75 ± 0.85
Claustrum3.3 ± 0.91
Epithalamus2.29 ± 0.86
Frontal Lobe2.39 ± 0.91
Globus Pallidus3.09 ± 0.78
Hypothalamus3.35 ± 0.92
Insula2.13 ± 0.42
Limbic Lobe2.34 ± 0.67
Mesencephalon2.6 ± 0.73
Myelencephalon2.54 ± 0.76
Occipital Lobe2.38 ± 0.58
Parietal Lobe2.38 ± 0.76
Pontine Tegmentum2.6 ± 0.92
Striatum2.74 ± 0.67
Subthalamus2.5 ± 0.7
Temporal Lobe2.36 ± 0.74
Thalamus2.37 ± 0.67
White Matter2.76 ± 0.22
Mouse Brain ISH
Gene Symbol Brain Structure ID Brain Structure Name Express Desity/Level (Meatured by ISH) Express Bar
Gpc3CBCerebellum4.64
6.18
Gpc3CTXCerebral cortex8.72
6.66
Gpc3HIPHippocampal region11.21
14.59
Gpc3HPFHippocampal formation13.78
16.31
Gpc3HYHypothalamus28.22
30.84
Gpc3LSXLateral septal complex49.09
61.31
Gpc3MBMidbrain11.62
13.7
Gpc3MYMedulla11.22
12.07
Gpc3OLFOlfactory bulb14.59
11.68
Gpc3PPons9.61
11.52
Gpc3PALPallidum27.67
33.29
Gpc3RHPRetrohippocampal region18.2
18.35
Gpc3sAMYStriatum-like amygdalar nuclei34.05
32.57
Gpc3STRStriatum12.35
11.9
Gpc3STRdStriatum dorsal region6.21
5.3
Gpc3STRvStriatum ventral region13.12
12.86
Gpc3THThalamus9.6
8.47
Peptide Top
Peptide Name Peptide Lengh Peptide Start Peptide End Peptide Sequence Source
PAp00502034 13 375 387 VAHVEHEETLSSR Peptide Atlas

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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