AutismKB 2.0

Annotation Detail for ARHGEF16


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Basic Information Top
Gene Symbol:ARHGEF16 ( GEF16,NBR )
Gene Full Name: Rho guanine nucleotide exchange factor (GEF) 16
Band: 1p36.32
Quick LinksEntrez ID:27237; OMIM: NA; Uniprot ID:ARHGG_HUMAN; ENSEMBL ID: ENSG00000130762; HGNC ID: 15515
Relate to Another Database: SFARIGene; denovo-db
Unigene EST Top
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
embryoid body2 / 7076128
blastocyst1 / 6231916
fetus3 / 5640125
neonate0 / 310970 
infant0 / 236200 
juvenile1 / 5555617
adult42 / 193912121
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adrenal tumor0 / 127940 
bladder carcinoma0 / 174750 
breast (mammary gland) tumor4 / 9417842
cervical tumor0 / 343660 
chondrosarcoma0 / 828230 
colorectal tumor4 / 11424635
esophageal tumor1 / 1729057
gastrointestinal tumor16 / 119369134
germ cell tumor8 / 26384530
glioma2 / 10688318
head and neck tumor3 / 13630222
kidney tumor0 / 689590 
leukemia1 / 9584210
liver tumor0 / 963590 
lung tumor2 / 10312719
lymphoma0 / 717550 
non-neoplasia0 / 972500 
normal38 / 336030711
ovarian tumor6 / 7668278
pancreatic tumor8 / 10461676
primitive neuroectodermal tumor of the CNS0 / 1256800 
prostate cancer1 / 1026809
retinoblastoma0 / 463560 
skin tumor1 / 1249498
soft tissue/muscle tissue tumor1 / 1251917
uterine tumor2 / 9025722
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adipose tissue0 / 131060 
adrenal gland0 / 331970 
ascites3 / 4001574
bladder0 / 297570 
blood0 / 1234780 
bone0 / 716550 
bone marrow0 / 488010 
brain8 / 11009897
cervix4 / 4817183
connective tissue0 / 1492550 
ear0 / 162120 
embryonic tissue3 / 21572213
esophagus1 / 2020949
eye2 / 2110549
heart0 / 896260 
intestine12 / 23447251
kidney6 / 21177728
larynx0 / 241450 
liver0 / 2077430 
lung6 / 33697417
lymph0 / 442700 
lymph node0 / 916100 
mammary gland5 / 15327132
mouth4 / 6705259
muscle2 / 10771518
nerve2 / 15768126
ovary6 / 10205158
pancreas10 / 21481246
parathyroid0 / 205390 
pharynx0 / 413280 
pituitary gland0 / 165850 
placenta8 / 28082528
prostate4 / 18934521
salivary gland0 / 201550 
skin2 / 2105749
spleen0 / 539520 
stomach14 / 96619144
testis1 / 3304423
thymus0 / 811310 
thyroid0 / 474730 
tonsil0 / 169990 
trachea2 / 5241338
umbilical cord0 / 136800 
uterus2 / 2328788
vascular0 / 517800 
Microarray in BioGPS Top
Select probe  
  • Microarray Platform: GeneAtlas U133A, gcrma
  • Affymatrix Probe ID: 208009_s_at
Cell line Expression level Expression bar
721_B_lymphoblasts6.7
Adipocyte5.25
AdrenalCortex7.4
Adrenalgland5.35
Amygdala5.8
Appendix5.5
AtrioventricularNode4.25
BDCA4+_DentriticCells5.6
Bonemarrow6.35
BronchialEpithelialCells5.85
CD105+_Endothelial5.5
CD14+_Monocytes5.65
CD19+_BCells(neg._sel.)5.65
CD33+_Myeloid7.05
CD34+6.45
CD4+_Tcells5.85
CD56+_NKCells6.2
CD71+_EarlyErythroid5.05
CD8+_Tcells5.2
CardiacMyocytes8.85
Caudatenucleus5.05
Cerebellum4.45
CerebellumPeduncles6.1
CiliaryGanglion3.9
CingulateCortex7.6
Colorectaladenocarcinoma6.7
DorsalRootGanglion5.05
FetalThyroid7.8
Fetalbrain6.1
Fetalliver4.75
Fetallung6.2
GlobusPallidus4.85
Heart8.8
Hypothalamus5.95
Kidney9.7
Leukemia_chronicMyelogenousK-5625.6
Leukemia_promyelocytic-HL-604.7
Leukemialymphoblastic(MOLT-4)4.4
Liver7.5
Lung5.85
Lymphnode6.2
Lymphoma_burkitts(Daudi)7.1
Lymphoma_burkitts(Raji)7.75
MedullaOblongata5
OccipitalLobe4.95
OlfactoryBulb10.45
Ovary3.85
Pancreas6.9
PancreaticIslet7
ParietalLobe7.05
Pituitary6.4
Placenta5.6
Pons9.25
PrefrontalCortex6.7
Prostate7.75
Salivarygland4.4
SkeletalMuscle7.2
Skin4.35
SmoothMuscle6.1
Spinalcord6.25
SubthalamicNucleus4.95
SuperiorCervicalGanglion8.9
TemporalLobe5.4
Testis5.05
TestisGermCell4.75
TestisIntersitial4.6
TestisLeydigCell6
TestisSeminiferousTubule6.8
Thalamus5.55
Thymus5.2
Thyroid9.65
Tongue7.4
Tonsil7.3
Trachea6.65
TrigeminalGanglion6.05
Uterus4.45
UterusCorpus5.25
WholeBlood5.85
Wholebrain4.5
colon8.1
pineal_day6.82
pineal_night6.64
retina6.575
small_intestine5.65
Allen Brain Atlas Top
Human Whole Brain Microarrayview in Allen Brain Atlas
  • Probe id     Donor id      
  • Probe name: CUST_2148_PI416261804
  • Donor H0351.2001
  • Sex: Male     Age: 24 years     Race/Ethnicity: African American     Handedness: Left
  • Tissue Receipt Date: 7/29/2009     Serology: Pass      Tissue pH :6.72     Additional Medical Information :History of asthma
  • Postmortem Interval: 23 hours (estimated time of death to time that tissue is frozen)
  • Toxicology: Positive for atropine and caffeine, at levels usually not toxicologically significant
Tissue Expression(mean ± stddev) Expression Bar
Amygdala2.68 ± 1.06
Basal Forebrain2.34 ± 0.77
Basal Part of Pons2.79 ± 0.72
Cerebellar Cortex2.21 ± 0.84
Cerebellar Nuclei2.87 ± 0.64
Claustrum2.82 ± 0.69
Epithalamus1.89 ± 0.83
Frontal Lobe2.43 ± 0.79
Globus Pallidus2.52 ± 0.77
Hypothalamus2.57 ± 0.67
Insula2.18 ± 0.72
Limbic Lobe2.44 ± 0.81
Mesencephalon2.57 ± 0.74
Myelencephalon2.45 ± 0.73
Occipital Lobe2.4 ± 0.93
Parietal Lobe2.44 ± 0.82
Pontine Tegmentum2.36 ± 0.83
Striatum2.43 ± 0.71
Subthalamus2.88 ± 0.82
Temporal Lobe2.42 ± 0.89
Thalamus2.53 ± 0.69
White Matter1.91 ± 0.5
Mouse Brain ISH
Gene Symbol Brain Structure ID Brain Structure Name Express Desity/Level (Meatured by ISH) Express Bar
Arhgef16PPons0.67
0.49
Peptide Top
Peptide Name Peptide Lengh Peptide Start Peptide End Peptide Sequence Source
PAp00027553 19 408 426 RPACGGLPMLSFLILPMQR Peptide Atlas

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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